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The map label for this gene is dapL [H]

Identifier: 138894021

GI number: 138894021

Start: 395951

End: 397126

Strand: Direct

Name: dapL [H]

Synonym: GTNG_0347

Alternate gene names: 138894021

Gene position: 395951-397126 (Clockwise)

Preceding gene: 138894020

Following gene: 138894022

Centisome position: 11.15

GC content: 51.62

Gene sequence:

>1176_bases
ATGAAGATGGCTTCCGACCTTGTGAGAAGAATGCCGCCGTATTTATTTTCGGACTTTGAGCGAAAAAAGGTCGAGCTTGC
GAAAAAAGGGGTTGATGTCATCGATTTAGGCATCGGGGCGCCAGATTTGCCGCCGCCGTCGTTTCTTATTGAGACGCTGA
AACGCGAGCTGGATGACCCACGCAATTATACGTATTCTCCGTACGCCGGCTGCCGCGAATATCGCGAAGCCGTTGCTGAC
TTTTATGAGCGGCAGTATGGTGTCAAGCTTGACCCAGACACTGAAGTGCTCGCTTTGATTGGCTCAAAAGAAGGCATTGT
CCATCTATTGCAGGCGCTGATTGATCCGGGGGATGCAGTGCTTGTTCCGAACCCGGGCTATCCGGTGTATCGAACTGCTA
TTCACCTTGCCCGAGGCACGCCGATCGACTTGCCGCTGGATGCAGCCCGTGACTACGCACCACAATTTTCCGCTATTACT
CCATCCACTTATGATCGAGTCAATATCATGCTATTAAACTATCCAAGCAATCCAACAGCATCATTAGCCACCATCGATGT
TTTCATAGAAGCAGTCATGCTTGCAAAAAAACATCGTTTTCTTATCGCCCATGATTCAGCCTATTCATTATTGACATTCG
GTGATGCCTTTGCTCCGAGCGTGCTGCAAGTTGACGGTGCCAAAGAAGTAGCCATCGAATTTGGATCTTTATCGAAAAGC
TATAACATGGCTGGTTGCCGCATCGGTTATATCGTCGGCAATAAGGAGGTCATTCGGGCGCTCTCCATCTTGAAAAGCAA
TATTGATACGTGTCAATTTTTGGCGGTGCAAAAAGCAGCGGCCGTTGCATTGCGGAGCGGAGATGAAGCCGCAAAGGAGA
ACAGCCGCATTTATGAAGAGCGGATGAAGGCAATGACGGTTGCACTTTGGCAAATAGGCGTGCCCGTTCAGCCGCCTCGA
GCGACGTTTTTTCTTTGGGTGCCAACGGCGGTCGGTTACTCTTCCGCTCAGTTCGCCGCTCGGTTGCTTGATGAGGCCGG
GGTGATCGTTACACCAGGGACGGCGTTTGGTTCAGCAGGGGAAGGGTATGTGCGCATATCACTCGCCGCTCCGAAGGAAC
GGCTGCTCGAAGCCGTTCGGCGCTGGAAAGCGATTGAATGGGAGGGACGGCCATGA

Upstream 100 bases:

>100_bases
AACAACGGTGAGTGATGATCCGGCTCCAGCCAGCATCGAACACCCTGTCGTTTGCTTGTTCCGCGCCTCAAACAATCGAA
TCGAAGGGGGAGAGGCCGCG

Downstream 100 bases:

>100_bases
AAAAGCGGGTGATGCGTGGCCTTTCTGTCCCGCAAGCGATTGTCGAATGCTTAAAACAAGAGCGTATTTCTCATTTGTTT
GGCGTGCCGGGAGAAAGTTA

Product: aspartate aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKMASDLVRRMPPYLFSDFERKKVELAKKGVDVIDLGIGAPDLPPPSFLIETLKRELDDPRNYTYSPYAGCREYREAVAD
FYERQYGVKLDPDTEVLALIGSKEGIVHLLQALIDPGDAVLVPNPGYPVYRTAIHLARGTPIDLPLDAARDYAPQFSAIT
PSTYDRVNIMLLNYPSNPTASLATIDVFIEAVMLAKKHRFLIAHDSAYSLLTFGDAFAPSVLQVDGAKEVAIEFGSLSKS
YNMAGCRIGYIVGNKEVIRALSILKSNIDTCQFLAVQKAAAVALRSGDEAAKENSRIYEERMKAMTVALWQIGVPVQPPR
ATFFLWVPTAVGYSSAQFAARLLDEAGVIVTPGTAFGSAGEGYVRISLAAPKERLLEAVRRWKAIEWEGRP

Sequences:

>Translated_391_residues
MKMASDLVRRMPPYLFSDFERKKVELAKKGVDVIDLGIGAPDLPPPSFLIETLKRELDDPRNYTYSPYAGCREYREAVAD
FYERQYGVKLDPDTEVLALIGSKEGIVHLLQALIDPGDAVLVPNPGYPVYRTAIHLARGTPIDLPLDAARDYAPQFSAIT
PSTYDRVNIMLLNYPSNPTASLATIDVFIEAVMLAKKHRFLIAHDSAYSLLTFGDAFAPSVLQVDGAKEVAIEFGSLSKS
YNMAGCRIGYIVGNKEVIRALSILKSNIDTCQFLAVQKAAAVALRSGDEAAKENSRIYEERMKAMTVALWQIGVPVQPPR
ATFFLWVPTAVGYSSAQFAARLLDEAGVIVTPGTAFGSAGEGYVRISLAAPKERLLEAVRRWKAIEWEGRP
>Mature_391_residues
MKMASDLVRRMPPYLFSDFERKKVELAKKGVDVIDLGIGAPDLPPPSFLIETLKRELDDPRNYTYSPYAGCREYREAVAD
FYERQYGVKLDPDTEVLALIGSKEGIVHLLQALIDPGDAVLVPNPGYPVYRTAIHLARGTPIDLPLDAARDYAPQFSAIT
PSTYDRVNIMLLNYPSNPTASLATIDVFIEAVMLAKKHRFLIAHDSAYSLLTFGDAFAPSVLQVDGAKEVAIEFGSLSKS
YNMAGCRIGYIVGNKEVIRALSILKSNIDTCQFLAVQKAAAVALRSGDEAAKENSRIYEERMKAMTVALWQIGVPVQPPR
ATFFLWVPTAVGYSSAQFAARLLDEAGVIVTPGTAFGSAGEGYVRISLAAPKERLLEAVRRWKAIEWEGRP

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=275, Percent_Identity=26.9090909090909, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI56713256, Length=275, Percent_Identity=26.9090909090909, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI95147551, Length=401, Percent_Identity=21.9451371571072, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI169881279, Length=401, Percent_Identity=21.9451371571072, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI7705897, Length=353, Percent_Identity=25.7790368271955, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI33469970, Length=353, Percent_Identity=25.7790368271955, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788722, Length=381, Percent_Identity=36.745406824147, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI1786816, Length=363, Percent_Identity=26.9972451790634, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788627, Length=363, Percent_Identity=26.7217630853994, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71994476, Length=262, Percent_Identity=25.5725190839695, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71994472, Length=262, Percent_Identity=25.5725190839695, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17567369, Length=260, Percent_Identity=23.0769230769231, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17567663, Length=372, Percent_Identity=26.0752688172043, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322401, Length=391, Percent_Identity=23.2736572890026, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320317, Length=371, Percent_Identity=22.1024258760108, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573069, Length=388, Percent_Identity=23.7113402061856, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24646114, Length=388, Percent_Identity=23.7113402061856, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28573067, Length=388, Percent_Identity=23.7113402061856, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28573065, Length=388, Percent_Identity=23.7113402061856, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 43023; Mature: 43023

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMASDLVRRMPPYLFSDFERKKVELAKKGVDVIDLGIGAPDLPPPSFLIETLKRELDDP
CCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCC
RNYTYSPYAGCREYREAVADFYERQYGVKLDPDTEVLALIGSKEGIVHLLQALIDPGDAV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEECCCCHHHHHHHHHHCCCCEE
LVPNPGYPVYRTAIHLARGTPIDLPLDAARDYAPQFSAITPSTYDRVNIMLLNYPSNPTA
EECCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCC
SLATIDVFIEAVMLAKKHRFLIAHDSAYSLLTFGDAFAPSVLQVDGAKEVAIEFGSLSKS
HHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEECCCCCCCEEEECCCHHEEEEHHCCCCC
YNMAGCRIGYIVGNKEVIRALSILKSNIDTCQFLAVQKAAAVALRSGDEAAKENSRIYEE
CCCCCEEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
RMKAMTVALWQIGVPVQPPRATFFLWVPTAVGYSSAQFAARLLDEAGVIVTPGTAFGSAG
HHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCC
EGYVRISLAAPKERLLEAVRRWKAIEWEGRP
CCEEEEEECCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKMASDLVRRMPPYLFSDFERKKVELAKKGVDVIDLGIGAPDLPPPSFLIETLKRELDDP
CCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCC
RNYTYSPYAGCREYREAVADFYERQYGVKLDPDTEVLALIGSKEGIVHLLQALIDPGDAV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEECCCCHHHHHHHHHHCCCCEE
LVPNPGYPVYRTAIHLARGTPIDLPLDAARDYAPQFSAITPSTYDRVNIMLLNYPSNPTA
EECCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCC
SLATIDVFIEAVMLAKKHRFLIAHDSAYSLLTFGDAFAPSVLQVDGAKEVAIEFGSLSKS
HHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEECCCCCCCEEEECCCHHEEEEHHCCCCC
YNMAGCRIGYIVGNKEVIRALSILKSNIDTCQFLAVQKAAAVALRSGDEAAKENSRIYEE
CCCCCEEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
RMKAMTVALWQIGVPVQPPRATFFLWVPTAVGYSSAQFAARLLDEAGVIVTPGTAFGSAG
HHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCC
EGYVRISLAAPKERLLEAVRRWKAIEWEGRP
CCEEEEEECCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]