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The map label for this gene is hemL1 [H]

Identifier: 138894157

GI number: 138894157

Start: 538305

End: 539591

Strand: Reverse

Name: hemL1 [H]

Synonym: GTNG_0483

Alternate gene names: 138894157

Gene position: 539591-538305 (Counterclockwise)

Preceding gene: 138894165

Following gene: 138894156

Centisome position: 15.2

GC content: 53.69

Gene sequence:

>1287_bases
ATGCAGTGGACAAAATCGGAACAATTATATGAAGAAGCACTTCGACACATTGTCGGCGGGGTGAACAGCCCATCCCGCTC
ATATAAAGCAGTCGGCGGTGGCGCTCCGGTCGTCATGGAACGGGCGCAAGGGGCCTATTTCTGGGATGTAGATGGCAACA
AATACATTGACTATTTGGCCGCCTACGGACCGATCATTACCGGACATGCCCACCCGCACATCACCGCGGCCATCCAGCGC
GCCGCGGAAACAGGGGTGTTGTACGGCACACCGACACCGCACGAAATTACATTTGCGAAAATGTTAAAAGAAGCGATTCC
TTCACTTGAGAAAGTGCGGTTTGTCAACTCAGGAACAGAAGCAGTGATGACGACCATCCGCGTCGCTCGAGCTTACACCG
GTCGCAGCAAAATCGTTAAATTCGCCGGCTGCTATCACGGTCACTCCGACCTCGTGCTTGTCGCCGCCGGCTCAGGTCCT
TCGACATTAGGGACGCCGGATTCAGCTGGCGTGCCGCAAAGCATTGCCCATGAAGTCATTACGGTGCCATATAATGATGT
GGAATCATTCCGTGAGGCGATGAACGTTTGGGGCGAACACGTCGCGGCCGTATTGGTTGAACCGATCGTCGGCAACTTCG
GAATTGTCCTTCCGAAACCCGGCTTTTTAGAAGCCGTGAACGATATCGCCCATGAAGCCGGGGCGCTCGTTATTTATGAT
GAGGTCATCACCGCTTTCCGTTTTATGTACGGGGGAGCGCAAAACTTGCTTGGCATTGAACCTGATATGACGGCCATGGG
GAAAATTATCGGTGGCGGCTTGCCGATTGGGGCGTACGGCGGACGCCAAGATATTATGGAACAAGTTGCTCCGCTTGGCC
CAGCCTACCAAGCTGGGACGATGGCTGGTAATCCAGCATCGATGCTCGCAGGTATCGCCTGCCTCGAAGTGTTGAAGCAA
GAAGGCGTATACGAGCATCTTGACCGGCTTGGCGCCATGCTCGAAGAAGGCATTATGACTCATGCCCGCCAATGCGGCCT
GCCGGTAACTATCAATCGCCTCAAAGGCGCGCTGACTGTCTTCTTTACAGAAGAAAAAGTTGAAAACTATGAGCAGGCCC
AGCGGAGCGATGGCGAGTTGTTTGCGAAATTTTTCAAGCTAATGCTCAAGCAAGGCGTCAATCTCGCACCGTCCAAGTAT
GAGGCATGGTTTATTACTCTCGCCCATACAGAAGACGACATCGCCTACACGATTGACGCGGTCGGTCGCGCGTTCCGACA
ACTATAA

Upstream 100 bases:

>100_bases
CCAAATGATGTCTTCTCTCTAGCGAGCACGACAGCCACAGTGAACAGCACATTATGGTAAAATAAAGGGGCAGTCATCGG
AAACAGGAGGATATCAAGCG

Downstream 100 bases:

>100_bases
TCGGCATGGCATGCGACCCTTGTCTCTAGCAGGCTAATGAAAAATGAATGTTTCCCGACAACTGCCATTTTTGAAAGGCT
CAAAAACAACGTTTTTCAAT

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1 [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MQWTKSEQLYEEALRHIVGGVNSPSRSYKAVGGGAPVVMERAQGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITAAIQR
AAETGVLYGTPTPHEITFAKMLKEAIPSLEKVRFVNSGTEAVMTTIRVARAYTGRSKIVKFAGCYHGHSDLVLVAAGSGP
STLGTPDSAGVPQSIAHEVITVPYNDVESFREAMNVWGEHVAAVLVEPIVGNFGIVLPKPGFLEAVNDIAHEAGALVIYD
EVITAFRFMYGGAQNLLGIEPDMTAMGKIIGGGLPIGAYGGRQDIMEQVAPLGPAYQAGTMAGNPASMLAGIACLEVLKQ
EGVYEHLDRLGAMLEEGIMTHARQCGLPVTINRLKGALTVFFTEEKVENYEQAQRSDGELFAKFFKLMLKQGVNLAPSKY
EAWFITLAHTEDDIAYTIDAVGRAFRQL

Sequences:

>Translated_428_residues
MQWTKSEQLYEEALRHIVGGVNSPSRSYKAVGGGAPVVMERAQGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITAAIQR
AAETGVLYGTPTPHEITFAKMLKEAIPSLEKVRFVNSGTEAVMTTIRVARAYTGRSKIVKFAGCYHGHSDLVLVAAGSGP
STLGTPDSAGVPQSIAHEVITVPYNDVESFREAMNVWGEHVAAVLVEPIVGNFGIVLPKPGFLEAVNDIAHEAGALVIYD
EVITAFRFMYGGAQNLLGIEPDMTAMGKIIGGGLPIGAYGGRQDIMEQVAPLGPAYQAGTMAGNPASMLAGIACLEVLKQ
EGVYEHLDRLGAMLEEGIMTHARQCGLPVTINRLKGALTVFFTEEKVENYEQAQRSDGELFAKFFKLMLKQGVNLAPSKY
EAWFITLAHTEDDIAYTIDAVGRAFRQL
>Mature_428_residues
MQWTKSEQLYEEALRHIVGGVNSPSRSYKAVGGGAPVVMERAQGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITAAIQR
AAETGVLYGTPTPHEITFAKMLKEAIPSLEKVRFVNSGTEAVMTTIRVARAYTGRSKIVKFAGCYHGHSDLVLVAAGSGP
STLGTPDSAGVPQSIAHEVITVPYNDVESFREAMNVWGEHVAAVLVEPIVGNFGIVLPKPGFLEAVNDIAHEAGALVIYD
EVITAFRFMYGGAQNLLGIEPDMTAMGKIIGGGLPIGAYGGRQDIMEQVAPLGPAYQAGTMAGNPASMLAGIACLEVLKQ
EGVYEHLDRLGAMLEEGIMTHARQCGLPVTINRLKGALTVFFTEEKVENYEQAQRSDGELFAKFFKLMLKQGVNLAPSKY
EAWFITLAHTEDDIAYTIDAVGRAFRQL

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=346, Percent_Identity=32.0809248554913, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI13994255, Length=335, Percent_Identity=26.5671641791045, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI24119277, Length=319, Percent_Identity=29.4670846394984, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI37574042, Length=336, Percent_Identity=28.2738095238095, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI226442705, Length=332, Percent_Identity=27.4096385542169, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI284507298, Length=264, Percent_Identity=31.4393939393939, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI226442709, Length=295, Percent_Identity=28.4745762711864, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1786349, Length=427, Percent_Identity=49.1803278688525, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1789016, Length=334, Percent_Identity=28.7425149700599, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI145693181, Length=321, Percent_Identity=32.7102803738318, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787560, Length=335, Percent_Identity=29.2537313432836, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1789759, Length=303, Percent_Identity=29.3729372937294, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1788044, Length=293, Percent_Identity=31.3993174061433, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1786991, Length=386, Percent_Identity=25.3886010362694, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25144271, Length=357, Percent_Identity=28.5714285714286, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25144274, Length=342, Percent_Identity=27.1929824561404, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71992977, Length=362, Percent_Identity=26.7955801104972, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32564660, Length=335, Percent_Identity=27.7611940298507, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71981843, Length=171, Percent_Identity=28.0701754385965, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=350, Percent_Identity=29.1428571428571, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21357415, Length=362, Percent_Identity=28.7292817679558, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI21356575, Length=327, Percent_Identity=28.1345565749235, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI161085790, Length=345, Percent_Identity=26.6666666666667, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574759, Length=345, Percent_Identity=26.6666666666667, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46206; Mature: 46206

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQWTKSEQLYEEALRHIVGGVNSPSRSYKAVGGGAPVVMERAQGAYFWDVDGNKYIDYLA
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCHHHHHHH
AYGPIITGHAHPHITAAIQRAAETGVLYGTPTPHEITFAKMLKEAIPSLEKVRFVNSGTE
HHCCEEECCCCCHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHH
AVMTTIRVARAYTGRSKIVKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPQSIAHEVI
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHCEE
TVPYNDVESFREAMNVWGEHVAAVLVEPIVGNFGIVLPKPGFLEAVNDIAHEAGALVIYD
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCEEEHH
EVITAFRFMYGGAQNLLGIEPDMTAMGKIIGGGLPIGAYGGRQDIMEQVAPLGPAYQAGT
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
MAGNPASMLAGIACLEVLKQEGVYEHLDRLGAMLEEGIMTHARQCGLPVTINRLKGALTV
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCCCEEEE
FFTEEKVENYEQAQRSDGELFAKFFKLMLKQGVNLAPSKYEAWFITLAHTEDDIAYTIDA
EEEHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCHHHHHHH
VGRAFRQL
HHHHHHCC
>Mature Secondary Structure
MQWTKSEQLYEEALRHIVGGVNSPSRSYKAVGGGAPVVMERAQGAYFWDVDGNKYIDYLA
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCHHHHHHH
AYGPIITGHAHPHITAAIQRAAETGVLYGTPTPHEITFAKMLKEAIPSLEKVRFVNSGTE
HHCCEEECCCCCHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHH
AVMTTIRVARAYTGRSKIVKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPQSIAHEVI
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHCEE
TVPYNDVESFREAMNVWGEHVAAVLVEPIVGNFGIVLPKPGFLEAVNDIAHEAGALVIYD
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCEEEHH
EVITAFRFMYGGAQNLLGIEPDMTAMGKIIGGGLPIGAYGGRQDIMEQVAPLGPAYQAGT
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
MAGNPASMLAGIACLEVLKQEGVYEHLDRLGAMLEEGIMTHARQCGLPVTINRLKGALTV
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCCCEEEE
FFTEEKVENYEQAQRSDGELFAKFFKLMLKQGVNLAPSKYEAWFITLAHTEDDIAYTIDA
EEEHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCHHHHHHH
VGRAFRQL
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA