Click here to switch to the map view.

The map label for this gene is ndhS [H]

Identifier: 138894027

GI number: 138894027

Start: 403524

End: 404030

Strand: Reverse

Name: ndhS [H]

Synonym: GTNG_0353

Alternate gene names: 138894027

Gene position: 404030-403524 (Counterclockwise)

Preceding gene: 138894028

Following gene: 138894026

Centisome position: 11.38

GC content: 49.9

Gene sequence:

>507_bases
ATGGAAGAAACGACCAAATGTGAGCTCGTGTTGCACATTAACGGAGAACAACGAACGGTCATCACCCGTCAAGCCGAAAC
ACTACTATTCGTCTTGCGGGACGAGCTCGGACTGACCGGGACCAAACCCGGCTGTTTAAATGGCGACTGCGGTGCCTGTA
CTGTCTTAGTCAACGGCACACCAATCAAATCGTGCATGATGCTTGCTATTGAGACTGTTGGTAAAGAAATTACCACAATC
GAGGGGCTCCGCGATACTCCTATTCAGCACGCCTTTGTCCGTCACTTCGCCTTTCAATGCGGCTATTGCACGCCTGGCTT
TATTATGAACATCCATGCGCTCATCGAGCAGCATCCAAACGCTGATCAGTCAACGATTCAAGAATGGCTGCAGTCAAATA
TTTGTCGCTGCACGAGCTATCAAGAAATCGAGGCGGCGGTGAAAGAAGCGCTTCAAGCCAAAAAAACGGACATACAGCCC
TCACATAACCGGATATCCCGAGTCTAG

Upstream 100 bases:

>100_bases
AGGCTCAGCAGACTATCGACTGTTTGTTGCCGCTCAGCTACTTGAAGACGCACTTCGCGAGTTAGGGGAAACCATCTAGA
CGGGAGGTCAACATACGGAC

Downstream 100 bases:

>100_bases
CAGGGATATCCTTTTTTGTGCGATGATTTTTCCATCCCATTCCAAATACCTATTGACAAAAATATAACGTTCACGTTAAC
GTTATATCTGTAGAAAACAC

Product: xanthine dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase small FeS subunit; NAH [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MEETTKCELVLHINGEQRTVITRQAETLLFVLRDELGLTGTKPGCLNGDCGACTVLVNGTPIKSCMMLAIETVGKEITTI
EGLRDTPIQHAFVRHFAFQCGYCTPGFIMNIHALIEQHPNADQSTIQEWLQSNICRCTSYQEIEAAVKEALQAKKTDIQP
SHNRISRV

Sequences:

>Translated_168_residues
MEETTKCELVLHINGEQRTVITRQAETLLFVLRDELGLTGTKPGCLNGDCGACTVLVNGTPIKSCMMLAIETVGKEITTI
EGLRDTPIQHAFVRHFAFQCGYCTPGFIMNIHALIEQHPNADQSTIQEWLQSNICRCTSYQEIEAAVKEALQAKKTDIQP
SHNRISRV
>Mature_168_residues
MEETTKCELVLHINGEQRTVITRQAETLLFVLRDELGLTGTKPGCLNGDCGACTVLVNGTPIKSCMMLAIETVGKEITTI
EGLRDTPIQHAFVRHFAFQCGYCTPGFIMNIHALIEQHPNADQSTIQEWLQSNICRCTSYQEIEAAVKEALQAKKTDIQP
SHNRISRV

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=157, Percent_Identity=35.031847133758, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI71773480, Length=159, Percent_Identity=36.4779874213836, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1786480, Length=163, Percent_Identity=44.1717791411043, Blast_Score=118, Evalue=2e-28,
Organism=Escherichia coli, GI1789232, Length=138, Percent_Identity=44.9275362318841, Blast_Score=99, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17540638, Length=152, Percent_Identity=41.4473684210526, Blast_Score=111, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17539860, Length=135, Percent_Identity=37.7777777777778, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI32566215, Length=155, Percent_Identity=35.4838709677419, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17737937, Length=159, Percent_Identity=35.8490566037736, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24647195, Length=138, Percent_Identity=37.6811594202899, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24647197, Length=138, Percent_Identity=37.6811594202899, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24647201, Length=132, Percent_Identity=37.8787878787879, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24647199, Length=132, Percent_Identity=36.3636363636364, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24647193, Length=133, Percent_Identity=33.8345864661654, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 18688; Mature: 18688

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
5.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEETTKCELVLHINGEQRTVITRQAETLLFVLRDELGLTGTKPGCLNGDCGACTVLVNGT
CCCCCEEEEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCC
PIKSCMMLAIETVGKEITTIEGLRDTPIQHAFVRHFAFQCGYCTPGFIMNIHALIEQHPN
CHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
ADQSTIQEWLQSNICRCTSYQEIEAAVKEALQAKKTDIQPSHNRISRV
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
>Mature Secondary Structure
MEETTKCELVLHINGEQRTVITRQAETLLFVLRDELGLTGTKPGCLNGDCGACTVLVNGT
CCCCCEEEEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCC
PIKSCMMLAIETVGKEITTIEGLRDTPIQHAFVRHFAFQCGYCTPGFIMNIHALIEQHPN
CHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
ADQSTIQEWLQSNICRCTSYQEIEAAVKEALQAKKTDIQPSHNRISRV
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA