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The map label for this gene is hemE [H]

Identifier: 138894243

GI number: 138894243

Start: 630000

End: 631037

Strand: Direct

Name: hemE [H]

Synonym: GTNG_0569

Alternate gene names: 138894243

Gene position: 630000-631037 (Clockwise)

Preceding gene: 138894242

Following gene: 138894244

Centisome position: 17.74

GC content: 52.79

Gene sequence:

>1038_bases
ATGACAAGACGAATCAACGATACCTTTTTGCGTGCCTGCCGGGGTGAAAAAACGGCTTATGTGCCGGTCTGGTACATGAG
GCAAGCTGGACGGTCGCAGCCGGAGTATCGGGCGCTGAAAGAAAAATATTCACTATTTGAGATTACGCACCAGCCGGAGC
TTTGCGCTTACGTCACGAGGCTTCCGGTTGAGCAATATGGCGTTGATGCTGCCATTTTATACAAAGACATTATGACCCCG
CTGCCAGCGATCGGTGTGGATGTAGAAATTCGCGGCGGCGTCGGGCCGGTGATCGCCAACCCGATCCGCTCGCTCCATGA
TGTTGAACGGCTAGGGGAGATCGATCCAGAACATGATGTGCCGTACGTGCTTGAGACGATCCGGCTCCTAGTCAACGAAC
AACTCGATGTGCCGCTCATCGGGTTTGCCGGCGCGCCGTTTACGTTGGCCAGCTACATGATTGAAGGAGGTCCATCCAAA
AACTATCATAAGACAAAGGCGTTTATGTATGCCGAACCGAAAGCGTGGTTCGCTTTAATGGACAAGCTCGCTGAGATGAC
GATCCGCTACGTGAAAGCACAAATTCAAGCCGGGGCAAGCGCGGTGCAAATTTTTGACTCTTGGGTTGGCGCTGTCAATG
CAGACGATTACCGGACATTTATTAAGCCGGCGATGGCGCGTATTTTTGCTGCCTTGCGTGAAGAAGGAGCGCCGCTCATC
ATGTTTGGCGTCGGTGCGAGCCACTTGGCACACGAATGGAATGACTTGCCGCTTGATGTCATCGGTCTTGATTGGCGGTT
ATCGATTCGCGAGGCGCGCCGTCGAGGCATTACAAAAGCCATTCAAGGCAACTTGGATCCAGCAGTGCTGCTTGCGCCGT
GGGATGTGATCGAGGAGCGGGTGAAGCGTATTTTGGACGAAGGGATGGAGCAGCCGGGCTATATTTTCAACTTAGGTCAT
GGCATTTTCCCGGATGTCCAACCGGCGACATTGAAACGGCTGACTGCCTTTATCCATGACTATACTTCAACGAAATAA

Upstream 100 bases:

>100_bases
GGACAGCGAAAGCTGTATAGTGAAAAAGAGATAAGCAATGTGAATGTGCAAAAAATGAGAAAACGGTTGTCTGGAATAGA
TGAAAGAAAGGCGGATGGAG

Downstream 100 bases:

>100_bases
AAGAGGTGCAACACAATGGCGAAAAAAACGGTCGGACTGCTTGTTATGGCGTATGGAACCCCGTATAAAGAAGACGATAT
CGAACGGTATTACACGCATA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTRRINDTFLRACRGEKTAYVPVWYMRQAGRSQPEYRALKEKYSLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTP
LPAIGVDVEIRGGVGPVIANPIRSLHDVERLGEIDPEHDVPYVLETIRLLVNEQLDVPLIGFAGAPFTLASYMIEGGPSK
NYHKTKAFMYAEPKAWFALMDKLAEMTIRYVKAQIQAGASAVQIFDSWVGAVNADDYRTFIKPAMARIFAALREEGAPLI
MFGVGASHLAHEWNDLPLDVIGLDWRLSIREARRRGITKAIQGNLDPAVLLAPWDVIEERVKRILDEGMEQPGYIFNLGH
GIFPDVQPATLKRLTAFIHDYTSTK

Sequences:

>Translated_345_residues
MTRRINDTFLRACRGEKTAYVPVWYMRQAGRSQPEYRALKEKYSLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTP
LPAIGVDVEIRGGVGPVIANPIRSLHDVERLGEIDPEHDVPYVLETIRLLVNEQLDVPLIGFAGAPFTLASYMIEGGPSK
NYHKTKAFMYAEPKAWFALMDKLAEMTIRYVKAQIQAGASAVQIFDSWVGAVNADDYRTFIKPAMARIFAALREEGAPLI
MFGVGASHLAHEWNDLPLDVIGLDWRLSIREARRRGITKAIQGNLDPAVLLAPWDVIEERVKRILDEGMEQPGYIFNLGH
GIFPDVQPATLKRLTAFIHDYTSTK
>Mature_344_residues
TRRINDTFLRACRGEKTAYVPVWYMRQAGRSQPEYRALKEKYSLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPL
PAIGVDVEIRGGVGPVIANPIRSLHDVERLGEIDPEHDVPYVLETIRLLVNEQLDVPLIGFAGAPFTLASYMIEGGPSKN
YHKTKAFMYAEPKAWFALMDKLAEMTIRYVKAQIQAGASAVQIFDSWVGAVNADDYRTFIKPAMARIFAALREEGAPLIM
FGVGASHLAHEWNDLPLDVIGLDWRLSIREARRRGITKAIQGNLDPAVLLAPWDVIEERVKRILDEGMEQPGYIFNLGHG
IFPDVQPATLKRLTAFIHDYTSTK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=350, Percent_Identity=38, Blast_Score=223, Evalue=2e-58,
Organism=Escherichia coli, GI2367337, Length=346, Percent_Identity=41.3294797687861, Blast_Score=249, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6320252, Length=353, Percent_Identity=32.2946175637394, Blast_Score=187, Evalue=1e-48,
Organism=Drosophila melanogaster, GI19921920, Length=343, Percent_Identity=35.5685131195335, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI221330099, Length=343, Percent_Identity=35.5685131195335, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38872; Mature: 38741

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRINDTFLRACRGEKTAYVPVWYMRQAGRSQPEYRALKEKYSLFEITHQPELCAYVTR
CCCCCHHHHHHHHCCCCCEEEHHHHHHHCCCCCHHHHHHHHHHHHHEECCCCHHHHHHHH
LPVEQYGVDAAILYKDIMTPLPAIGVDVEIRGGVGPVIANPIRSLHDVERLGEIDPEHDV
CCHHHHCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
PYVLETIRLLVNEQLDVPLIGFAGAPFTLASYMIEGGPSKNYHKTKAFMYAEPKAWFALM
HHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHEEEEECCHHHHHHH
DKLAEMTIRYVKAQIQAGASAVQIFDSWVGAVNADDYRTFIKPAMARIFAALREEGAPLI
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
MFGVGASHLAHEWNDLPLDVIGLDWRLSIREARRRGITKAIQGNLDPAVLLAPWDVIEER
EEECCHHHHHHHCCCCCEEEEECCEEEHHHHHHHCCCHHHHHCCCCCEEEECCHHHHHHH
VKRILDEGMEQPGYIFNLGHGIFPDVQPATLKRLTAFIHDYTSTK
HHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRRINDTFLRACRGEKTAYVPVWYMRQAGRSQPEYRALKEKYSLFEITHQPELCAYVTR
CCCCHHHHHHHHCCCCCEEEHHHHHHHCCCCCHHHHHHHHHHHHHEECCCCHHHHHHHH
LPVEQYGVDAAILYKDIMTPLPAIGVDVEIRGGVGPVIANPIRSLHDVERLGEIDPEHDV
CCHHHHCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
PYVLETIRLLVNEQLDVPLIGFAGAPFTLASYMIEGGPSKNYHKTKAFMYAEPKAWFALM
HHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHEEEEECCHHHHHHH
DKLAEMTIRYVKAQIQAGASAVQIFDSWVGAVNADDYRTFIKPAMARIFAALREEGAPLI
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
MFGVGASHLAHEWNDLPLDVIGLDWRLSIREARRRGITKAIQGNLDPAVLLAPWDVIEER
EEECCHHHHHHHCCCCCEEEEECCEEEHHHHHHHCCCHHHHHCCCCCEEEECCHHHHHHH
VKRILDEGMEQPGYIFNLGHGIFPDVQPATLKRLTAFIHDYTSTK
HHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA