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The map label for this gene is purC [H]

Identifier: 138893916

GI number: 138893916

Start: 268128

End: 268859

Strand: Direct

Name: purC [H]

Synonym: GTNG_0240

Alternate gene names: 138893916

Gene position: 268128-268859 (Clockwise)

Preceding gene: 138893915

Following gene: 138893917

Centisome position: 7.55

GC content: 49.45

Gene sequence:

>732_bases
ATGATGCCGACAAAACAACAGCTGCTGTATGAAGGGAAAGCGAAAAAAATTTATGCGACTGACGAGGCAGATGTACTTTG
GGTTGAGTACAAAGACAGCGCCACCGCATTTAACGGAGAGAAAAAGGCGACGATCACCGGCAAAGGGCGGCTCAATAACG
AGATTTCTAGTTTATTGTTTATGAAATTGCAAGAAGCAGGCGTTGCCAACCATTTTATTCAAAAGCTGTCGCCCACCGAG
CAGCTTGTCAAAAGCGTGACGATTATTCCTCTTGAAGTCGTCGTCCGTAACGTCGTGGCCGGGAGTTTGGCGAAGCGGAT
TGGCTTGGCGGAAGGGACGCCTCTCGAAGTGCCGCTTGTCGAGTTTTACTACAAAAACGATGACCTTGGCGACCCATTAC
TGTTAGAAGACCATATCACGATTTTGAAGCTTGCCAGCCGCGAGGAGATCGCCCAACTGAAAAGTGAAGCGCTGAAAGTG
AACGACGTATTGCGCGCCCATTTTGCCGAGCGAAAAGTGAGATTAATTGATTTTAAGCTTGAGTTCGGCCGCACGACGGA
CGGTGCCATCCTCTTAGCGGATGAGGTTTCGCCGGATACGTGCCGGCTTTGGGACGCCGAGACGAATGAGAAACTGGATA
AAGACGTGTTCCGCCGCGACCTTGGTAGTTTAACAGAGGCGTACGAAGTCATTTTACAACGGTTAGGGGGAGAATCGGCA
TGTATAAAGTAA

Upstream 100 bases:

>100_bases
ATTTTTGCCCGCTTAGGATTAGAGTAAGTGACAACCGGCTGGTTCTAATGCCGGCCGGTTACACAAAAAATTTTCAATAT
TCTGTACCACGGAGGCTTGG

Downstream 100 bases:

>100_bases
AAGTGTATGTGACGTTGCGTGAGAGTGTGTTAGATCCGCAAGGGACAGCGGTGAAAGGGGCGCTGCACAGCTTGTCGTAT
ACGGAGGTGAAAGACGTAAG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MMPTKQQLLYEGKAKKIYATDEADVLWVEYKDSATAFNGEKKATITGKGRLNNEISSLLFMKLQEAGVANHFIQKLSPTE
QLVKSVTIIPLEVVVRNVVAGSLAKRIGLAEGTPLEVPLVEFYYKNDDLGDPLLLEDHITILKLASREEIAQLKSEALKV
NDVLRAHFAERKVRLIDFKLEFGRTTDGAILLADEVSPDTCRLWDAETNEKLDKDVFRRDLGSLTEAYEVILQRLGGESA
CIK

Sequences:

>Translated_243_residues
MMPTKQQLLYEGKAKKIYATDEADVLWVEYKDSATAFNGEKKATITGKGRLNNEISSLLFMKLQEAGVANHFIQKLSPTE
QLVKSVTIIPLEVVVRNVVAGSLAKRIGLAEGTPLEVPLVEFYYKNDDLGDPLLLEDHITILKLASREEIAQLKSEALKV
NDVLRAHFAERKVRLIDFKLEFGRTTDGAILLADEVSPDTCRLWDAETNEKLDKDVFRRDLGSLTEAYEVILQRLGGESA
CIK
>Mature_243_residues
MMPTKQQLLYEGKAKKIYATDEADVLWVEYKDSATAFNGEKKATITGKGRLNNEISSLLFMKLQEAGVANHFIQKLSPTE
QLVKSVTIIPLEVVVRNVVAGSLAKRIGLAEGTPLEVPLVEFYYKNDDLGDPLLLEDHITILKLASREEIAQLKSEALKV
NDVLRAHFAERKVRLIDFKLEFGRTTDGAILLADEVSPDTCRLWDAETNEKLDKDVFRRDLGSLTEAYEVILQRLGGESA
CIK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=227, Percent_Identity=32.15859030837, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI5453539, Length=227, Percent_Identity=32.15859030837, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI119220559, Length=234, Percent_Identity=30.7692307692308, Blast_Score=101, Evalue=7e-22,
Organism=Escherichia coli, GI1788820, Length=232, Percent_Identity=44.3965517241379, Blast_Score=200, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17531275, Length=237, Percent_Identity=36.7088607594937, Blast_Score=123, Evalue=9e-29,
Organism=Drosophila melanogaster, GI18860083, Length=230, Percent_Identity=30.8695652173913, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24583917, Length=247, Percent_Identity=27.9352226720648, Blast_Score=98, Evalue=5e-21,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27193; Mature: 27193

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPTKQQLLYEGKAKKIYATDEADVLWVEYKDSATAFNGEKKATITGKGRLNNEISSLLF
CCCCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCEECCCCEEEEEECCCCHHHHHHHHH
MKLQEAGVANHFIQKLSPTEQLVKSVTIIPLEVVVRNVVAGSLAKRIGLAEGTPLEVPLV
HHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
EFYYKNDDLGDPLLLEDHITILKLASREEIAQLKSEALKVNDVLRAHFAERKVRLIDFKL
EEEECCCCCCCCEEEECCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEE
EFGRTTDGAILLADEVSPDTCRLWDAETNEKLDKDVFRRDLGSLTEAYEVILQRLGGESA
ECCCCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
CIK
CCC
>Mature Secondary Structure
MMPTKQQLLYEGKAKKIYATDEADVLWVEYKDSATAFNGEKKATITGKGRLNNEISSLLF
CCCCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCEECCCCEEEEEECCCCHHHHHHHHH
MKLQEAGVANHFIQKLSPTEQLVKSVTIIPLEVVVRNVVAGSLAKRIGLAEGTPLEVPLV
HHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
EFYYKNDDLGDPLLLEDHITILKLASREEIAQLKSEALKVNDVLRAHFAERKVRLIDFKL
EEEECCCCCCCCEEEECCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEE
EFGRTTDGAILLADEVSPDTCRLWDAETNEKLDKDVFRRDLGSLTEAYEVILQRLGGESA
ECCCCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
CIK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA