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The map label for this gene is kinA [H]

Identifier: 138894544

GI number: 138894544

Start: 947148

End: 948404

Strand: Direct

Name: kinA [H]

Synonym: GTNG_0874

Alternate gene names: 138894544

Gene position: 947148-948404 (Clockwise)

Preceding gene: 138894543

Following gene: 138894547

Centisome position: 26.68

GC content: 47.89

Gene sequence:

>1257_bases
ATGGCAATTTACGTTACAGGTAGTGTTTTATGGCTAACTGTCACCGACTCCCTGCTCAATGTGCTGACGGTCAGCCGCGG
CGTGTACGTTGCGCTTAGCGCCGCCAAAGGGACGGTCTTTATTTTTCTGTCGGTCGTGTTCTTATATCAGCTGCTAAAAA
AACACGAACAGCTTGTGAAAGTGGAAGAAAATGAACAGCAGTTGTTGAAGCTCATTAACTCGATGCCCGACTTTGTTTGT
TTTAAAGACAGCGAAGGGCGGTGGCTGCGCGTCAATGATTTCGGTCGGCGGCTTTACCATCTCGAGCATATTGATTATGT
CGGAAAAACGGATCGCGAGCTTGGCGAACTCGTACCCTTTTTCAAAGATGCGTTTGAGCAGTGTATCGAATCGGATCGCG
AGGCGTGGGAAATCGGGGCGTTGACGCGCCGCGAGGAGTCGCTCGAGACGCCGGATGGGGAACTGAAGACATTTGATGTC
ATTAAAGTGCCGCTGTTTGAAGAAAACGGTGCGCGAAAAGGATTGTTAACGATCGGGCGAGACATTACCCAACAAAAGCG
CACCGAGGAGTTGCTGCTGAAAAAAGAGAAGCTGTCGGTGCTCGGAGAGCTAGCAGCTGGCATTGCTCATGAAATTCGCA
ATCCGCTTACCTCACTAAAAGGCTTTATGCAAGTGATGCAAGAAACGCGTGAAGTGAATGATGACCACGTGCGCATTATG
CTGAGTGAGCTTGGCCGCGTCAACCAAATCGTCAGCGAGCTGCTTGTGCTGGCTAAGCCGCAAAGTCCTGATTACCGGCC
GTTTTTGTTGGAAGAGGCCATTTCCTATGTTATTAACCTCATCGGTCATGAGGCGACATTAAATAACGTTTCCATTTCCG
TTCGTAACAACGCGCCAAAAGCTTGCGTGTATGGCGACCAAAACCAAATTGTTCAAGTGCTTTTAAACGTTATGAAAAAC
GCTATTGAAGCAATGCCGAATGGAGGAAACTTGCATGTCCATGTTTCTGAAGCTGAAAGTCTGATCCGTTTGGACATTGC
TGACACTGGCATCGGCATTTCGAAAGAGCGGTTGCAAAAAATCGGTGAGCCATTTTTTACTTTGAAAGAAAAAGGAATGG
GGCTTGGACTGACAACAAGCATGAAAATTGTCCAAGAACATAAAGGGACAATGCAGATTGAAAGTGAAGTTGGAAAAGGA
ACGGTCGTCCACTTGACGTTTCCGTCCGGGTGTGCGTTTGTAGACGCGAATGACTAG

Upstream 100 bases:

>100_bases
CTCGGATGGGCGCGAGAGATGTAGACCAGCGGATGGCGCGGCCGCCACTGACTTTGTATGTTAGGGGTTCGATGACAAAG
TGTTAAACAAATCAAAAGTC

Downstream 100 bases:

>100_bases
CAGAAGATGACATCCTAGAAACAGGCGTTCCCAAATGGTGTGGGAACGCCTGCTTTGCTATTGCTCCACCCACGTCGACA
AGGTCTCGATGGGCAACCGG

Product: sporulation kinase A

Products: NA

Alternate protein names: Stage II sporulation protein F; Stage II sporulation protein J [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MAIYVTGSVLWLTVTDSLLNVLTVSRGVYVALSAAKGTVFIFLSVVFLYQLLKKHEQLVKVEENEQQLLKLINSMPDFVC
FKDSEGRWLRVNDFGRRLYHLEHIDYVGKTDRELGELVPFFKDAFEQCIESDREAWEIGALTRREESLETPDGELKTFDV
IKVPLFEENGARKGLLTIGRDITQQKRTEELLLKKEKLSVLGELAAGIAHEIRNPLTSLKGFMQVMQETREVNDDHVRIM
LSELGRVNQIVSELLVLAKPQSPDYRPFLLEEAISYVINLIGHEATLNNVSISVRNNAPKACVYGDQNQIVQVLLNVMKN
AIEAMPNGGNLHVHVSEAESLIRLDIADTGIGISKERLQKIGEPFFTLKEKGMGLGLTTSMKIVQEHKGTMQIESEVGKG
TVVHLTFPSGCAFVDAND

Sequences:

>Translated_418_residues
MAIYVTGSVLWLTVTDSLLNVLTVSRGVYVALSAAKGTVFIFLSVVFLYQLLKKHEQLVKVEENEQQLLKLINSMPDFVC
FKDSEGRWLRVNDFGRRLYHLEHIDYVGKTDRELGELVPFFKDAFEQCIESDREAWEIGALTRREESLETPDGELKTFDV
IKVPLFEENGARKGLLTIGRDITQQKRTEELLLKKEKLSVLGELAAGIAHEIRNPLTSLKGFMQVMQETREVNDDHVRIM
LSELGRVNQIVSELLVLAKPQSPDYRPFLLEEAISYVINLIGHEATLNNVSISVRNNAPKACVYGDQNQIVQVLLNVMKN
AIEAMPNGGNLHVHVSEAESLIRLDIADTGIGISKERLQKIGEPFFTLKEKGMGLGLTTSMKIVQEHKGTMQIESEVGKG
TVVHLTFPSGCAFVDAND
>Mature_417_residues
AIYVTGSVLWLTVTDSLLNVLTVSRGVYVALSAAKGTVFIFLSVVFLYQLLKKHEQLVKVEENEQQLLKLINSMPDFVCF
KDSEGRWLRVNDFGRRLYHLEHIDYVGKTDRELGELVPFFKDAFEQCIESDREAWEIGALTRREESLETPDGELKTFDVI
KVPLFEENGARKGLLTIGRDITQQKRTEELLLKKEKLSVLGELAAGIAHEIRNPLTSLKGFMQVMQETREVNDDHVRIML
SELGRVNQIVSELLVLAKPQSPDYRPFLLEEAISYVINLIGHEATLNNVSISVRNNAPKACVYGDQNQIVQVLLNVMKNA
IEAMPNGGNLHVHVSEAESLIRLDIADTGIGISKERLQKIGEPFFTLKEKGMGLGLTTSMKIVQEHKGTMQIESEVGKGT
VVHLTFPSGCAFVDAND

Specific function: Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. It also autophosphorylates in the presence of ATP [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=36.697247706422, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=30.0411522633745, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI48994928, Length=386, Percent_Identity=24.3523316062176, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786600, Length=252, Percent_Identity=27.3809523809524, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790300, Length=234, Percent_Identity=28.2051282051282, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788393, Length=202, Percent_Identity=25.2475247524752, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1786783, Length=237, Percent_Identity=26.5822784810127, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789149, Length=226, Percent_Identity=24.7787610619469, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI145693157, Length=371, Percent_Identity=22.911051212938, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=22.9074889867841, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790551, Length=191, Percent_Identity=25.130890052356, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1790346, Length=217, Percent_Identity=25.3456221198157, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR013655
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF08447 PAS_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46866; Mature: 46735

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIYVTGSVLWLTVTDSLLNVLTVSRGVYVALSAAKGTVFIFLSVVFLYQLLKKHEQLVK
CEEEEECCEEEEEEHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHC
VEENEQQLLKLINSMPDFVCFKDSEGRWLRVNDFGRRLYHLEHIDYVGKTDRELGELVPF
CCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FKDAFEQCIESDREAWEIGALTRREESLETPDGELKTFDVIKVPLFEENGARKGLLTIGR
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEECCCCCCCCHHHHHH
DITQQKRTEELLLKKEKLSVLGELAAGIAHEIRNPLTSLKGFMQVMQETREVNDDHVRIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LSELGRVNQIVSELLVLAKPQSPDYRPFLLEEAISYVINLIGHEATLNNVSISVRNNAPK
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCC
ACVYGDQNQIVQVLLNVMKNAIEAMPNGGNLHVHVSEAESLIRLDIADTGIGISKERLQK
EEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHH
IGEPFFTLKEKGMGLGLTTSMKIVQEHKGTMQIESEVGKGTVVHLTFPSGCAFVDAND
HCCCHHHHHHCCCCCCCHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCCEEEEECCC
>Mature Secondary Structure 
AIYVTGSVLWLTVTDSLLNVLTVSRGVYVALSAAKGTVFIFLSVVFLYQLLKKHEQLVK
EEEEECCEEEEEEHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHC
VEENEQQLLKLINSMPDFVCFKDSEGRWLRVNDFGRRLYHLEHIDYVGKTDRELGELVPF
CCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FKDAFEQCIESDREAWEIGALTRREESLETPDGELKTFDVIKVPLFEENGARKGLLTIGR
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEECCCCCCCCHHHHHH
DITQQKRTEELLLKKEKLSVLGELAAGIAHEIRNPLTSLKGFMQVMQETREVNDDHVRIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LSELGRVNQIVSELLVLAKPQSPDYRPFLLEEAISYVINLIGHEATLNNVSISVRNNAPK
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCC
ACVYGDQNQIVQVLLNVMKNAIEAMPNGGNLHVHVSEAESLIRLDIADTGIGISKERLQK
EEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHH
IGEPFFTLKEKGMGLGLTTSMKIVQEHKGTMQIESEVGKGTVVHLTFPSGCAFVDAND
HCCCHHHHHHCCCCCCCHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2104615; 2509430; 9384377 [H]