Click here to switch to the map view.

The map label for this gene is moaA [H]

Identifier: 138894331

GI number: 138894331

Start: 737983

End: 739008

Strand: Direct

Name: moaA [H]

Synonym: GTNG_0659

Alternate gene names: 138894331

Gene position: 737983-739008 (Clockwise)

Preceding gene: 138894330

Following gene: 138894333

Centisome position: 20.79

GC content: 54.0

Gene sequence:

>1026_bases
ATGAGCGAGCGCAACCGGACGGACGTCATGGACCGCCTGTCCCGCCCGCTTCGCGATTTGCGGTTATCGGTGATCGACCA
ATGTAACTTTCGCTGCATCTATTGCATGCCGGCTGAGGTGTTCGGGCCGAATTTTCGCTTTTTGGCGGAAGGCGAGCTGT
TGACGGTCGAGGAAATGGCGCTTCTATCGGAATGTTTTGTTGAGCTTGGCGTCGAAAAAATCCGCCTGACAGGGGGCGAA
CCGCTCTTAAGGCGTGATTTGGACGCGCTTGTTGCCCGGCTGTCTGCGATTCCCGGCCTGCGCGATATCGGCTTGACGAC
CAACGGTGTTCATTTAGTGAAATGGGCGCAGCGGTTGAAAGAAGCCGGGTTGAAGCGCGTCAACGTCAGCTTGGATGCGT
TAGATGATGATATTTTCCGCAAAATGAACGGCATCGGCGTCGGCGTCGCTCCTGTGTTAAAAGGCATTGAAGCCGCCCGG
GCGGCGGGACTCGGCGTCAAAGTGAACATGGTCGTCAAAAAAGGGTGGAATGACTCGCAAATCGTGCCGATGGCGTCGTA
TTTTAAAGACTTAGGCATTCCGCTCCGCTTGATTGAATTTATGGACGTCGGCACGACCAACGGCTGGGATTACTCCCATG
TCGTGACGAAAAAAGAGATGTATGAGCAAATCAACGCCATGCATCCGCTCGAACCGATCGAAAAAGCGTATTTCGGCGAG
GTGGCGAGCCGCTACCGCTACGTCGGCACGGAGGTGGAAGTCGGTTTCATCGCCTCAGTGACGGAAACGTTTTGTCGAAG
CTGCACAAGAGCGCGCATTTCTGCAGACGGGAAGCTGTATACGTGTTTGTTTGCCTCGAAAGGCGTGTCGTTGAAAGATA
AACTGCGCGCTGGGGCAACGAAAGAGGAACTGAAGTCGTTAATCACCGCGGTTTGGAACCAGCGGACAGACCGCTATTCA
GAAGAACGGACGGAAGAAACGGCGAAACAACGGGTGAAAATTGAAATGTCGTATATTGGGGGGTAA

Upstream 100 bases:

>100_bases
TAGTTTGTTGGTCTTTGCGACGAAACTTGGTCGTTTACGGGAATAAAAAAAGCCGCTTGACAACATTGTGCGGCAAACGA
AACAGAAAGGAGGGAGCGAG

Downstream 100 bases:

>100_bases
CAAAGAAGCGGGGCTGCTCTTTCCATCGAAGAAGCAGCCCCGCTTTTTATCGCTCGACGCGCCTGCCTTTACCTTAGAAA
TGGGGGAATGGTTTGGCTTG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MSERNRTDVMDRLSRPLRDLRLSVIDQCNFRCIYCMPAEVFGPNFRFLAEGELLTVEEMALLSECFVELGVEKIRLTGGE
PLLRRDLDALVARLSAIPGLRDIGLTTNGVHLVKWAQRLKEAGLKRVNVSLDALDDDIFRKMNGIGVGVAPVLKGIEAAR
AAGLGVKVNMVVKKGWNDSQIVPMASYFKDLGIPLRLIEFMDVGTTNGWDYSHVVTKKEMYEQINAMHPLEPIEKAYFGE
VASRYRYVGTEVEVGFIASVTETFCRSCTRARISADGKLYTCLFASKGVSLKDKLRAGATKEELKSLITAVWNQRTDRYS
EERTEETAKQRVKIEMSYIGG

Sequences:

>Translated_341_residues
MSERNRTDVMDRLSRPLRDLRLSVIDQCNFRCIYCMPAEVFGPNFRFLAEGELLTVEEMALLSECFVELGVEKIRLTGGE
PLLRRDLDALVARLSAIPGLRDIGLTTNGVHLVKWAQRLKEAGLKRVNVSLDALDDDIFRKMNGIGVGVAPVLKGIEAAR
AAGLGVKVNMVVKKGWNDSQIVPMASYFKDLGIPLRLIEFMDVGTTNGWDYSHVVTKKEMYEQINAMHPLEPIEKAYFGE
VASRYRYVGTEVEVGFIASVTETFCRSCTRARISADGKLYTCLFASKGVSLKDKLRAGATKEELKSLITAVWNQRTDRYS
EERTEETAKQRVKIEMSYIGG
>Mature_340_residues
SERNRTDVMDRLSRPLRDLRLSVIDQCNFRCIYCMPAEVFGPNFRFLAEGELLTVEEMALLSECFVELGVEKIRLTGGEP
LLRRDLDALVARLSAIPGLRDIGLTTNGVHLVKWAQRLKEAGLKRVNVSLDALDDDIFRKMNGIGVGVAPVLKGIEAARA
AGLGVKVNMVVKKGWNDSQIVPMASYFKDLGIPLRLIEFMDVGTTNGWDYSHVVTKKEMYEQINAMHPLEPIEKAYFGEV
ASRYRYVGTEVEVGFIASVTETFCRSCTRARISADGKLYTCLFASKGVSLKDKLRAGATKEELKSLITAVWNQRTDRYSE
ERTEETAKQRVKIEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=340, Percent_Identity=37.3529411764706, Blast_Score=207, Evalue=8e-54,
Organism=Homo sapiens, GI22027536, Length=340, Percent_Identity=37.3529411764706, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1786999, Length=338, Percent_Identity=32.5443786982249, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI32566331, Length=326, Percent_Identity=36.1963190184049, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI32566329, Length=304, Percent_Identity=36.5131578947368, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17561210, Length=304, Percent_Identity=36.5131578947368, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI28574490, Length=319, Percent_Identity=35.7366771159875, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI28574488, Length=318, Percent_Identity=35.8490566037736, Blast_Score=190, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38232; Mature: 38101

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERNRTDVMDRLSRPLRDLRLSVIDQCNFRCIYCMPAEVFGPNFRFLAEGELLTVEEMA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCCCCEEEECCCEEHHHHHH
LLSECFVELGVEKIRLTGGEPLLRRDLDALVARLSAIPGLRDIGLTTNGVHLVKWAQRLK
HHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHH
EAGLKRVNVSLDALDDDIFRKMNGIGVGVAPVLKGIEAARAAGLGVKVNMVVKKGWNDSQ
HCCCEEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCC
IVPMASYFKDLGIPLRLIEFMDVGTTNGWDYSHVVTKKEMYEQINAMHPLEPIEKAYFGE
CCCHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VASRYRYVGTEVEVGFIASVTETFCRSCTRARISADGKLYTCLFASKGVSLKDKLRAGAT
HHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHCCCC
KEELKSLITAVWNQRTDRYSEERTEETAKQRVKIEMSYIGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCC
>Mature Secondary Structure 
SERNRTDVMDRLSRPLRDLRLSVIDQCNFRCIYCMPAEVFGPNFRFLAEGELLTVEEMA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCCCCEEEECCCEEHHHHHH
LLSECFVELGVEKIRLTGGEPLLRRDLDALVARLSAIPGLRDIGLTTNGVHLVKWAQRLK
HHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHH
EAGLKRVNVSLDALDDDIFRKMNGIGVGVAPVLKGIEAARAAGLGVKVNMVVKKGWNDSQ
HCCCEEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCC
IVPMASYFKDLGIPLRLIEFMDVGTTNGWDYSHVVTKKEMYEQINAMHPLEPIEKAYFGE
CCCHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VASRYRYVGTEVEVGFIASVTETFCRSCTRARISADGKLYTCLFASKGVSLKDKLRAGAT
HHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHCCCC
KEELKSLITAVWNQRTDRYSEERTEETAKQRVKIEMSYIGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA