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The map label for this gene is ilvI [H]

Identifier: 138894323

GI number: 138894323

Start: 727543

End: 729216

Strand: Reverse

Name: ilvI [H]

Synonym: GTNG_0651

Alternate gene names: 138894323

Gene position: 729216-727543 (Counterclockwise)

Preceding gene: 138894329

Following gene: 138894314

Centisome position: 20.54

GC content: 50.66

Gene sequence:

>1674_bases
ATGGTTCATCTTCCCACACGTCTCGGGGCTGATGTACTTGTTGAATCGTTAGCCGTTCAAGGAATCGCCCATATGTTTGG
CTGCTGCCATGAAAGCATGCTGCCTGTACGCCATGTGCTAAACCACCATCCAGGCCTGTCATATATCGAAATGAAACACG
AACAGGCGGCTGTTCATGCCGCTGATGGCTATGCCCGCGCTTCAGGGAAGCTCGGCGTGGCAATCATCGGGGCAGGAGTC
ACAAACGGCATTACCGGAATCACCACCGCATTAAGCGATTCTATACCGCTGCTTGCCATTATTGGACGGCCTTCACCGGA
AGAGCATTTATACGCTCCCGATCTCGACATGTTGAGTCTTTGTACGCCAGTGACGAAATACCATTTGCAAGTAAGCAAGA
TCAATGATATTCCATCCACTATTCAGCGCGCTTACGAAATCGCGCTCGATGGCAGGCCGGGACCGGTGACGGTGGAAATT
CCCACCCATCTCCTCCACCAGGAAACGGCGGAGGCGTACCCGATGCAAAAAGCCGTACTTCCGAAGCCGAAAAACATTCG
GAGAAAATCGCTCGAAGCGGCCATCACCACCATTGAAAACGCCAAAAAGCCAGTCTTGTTTATCGGCGGTGGGGTCATTC
ATTCCGGCGCTTCGGAGTGGGTGCGCGAGGTGGCCACGCAAAGCCAAATCCCTGTCGTCAGTTCCCTGATGGGAATCGGT
GCCTTCGATAAAACGAACCCGCTCTACTTAGGAATGGTGGGGATGCACGGAACATACGCGGCCAACAAGGCGGTTCATCA
ATGTGATGTATTGATTTGTGTCGGCGTGCGCTTCAGCGATCGGGTAACGGGGAAAATTAGCGGGTTTTCACCGAAGTCGA
AAAAAATTCACGTCGATATTGACGCTGCGGAAATCAATAAAAATATCCATGTTGATATTCCGATTGTCGGGGATGCAACA
CAATTTTTCCGCTCTTTAGCCGGTCGGCTTCGTTACCCGCTCGTTCGGGAACATACGAAAGACTGGGTGGCAGAGGTAAC
AAAATGGCAGCGGACAGTGCCCCGTTTCGATACATCGACGAGCCGCTTAAAGCCTCAAAACGTAATTCGCCTGCTCTCAG
CTTTGACGGAAGAAGACGCCATTGTCGTTACCGATGTCGGGCAACACCAAATATGGACGGCCCACCACTATACATTTACA
AAACCACGGACATTTTTAACGTCAGGTGGGCTCGGAACGATGGGGTATGGACTTCCGGCAGCCATTGGCGCCGCTGTCGC
CTCTCCGGGCAAGAAGGTGATTTGTATCAGCGGGGATGGCTGCTTTCAAATGAATGTACAAGAGATGATGACCGCCGTCG
CCTACAAACTTCCAATTAAAATCGCCGTTTTGAATAATGGCTACTTAGGAATGGTGCGTCAATGGCAGGAACTGTTTTAC
CAAAAGCGTTATTCAGCAGTGAAGATTACATCCCCCCATTTTGCTAAGCTTGCCGAAGCATACGGAGCCATAGGATATGC
GGTCGATTCAGAAGAGGAAGCGGAAGATATCATAAAAAAAGCGTTAAAACATGATGGGCCAGTCTTGCTTGATTTCAATA
TTGCCGAGGAAGAAAACGTCTATCCGATCGTCCCTCCAGGGCAAAGCAACGAGCAAGCCATTTTGTCCCATTGA

Upstream 100 bases:

>100_bases
CAGAAAAAGATATCCCTTATACCCTAATGTGATGATATTCACATACAGTGCTCACATCCGTTGTTTAAAATGTAAGAAAA
TTAAAAAAGGAAGTGGAAAC

Downstream 100 bases:

>100_bases
CTCATCTGCATTGAAAAAGCGTCCGACAACTAGCTTGCGGACGCTTTTTTGACTGAAAGTGACGCATGTCACTTCATTTT
CTCTTAACCATTTTATAATA

Product: acetolactate synthase large subunit-like protein

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MVHLPTRLGADVLVESLAVQGIAHMFGCCHESMLPVRHVLNHHPGLSYIEMKHEQAAVHAADGYARASGKLGVAIIGAGV
TNGITGITTALSDSIPLLAIIGRPSPEEHLYAPDLDMLSLCTPVTKYHLQVSKINDIPSTIQRAYEIALDGRPGPVTVEI
PTHLLHQETAEAYPMQKAVLPKPKNIRRKSLEAAITTIENAKKPVLFIGGGVIHSGASEWVREVATQSQIPVVSSLMGIG
AFDKTNPLYLGMVGMHGTYAANKAVHQCDVLICVGVRFSDRVTGKISGFSPKSKKIHVDIDAAEINKNIHVDIPIVGDAT
QFFRSLAGRLRYPLVREHTKDWVAEVTKWQRTVPRFDTSTSRLKPQNVIRLLSALTEEDAIVVTDVGQHQIWTAHHYTFT
KPRTFLTSGGLGTMGYGLPAAIGAAVASPGKKVICISGDGCFQMNVQEMMTAVAYKLPIKIAVLNNGYLGMVRQWQELFY
QKRYSAVKITSPHFAKLAEAYGAIGYAVDSEEEAEDIIKKALKHDGPVLLDFNIAEEENVYPIVPPGQSNEQAILSH

Sequences:

>Translated_557_residues
MVHLPTRLGADVLVESLAVQGIAHMFGCCHESMLPVRHVLNHHPGLSYIEMKHEQAAVHAADGYARASGKLGVAIIGAGV
TNGITGITTALSDSIPLLAIIGRPSPEEHLYAPDLDMLSLCTPVTKYHLQVSKINDIPSTIQRAYEIALDGRPGPVTVEI
PTHLLHQETAEAYPMQKAVLPKPKNIRRKSLEAAITTIENAKKPVLFIGGGVIHSGASEWVREVATQSQIPVVSSLMGIG
AFDKTNPLYLGMVGMHGTYAANKAVHQCDVLICVGVRFSDRVTGKISGFSPKSKKIHVDIDAAEINKNIHVDIPIVGDAT
QFFRSLAGRLRYPLVREHTKDWVAEVTKWQRTVPRFDTSTSRLKPQNVIRLLSALTEEDAIVVTDVGQHQIWTAHHYTFT
KPRTFLTSGGLGTMGYGLPAAIGAAVASPGKKVICISGDGCFQMNVQEMMTAVAYKLPIKIAVLNNGYLGMVRQWQELFY
QKRYSAVKITSPHFAKLAEAYGAIGYAVDSEEEAEDIIKKALKHDGPVLLDFNIAEEENVYPIVPPGQSNEQAILSH
>Mature_557_residues
MVHLPTRLGADVLVESLAVQGIAHMFGCCHESMLPVRHVLNHHPGLSYIEMKHEQAAVHAADGYARASGKLGVAIIGAGV
TNGITGITTALSDSIPLLAIIGRPSPEEHLYAPDLDMLSLCTPVTKYHLQVSKINDIPSTIQRAYEIALDGRPGPVTVEI
PTHLLHQETAEAYPMQKAVLPKPKNIRRKSLEAAITTIENAKKPVLFIGGGVIHSGASEWVREVATQSQIPVVSSLMGIG
AFDKTNPLYLGMVGMHGTYAANKAVHQCDVLICVGVRFSDRVTGKISGFSPKSKKIHVDIDAAEINKNIHVDIPIVGDAT
QFFRSLAGRLRYPLVREHTKDWVAEVTKWQRTVPRFDTSTSRLKPQNVIRLLSALTEEDAIVVTDVGQHQIWTAHHYTFT
KPRTFLTSGGLGTMGYGLPAAIGAAVASPGKKVICISGDGCFQMNVQEMMTAVAYKLPIKIAVLNNGYLGMVRQWQELFY
QKRYSAVKITSPHFAKLAEAYGAIGYAVDSEEEAEDIIKKALKHDGPVLLDFNIAEEENVYPIVPPGQSNEQAILSH

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=551, Percent_Identity=27.0417422867514, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI21361361, Length=534, Percent_Identity=25.8426966292135, Blast_Score=131, Evalue=2e-30,
Organism=Escherichia coli, GI87081685, Length=566, Percent_Identity=40.6360424028269, Blast_Score=435, Evalue=1e-123,
Organism=Escherichia coli, GI1790104, Length=558, Percent_Identity=38.7096774193548, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1786717, Length=537, Percent_Identity=30.9124767225326, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1787096, Length=562, Percent_Identity=27.5800711743772, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1788716, Length=568, Percent_Identity=26.5845070422535, Blast_Score=162, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17531299, Length=567, Percent_Identity=26.4550264550265, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17531301, Length=566, Percent_Identity=26.1484098939929, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17542570, Length=579, Percent_Identity=25.0431778929188, Blast_Score=132, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6323755, Length=576, Percent_Identity=38.3680555555556, Blast_Score=381, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6321524, Length=489, Percent_Identity=23.5173824130879, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6323163, Length=478, Percent_Identity=23.6401673640167, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323073, Length=492, Percent_Identity=22.7642276422764, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320816, Length=452, Percent_Identity=24.1150442477876, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19922626, Length=570, Percent_Identity=25.2631578947368, Blast_Score=155, Evalue=9e-38,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 60653; Mature: 60653

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHLPTRLGADVLVESLAVQGIAHMFGCCHESMLPVRHVLNHHPGLSYIEMKHEQAAVHA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHEEC
ADGYARASGKLGVAIIGAGVTNGITGITTALSDSIPLLAIIGRPSPEEHLYAPDLDMLSL
CCCCEECCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCEECCCCHHHHH
CTPVTKYHLQVSKINDIPSTIQRAYEIALDGRPGPVTVEIPTHLLHQETAEAYPMQKAVL
HHHHHHHEEEEECCCCCHHHHHHHHHEEECCCCCCEEEECCHHHHHHHHHHHCCCHHHCC
PKPKNIRRKSLEAAITTIENAKKPVLFIGGGVIHSGASEWVREVATQSQIPVVSSLMGIG
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHHHHHHCCCCCCHHHHHHHCC
AFDKTNPLYLGMVGMHGTYAANKAVHQCDVLICVGVRFSDRVTGKISGFSPKSKKIHVDI
CCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCEECCCCEEEECCCCCCCCEEEEEE
DAAEINKNIHVDIPIVGDATQFFRSLAGRLRYPLVREHTKDWVAEVTKWQRTVPRFDTST
EHHHHCCCEEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
SRLKPQNVIRLLSALTEEDAIVVTDVGQHQIWTAHHYTFTKPRTFLTSGGLGTMGYGLPA
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEECCCCEEEECCCCCCCCCCHHH
AIGAAVASPGKKVICISGDGCFQMNVQEMMTAVAYKLPIKIAVLNNGYLGMVRQWQELFY
HHHHHHCCCCCEEEEECCCCCEEECHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHH
QKRYSAVKITSPHFAKLAEAYGAIGYAVDSEEEAEDIIKKALKHDGPVLLDFNIAEEENV
HHCCCEEEECCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEEECCCCCE
YPIVPPGQSNEQAILSH
EEECCCCCCCCCCCCCC
>Mature Secondary Structure
MVHLPTRLGADVLVESLAVQGIAHMFGCCHESMLPVRHVLNHHPGLSYIEMKHEQAAVHA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHEEC
ADGYARASGKLGVAIIGAGVTNGITGITTALSDSIPLLAIIGRPSPEEHLYAPDLDMLSL
CCCCEECCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCEECCCCHHHHH
CTPVTKYHLQVSKINDIPSTIQRAYEIALDGRPGPVTVEIPTHLLHQETAEAYPMQKAVL
HHHHHHHEEEEECCCCCHHHHHHHHHEEECCCCCCEEEECCHHHHHHHHHHHCCCHHHCC
PKPKNIRRKSLEAAITTIENAKKPVLFIGGGVIHSGASEWVREVATQSQIPVVSSLMGIG
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHHHHHHCCCCCCHHHHHHHCC
AFDKTNPLYLGMVGMHGTYAANKAVHQCDVLICVGVRFSDRVTGKISGFSPKSKKIHVDI
CCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCEECCCCEEEECCCCCCCCEEEEEE
DAAEINKNIHVDIPIVGDATQFFRSLAGRLRYPLVREHTKDWVAEVTKWQRTVPRFDTST
EHHHHCCCEEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
SRLKPQNVIRLLSALTEEDAIVVTDVGQHQIWTAHHYTFTKPRTFLTSGGLGTMGYGLPA
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEECCCCEEEECCCCCCCCCCHHH
AIGAAVASPGKKVICISGDGCFQMNVQEMMTAVAYKLPIKIAVLNNGYLGMVRQWQELFY
HHHHHHCCCCCEEEEECCCCCEEECHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHH
QKRYSAVKITSPHFAKLAEAYGAIGYAVDSEEEAEDIIKKALKHDGPVLLDFNIAEEENV
HHCCCEEEECCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEEECCCCCE
YPIVPPGQSNEQAILSH
EEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]