Click here to switch to the map view.

The map label for this gene is clpB [H]

Identifier: 138894350

GI number: 138894350

Start: 756747

End: 759332

Strand: Direct

Name: clpB [H]

Synonym: GTNG_0678

Alternate gene names: 138894350

Gene position: 756747-759332 (Clockwise)

Preceding gene: 138894349

Following gene: 138894351

Centisome position: 21.31

GC content: 54.56

Gene sequence:

>2586_bases
ATGGACGCAAGCCGTTTGACAGAAAAACTGCAAGAAGCGCTCATGGCGGCGCAGTCGCTCGCCAAAGAACGCCATCATCA
ACAGCTTGATGTTGAGCATCTTCTGAGCGCGCTGCTTGAACAAGAAGGTGGCTTGGCGCCGCGGCTGTTGGAGCTTTCCG
GTGCCGATCGGAACAAGGTAGTCGGTTTTCTAAACGAGCAGCTTCGTCATAAGCCGGAAGTGCACGGGACGGAGGGGCAG
CTATACATTGCCCCGGCGTTGGCGCGGCTGCTTGACGAAGCAGAAGCCGAAGCGAAACGAATGCAAGATGAATACGTGTC
GGTTGAGCATGTGCTGCTCGCTTTGCCGTCCGGTGCTGAGCATATCGCCCGGCGTCTGGCGTCGTTTGGGTTGACACGTG
AAGCGCTGTTGACAGCATTGACAAAAGTAAGGGGGAATCAACGCGTGACAAGTCCGCATCCGGAAGCGACGTATGAGGCG
TTGACAAAATATGGGCGCGATTTAGTCGCCGAAGTGAAGGCGGGAAAAATCGACCCGGTGATTGGCCGTGACAGTGAAAT
TCGTCGCGTGATTCGCATTTTGTCACGGAAAACGAAAAACAATCCAGTGCTGATCGGCGAACCGGGCGTTGGGAAAACGG
CCATTGTTGAAGGGCTCGCCCAGCGCATCGTCCGCAAAGACGTTCCGGAAGGGCTGAAAGACAAAACGATTTTCGCGCTT
GATATGAGCGCGCTTGTTGCCGGGGCGAAGTTTCGCGGCGAATTTGAGGAGCGGCTGAAGGCGGTACTGAACGAAATCAA
AAAAAGCGATGGCCGTATCATTTTGTTTATTGATGAGCTACATACGATTGTTGGTGCCGGTAAGGCAGAAGGGGCGATCG
ACGCCGGCAATATGTTGAAGCCGATGCTCGCCCGCGGCGAACTGCGCTGCATCGGGGCAACGACGCTGGATGAATATCGA
CAATATATTGAAAAAGACCCAGCGCTCGAGCGCCGTTTCCAGCAAGTGCTCGTCGAAGAGCCGAGCGTTGAAGATACGAT
TTCGATTTTGCGTGGATTAAAAGAACGGTACGAAGTGCACCATGGCGTGAAAATTCACGACCGTGCGCTCGTCGCGGCCG
CAGTATTGTCTGACCGTTACATTTCCGACCGCTTTTTGCCTGATAAAGCGATTGATTTGGTCGATGAAGCGTGCGCAACG
ATCCGCACGGAAATGGAATCGATGCCGTCCGAGCTCGATGAGGTGATGCGCCGCGTCATGCAGCTTGAAATCGAAGAGGC
TGCCTTAAGCAAAGAAACAGATGAGGCAAGTCGGACACGGCTTGAGGCGCTGCAAAATGAACTTGCTAACTTGCGCGAGA
GAGCGAATGCCATGAAAGCAAAATGGCAACAAGAAAAAGAGACGCTCGATCGTGTCCGCCGCGTGCGCGAGGAGCTCGAA
CGGGCCAAGCGCGAGCTTGAAGAAGCAGAAAACGACTACGATTTAAACAAAGCGGCCGAATTGCGCCATGGACGCATCCC
GCAGCTTGAGAAACAACTGAAGCAGCTCGAGCAGGAAGCAAGCGGCCAAGGAGAAGGAAAGCTGTTGCGCGAGGAAGTGA
CGGAAGAAGAAATCGCCGAAATTGTTTCACGTTGGACCGGCATTCCACTCACCCGCCTTGTGGAAGGGGAAAGAGAGAAG
CTGCTCCGTCTCCATGAATTGCTGCACGAGCGGGTCATCGGCCAAGACGAGGCGGTCGAACTTGTCGCTGATGCCGTCTT
GCGGGCGAGAGCGGGCATTAAAGACCCGAATCGCCCGATCGGTTCGTTTCTTTTTCTCGGCCCGACCGGTGTCGGCAAAA
CAGAGCTCGCCAAAACGCTCGCCGAAGCGCTGTTTGACAGCGAAGAGCAGCTAATTCGTCTTGACATGTCCGAGTATATG
GAAAAGCATGCCGTTTCCCGCCTGATCGGGGCGCCGCCTGGTTATGTCGGCTACGAGGAAGGCGGTCAGCTGACAGAGGC
GGTGCGGCGCAAGCCATATTCCGTTTTGCTGCTTGATGAAATCGAAAAAGCGCACCCGGACGTGTTTAATCTTTTGCTAC
AGCTGTTGGATGATGGACGGCTCACTGACTCGCAAGGACGGACCGTCGATTTTAAAAACACGGTCGTCATTATGACGTCT
AACATCGGCTCGCCGCTCTTATTAGAAAGCCGCAACGGCGAAATCGAAGAAGAGACACGGAAACAGGTGCTTGATCAACT
GCGCGCCCATTTCCGCCCCGAGTTTTTAAACCGGATCGATGATGTCGTCTTGTTTAAGCCGCTGTCAACGAATGAGGTCA
AAGGCATCGTCGCTAAGTTTGCCCGCGAATTGTCGCGTCGTTTGGCCGATCGGCATATTGAGCTCGTGCTGACGGAAGAA
GCGAAACAGCATATCGCCGAAGCCGGCTTTGATCCGGTATACGGCGCCCGCCCCTTGAAGCGGTTTATGCAAAAGCAGAT
TGAAACCCCGCTTGCCAAAGAGTTGATCGCCGGGCGGGTGAAAGATTACAGCACTGTCACGGTCGATGTCGAAAACGGCC
AGCTTGTGATCCGTCCGTCCGCGTAA

Upstream 100 bases:

>100_bases
AAAAAAGCCATTCCGTTTTGGAGTGGCTTTTGATTTGCCGTGCGCCGTGCAATCCGCTATAATGATTTATAGTCAAAGAA
GGTCAAATGGAGGGAACGGC

Downstream 100 bases:

>100_bases
AAACGTTTTTAGGCGAAGGGGCTATATCACTGACGGGAGAGATGGTTTCTTTTGACGGCAACGAAAAATGGTGCGGCGGT
CCAAAAGGTGTCCCGATATA

Product: ATP-dependent Clp protease, ATP-binding subunit ClpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 861; Mature: 861

Protein sequence:

>861_residues
MDASRLTEKLQEALMAAQSLAKERHHQQLDVEHLLSALLEQEGGLAPRLLELSGADRNKVVGFLNEQLRHKPEVHGTEGQ
LYIAPALARLLDEAEAEAKRMQDEYVSVEHVLLALPSGAEHIARRLASFGLTREALLTALTKVRGNQRVTSPHPEATYEA
LTKYGRDLVAEVKAGKIDPVIGRDSEIRRVIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVRKDVPEGLKDKTIFAL
DMSALVAGAKFRGEFEERLKAVLNEIKKSDGRIILFIDELHTIVGAGKAEGAIDAGNMLKPMLARGELRCIGATTLDEYR
QYIEKDPALERRFQQVLVEEPSVEDTISILRGLKERYEVHHGVKIHDRALVAAAVLSDRYISDRFLPDKAIDLVDEACAT
IRTEMESMPSELDEVMRRVMQLEIEEAALSKETDEASRTRLEALQNELANLRERANAMKAKWQQEKETLDRVRRVREELE
RAKRELEEAENDYDLNKAAELRHGRIPQLEKQLKQLEQEASGQGEGKLLREEVTEEEIAEIVSRWTGIPLTRLVEGEREK
LLRLHELLHERVIGQDEAVELVADAVLRARAGIKDPNRPIGSFLFLGPTGVGKTELAKTLAEALFDSEEQLIRLDMSEYM
EKHAVSRLIGAPPGYVGYEEGGQLTEAVRRKPYSVLLLDEIEKAHPDVFNLLLQLLDDGRLTDSQGRTVDFKNTVVIMTS
NIGSPLLLESRNGEIEEETRKQVLDQLRAHFRPEFLNRIDDVVLFKPLSTNEVKGIVAKFARELSRRLADRHIELVLTEE
AKQHIAEAGFDPVYGARPLKRFMQKQIETPLAKELIAGRVKDYSTVTVDVENGQLVIRPSA

Sequences:

>Translated_861_residues
MDASRLTEKLQEALMAAQSLAKERHHQQLDVEHLLSALLEQEGGLAPRLLELSGADRNKVVGFLNEQLRHKPEVHGTEGQ
LYIAPALARLLDEAEAEAKRMQDEYVSVEHVLLALPSGAEHIARRLASFGLTREALLTALTKVRGNQRVTSPHPEATYEA
LTKYGRDLVAEVKAGKIDPVIGRDSEIRRVIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVRKDVPEGLKDKTIFAL
DMSALVAGAKFRGEFEERLKAVLNEIKKSDGRIILFIDELHTIVGAGKAEGAIDAGNMLKPMLARGELRCIGATTLDEYR
QYIEKDPALERRFQQVLVEEPSVEDTISILRGLKERYEVHHGVKIHDRALVAAAVLSDRYISDRFLPDKAIDLVDEACAT
IRTEMESMPSELDEVMRRVMQLEIEEAALSKETDEASRTRLEALQNELANLRERANAMKAKWQQEKETLDRVRRVREELE
RAKRELEEAENDYDLNKAAELRHGRIPQLEKQLKQLEQEASGQGEGKLLREEVTEEEIAEIVSRWTGIPLTRLVEGEREK
LLRLHELLHERVIGQDEAVELVADAVLRARAGIKDPNRPIGSFLFLGPTGVGKTELAKTLAEALFDSEEQLIRLDMSEYM
EKHAVSRLIGAPPGYVGYEEGGQLTEAVRRKPYSVLLLDEIEKAHPDVFNLLLQLLDDGRLTDSQGRTVDFKNTVVIMTS
NIGSPLLLESRNGEIEEETRKQVLDQLRAHFRPEFLNRIDDVVLFKPLSTNEVKGIVAKFARELSRRLADRHIELVLTEE
AKQHIAEAGFDPVYGARPLKRFMQKQIETPLAKELIAGRVKDYSTVTVDVENGQLVIRPSA
>Mature_861_residues
MDASRLTEKLQEALMAAQSLAKERHHQQLDVEHLLSALLEQEGGLAPRLLELSGADRNKVVGFLNEQLRHKPEVHGTEGQ
LYIAPALARLLDEAEAEAKRMQDEYVSVEHVLLALPSGAEHIARRLASFGLTREALLTALTKVRGNQRVTSPHPEATYEA
LTKYGRDLVAEVKAGKIDPVIGRDSEIRRVIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVRKDVPEGLKDKTIFAL
DMSALVAGAKFRGEFEERLKAVLNEIKKSDGRIILFIDELHTIVGAGKAEGAIDAGNMLKPMLARGELRCIGATTLDEYR
QYIEKDPALERRFQQVLVEEPSVEDTISILRGLKERYEVHHGVKIHDRALVAAAVLSDRYISDRFLPDKAIDLVDEACAT
IRTEMESMPSELDEVMRRVMQLEIEEAALSKETDEASRTRLEALQNELANLRERANAMKAKWQQEKETLDRVRRVREELE
RAKRELEEAENDYDLNKAAELRHGRIPQLEKQLKQLEQEASGQGEGKLLREEVTEEEIAEIVSRWTGIPLTRLVEGEREK
LLRLHELLHERVIGQDEAVELVADAVLRARAGIKDPNRPIGSFLFLGPTGVGKTELAKTLAEALFDSEEQLIRLDMSEYM
EKHAVSRLIGAPPGYVGYEEGGQLTEAVRRKPYSVLLLDEIEKAHPDVFNLLLQLLDDGRLTDSQGRTVDFKNTVVIMTS
NIGSPLLLESRNGEIEEETRKQVLDQLRAHFRPEFLNRIDDVVLFKPLSTNEVKGIVAKFARELSRRLADRHIELVLTEE
AKQHIAEAGFDPVYGARPLKRFMQKQIETPLAKELIAGRVKDYSTVTVDVENGQLVIRPSA

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=329, Percent_Identity=37.6899696048632, Blast_Score=209, Evalue=8e-54,
Organism=Escherichia coli, GI1788943, Length=860, Percent_Identity=56.7441860465116, Blast_Score=952, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=319, Percent_Identity=45.4545454545455, Blast_Score=292, Evalue=6e-80,
Organism=Saccharomyces cerevisiae, GI6320464, Length=713, Percent_Identity=53.2959326788219, Blast_Score=767, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=874, Percent_Identity=42.6773455377574, Blast_Score=681, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 96843; Mature: 96843

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDASRLTEKLQEALMAAQSLAKERHHQQLDVEHLLSALLEQEGGLAPRLLELSGADRNKV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHCCCCCHHHH
VGFLNEQLRHKPEVHGTEGQLYIAPALARLLDEAEAEAKRMQDEYVSVEHVLLALPSGAE
HHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
HIARRLASFGLTREALLTALTKVRGNQRVTSPHPEATYEALTKYGRDLVAEVKAGKIDPV
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
IGRDSEIRRVIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVRKDVPEGLKDKTIFAL
CCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
DMSALVAGAKFRGEFEERLKAVLNEIKKSDGRIILFIDELHTIVGAGKAEGAIDAGNMLK
EHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHH
PMLARGELRCIGATTLDEYRQYIEKDPALERRFQQVLVEEPSVEDTISILRGLKERYEVH
HHHHCCCEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
HGVKIHDRALVAAAVLSDRYISDRFLPDKAIDLVDEACATIRTEMESMPSELDEVMRRVM
CCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLEIEEAALSKETDEASRTRLEALQNELANLRERANAMKAKWQQEKETLDRVRRVREELE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAKRELEEAENDYDLNKAAELRHGRIPQLEKQLKQLEQEASGQGEGKLLREEVTEEEIAE
HHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHH
IVSRWTGIPLTRLVEGEREKLLRLHELLHERVIGQDEAVELVADAVLRARAGIKDPNRPI
HHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GSFLFLGPTGVGKTELAKTLAEALFDSEEQLIRLDMSEYMEKHAVSRLIGAPPGYVGYEE
CCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GGQLTEAVRRKPYSVLLLDEIEKAHPDVFNLLLQLLDDGRLTDSQGRTVDFKNTVVIMTS
CCHHHHHHHCCCCEEEEHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEEC
NIGSPLLLESRNGEIEEETRKQVLDQLRAHFRPEFLNRIDDVVLFKPLSTNEVKGIVAKF
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCCCCHHHHHHHHHH
ARELSRRLADRHIELVLTEEAKQHIAEAGFDPVYGARPLKRFMQKQIETPLAKELIAGRV
HHHHHHHHHHHHHHHEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHC
KDYSTVTVDVENGQLVIRPSA
CCCCEEEEEECCCEEEEECCC
>Mature Secondary Structure
MDASRLTEKLQEALMAAQSLAKERHHQQLDVEHLLSALLEQEGGLAPRLLELSGADRNKV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHCCCCCHHHH
VGFLNEQLRHKPEVHGTEGQLYIAPALARLLDEAEAEAKRMQDEYVSVEHVLLALPSGAE
HHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
HIARRLASFGLTREALLTALTKVRGNQRVTSPHPEATYEALTKYGRDLVAEVKAGKIDPV
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
IGRDSEIRRVIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVRKDVPEGLKDKTIFAL
CCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
DMSALVAGAKFRGEFEERLKAVLNEIKKSDGRIILFIDELHTIVGAGKAEGAIDAGNMLK
EHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHH
PMLARGELRCIGATTLDEYRQYIEKDPALERRFQQVLVEEPSVEDTISILRGLKERYEVH
HHHHCCCEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
HGVKIHDRALVAAAVLSDRYISDRFLPDKAIDLVDEACATIRTEMESMPSELDEVMRRVM
CCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLEIEEAALSKETDEASRTRLEALQNELANLRERANAMKAKWQQEKETLDRVRRVREELE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAKRELEEAENDYDLNKAAELRHGRIPQLEKQLKQLEQEASGQGEGKLLREEVTEEEIAE
HHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHH
IVSRWTGIPLTRLVEGEREKLLRLHELLHERVIGQDEAVELVADAVLRARAGIKDPNRPI
HHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GSFLFLGPTGVGKTELAKTLAEALFDSEEQLIRLDMSEYMEKHAVSRLIGAPPGYVGYEE
CCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GGQLTEAVRRKPYSVLLLDEIEKAHPDVFNLLLQLLDDGRLTDSQGRTVDFKNTVVIMTS
CCHHHHHHHCCCCEEEEHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEEC
NIGSPLLLESRNGEIEEETRKQVLDQLRAHFRPEFLNRIDDVVLFKPLSTNEVKGIVAKF
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCCCCHHHHHHHHHH
ARELSRRLADRHIELVLTEEAKQHIAEAGFDPVYGARPLKRFMQKQIETPLAKELIAGRV
HHHHHHHHHHHHHHHEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHC
KDYSTVTVDVENGQLVIRPSA
CCCCEEEEEECCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]