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The map label for this gene is hisC [C]

Identifier: 13474906

GI number: 13474906

Start: 4759789

End: 4761138

Strand: Direct

Name: hisC [C]

Synonym: mlr5890

Alternate gene names: 13474906

Gene position: 4759789-4761138 (Clockwise)

Preceding gene: 13474904

Following gene: 13474907

Centisome position: 67.65

GC content: 56.89

Gene sequence:

>1350_bases
TTGCGCGGCTCCGCTTGGCGGCCCGACGCGCCGACCGGGATTTATCGATTGAGTGCTGATGTTCTACGCAATCTTCTGGC
CGAAAGCCGCGCCGCGGCATCTCTGCATCAGGCCTTCAGCAGGTTAGTCGCGGGCCTGTCCCAGCTGGACGTAGCGTTGC
CTGGCAATGTGCTGACTGCCGGCTCCAAGCTGCTCGATATTTGCGACGGTGTCGACGCATCCATCGCGGAATTTCGGTGT
GACAAGGAGAACGTGCTGCGGCGTCTGGAAACGAGCGTCGGAGGTTATTGGCGCAAGCCAATCGCCGAGTACATGCTTCT
TTGCAATACCCGCTTCCCTCCCAAGACTTTTTACGATCGGCTGGCGGCGAGGCTCGAAGGCGTGTTGACATGCTATCCTT
CTCAGCAGATCGATATCGCTTCAGTTGTTGGCACGATGACCTCGCAGCAGCCGGACTTTATTGCAGTCGGAAACGGGGTG
ACCGACCTCATCCAGGCGCTCTATTCAACGCTGAACCCAACAATCGCGATTCCCGTGCCGACGTTCGCCGGCTTTCAAAC
ACCTCTCGATGACGAACAAAAGAACAACTTCGTCCTCACCCCGCCCTATTTCGATCTCGACGTTCGAGCTTTCCTGGAAT
TCGTACTGGCGACAGGCGCGGATACGGCAATCGTTGTAAATCCAAACAATCCGACCGGTCGACTTGTTGATCATGCTGAC
GTGGCATGGCTGGCGGAGGCCCTAGGATCTCGAGGGCGACGGCTGATCGTGGATGAATCGTTCATTGATTTTCCCGCTGA
TGGCCGACCAAACAGCGTTGAGAATCTGGTTCCGTCCTGTGCCAATTTGATCGTGGTGAAGAGCCTTGGAAAGGTCTTCG
GACTTGGCGGAATCCGGCTCGCCTACCTCATGGCTGGCGATCCCACCCTCGTTGCCGCCGTGCGCCGGAAACTGCCGCTG
TGGAACATTAACGGCATTGCGGAATACACACTGTTCCTGCTTCCCGAATTCGCAGAGGAATTGGAACACAGTCTAGACAT
GTTGCGAGAAGATAGAGAGCTGTTCATCGAGGAGCTGCGGACGGTACCGGGCCTCGACGTCGTACCTTCGCAAACGAATT
TCATCTTGTGCCGGCTGCCTGAAAATTCGGTATCCGCTGCCGAGCTCAAGCGCCGCCTCGTTCTGTTCGAATCCGTCCTC
GTAAGAGAATGCGGCTATCAAGCCATGAACGACGCAGATCGATATCTGCGCCTGACGGTTCGAAGTCGGACGGAAAACGA
AAGGCTGGCAAAAGCTCTGCGGCGCACCTTAAGCCGCTCAACGGCCTCTGAGAGTGACGCCCTGACGTGA

Upstream 100 bases:

>100_bases
CATTGAGAAGTTCCGCCAACATGATGGCGATACTCTCCTGATATGGGGAACACCGCTTTTCGACAGTGAGGTTCTTGACG
GTATCAATACCAACAAGGGT

Downstream 100 bases:

>100_bases
CATTTGCGCAGCGAACTGAATAGTCTTTTTTCGAATGCCGCGAGAGAGAGAAGCATGTCGCTTAGTTACAATCGTCATAA
AAGGCTCGTTGAAATCATCC

Product: hypothetical protein

Products: 2-Oxoglutarate; L-Histidinol phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MRGSAWRPDAPTGIYRLSADVLRNLLAESRAAASLHQAFSRLVAGLSQLDVALPGNVLTAGSKLLDICDGVDASIAEFRC
DKENVLRRLETSVGGYWRKPIAEYMLLCNTRFPPKTFYDRLAARLEGVLTCYPSQQIDIASVVGTMTSQQPDFIAVGNGV
TDLIQALYSTLNPTIAIPVPTFAGFQTPLDDEQKNNFVLTPPYFDLDVRAFLEFVLATGADTAIVVNPNNPTGRLVDHAD
VAWLAEALGSRGRRLIVDESFIDFPADGRPNSVENLVPSCANLIVVKSLGKVFGLGGIRLAYLMAGDPTLVAAVRRKLPL
WNINGIAEYTLFLLPEFAEELEHSLDMLREDRELFIEELRTVPGLDVVPSQTNFILCRLPENSVSAAELKRRLVLFESVL
VRECGYQAMNDADRYLRLTVRSRTENERLAKALRRTLSRSTASESDALT

Sequences:

>Translated_449_residues
MRGSAWRPDAPTGIYRLSADVLRNLLAESRAAASLHQAFSRLVAGLSQLDVALPGNVLTAGSKLLDICDGVDASIAEFRC
DKENVLRRLETSVGGYWRKPIAEYMLLCNTRFPPKTFYDRLAARLEGVLTCYPSQQIDIASVVGTMTSQQPDFIAVGNGV
TDLIQALYSTLNPTIAIPVPTFAGFQTPLDDEQKNNFVLTPPYFDLDVRAFLEFVLATGADTAIVVNPNNPTGRLVDHAD
VAWLAEALGSRGRRLIVDESFIDFPADGRPNSVENLVPSCANLIVVKSLGKVFGLGGIRLAYLMAGDPTLVAAVRRKLPL
WNINGIAEYTLFLLPEFAEELEHSLDMLREDRELFIEELRTVPGLDVVPSQTNFILCRLPENSVSAAELKRRLVLFESVL
VRECGYQAMNDADRYLRLTVRSRTENERLAKALRRTLSRSTASESDALT
>Mature_449_residues
MRGSAWRPDAPTGIYRLSADVLRNLLAESRAAASLHQAFSRLVAGLSQLDVALPGNVLTAGSKLLDICDGVDASIAEFRC
DKENVLRRLETSVGGYWRKPIAEYMLLCNTRFPPKTFYDRLAARLEGVLTCYPSQQIDIASVVGTMTSQQPDFIAVGNGV
TDLIQALYSTLNPTIAIPVPTFAGFQTPLDDEQKNNFVLTPPYFDLDVRAFLEFVLATGADTAIVVNPNNPTGRLVDHAD
VAWLAEALGSRGRRLIVDESFIDFPADGRPNSVENLVPSCANLIVVKSLGKVFGLGGIRLAYLMAGDPTLVAAVRRKLPL
WNINGIAEYTLFLLPEFAEELEHSLDMLREDRELFIEELRTVPGLDVVPSQTNFILCRLPENSVSAAELKRRLVLFESVL
VRECGYQAMNDADRYLRLTVRSRTENERLAKALRRTLSRSTASESDALT

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To Rhizobium NGR234A y4qD [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=224, Percent_Identity=26.7857142857143, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9 [C]

Molecular weight: Translated: 49534; Mature: 49534

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGSAWRPDAPTGIYRLSADVLRNLLAESRAAASLHQAFSRLVAGLSQLDVALPGNVLTA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHC
GSKLLDICDGVDASIAEFRCDKENVLRRLETSVGGYWRKPIAEYMLLCNTRFPPKTFYDR
CHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHH
LAARLEGVLTCYPSQQIDIASVVGTMTSQQPDFIAVGNGVTDLIQALYSTLNPTIAIPVP
HHHHHHHHEEECCCCCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCEEEEECC
TFAGFQTPLDDEQKNNFVLTPPYFDLDVRAFLEFVLATGADTAIVVNPNNPTGRLVDHAD
CCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEECHHH
VAWLAEALGSRGRRLIVDESFIDFPADGRPNSVENLVPSCANLIVVKSLGKVFGLGGIRL
HHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
AYLMAGDPTLVAAVRRKLPLWNINGIAEYTLFLLPEFAEELEHSLDMLREDRELFIEELR
EEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVPGLDVVPSQTNFILCRLPENSVSAAELKRRLVLFESVLVRECGYQAMNDADRYLRLTV
CCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEE
RSRTENERLAKALRRTLSRSTASESDALT
CCCCCHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRGSAWRPDAPTGIYRLSADVLRNLLAESRAAASLHQAFSRLVAGLSQLDVALPGNVLTA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHC
GSKLLDICDGVDASIAEFRCDKENVLRRLETSVGGYWRKPIAEYMLLCNTRFPPKTFYDR
CHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHH
LAARLEGVLTCYPSQQIDIASVVGTMTSQQPDFIAVGNGVTDLIQALYSTLNPTIAIPVP
HHHHHHHHEEECCCCCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCEEEEECC
TFAGFQTPLDDEQKNNFVLTPPYFDLDVRAFLEFVLATGADTAIVVNPNNPTGRLVDHAD
CCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEECHHH
VAWLAEALGSRGRRLIVDESFIDFPADGRPNSVENLVPSCANLIVVKSLGKVFGLGGIRL
HHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
AYLMAGDPTLVAAVRRKLPLWNINGIAEYTLFLLPEFAEELEHSLDMLREDRELFIEELR
EEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVPGLDVVPSQTNFILCRLPENSVSAAELKRRLVLFESVLVRECGYQAMNDADRYLRLTV
CCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEE
RSRTENERLAKALRRTLSRSTASESDALT
CCCCCHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-Glutamate; 3-(Imidazol-4-yl)-2-oxopropyl phosphate [C]

Specific reaction: L-Glutamate + 3-(Imidazol-4-yl)-2-oxopropyl phosphate --> 2-Oxoglutarate + L-Histidinol phosphate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]