Click here to switch to the map view.

The map label for this gene is ycsA [H]

Identifier: 138893967

GI number: 138893967

Start: 328862

End: 329935

Strand: Direct

Name: ycsA [H]

Synonym: GTNG_0291

Alternate gene names: 138893967

Gene position: 328862-329935 (Clockwise)

Preceding gene: 138893966

Following gene: 138893968

Centisome position: 9.26

GC content: 39.29

Gene sequence:

>1074_bases
ATGAGGGAGTTTCGGATAGCAGTTCTTCCAGGTGATGGAATAGGTCCTGAAGTAATGAATGAGGCGTTAAAAGTTTTACG
GATACTCAAAGATAAAGATTACACATTTCAATTTCATGCAGATATGTTTTTGTGGAATTCAGAGTATTACTTGCAGCATG
GGAGAATGATGCCAGAAAACGGTCTAGATATATTAAAGAATTACGATGCCATCTTGTTCGGTGCTATCGGAGACCCACGT
GTGCCTGATGATATATCTGTGTGGGAATTGATTATGCCAATACGGAAAAGGTTTTGTCAATATGTGAATCTTCGACCTGT
GAAAAAACTGAAGGGAATTCCTGAACAATTTATCCATCAAGAACGCCCTATCAATTTTGTAATAGTAAGAGAAAATGCAG
AGGGTGAATATTCTAATAGTGGAGGAAGAATATATCAGGGAACTGATCAAGAAATAGCTGTTCAAAATACAATCATCACA
AGGAAGGGAACAGAGAGAATAGCAAGATATGCATTTCAATATGCTAAAAAACATGGTTATCAAAAAGTTATAAATGCAAC
AAAGTCAAATGCGGTAGTCCACTCGATGAAATTGTGGGACGAGGTGATTGAGCATGTTGCCAGCGAATATCCAGATATTC
AATTAGAAAAGTACTATATTGATGCTTTAGCTGCATACTTTGTTCAAAGACCTGATACACTTCAAGTTATTGTCGCCTCT
AATTTATTCGGTGATATCCTTTCAGATTTAGGCTCTGCTTTAGTAGGGGGACTAGGTATATCGCCTTCCGCTAACATCAA
CCCGGAAGGGGTATTTCCATCGATGTTTGAGCCGGTACATGGGTCAGCCCCAGACATTGCGGGAAAGGGAAAAGCGAATC
CGATTGCCCAAATTTGGTCAGCAGCGCTAATGCTTCAATCTTTAGGCAGAGAGGATTTAGCTAGTATTATCTTAAAAGCA
ATTGAAAAGGTAACCGAGCACGGAGAAAAATTGACAGAGGATCTTGGTGGCAATTCAACAACCGCTGAAATGGGAGAAGA
AATCGTTCGACAAATAGTCAAAATAATGGGCTAA

Upstream 100 bases:

>100_bases
TCATCAAGTTGATGAGTACGTAGATATCGATGAACTCGCTGAAACGACTGAAATCTATAGAACAGCAGCTTTGCTGTTCT
TAAATGAAGAGGTTTAGAGA

Downstream 100 bases:

>100_bases
AGGTAGAGAGGTGAGATCAATTGTGTATGCGCTTTCTAGACAAAGTCGTTATCGTAACAGGAGCAGCAGGAGGTATGGGG
AAAGCAGCCGTAAAGCGTTT

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MREFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADMFLWNSEYYLQHGRMMPENGLDILKNYDAILFGAIGDPR
VPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQFIHQERPINFVIVRENAEGEYSNSGGRIYQGTDQEIAVQNTIIT
RKGTERIARYAFQYAKKHGYQKVINATKSNAVVHSMKLWDEVIEHVASEYPDIQLEKYYIDALAAYFVQRPDTLQVIVAS
NLFGDILSDLGSALVGGLGISPSANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQIWSAALMLQSLGREDLASIILKA
IEKVTEHGEKLTEDLGGNSTTAEMGEEIVRQIVKIMG

Sequences:

>Translated_357_residues
MREFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADMFLWNSEYYLQHGRMMPENGLDILKNYDAILFGAIGDPR
VPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQFIHQERPINFVIVRENAEGEYSNSGGRIYQGTDQEIAVQNTIIT
RKGTERIARYAFQYAKKHGYQKVINATKSNAVVHSMKLWDEVIEHVASEYPDIQLEKYYIDALAAYFVQRPDTLQVIVAS
NLFGDILSDLGSALVGGLGISPSANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQIWSAALMLQSLGREDLASIILKA
IEKVTEHGEKLTEDLGGNSTTAEMGEEIVRQIVKIMG
>Mature_357_residues
MREFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADMFLWNSEYYLQHGRMMPENGLDILKNYDAILFGAIGDPR
VPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQFIHQERPINFVIVRENAEGEYSNSGGRIYQGTDQEIAVQNTIIT
RKGTERIARYAFQYAKKHGYQKVINATKSNAVVHSMKLWDEVIEHVASEYPDIQLEKYYIDALAAYFVQRPDTLQVIVAS
NLFGDILSDLGSALVGGLGISPSANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQIWSAALMLQSLGREDLASIILKA
IEKVTEHGEKLTEDLGGNSTTAEMGEEIVRQIVKIMG

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=352, Percent_Identity=34.6590909090909, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI28178821, Length=356, Percent_Identity=30.6179775280899, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI28178816, Length=353, Percent_Identity=30.5949008498584, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI4758582, Length=353, Percent_Identity=29.4617563739377, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI28178838, Length=317, Percent_Identity=29.3375394321767, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI28178819, Length=196, Percent_Identity=35.7142857142857, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1788101, Length=362, Percent_Identity=48.8950276243094, Blast_Score=345, Evalue=2e-96,
Organism=Escherichia coli, GI87081683, Length=368, Percent_Identity=38.5869565217391, Blast_Score=215, Evalue=3e-57,
Organism=Escherichia coli, GI1787381, Length=360, Percent_Identity=29.1666666666667, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71986051, Length=353, Percent_Identity=33.4277620396601, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17550882, Length=350, Percent_Identity=31.7142857142857, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI25144293, Length=362, Percent_Identity=29.0055248618785, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17505779, Length=352, Percent_Identity=28.9772727272727, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322097, Length=361, Percent_Identity=34.9030470914127, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6324709, Length=355, Percent_Identity=34.3661971830986, Blast_Score=172, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6319830, Length=368, Percent_Identity=33.4239130434783, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324291, Length=359, Percent_Identity=30.9192200557103, Blast_Score=145, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24643268, Length=349, Percent_Identity=34.9570200573066, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24643270, Length=349, Percent_Identity=34.9570200573066, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24661184, Length=353, Percent_Identity=31.4447592067989, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI161078633, Length=354, Percent_Identity=27.4011299435028, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24650122, Length=354, Percent_Identity=27.4011299435028, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI161078637, Length=354, Percent_Identity=27.4011299435028, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI161078635, Length=354, Percent_Identity=27.4011299435028, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI161078639, Length=352, Percent_Identity=27.5568181818182, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI281362242, Length=348, Percent_Identity=29.8850574712644, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24648872, Length=348, Percent_Identity=29.8850574712644, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20130355, Length=350, Percent_Identity=26, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 39983; Mature: 39983

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADMFLWNSEYYLQHGRMMPEN
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHCCCCCCCC
GLDILKNYDAILFGAIGDPRVPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQFIHQ
CHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHC
ERPINFVIVRENAEGEYSNSGGRIYQGTDQEIAVQNTIITRKGTERIARYAFQYAKKHGY
CCCCEEEEEEECCCCCCCCCCCEEEECCCCCEEHHHHEECCCCHHHHHHHHHHHHHHHCH
QKVINATKSNAVVHSMKLWDEVIEHVASEYPDIQLEKYYIDALAAYFVQRPDTLQVIVAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEHHHH
NLFGDILSDLGSALVGGLGISPSANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQIWS
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHH
AALMLQSLGREDLASIILKAIEKVTEHGEKLTEDLGGNSTTAEMGEEIVRQIVKIMG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MREFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADMFLWNSEYYLQHGRMMPEN
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHCCCCCCCC
GLDILKNYDAILFGAIGDPRVPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQFIHQ
CHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHC
ERPINFVIVRENAEGEYSNSGGRIYQGTDQEIAVQNTIITRKGTERIARYAFQYAKKHGY
CCCCEEEEEEECCCCCCCCCCCEEEECCCCCEEHHHHEECCCCHHHHHHHHHHHHHHHCH
QKVINATKSNAVVHSMKLWDEVIEHVASEYPDIQLEKYYIDALAAYFVQRPDTLQVIVAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEHHHH
NLFGDILSDLGSALVGGLGISPSANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQIWS
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHH
AALMLQSLGREDLASIILKAIEKVTEHGEKLTEDLGGNSTTAEMGEEIVRQIVKIMG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10568751 [H]