Click here to switch to the map view.

The map label for this gene is hutH

Identifier: 138894036

GI number: 138894036

Start: 411431

End: 412945

Strand: Direct

Name: hutH

Synonym: GTNG_0362

Alternate gene names: 138894036

Gene position: 411431-412945 (Clockwise)

Preceding gene: 138894035

Following gene: 138894037

Centisome position: 11.59

GC content: 55.18

Gene sequence:

>1515_bases
ATGATTGTGTTGACTGGGCATTCATTAACGATTGCCGAGGCAAGACGCGTCATTTATGATAGAGAACCGGTGGCAGCCGC
TTTGGAGAGCATGGAAGCGGTTCGGAAAAGTCGAGCAGCTGTGGAACAGGCGATTGCGAGCGGCAGGACGATTTATGGCG
TGAATACCGGCTTTGGCAAACTTGCCGATGTGCGCATTGATGGAAGTGATCTTGAGCAGTTGCAAATCAATCTTCTCCGA
TCGCACGCTTGCGCAGTTGGTGAGCCGTTTGCCGAGGAAGTGGTGCGGGCGATGCTTCTTTTACGGGCGAATGCTTTATT
AAAGGGATATTCCGGCATAAGGCCGGTGGTGATTGAGCGGCTGCTCGCGTTTCTTAATTCCGGTATCCATCCGATTGTTC
CGCAGCAAGGTTCCCTCGGCGCCAGCGGCGATTTAGCGCCGCTTGCCCATTTGGCGTTGGCGCTTGTCGGTGAAGGGGAG
GTGATGTACCAAGGGCAGCGGATGCCTGCCATCCAAGCGCTTTCGCAAGCGGGAATTCCTCCGCTCTCTCTGAAAGAGAA
GGAGGGGTTGGCGCTTATTAACGGTACGCAGGCGATGACAGCTATGGGGGTGATCGCTTATCTTGAGGCGGAACAGCTTG
CTTACGACAGCGAGTGGATCGCCGCGTTAACAATCGAGGCGCTTTATGGCGTGATCGATGCGTTTGATGCCCGCATCCAC
GAAGCCCGTGGATTTTTAGAGCAGGCGGAGGTGGCCGAGCGGCTGCGTCGCTATCTAGATGGCAGTCAGCTTATCACAAG
GCAAGGAGAGCGGCGCGTGCAAGATGCGTACTCGATCCGTTGCATTCCGCAAGTGCATGGAGCATCGCTCAGAGCGCTTC
GCTATGTAAAGGAAACACTTGAAATCGAAATGAACGCTGCTACGGACAATCCGCTTATTTTTGCGGACGGAGCCGTGCTC
TCGGGCGGCAATTTTCACGGCCAACCTGTTGCGATCGCCATGGATTTGTTAAAAATCGCGGTGGCGGAACTGGCCAATAT
GAGCGAGCGGCGTATTGAGCGGCTTGTCAATCCGCAGCTTAGCGAAGGCTTGCCGCCGTTTTTAAGCCCAGAGCCAGGCC
TACAGTCGGGGGCGATGATCATGCAGTACGTTGCCGCTTCGCTCGTATCAGAAAACAAGACGCTGGCCCATCCAGCAAGC
GTTGATTCCATCCCGTCATCGGCCAACCAAGAAGACCATGTCAGCATGGGAACGACTGCTGCCCGTCATGCGTATCTGAT
CGTGCAGAATGTGAGAAAAGTATTGGCCATCGAGCTCATTTGCGCTTTACAGGCGGTAGAGGAGCGCGGCATTGATCAGC
TGGCACCGTCAACAAGTCAGCTTTACCATCAGGCGCGCCGCATTGTTCCTTCCATTGTGGCGGATCGCGTGTTTTCCCGT
GATATTGAAGCGGTGGATGCTTGGTTGAAGCAGCAGGCGATAAGAGACCGTTTGGCCGGCGGAGCGAGCGTGTAA

Upstream 100 bases:

>100_bases
GGATCAGCCTAGAGCGATGAGTCATGAGGAGGCGAATACTGCCTGAAACGGCGGGGCGCCTCCTTTTTGTTTTTTGATAT
GAACGAAGGGAGATGGGGTC

Downstream 100 bases:

>100_bases
AACAAGTCATAGGACAACATACGTCCTCCGGTTTGGAGCATATAGTAAAGGATATCGTCAGCCATTTTTCGCATCTAGTC
ATAATGGAGGCGATACAAAA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MIVLTGHSLTIAEARRVIYDREPVAAALESMEAVRKSRAAVEQAIASGRTIYGVNTGFGKLADVRIDGSDLEQLQINLLR
SHACAVGEPFAEEVVRAMLLLRANALLKGYSGIRPVVIERLLAFLNSGIHPIVPQQGSLGASGDLAPLAHLALALVGEGE
VMYQGQRMPAIQALSQAGIPPLSLKEKEGLALINGTQAMTAMGVIAYLEAEQLAYDSEWIAALTIEALYGVIDAFDARIH
EARGFLEQAEVAERLRRYLDGSQLITRQGERRVQDAYSIRCIPQVHGASLRALRYVKETLEIEMNAATDNPLIFADGAVL
SGGNFHGQPVAIAMDLLKIAVAELANMSERRIERLVNPQLSEGLPPFLSPEPGLQSGAMIMQYVAASLVSENKTLAHPAS
VDSIPSSANQEDHVSMGTTAARHAYLIVQNVRKVLAIELICALQAVEERGIDQLAPSTSQLYHQARRIVPSIVADRVFSR
DIEAVDAWLKQQAIRDRLAGGASV

Sequences:

>Translated_504_residues
MIVLTGHSLTIAEARRVIYDREPVAAALESMEAVRKSRAAVEQAIASGRTIYGVNTGFGKLADVRIDGSDLEQLQINLLR
SHACAVGEPFAEEVVRAMLLLRANALLKGYSGIRPVVIERLLAFLNSGIHPIVPQQGSLGASGDLAPLAHLALALVGEGE
VMYQGQRMPAIQALSQAGIPPLSLKEKEGLALINGTQAMTAMGVIAYLEAEQLAYDSEWIAALTIEALYGVIDAFDARIH
EARGFLEQAEVAERLRRYLDGSQLITRQGERRVQDAYSIRCIPQVHGASLRALRYVKETLEIEMNAATDNPLIFADGAVL
SGGNFHGQPVAIAMDLLKIAVAELANMSERRIERLVNPQLSEGLPPFLSPEPGLQSGAMIMQYVAASLVSENKTLAHPAS
VDSIPSSANQEDHVSMGTTAARHAYLIVQNVRKVLAIELICALQAVEERGIDQLAPSTSQLYHQARRIVPSIVADRVFSR
DIEAVDAWLKQQAIRDRLAGGASV
>Mature_504_residues
MIVLTGHSLTIAEARRVIYDREPVAAALESMEAVRKSRAAVEQAIASGRTIYGVNTGFGKLADVRIDGSDLEQLQINLLR
SHACAVGEPFAEEVVRAMLLLRANALLKGYSGIRPVVIERLLAFLNSGIHPIVPQQGSLGASGDLAPLAHLALALVGEGE
VMYQGQRMPAIQALSQAGIPPLSLKEKEGLALINGTQAMTAMGVIAYLEAEQLAYDSEWIAALTIEALYGVIDAFDARIH
EARGFLEQAEVAERLRRYLDGSQLITRQGERRVQDAYSIRCIPQVHGASLRALRYVKETLEIEMNAATDNPLIFADGAVL
SGGNFHGQPVAIAMDLLKIAVAELANMSERRIERLVNPQLSEGLPPFLSPEPGLQSGAMIMQYVAASLVSENKTLAHPAS
VDSIPSSANQEDHVSMGTTAARHAYLIVQNVRKVLAIELICALQAVEERGIDQLAPSTSQLYHQARRIVPSIVADRVFSR
DIEAVDAWLKQQAIRDRLAGGASV

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=501, Percent_Identity=45.1097804391218, Blast_Score=394, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17567831, Length=506, Percent_Identity=45.2569169960474, Blast_Score=382, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_GEOTN (A4IK90)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001124489.1
- ProteinModelPortal:   A4IK90
- SMR:   A4IK90
- STRING:   A4IK90
- GeneID:   4965306
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_0362
- NMPDR:   fig|420246.5.peg.347
- eggNOG:   COG2986
- HOGENOM:   HBG510887
- OMA:   QKGQIDS
- ProtClustDB:   PRK09367
- BioCyc:   GTHE420246:GTNG_0362-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 54432; Mature: 54432

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVLTGHSLTIAEARRVIYDREPVAAALESMEAVRKSRAAVEQAIASGRTIYGVNTGFGK
CEEECCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
LADVRIDGSDLEQLQINLLRSHACAVGEPFAEEVVRAMLLLRANALLKGYSGIRPVVIER
EEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LLAFLNSGIHPIVPQQGSLGASGDLAPLAHLALALVGEGEVMYQGQRMPAIQALSQAGIP
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHCCCC
PLSLKEKEGLALINGTQAMTAMGVIAYLEAEQLAYDSEWIAALTIEALYGVIDAFDARIH
CCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
EARGFLEQAEVAERLRRYLDGSQLITRQGERRVQDAYSIRCIPQVHGASLRALRYVKETL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHH
EIEMNAATDNPLIFADGAVLSGGNFHGQPVAIAMDLLKIAVAELANMSERRIERLVNPQL
HEEEECCCCCCEEEECCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHH
SEGLPPFLSPEPGLQSGAMIMQYVAASLVSENKTLAHPASVDSIPSSANQEDHVSMGTTA
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
ARHAYLIVQNVRKVLAIELICALQAVEERGIDQLAPSTSQLYHQARRIVPSIVADRVFSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
DIEAVDAWLKQQAIRDRLAGGASV
HHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIVLTGHSLTIAEARRVIYDREPVAAALESMEAVRKSRAAVEQAIASGRTIYGVNTGFGK
CEEECCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
LADVRIDGSDLEQLQINLLRSHACAVGEPFAEEVVRAMLLLRANALLKGYSGIRPVVIER
EEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LLAFLNSGIHPIVPQQGSLGASGDLAPLAHLALALVGEGEVMYQGQRMPAIQALSQAGIP
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHCCCC
PLSLKEKEGLALINGTQAMTAMGVIAYLEAEQLAYDSEWIAALTIEALYGVIDAFDARIH
CCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
EARGFLEQAEVAERLRRYLDGSQLITRQGERRVQDAYSIRCIPQVHGASLRALRYVKETL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHH
EIEMNAATDNPLIFADGAVLSGGNFHGQPVAIAMDLLKIAVAELANMSERRIERLVNPQL
HEEEECCCCCCEEEECCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHH
SEGLPPFLSPEPGLQSGAMIMQYVAASLVSENKTLAHPASVDSIPSSANQEDHVSMGTTA
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
ARHAYLIVQNVRKVLAIELICALQAVEERGIDQLAPSTSQLYHQARRIVPSIVADRVFSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
DIEAVDAWLKQQAIRDRLAGGASV
HHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA