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The map label for this gene is tipA [H]

Identifier: 138894118

GI number: 138894118

Start: 497406

End: 498158

Strand: Direct

Name: tipA [H]

Synonym: GTNG_0444

Alternate gene names: 138894118

Gene position: 497406-498158 (Clockwise)

Preceding gene: 138894117

Following gene: 138894119

Centisome position: 14.01

GC content: 48.87

Gene sequence:

>753_bases
GTGCATGAACTGGCCAAATTGGCAGGAGTGACAAGCCGGACGCTTCGGTATTACGATGAGATTGGTTTGCTCAAGCCGGC
ACGGTTGAGCGATGCCGGGTATCGGCTGTACGGACCGCGTGAAGTCGATCTTTTGCAGCAAATTCTCTTTTACCGTGAAC
TTGGCGTGGATTTGGAAACGATCAAACAAATCGTTCATTCCCCGGAATTTGACGAACTTGAAGCGTTGCGGCAGCATCGC
CAACAGCTATTGGAAAAAAGACGCCATCTTGATGCATTGATTGCGAGCGTTGAAAAAACGATTATTGCCAAAGAAGGAGG
AATCACGATGAGTGACAAAGAAAAGTTTGCCGCGTTCAAGGAGCGGCTGATTGAAGAAAACGAGCGGAAATATGGAGAAG
AAATTCGCCAGAAGTATGGCGACGAACAGGTCGATCGTTCCAACAATAGACTGCGGAATATGACAAAGGAACAGTTTGAT
GAGGCGGAACGGCTCGGCAAGGAAGTGCTAGAGGTGTTGAAAGAAGCGATGCAAGATGGTGACCCGGCCGGAGAGAAGGC
GCAACGGGCGGCTGATTTGCACCGTCAATGGCTTTGCTTCTGGTGGGATCATTATTCCAAAGAAGCTCATGCCGGGTTGG
CGCACATGTATGTTGAGGATGAACGGTTCAAAGCGCACTATGACCAAGTGCATCCGGGAGCGGCTGAATTTCTTAAAGAA
GCGATTTTGATTTATACGGGAATGAAGAAGTAA

Upstream 100 bases:

>100_bases
GACGAATGTTAGGAGCCCTTTTTTCTTTTTTCCTCTTTACTTTTACGTTACGTCAAGGTGTATCGTCATGAATAGGGAGG
TGAGGAACATCGAATACACC

Downstream 100 bases:

>100_bases
GCCGGGCGCAGCCTGTTTCCTATCGGGAAGCAGGCTGCATTTTTTGTGGGGAGGAGTGGATGATGGCCAGCGCGCACAAA
AAGTACATAGATAATCTAAT

Product: transcriptional activator TipA

Products: NA

Alternate protein names: Multidrug transporter activation protein [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MHELAKLAGVTSRTLRYYDEIGLLKPARLSDAGYRLYGPREVDLLQQILFYRELGVDLETIKQIVHSPEFDELEALRQHR
QQLLEKRRHLDALIASVEKTIIAKEGGITMSDKEKFAAFKERLIEENERKYGEEIRQKYGDEQVDRSNNRLRNMTKEQFD
EAERLGKEVLEVLKEAMQDGDPAGEKAQRAADLHRQWLCFWWDHYSKEAHAGLAHMYVEDERFKAHYDQVHPGAAEFLKE
AILIYTGMKK

Sequences:

>Translated_250_residues
MHELAKLAGVTSRTLRYYDEIGLLKPARLSDAGYRLYGPREVDLLQQILFYRELGVDLETIKQIVHSPEFDELEALRQHR
QQLLEKRRHLDALIASVEKTIIAKEGGITMSDKEKFAAFKERLIEENERKYGEEIRQKYGDEQVDRSNNRLRNMTKEQFD
EAERLGKEVLEVLKEAMQDGDPAGEKAQRAADLHRQWLCFWWDHYSKEAHAGLAHMYVEDERFKAHYDQVHPGAAEFLKE
AILIYTGMKK
>Mature_250_residues
MHELAKLAGVTSRTLRYYDEIGLLKPARLSDAGYRLYGPREVDLLQQILFYRELGVDLETIKQIVHSPEFDELEALRQHR
QQLLEKRRHLDALIASVEKTIIAKEGGITMSDKEKFAAFKERLIEENERKYGEEIRQKYGDEQVDRSNNRLRNMTKEQFD
EAERLGKEVLEVLKEAMQDGDPAGEKAQRAADLHRQWLCFWWDHYSKEAHAGLAHMYVEDERFKAHYDQVHPGAAEFLKE
AILIYTGMKK

Specific function: Global transcriptional regulator that activates transcription of bmr and blt by binding directly to their promoter. Stimulates also the expression of the mta gene itself, ydfK and ymfE [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR012925
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind; PF07739 TipAS [H]

EC number: NA

Molecular weight: Translated: 29276; Mature: 29276

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCC
>Mature Secondary Structure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HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9150240; 9384377 [H]