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The map label for this gene is kduD [C]

Identifier: 13474897

GI number: 13474897

Start: 4749081

End: 4749659

Strand: Direct

Name: kduD [C]

Synonym: mlr5880

Alternate gene names: 13474897

Gene position: 4749081-4749659 (Clockwise)

Preceding gene: 13474896

Following gene: 13474898

Centisome position: 67.5

GC content: 60.62

Gene sequence:

>579_bases
GTGCTGCTATTGCCGATACGTTTGTGCGAGGGATCGAAATCCCGCAACAGATTGAGCGGGTGCTGGACGTCAATCTCACC
GGCACCTTCACCTGCGCGCGAGGCGATCAAGTCGATGGACGCCGGCGGCGTAATCCTCAATCTTGGATCGATCAATAGTT
TCCTGCCCTTCGTGCCGCGCCATGCCTATGGGGCGTCCACGGCGGGTATGAACATTCTGACCCGGTGCATGGCGGCCGAA
CTCGGGTCGGTCGGCATCCGAACGGCCACCGTCGCTCTTGGCTATATCCGTACGCCTGACATTGCTCAGTTGGTCGAGTC
CGGCTGCATCGATTCCGTAGCGATCAAACGGCGCATCCCGATGGGGCGGATGGGAGAGCCCGAAGACGTCGCCGAGGCAG
TGTTCTTTCTGGCCTCGCCTGATGCCTCATACGTAAACGGCTCGACCCTCTACGTGGACGGCGGCTTGACCTCGTTGGCT
GACGCGCGAAACGCCCAGCCAACCGATCAAGAAAATCCAACGGAATGTTCGCCGGCGACGGGTTGCGGTTCGTCGAAGCC
GACGAGGTTCGAGGATTGA

Upstream 100 bases:

>100_bases
CACGTGGCGAAATCCGTCGACTTGGCGGTCGAGAGCGACGTGGTGGCGCTGTTCGAGGAAATACGGGGGCGCTTCGGTCG
CATCGAGGTCCTCGTCAACT

Downstream 100 bases:

>100_bases
GACTGCGGCTGCATGGAACGTGCCAAGCGCGGCTTGCCAAGTGATCGTCTTCATCGGTGACGGAAAACTCGTCATCAGGG
TCGAATGACTAGCCAGGTTT

Product: hypothetical protein

Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]

Alternate protein names: NA

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MLLLPIRLCEGSKSRNRLSGCWTSISPAPSPAREAIKSMDAGGVILNLGSINSFLPFVPRHAYGASTAGMNILTRCMAAE
LGSVGIRTATVALGYIRTPDIAQLVESGCIDSVAIKRRIPMGRMGEPEDVAEAVFFLASPDASYVNGSTLYVDGGLTSLA
DARNAQPTDQENPTECSPATGCGSSKPTRFED

Sequences:

>Translated_192_residues
MLLLPIRLCEGSKSRNRLSGCWTSISPAPSPAREAIKSMDAGGVILNLGSINSFLPFVPRHAYGASTAGMNILTRCMAAE
LGSVGIRTATVALGYIRTPDIAQLVESGCIDSVAIKRRIPMGRMGEPEDVAEAVFFLASPDASYVNGSTLYVDGGLTSLA
DARNAQPTDQENPTECSPATGCGSSKPTRFED
>Mature_192_residues
MLLLPIRLCEGSKSRNRLSGCWTSISPAPSPAREAIKSMDAGGVILNLGSINSFLPFVPRHAYGASTAGMNILTRCMAAE
LGSVGIRTATVALGYIRTPDIAQLVESGCIDSVAIKRRIPMGRMGEPEDVAEAVFFLASPDASYVNGSTLYVDGGLTSLA
DARNAQPTDQENPTECSPATGCGSSKPTRFED

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=125, Percent_Identity=43.2, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI40254992, Length=148, Percent_Identity=33.7837837837838, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1789208, Length=114, Percent_Identity=40.3508771929825, Blast_Score=70, Evalue=7e-14,
Organism=Escherichia coli, GI2367175, Length=129, Percent_Identity=38.7596899224806, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790717, Length=114, Percent_Identity=34.2105263157895, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1787335, Length=114, Percent_Identity=34.2105263157895, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI87082160, Length=135, Percent_Identity=34.0740740740741, Blast_Score=63, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=113, Percent_Identity=37.1681415929204, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=116, Percent_Identity=37.0689655172414, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=112, Percent_Identity=38.3928571428571, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=103, Percent_Identity=36.8932038834951, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24639444, Length=125, Percent_Identity=40, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24644337, Length=120, Percent_Identity=39.1666666666667, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355319, Length=114, Percent_Identity=35.9649122807018, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21357041, Length=120, Percent_Identity=37.5, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI23397609, Length=123, Percent_Identity=34.9593495934959, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125 [C]

Molecular weight: Translated: 20183; Mature: 20183

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLLPIRLCEGSKSRNRLSGCWTSISPAPSPAREAIKSMDAGGVILNLGSINSFLPFVPR
CEEEEEEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEECCCCCHHHHCCCC
HAYGASTAGMNILTRCMAAELGSVGIRTATVALGYIRTPDIAQLVESGCIDSVAIKRRIP
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHEECCCCCCHHHHHHHHCCHHHHHHHHCCC
MGRMGEPEDVAEAVFFLASPDASYVNGSTLYVDGGLTSLADARNAQPTDQENPTECSPAT
CCCCCCHHHHHHHHHHHCCCCCCEECCCEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCC
GCGSSKPTRFED
CCCCCCCCCCCC
>Mature Secondary Structure
MLLLPIRLCEGSKSRNRLSGCWTSISPAPSPAREAIKSMDAGGVILNLGSINSFLPFVPR
CEEEEEEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEECCCCCHHHHCCCC
HAYGASTAGMNILTRCMAAELGSVGIRTATVALGYIRTPDIAQLVESGCIDSVAIKRRIP
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHEECCCCCCHHHHHHHHCCHHHHHHHHCCC
MGRMGEPEDVAEAVFFLASPDASYVNGSTLYVDGGLTSLADARNAQPTDQENPTECSPAT
CCCCCCHHHHHHHHHHHCCCCCCEECCCEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCC
GCGSSKPTRFED
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 15.4 {2-deoxygluconate}} [C]

Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]

Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]