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The map label for this gene is acdA [H]

Identifier: 138894126

GI number: 138894126

Start: 508068

End: 509264

Strand: Reverse

Name: acdA [H]

Synonym: GTNG_0452

Alternate gene names: 138894126

Gene position: 509264-508068 (Counterclockwise)

Preceding gene: 138894127

Following gene: 138894110

Centisome position: 14.34

GC content: 52.3

Gene sequence:

>1197_bases
ATGAACTTCGACTTTACACCAGAACAAGAGATGTTGCGGCAAACGGTTCGCAAGTTTGTCGACAAAGAAATTATGCCGTA
TATCAAAGAATGGGATGAGCGCGGCGAATTTGACCGCAACATTTTCAAACGGCTCGCCGAGCTCAATTTAATGGGTGTCT
GCATTCCAGAACAATATGGCGGCATGGGCATGGACTACAACTCGCTCGCCATCGTCTGCGAAGAGCTCGAGCGCGGTGAC
ACCGCCTTCCGCACCGCTGTCTCGGTTCACACCGGTCTGAACAGCTTGACGCTATTGCAATGGGGGACGGAAGAACAAAA
ACAAAAATATCTCATCCCGCAAGCCCGCGGGGAAAAAATCGGCGCCTTTGGCCTAACCGAACCAAACGCCGGCTCAGACG
TTGCTTCGATTCAAACGACCGCTGTCCGTGATGGCGATGACTATATTTTAAACGGGCAAAAAACGTGGATTTCCCTTGCT
GACATCGCCGACCATTTCCTTGTATTCGCCTACACGGATAAATCGAAAAAACATCGCGGCATTTCCGCCTTCATCGTCGA
ACGGACAATGCCCGGGTTTTCGTCGCGCCCGATTAAAGGGAAGCTCGGCATCCGCTCCGGCAACACGGGCGAGCTGTTTT
TTGACAACGTCCGCGTCCCAAAAGAAAACTTGCTCGGTGAGGAAGGAGAAGGGTTCAAGATCGCCATGTCAGCACTCGAC
AATGGCCGCTTCACCGTCGCTGCCGGCGCCGTCGGCCTCATTATGGCGTGTTTAGAGGCGAGCGTCAAATATTGCCATGA
ACGAAAAACGTTTGGTAAAGAAATCGGTCGCCACCAGCTTGTTCAGCAAATGATCGCCCGCATGGAAGCCGGCTTGCAAA
TCAGCCGCCTGCTTGTCTACAAAGTCGGATTTCTGAAAAATGAAGGTCGACGCTGCACGCGGGAAACGTCGCTCGCCAAA
TGGATCGCTTGTGACTATGCCAACCAAGCAGCCGATGATGCGGTTCAAGTCCATGGCGCTTATGGCTACTCGAACGAATA
TCCAGTCGAGCGTTACTTACGCAACTCGAAAGCACCGGTCATTTACGAAGGTACACGGGAAATTCATACGATTATGCAGG
CTGAGTACGTGCTTGGCTACCGTAAGGACAAACCGTTGCGCAAAACATTGCCGGCATGGCGGCCAGACGAGAACTAA

Upstream 100 bases:

>100_bases
ACCAACGCAAGAGACATGGCTTCCCGCAACGGCTCGGCGCCCGCAAGCGCCAAGCAAACGCGGACATATACAATAGATGC
ATAGGAGGAGTAAAACGATG

Downstream 100 bases:

>100_bases
AACAACAGCGAAACGGCAGTTGTCCAAATCGCCGCTCTGTGCAAAAACGCGGCTGTCCTCATCCGCCGATGAGGAACAGC
CGCTTATTGTTCTTTCTCGT

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MNFDFTPEQEMLRQTVRKFVDKEIMPYIKEWDERGEFDRNIFKRLAELNLMGVCIPEQYGGMGMDYNSLAIVCEELERGD
TAFRTAVSVHTGLNSLTLLQWGTEEQKQKYLIPQARGEKIGAFGLTEPNAGSDVASIQTTAVRDGDDYILNGQKTWISLA
DIADHFLVFAYTDKSKKHRGISAFIVERTMPGFSSRPIKGKLGIRSGNTGELFFDNVRVPKENLLGEEGEGFKIAMSALD
NGRFTVAAGAVGLIMACLEASVKYCHERKTFGKEIGRHQLVQQMIARMEAGLQISRLLVYKVGFLKNEGRRCTRETSLAK
WIACDYANQAADDAVQVHGAYGYSNEYPVERYLRNSKAPVIYEGTREIHTIMQAEYVLGYRKDKPLRKTLPAWRPDEN

Sequences:

>Translated_398_residues
MNFDFTPEQEMLRQTVRKFVDKEIMPYIKEWDERGEFDRNIFKRLAELNLMGVCIPEQYGGMGMDYNSLAIVCEELERGD
TAFRTAVSVHTGLNSLTLLQWGTEEQKQKYLIPQARGEKIGAFGLTEPNAGSDVASIQTTAVRDGDDYILNGQKTWISLA
DIADHFLVFAYTDKSKKHRGISAFIVERTMPGFSSRPIKGKLGIRSGNTGELFFDNVRVPKENLLGEEGEGFKIAMSALD
NGRFTVAAGAVGLIMACLEASVKYCHERKTFGKEIGRHQLVQQMIARMEAGLQISRLLVYKVGFLKNEGRRCTRETSLAK
WIACDYANQAADDAVQVHGAYGYSNEYPVERYLRNSKAPVIYEGTREIHTIMQAEYVLGYRKDKPLRKTLPAWRPDEN
>Mature_398_residues
MNFDFTPEQEMLRQTVRKFVDKEIMPYIKEWDERGEFDRNIFKRLAELNLMGVCIPEQYGGMGMDYNSLAIVCEELERGD
TAFRTAVSVHTGLNSLTLLQWGTEEQKQKYLIPQARGEKIGAFGLTEPNAGSDVASIQTTAVRDGDDYILNGQKTWISLA
DIADHFLVFAYTDKSKKHRGISAFIVERTMPGFSSRPIKGKLGIRSGNTGELFFDNVRVPKENLLGEEGEGFKIAMSALD
NGRFTVAAGAVGLIMACLEASVKYCHERKTFGKEIGRHQLVQQMIARMEAGLQISRLLVYKVGFLKNEGRRCTRETSLAK
WIACDYANQAADDAVQVHGAYGYSNEYPVERYLRNSKAPVIYEGTREIHTIMQAEYVLGYRKDKPLRKTLPAWRPDEN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=38.7267904509284, Blast_Score=281, Evalue=8e-76,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=39.4805194805195, Blast_Score=275, Evalue=7e-74,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=39.4805194805195, Blast_Score=274, Evalue=9e-74,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=36.7292225201072, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI226958412, Length=372, Percent_Identity=39.247311827957, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI226958414, Length=367, Percent_Identity=38.1471389645777, Blast_Score=245, Evalue=6e-65,
Organism=Homo sapiens, GI4501857, Length=368, Percent_Identity=37.2282608695652, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI21361497, Length=362, Percent_Identity=37.5690607734807, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI4557235, Length=379, Percent_Identity=34.8284960422164, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI76496475, Length=379, Percent_Identity=34.8284960422164, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4503943, Length=377, Percent_Identity=33.9522546419098, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI7656849, Length=372, Percent_Identity=32.7956989247312, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI7669494, Length=361, Percent_Identity=34.0720221606648, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI211971008, Length=341, Percent_Identity=30.791788856305, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI48976061, Length=341, Percent_Identity=30.791788856305, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI38505218, Length=393, Percent_Identity=29.2620865139949, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI218563752, Length=231, Percent_Identity=26.4069264069264, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI297206874, Length=154, Percent_Identity=31.1688311688312, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI30089972, Length=154, Percent_Identity=31.1688311688312, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786223, Length=379, Percent_Identity=28.2321899736148, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=29.639175257732, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI87082384, Length=290, Percent_Identity=29.3103448275862, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081702, Length=346, Percent_Identity=24.8554913294798, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17508101, Length=365, Percent_Identity=38.3561643835616, Blast_Score=271, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17569725, Length=383, Percent_Identity=39.686684073107, Blast_Score=270, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17534899, Length=375, Percent_Identity=39.7333333333333, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17538396, Length=372, Percent_Identity=37.0967741935484, Blast_Score=264, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=37.7952755905512, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=36.1643835616438, Blast_Score=254, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI71985184, Length=345, Percent_Identity=38.5507246376812, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71990804, Length=306, Percent_Identity=38.562091503268, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17534353, Length=379, Percent_Identity=32.9815303430079, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71985192, Length=276, Percent_Identity=40.5797101449275, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17533517, Length=371, Percent_Identity=30.9973045822102, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71982178, Length=267, Percent_Identity=35.9550561797753, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=39.8268398268398, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17551932, Length=360, Percent_Identity=30.2777777777778, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17505929, Length=361, Percent_Identity=29.9168975069252, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=31.1203319502075, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17562446, Length=330, Percent_Identity=28.7878787878788, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=25.5681818181818, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540842, Length=267, Percent_Identity=28.8389513108614, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI86563383, Length=269, Percent_Identity=26.3940520446097, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI86563381, Length=269, Percent_Identity=26.3940520446097, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646207, Length=377, Percent_Identity=41.6445623342175, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=39.0374331550802, Blast_Score=284, Evalue=8e-77,
Organism=Drosophila melanogaster, GI24660351, Length=374, Percent_Identity=41.1764705882353, Blast_Score=277, Evalue=7e-75,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=38.9041095890411, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI21355753, Length=371, Percent_Identity=37.7358490566038, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI19920834, Length=383, Percent_Identity=35.509138381201, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI281363737, Length=346, Percent_Identity=33.8150289017341, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 44986; Mature: 44986

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDFTPEQEMLRQTVRKFVDKEIMPYIKEWDERGEFDRNIFKRLAELNLMGVCIPEQYG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCHHHC
GMGMDYNSLAIVCEELERGDTAFRTAVSVHTGLNSLTLLQWGTEEQKQKYLIPQARGEKI
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHCCCCCCCCCCC
GAFGLTEPNAGSDVASIQTTAVRDGDDYILNGQKTWISLADIADHFLVFAYTDKSKKHRG
CCCCCCCCCCCCCHHHEEEEEEECCCCEEECCCHHEEEHHHHHCCEEEEEEECCCCCCCC
ISAFIVERTMPGFSSRPIKGKLGIRSGNTGELFFDNVRVPKENLLGEEGEGFKIAMSALD
CEEEEEECCCCCCCCCCCCCEEECCCCCCCCEEECCCCCCHHHHCCCCCCCEEEEEEECC
NGRFTVAAGAVGLIMACLEASVKYCHERKTFGKEIGRHQLVQQMIARMEAGLQISRLLVY
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KVGFLKNEGRRCTRETSLAKWIACDYANQAADDAVQVHGAYGYSNEYPVERYLRNSKAPV
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCE
IYEGTREIHTIMQAEYVLGYRKDKPLRKTLPAWRPDEN
EECCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCC
>Mature Secondary Structure
MNFDFTPEQEMLRQTVRKFVDKEIMPYIKEWDERGEFDRNIFKRLAELNLMGVCIPEQYG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCHHHC
GMGMDYNSLAIVCEELERGDTAFRTAVSVHTGLNSLTLLQWGTEEQKQKYLIPQARGEKI
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHCCCCCCCCCCC
GAFGLTEPNAGSDVASIQTTAVRDGDDYILNGQKTWISLADIADHFLVFAYTDKSKKHRG
CCCCCCCCCCCCCHHHEEEEEEECCCCEEECCCHHEEEHHHHHCCEEEEEEECCCCCCCC
ISAFIVERTMPGFSSRPIKGKLGIRSGNTGELFFDNVRVPKENLLGEEGEGFKIAMSALD
CEEEEEECCCCCCCCCCCCCEEECCCCCCCCEEECCCCCCHHHHCCCCCCCEEEEEEECC
NGRFTVAAGAVGLIMACLEASVKYCHERKTFGKEIGRHQLVQQMIARMEAGLQISRLLVY
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KVGFLKNEGRRCTRETSLAKWIACDYANQAADDAVQVHGAYGYSNEYPVERYLRNSKAPV
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCE
IYEGTREIHTIMQAEYVLGYRKDKPLRKTLPAWRPDEN
EECCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]