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The map label for this gene is thiO [H]

Identifier: 138894210

GI number: 138894210

Start: 598626

End: 599765

Strand: Direct

Name: thiO [H]

Synonym: GTNG_0536

Alternate gene names: 138894210

Gene position: 598626-599765 (Clockwise)

Preceding gene: 138894209

Following gene: 138894211

Centisome position: 16.86

GC content: 56.4

Gene sequence:

>1140_bases
GTGACTATACATTATTATGACGTTGCCATTGTTGGCGGTGGGGTGATCGGGGCGGCGGTGGCCTTCGAGCTTGCCAAACG
GAAGTATCGCGTCGCGATTTTAGAAAAAGGAACGATGGCTGGTGAGTCGTCGAGCGCAGCCGCCGGCATGCTCGGAGCAC
AAGCAGAATTTTCTACGCCAAGTCCGCTCGTGCCGCTCGCCTTAAAAAGCAGGACCCTTATGCCGTCCTTGGCGGAAGAG
TTGAAGGAACGAACGGGGATTGACATCGGCCTCGTCGAAAAAGGGATGATCAAAATAGCGACAACGGAGGAAGAGGCGGA
AGATCTCCGCCGGCATTATACATTTTGGAGCGCGACGGACCAGCCGGTGCGCTGGCTGACGAAAGAGGAAGTGCTTGAGA
TTGAGCCCCGCCTCGCAATGGAAGCGATTGTTGGGGCCATGTACATTGAAGGCGACGGACAAGTGAGCGCCCCGGATTTG
GCTGCTGCTCTCGTCCATGCTGCTGTATCAGCCGGCGCTCGCTTATATGAGTATACAGAAGTATTGAACATCCGTTCAGA
CGCCGGTGGGCATCACCTTGACACAACGGATGGAACATTTTCGGCTGAGGCGGTCGTCATCGCCTCGGGCGCCTGGGCGT
CGCAGCTTGGCAACCTGCTTGGGCTTCCTCTTTCTGTGTCCCCAGTCAAAGGGGAGTGCGTCATGGTGCGTACACCGGTT
CCGTTGTTGCAGGCGACCGTGTTTGCCAAAAACGGTTGCTATATTGTGCCGAAGCGAGGCAACCAACTGTTGATTGGTGC
GACGTCCACTCCGGGCACATACGACCGGCATGTGTGCGCCGGCGGGGTCATGAATTTGCTTCATCGCGCTGCCCGCCTGC
TTCCGGATGTCAAACAGGCAGAATGGGTGAGGGCGTGGAGCGGCATCCGTCCGCAGACGAAAGACGGTTTGCCATATATC
GGCGAACATCCGGAGCGACACGGCGTGTTTGTCGCTGCCGGCCATTATCGAAACGGGATTTTGCTCAGCGCGATTACCGG
GCAGCTAATGGCCGACTTAATCGAACGGAAAGAGCCTGAGGTTGATTTGTCACCGTTTTCTTTGACACGCCATTCAGAAG
AAAAGGTGGGGATTGAATGA

Upstream 100 bases:

>100_bases
GGGCAGCGGGAGTGGCGGTGTTGTCGGCGATTTTTTTCGCAGCTGATCCGGTCAGTGAAGCGAAACGGCTAGCTGAAATT
GTCAAGGGGGAGAGGATCAA

Downstream 100 bases:

>100_bases
CATTGATCGTTAACGGGGAGACGATCACCGTGCCCGATGAGGTGAAAACGGTTAGTGATTTGCTTTCGCATTTCCGTCTT
GATAATAAACTGGCGATTGT

Product: glycine oxidase

Products: NA

Alternate protein names: GO [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MTIHYYDVAIVGGGVIGAAVAFELAKRKYRVAILEKGTMAGESSSAAAGMLGAQAEFSTPSPLVPLALKSRTLMPSLAEE
LKERTGIDIGLVEKGMIKIATTEEEAEDLRRHYTFWSATDQPVRWLTKEEVLEIEPRLAMEAIVGAMYIEGDGQVSAPDL
AAALVHAAVSAGARLYEYTEVLNIRSDAGGHHLDTTDGTFSAEAVVIASGAWASQLGNLLGLPLSVSPVKGECVMVRTPV
PLLQATVFAKNGCYIVPKRGNQLLIGATSTPGTYDRHVCAGGVMNLLHRAARLLPDVKQAEWVRAWSGIRPQTKDGLPYI
GEHPERHGVFVAAGHYRNGILLSAITGQLMADLIERKEPEVDLSPFSLTRHSEEKVGIE

Sequences:

>Translated_379_residues
MTIHYYDVAIVGGGVIGAAVAFELAKRKYRVAILEKGTMAGESSSAAAGMLGAQAEFSTPSPLVPLALKSRTLMPSLAEE
LKERTGIDIGLVEKGMIKIATTEEEAEDLRRHYTFWSATDQPVRWLTKEEVLEIEPRLAMEAIVGAMYIEGDGQVSAPDL
AAALVHAAVSAGARLYEYTEVLNIRSDAGGHHLDTTDGTFSAEAVVIASGAWASQLGNLLGLPLSVSPVKGECVMVRTPV
PLLQATVFAKNGCYIVPKRGNQLLIGATSTPGTYDRHVCAGGVMNLLHRAARLLPDVKQAEWVRAWSGIRPQTKDGLPYI
GEHPERHGVFVAAGHYRNGILLSAITGQLMADLIERKEPEVDLSPFSLTRHSEEKVGIE
>Mature_378_residues
TIHYYDVAIVGGGVIGAAVAFELAKRKYRVAILEKGTMAGESSSAAAGMLGAQAEFSTPSPLVPLALKSRTLMPSLAEEL
KERTGIDIGLVEKGMIKIATTEEEAEDLRRHYTFWSATDQPVRWLTKEEVLEIEPRLAMEAIVGAMYIEGDGQVSAPDLA
AALVHAAVSAGARLYEYTEVLNIRSDAGGHHLDTTDGTFSAEAVVIASGAWASQLGNLLGLPLSVSPVKGECVMVRTPVP
LLQATVFAKNGCYIVPKRGNQLLIGATSTPGTYDRHVCAGGVMNLLHRAARLLPDVKQAEWVRAWSGIRPQTKDGLPYIG
EHPERHGVFVAAGHYRNGILLSAITGQLMADLIERKEPEVDLSPFSLTRHSEEKVGIE

Specific function: Catalyzes the FAD-dependent oxidative deamination of various amines and D-amino acids to yield the corresponding alpha- keto acids, ammonia/amine, and hydrogen peroxide. Oxidizes sarcosine (N-methylglycine), N-ethylglycine and glycine. Can also oxidize th

COG id: COG0665

COG function: function code E; Glycine/D-amino acid oxidases (deaminating)

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DAO family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=399, Percent_Identity=26.5664160401003, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI194306651, Length=382, Percent_Identity=25.9162303664921, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI197927446, Length=386, Percent_Identity=22.7979274611399, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI21361378, Length=386, Percent_Identity=22.7979274611399, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1787438, Length=421, Percent_Identity=22.5653206650831, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71994045, Length=391, Percent_Identity=24.0409207161125, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71994052, Length=394, Percent_Identity=24.8730964467005, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI20130091, Length=390, Percent_Identity=25.8974358974359, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR012727 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.4.3.19 [H]

Molecular weight: Translated: 40730; Mature: 40599

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIHYYDVAIVGGGVIGAAVAFELAKRKYRVAILEKGTMAGESSSAAAGMLGAQAEFSTP
CEEEEEEEEEECCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCHHHHCCCCCCCCCC
SPLVPLALKSRTLMPSLAEELKERTGIDIGLVEKGMIKIATTEEEAEDLRRHYTFWSATD
CCCCCHHHCCCCCCHHHHHHHHHHHCCEEEEECCCEEEEEECHHHHHHHHHHCEEECCCC
QPVRWLTKEEVLEIEPRLAMEAIVGAMYIEGDGQVSAPDLAAALVHAAVSAGARLYEYTE
CHHHHHCHHHHHHCCHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
VLNIRSDAGGHHLDTTDGTFSAEAVVIASGAWASQLGNLLGLPLSVSPVKGECVMVRTPV
HHHCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCEECCCCCCCEEEEECCC
PLLQATVFAKNGCYIVPKRGNQLLIGATSTPGTYDRHVCAGGVMNLLHRAARLLPDVKQA
HHHHHHEEECCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
EWVRAWSGIRPQTKDGLPYIGEHPERHGVFVAAGHYRNGILLSAITGQLMADLIERKEPE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHHCCCCC
VDLSPFSLTRHSEEKVGIE
CCCCCCEECCCCCHHCCCC
>Mature Secondary Structure 
TIHYYDVAIVGGGVIGAAVAFELAKRKYRVAILEKGTMAGESSSAAAGMLGAQAEFSTP
EEEEEEEEEECCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCHHHHCCCCCCCCCC
SPLVPLALKSRTLMPSLAEELKERTGIDIGLVEKGMIKIATTEEEAEDLRRHYTFWSATD
CCCCCHHHCCCCCCHHHHHHHHHHHCCEEEEECCCEEEEEECHHHHHHHHHHCEEECCCC
QPVRWLTKEEVLEIEPRLAMEAIVGAMYIEGDGQVSAPDLAAALVHAAVSAGARLYEYTE
CHHHHHCHHHHHHCCHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
VLNIRSDAGGHHLDTTDGTFSAEAVVIASGAWASQLGNLLGLPLSVSPVKGECVMVRTPV
HHHCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCEECCCCCCCEEEEECCC
PLLQATVFAKNGCYIVPKRGNQLLIGATSTPGTYDRHVCAGGVMNLLHRAARLLPDVKQA
HHHHHHEEECCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
EWVRAWSGIRPQTKDGLPYIGEHPERHGVFVAAGHYRNGILLSAITGQLMADLIERKEPE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHHCCCCC
VDLSPFSLTRHSEEKVGIE
CCCCCCEECCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9827558; 11744710 [H]