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The map label for this gene is hbpA [H]

Identifier: 13474908

GI number: 13474908

Start: 4762175

End: 4763737

Strand: Direct

Name: hbpA [H]

Synonym: mlr5892

Alternate gene names: 13474908

Gene position: 4762175-4763737 (Clockwise)

Preceding gene: 13474907

Following gene: 13474909

Centisome position: 67.68

GC content: 60.4

Gene sequence:

>1563_bases
ATGCAAACGACACGTCGCAGATTTCTCGGCATGAGCGCCATGGCGGCTGGCGCAATAGCATTGCCGAACACGATCATGGC
GGCAGCCGGCCGGCGGCCGAACCTCAATATTGCCGTTCAGGACCTGCGCACAATTCTGGAACCGGTGGACGGCTCCTCCA
TCGCCAACGTTTCCTGGCGGGTGCAATACAGCGTTTTCGATCAGCTTTTACGGACCGACTACAACGACAATTTTCGCCTG
AATTTCGCGCTCGCGACATCATTGAAGCAAATCGACGCCACGATCCATGAGATCAGGTTGCGCGACAATGTGAAGTTTCA
TGACGGGTCCACAATGACGGCGGATGACGTTGTCTTCTCGCTCGGGCCGGATCGACTGCGCGGCGAAAAAGCGCCGGGCG
CGGCCGTGTTTGCCAACTTCCTCTCCTCGCTTGCCGATGTGCAGAAGATCAATGATCGCACTGTCCGTTTGATCACCAGG
ACAGAGGATCCGGTCTTCGCCCAGCGGCTCGGCGCCTGGGGCACGCAGATCATCAGCGCCAGGGCACGGGCTGGCGCCAG
CAGCTATGACGCCTGGGCGGCGAAGCCGATCGGCACCGGCCCTTACAAGATCGGCGAGGTCCGCAATGGCGACGAGATCA
CGCTGGTGGCGCACGACGAATATTGGGGAGGCCAGCCGCCATTTGCCTCGATCCGCTTCAAGCGGCTGCCGGAAATCGCC
GCGCGCATCGCCGGACTGAAGTCGGGCGATTACGATATCGTCACAGACATCACTCCGGACCACATTGCCGAAATTGAGGG
TGTCAACGGCCTCTCGATTGTTGGTGGCGAAGCCATGTGGTTCCGCTTTCTCACATTTGCTCCGCTCAGGACTCCCATCC
TGAAAGATGTCGATCTGCGTCGCGCGCTCGCTCTCGCTATCGATCGCGGTGCGCTGGCGGACGGCCTCTGGGACGGCCGG
GCGAAAGCGCTGACCAGCTGGCAGCTACCGATCTTCGGCGAGATCAACGACCCCAACCGCAAGGGAGTGTCCTATGATCC
GGCGCAGGTCAAGGAACTGCTCGCCAAGTCATCCTACAGGGGCGAGGAAATCCCTTACCCTTCCGTCGGCACCTATTATC
CGATGCAGCTCGCCGAGAACCAGGCGCTTGTCGAGATGTGGAAGGCTGCCGGGATCAACGTCAAGCTGATCATGTGTGAG
AACTGGACGCAGGTCGGCGACATTGGCGGCATCAATGACACGTCCGGCGGCGCCTTCTACGCCGATCCCGTTTCCATGCT
GTGGCAGATTATCGGTCCGACCAATGACCTCCAGTCGACAGGTGGCTGGACCAATGCCGAGTTCAACCGGCTCGGTCACG
AGCTTGAAACGACGACCGATCTCGCCAAGCGCCAGGCGGCCTTCAAACGGATGCAGGACATTGTCGAGATCGAGGACCCT
TGCATCACGCCGCTGCATTCCATGCCCTTCATCTATGGGCAGAAGGCGGATGTCAGCTGGCAGCCCAACCCGTTACCGCA
AATGTATCTCGGCCCGAAGATGCCGCCTGAGCCGGTGGCCTGA

Upstream 100 bases:

>100_bases
CAAAAAACCGTCACATAACCGCGCTATGTCTCATCCCGTCTCGGGAGCGGATTTCATTCGCTCCGATTGTCATCCCGACT
GAAAGAGAGGGGATTTTGAT

Downstream 100 bases:

>100_bases
GTTCCATGCTGCACAAGTCCTTCCAGAACAGCGCGGGCGCCGCGCTGTTGCCGGCCCATGACATCGGGGCTTCCGCCACC
AAACCTGCCATAAGCATTGC

Product: extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MQTTRRRFLGMSAMAAGAIALPNTIMAAAGRRPNLNIAVQDLRTILEPVDGSSIANVSWRVQYSVFDQLLRTDYNDNFRL
NFALATSLKQIDATIHEIRLRDNVKFHDGSTMTADDVVFSLGPDRLRGEKAPGAAVFANFLSSLADVQKINDRTVRLITR
TEDPVFAQRLGAWGTQIISARARAGASSYDAWAAKPIGTGPYKIGEVRNGDEITLVAHDEYWGGQPPFASIRFKRLPEIA
ARIAGLKSGDYDIVTDITPDHIAEIEGVNGLSIVGGEAMWFRFLTFAPLRTPILKDVDLRRALALAIDRGALADGLWDGR
AKALTSWQLPIFGEINDPNRKGVSYDPAQVKELLAKSSYRGEEIPYPSVGTYYPMQLAENQALVEMWKAAGINVKLIMCE
NWTQVGDIGGINDTSGGAFYADPVSMLWQIIGPTNDLQSTGGWTNAEFNRLGHELETTTDLAKRQAAFKRMQDIVEIEDP
CITPLHSMPFIYGQKADVSWQPNPLPQMYLGPKMPPEPVA

Sequences:

>Translated_520_residues
MQTTRRRFLGMSAMAAGAIALPNTIMAAAGRRPNLNIAVQDLRTILEPVDGSSIANVSWRVQYSVFDQLLRTDYNDNFRL
NFALATSLKQIDATIHEIRLRDNVKFHDGSTMTADDVVFSLGPDRLRGEKAPGAAVFANFLSSLADVQKINDRTVRLITR
TEDPVFAQRLGAWGTQIISARARAGASSYDAWAAKPIGTGPYKIGEVRNGDEITLVAHDEYWGGQPPFASIRFKRLPEIA
ARIAGLKSGDYDIVTDITPDHIAEIEGVNGLSIVGGEAMWFRFLTFAPLRTPILKDVDLRRALALAIDRGALADGLWDGR
AKALTSWQLPIFGEINDPNRKGVSYDPAQVKELLAKSSYRGEEIPYPSVGTYYPMQLAENQALVEMWKAAGINVKLIMCE
NWTQVGDIGGINDTSGGAFYADPVSMLWQIIGPTNDLQSTGGWTNAEFNRLGHELETTTDLAKRQAAFKRMQDIVEIEDP
CITPLHSMPFIYGQKADVSWQPNPLPQMYLGPKMPPEPVA
>Mature_520_residues
MQTTRRRFLGMSAMAAGAIALPNTIMAAAGRRPNLNIAVQDLRTILEPVDGSSIANVSWRVQYSVFDQLLRTDYNDNFRL
NFALATSLKQIDATIHEIRLRDNVKFHDGSTMTADDVVFSLGPDRLRGEKAPGAAVFANFLSSLADVQKINDRTVRLITR
TEDPVFAQRLGAWGTQIISARARAGASSYDAWAAKPIGTGPYKIGEVRNGDEITLVAHDEYWGGQPPFASIRFKRLPEIA
ARIAGLKSGDYDIVTDITPDHIAEIEGVNGLSIVGGEAMWFRFLTFAPLRTPILKDVDLRRALALAIDRGALADGLWDGR
AKALTSWQLPIFGEINDPNRKGVSYDPAQVKELLAKSSYRGEEIPYPSVGTYYPMQLAENQALVEMWKAAGINVKLIMCE
NWTQVGDIGGINDTSGGAFYADPVSMLWQIIGPTNDLQSTGGWTNAEFNRLGHELETTTDLAKRQAAFKRMQDIVEIEDP
CITPLHSMPFIYGQKADVSWQPNPLPQMYLGPKMPPEPVA

Specific function: Important role in heme acquisition or metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=435, Percent_Identity=23.9080459770115, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1787551, Length=374, Percent_Identity=25.4010695187166, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787762, Length=462, Percent_Identity=23.8095238095238, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787052, Length=481, Percent_Identity=22.8690228690229, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789397, Length=454, Percent_Identity=24.0088105726872, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 57296; Mature: 57296

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTTRRRFLGMSAMAAGAIALPNTIMAAAGRRPNLNIAVQDLRTILEPVDGSSIANVSWR
CCCHHHHHHCHHHHHCCCHHCCHHHHHHCCCCCCCCEEHHHHHHHHCCCCCCCEECEEEE
VQYSVFDQLLRTDYNDNFRLNFALATSLKQIDATIHEIRLRDNVKFHDGSTMTADDVVFS
EEHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHECCCEEECCCCCCCHHHEEEE
LGPDRLRGEKAPGAAVFANFLSSLADVQKINDRTVRLITRTEDPVFAQRLGAWGTQIISA
CCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHH
RARAGASSYDAWAAKPIGTGPYKIGEVRNGDEITLVAHDEYWGGQPPFASIRFKRLPEIA
HHHCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHH
ARIAGLKSGDYDIVTDITPDHIAEIEGVNGLSIVGGEAMWFRFLTFAPLRTPILKDVDLR
HHHHCCCCCCCEEEECCCHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHH
RALALAIDRGALADGLWDGRAKALTSWQLPIFGEINDPNRKGVSYDPAQVKELLAKSSYR
HHHHHHHCCCHHHCCCCCCCHHHEEEECCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCC
GEEIPYPSVGTYYPMQLAENQALVEMWKAAGINVKLIMCENWTQVGDIGGINDTSGGAFY
CCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCEEE
ADPVSMLWQIIGPTNDLQSTGGWTNAEFNRLGHELETTTDLAKRQAAFKRMQDIVEIEDP
ECHHHHHHHHHCCCCCHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
CITPLHSMPFIYGQKADVSWQPNPLPQMYLGPKMPPEPVA
CCCCHHHCCEEECCCCCCCCCCCCCCCHHCCCCCCCCCCC
>Mature Secondary Structure
MQTTRRRFLGMSAMAAGAIALPNTIMAAAGRRPNLNIAVQDLRTILEPVDGSSIANVSWR
CCCHHHHHHCHHHHHCCCHHCCHHHHHHCCCCCCCCEEHHHHHHHHCCCCCCCEECEEEE
VQYSVFDQLLRTDYNDNFRLNFALATSLKQIDATIHEIRLRDNVKFHDGSTMTADDVVFS
EEHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHECCCEEECCCCCCCHHHEEEE
LGPDRLRGEKAPGAAVFANFLSSLADVQKINDRTVRLITRTEDPVFAQRLGAWGTQIISA
CCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHH
RARAGASSYDAWAAKPIGTGPYKIGEVRNGDEITLVAHDEYWGGQPPFASIRFKRLPEIA
HHHCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHH
ARIAGLKSGDYDIVTDITPDHIAEIEGVNGLSIVGGEAMWFRFLTFAPLRTPILKDVDLR
HHHHCCCCCCCEEEECCCHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHH
RALALAIDRGALADGLWDGRAKALTSWQLPIFGEINDPNRKGVSYDPAQVKELLAKSSYR
HHHHHHHCCCHHHCCCCCCCHHHEEEECCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCC
GEEIPYPSVGTYYPMQLAENQALVEMWKAAGINVKLIMCENWTQVGDIGGINDTSGGAFY
CCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCEEE
ADPVSMLWQIIGPTNDLQSTGGWTNAEFNRLGHELETTTDLAKRQAAFKRMQDIVEIEDP
ECHHHHHHHHHCCCCCHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
CITPLHSMPFIYGQKADVSWQPNPLPQMYLGPKMPPEPVA
CCCCHHHCCEEECCCCCCCCCCCCCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]