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The map label for this gene is moeA [H]

Identifier: 138894334

GI number: 138894334

Start: 741112

End: 742371

Strand: Direct

Name: moeA [H]

Synonym: GTNG_0662

Alternate gene names: 138894334

Gene position: 741112-742371 (Clockwise)

Preceding gene: 138894333

Following gene: 138894335

Centisome position: 20.87

GC content: 57.3

Gene sequence:

>1260_bases
ATGGTCGAAAGACGAACCCCGATTCCCGTAGCGGAAGCGATCAATCGGGTGATGTGCTATGCCGGGGTGGGGGAAGAGGA
AACGGTGCCGCTTCGGCAGTCGTATGGCCGCTATTTGGCGGAAGATTTGTGCGCCGACCATGACGTGCCGCCGTTTGACC
GCTCCCCGTATGACGGATTTGCCATTCGCGCCGCTGATTCGCAAGAGGCGGGGCTGGACCATCCAGTAGAGTTTGAGGTG
ATTGAGGCAATCGGCGCCGGACAAGTCGCCACCAAGACGGTCGGTCCGTTTCAAGCGGTGCGTCTAATGACTGGGGCACA
AATTCCGAATGGATGCGATGCGGTCGTCATGTTGGAGCTGACCAAACAGTATGAACGGGATGGAAAAACGTATATGTCGA
TTAAGCGCCCGTTCCGCCCAGGCGACAACATCTCGTTTCAAGGGGAGGACGCAAAAAAAGGGACGCCGCTTGTCAAAAAA
GGAACGCGCATCAATCCGGGAGTGGCGGCGCTGTTGGCGACGTTCGGCTATGCCGAAGTGAAGGTGGCGAAAAAACCGCG
GATCGGATTGTTTGCGACCGGCAGCGAGCTGCTTGATGTCTCTGAACCGCTCGTTCCAGGGAAAATCCGTAACAGCAACG
CCTACATGATTGAGGCACAGGCGCTAAAAAGCGGCGCTGAGCTGATCTATTTTGGCCAGCTGGCCGATGACCTTGATGCA
TGCTTTCACGCCGTGCGCGAGGCGCTCGACCAAGTGGACATGCTCATTACGACCGGGGGTGTCTCGGTCGGCGATTACGA
CTATTTGCCCGCCATTTACGAGCGGCTTCAGGCGAACGTTTTGTTTAACAAAATCGCCATGCGCCCGGGAAGCGTGACGA
CCGTCGCCGAGTGGAATGGCAAGCTGCTGTTTGGGCTATCTGGCAACCCATCGGCATGCTATGTCGGCTATGAACTGTTT
GTCCGCCCGGTCGTGCGGACGCGCTTATTTTCTACCAAGCCGTATTTGAAGAAAGTGAAAGCGACGCTTGGCGCCGATTT
TCCAAAGCCGAATCCGTTCACCCGCTTCGTGCGCAGCCGTGTCGAAGCGATCGATGGGCGACTCATCGTCAAACCGGTCG
GCATGGATAAGTCGAACATCGTCACCTCGCTCGCGGCGGCCAACGCCTTGATGGTGCTGCCAGGCGGGACGAGAGGGTTC
GCTAAGGATGACGAAGTGGACGTATGGCTGCTCGATGATGACGAGGGATCGAGCGAATGA

Upstream 100 bases:

>100_bases
GAAAAGTTGGCAGAAGGCATCAAACAGCTGCAACAATGGCAACAACGTTAAAAGAATGATATCGTTGCCGCCAGCCGTAG
GATCGAAAGGAGAGAGAGAC

Downstream 100 bases:

>100_bases
ATGTCTGGCAAGTTGTCGGCTATAAACATACGGGCAAGACAACGCTCGTCGAAAAATGGGTGGCGGCCGCTGTCCGGGAA
GGATGGCGCGTCGGGACGGT

Product: molybdopterin biosynthesis MoeA protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MVERRTPIPVAEAINRVMCYAGVGEEETVPLRQSYGRYLAEDLCADHDVPPFDRSPYDGFAIRAADSQEAGLDHPVEFEV
IEAIGAGQVATKTVGPFQAVRLMTGAQIPNGCDAVVMLELTKQYERDGKTYMSIKRPFRPGDNISFQGEDAKKGTPLVKK
GTRINPGVAALLATFGYAEVKVAKKPRIGLFATGSELLDVSEPLVPGKIRNSNAYMIEAQALKSGAELIYFGQLADDLDA
CFHAVREALDQVDMLITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEWNGKLLFGLSGNPSACYVGYELF
VRPVVRTRLFSTKPYLKKVKATLGADFPKPNPFTRFVRSRVEAIDGRLIVKPVGMDKSNIVTSLAAANALMVLPGGTRGF
AKDDEVDVWLLDDDEGSSE

Sequences:

>Translated_419_residues
MVERRTPIPVAEAINRVMCYAGVGEEETVPLRQSYGRYLAEDLCADHDVPPFDRSPYDGFAIRAADSQEAGLDHPVEFEV
IEAIGAGQVATKTVGPFQAVRLMTGAQIPNGCDAVVMLELTKQYERDGKTYMSIKRPFRPGDNISFQGEDAKKGTPLVKK
GTRINPGVAALLATFGYAEVKVAKKPRIGLFATGSELLDVSEPLVPGKIRNSNAYMIEAQALKSGAELIYFGQLADDLDA
CFHAVREALDQVDMLITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEWNGKLLFGLSGNPSACYVGYELF
VRPVVRTRLFSTKPYLKKVKATLGADFPKPNPFTRFVRSRVEAIDGRLIVKPVGMDKSNIVTSLAAANALMVLPGGTRGF
AKDDEVDVWLLDDDEGSSE
>Mature_419_residues
MVERRTPIPVAEAINRVMCYAGVGEEETVPLRQSYGRYLAEDLCADHDVPPFDRSPYDGFAIRAADSQEAGLDHPVEFEV
IEAIGAGQVATKTVGPFQAVRLMTGAQIPNGCDAVVMLELTKQYERDGKTYMSIKRPFRPGDNISFQGEDAKKGTPLVKK
GTRINPGVAALLATFGYAEVKVAKKPRIGLFATGSELLDVSEPLVPGKIRNSNAYMIEAQALKSGAELIYFGQLADDLDA
CFHAVREALDQVDMLITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEWNGKLLFGLSGNPSACYVGYELF
VRPVVRTRLFSTKPYLKKVKATLGADFPKPNPFTRFVRSRVEAIDGRLIVKPVGMDKSNIVTSLAAANALMVLPGGTRGF
AKDDEVDVWLLDDDEGSSE

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=426, Percent_Identity=34.037558685446, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI10880983, Length=426, Percent_Identity=34.037558685446, Blast_Score=202, Evalue=5e-52,
Organism=Escherichia coli, GI1787049, Length=372, Percent_Identity=34.6774193548387, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI25147659, Length=374, Percent_Identity=30.4812834224599, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=402, Percent_Identity=26.1194029850746, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI17136978, Length=422, Percent_Identity=27.4881516587678, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24638841, Length=422, Percent_Identity=27.4881516587678, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45612; Mature: 45612

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVERRTPIPVAEAINRVMCYAGVGEEETVPLRQSYGRYLAEDLCADHDVPPFDRSPYDGF
CCCCCCCCCHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAADSQEAGLDHPVEFEVIEAIGAGQVATKTVGPFQAVRLMTGAQIPNGCDAVVMLEL
EEEECCCCCCCCCCCCCHHHHHHCCCCCHHHCCCCHHHHHHHHHCCCCCCCCCEEEEEHH
TKQYERDGKTYMSIKRPFRPGDNISFQGEDAKKGTPLVKKGTRINPGVAALLATFGYAEV
HHHHHHCCCEEEEEECCCCCCCCCEECCCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCEE
KVAKKPRIGLFATGSELLDVSEPLVPGKIRNSNAYMIEAQALKSGAELIYFGQLADDLDA
EEECCCCEEEEECCHHHHHCCCCCCCCEEECCCEEEEEHHHHCCCCCEEEECCHHHHHHH
CFHAVREALDQVDMLITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEWNG
HHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
KLLFGLSGNPSACYVGYELFVRPVVRTRLFSTKPYLKKVKATLGADFPKPNPFTRFVRSR
EEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHH
VEAIDGRLIVKPVGMDKSNIVTSLAAANALMVLPGGTRGFAKDDEVDVWLLDDDEGSSE
HHHHCCEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MVERRTPIPVAEAINRVMCYAGVGEEETVPLRQSYGRYLAEDLCADHDVPPFDRSPYDGF
CCCCCCCCCHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAADSQEAGLDHPVEFEVIEAIGAGQVATKTVGPFQAVRLMTGAQIPNGCDAVVMLEL
EEEECCCCCCCCCCCCCHHHHHHCCCCCHHHCCCCHHHHHHHHHCCCCCCCCCEEEEEHH
TKQYERDGKTYMSIKRPFRPGDNISFQGEDAKKGTPLVKKGTRINPGVAALLATFGYAEV
HHHHHHCCCEEEEEECCCCCCCCCEECCCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCEE
KVAKKPRIGLFATGSELLDVSEPLVPGKIRNSNAYMIEAQALKSGAELIYFGQLADDLDA
EEECCCCEEEEECCHHHHHCCCCCCCCEEECCCEEEEEHHHHCCCCCEEEECCHHHHHHH
CFHAVREALDQVDMLITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEWNG
HHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
KLLFGLSGNPSACYVGYELFVRPVVRTRLFSTKPYLKKVKATLGADFPKPNPFTRFVRSR
EEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHH
VEAIDGRLIVKPVGMDKSNIVTSLAAANALMVLPGGTRGFAKDDEVDVWLLDDDEGSSE
HHHHCCEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]