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The map label for this gene is argF

Identifier: 13474701

GI number: 13474701

Start: 4538073

End: 4538984

Strand: Direct

Name: argF

Synonym: mlr5647

Alternate gene names: 13474701

Gene position: 4538073-4538984 (Clockwise)

Preceding gene: 13474700

Following gene: 13474702

Centisome position: 64.5

GC content: 64.58

Gene sequence:

>912_bases
ATGTCAGTTCGCCATTTCACCGATCTTTCCACTGTTTCCGAGGGCGACCTGCGCTTCATGCTGGACGACGCGGTGGTGCG
AAAGGCACGCCTCAAGGCCGGCGAGCGCACGAGGCCGCTCGAAGGCAAGGTGCTGGCGATGATCTTCGACAAGCCGTCGA
CGCGCACGCGCGTCTCGTTCGACGTCGGCATGCGCCAGCTTGGCGGCGAGACAATCATGCTGACCGGCACCGAGATGCAG
CTCGGCCGCTCCGAAACCATTGCCGACACCGCCAAGGTTCTGTCGCGCTATGTCGACGCGATCATGATCCGCACCACCTC
GCATGACCGGCTGCTGGAGCTGACCGAGAACGCCACGGTGCCGGTGATCAACGGGCTGACGGACGATACCCATCCGTGCC
AGCTGATGGCCGACATCATGACCTTCGAGGAGCATCGCGGTCCGGTGGCCGGCAAGACCATCGCCTGGACTGGCGACGGC
AACAATGTGCTGCATTCGCTGCTCGAAGCCTCGGCGCGGTTCCGCTTCAACCTCAACGTCGCCGTGCCCGAGGGCAGCGA
GCCGGCGCAGAAGCACATCGACTGGTCCAAGGCGCATGGCGGCAAGCTGCATTTCACCCGTTCGCCCGAGGAAGCCGTCG
ACCAGGCCGACTGTGTCGTCACCGATTGCTGGGTGTCGATGGGTCAGGAGCACCGCGCCCGCGGCCACAACGTGTTCTCA
CCCTACCAGGTCAATGCCAAGCTGATGGCGCATGCCAAGCCGGACGCGCTGTTCATGCACTGCCTGCCGGCGCATCGCGG
CGAGGAAGTGACCGACGAGGTTATCGACGGACCCCATTCGGTGGTCTTCGACGAGGCCGAGAACCGGCTCCACGCCCAGA
AGGCGGTGCTTGCCTGGTGTCTTGGGGCTTGA

Upstream 100 bases:

>100_bases
GCCGAGATCCACGAAGCGCTCAATCGCATCCGTGCCGGTGCCAAAGGCCTGGCGGATGCCATCGCCGTGGCCGCCGCGAA
GTAATTCCGGAAAATTGCTG

Downstream 100 bases:

>100_bases
AGTGTCTTGGAGTTTGAAAGGTCTGGGCGCTTGATCTGCGGGGGCGCGATGCCTATCTGCGCCGCATCACGCAAATCAAG
CGCGTTTGGACGCATGCACC

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSVRHFTDLSTVSEGDLRFMLDDAVVRKARLKAGERTRPLEGKVLAMIFDKPSTRTRVSFDVGMRQLGGETIMLTGTEMQ
LGRSETIADTAKVLSRYVDAIMIRTTSHDRLLELTENATVPVINGLTDDTHPCQLMADIMTFEEHRGPVAGKTIAWTGDG
NNVLHSLLEASARFRFNLNVAVPEGSEPAQKHIDWSKAHGGKLHFTRSPEEAVDQADCVVTDCWVSMGQEHRARGHNVFS
PYQVNAKLMAHAKPDALFMHCLPAHRGEEVTDEVIDGPHSVVFDEAENRLHAQKAVLAWCLGA

Sequences:

>Translated_303_residues
MSVRHFTDLSTVSEGDLRFMLDDAVVRKARLKAGERTRPLEGKVLAMIFDKPSTRTRVSFDVGMRQLGGETIMLTGTEMQ
LGRSETIADTAKVLSRYVDAIMIRTTSHDRLLELTENATVPVINGLTDDTHPCQLMADIMTFEEHRGPVAGKTIAWTGDG
NNVLHSLLEASARFRFNLNVAVPEGSEPAQKHIDWSKAHGGKLHFTRSPEEAVDQADCVVTDCWVSMGQEHRARGHNVFS
PYQVNAKLMAHAKPDALFMHCLPAHRGEEVTDEVIDGPHSVVFDEAENRLHAQKAVLAWCLGA
>Mature_302_residues
SVRHFTDLSTVSEGDLRFMLDDAVVRKARLKAGERTRPLEGKVLAMIFDKPSTRTRVSFDVGMRQLGGETIMLTGTEMQL
GRSETIADTAKVLSRYVDAIMIRTTSHDRLLELTENATVPVINGLTDDTHPCQLMADIMTFEEHRGPVAGKTIAWTGDGN
NVLHSLLEASARFRFNLNVAVPEGSEPAQKHIDWSKAHGGKLHFTRSPEEAVDQADCVVTDCWVSMGQEHRARGHNVFSP
YQVNAKLMAHAKPDALFMHCLPAHRGEEVTDEVIDGPHSVVFDEAENRLHAQKAVLAWCLGA

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=304, Percent_Identity=40.4605263157895, Blast_Score=225, Evalue=3e-59,
Organism=Homo sapiens, GI18105007, Length=270, Percent_Identity=29.2592592592593, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1786469, Length=330, Percent_Identity=38.4848484848485, Blast_Score=198, Evalue=3e-52,
Organism=Escherichia coli, GI1790703, Length=329, Percent_Identity=37.6899696048632, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI2367364, Length=309, Percent_Identity=30.7443365695793, Blast_Score=115, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI193204318, Length=295, Percent_Identity=30.5084745762712, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6322373, Length=311, Percent_Identity=34.0836012861736, Blast_Score=187, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6322331, Length=271, Percent_Identity=28.4132841328413, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24642586, Length=312, Percent_Identity=26.9230769230769, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OTC_RHILO (Q98BB6)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_106270.1
- ProteinModelPortal:   Q98BB6
- SMR:   Q98BB6
- GeneID:   1228931
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr5647
- NMPDR:   fig|266835.1.peg.4374
- HOGENOM:   HBG579429
- OMA:   CVVTDTW
- ProtClustDB:   PRK00779
- BRENDA:   2.1.3.3
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 33548; Mature: 33416

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 104-104 BINDING 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRHFTDLSTVSEGDLRFMLDDAVVRKARLKAGERTRPLEGKVLAMIFDKPSTRTRVSF
CCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEEH
DVGMRQLGGETIMLTGTEMQLGRSETIADTAKVLSRYVDAIMIRTTSHDRLLELTENATV
HHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCHHEEECCCCCE
PVINGLTDDTHPCQLMADIMTFEEHRGPVAGKTIAWTGDGNNVLHSLLEASARFRFNLNV
EEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCEEEEEEEE
AVPEGSEPAQKHIDWSKAHGGKLHFTRSPEEAVDQADCVVTDCWVSMGQEHRARGHNVFS
ECCCCCCHHHHCCCHHHCCCCEEEEECCHHHHHHHHHHEEEHHHHHCCHHHHHCCCCCCC
PYQVNAKLMAHAKPDALFMHCLPAHRGEEVTDEVIDGPHSVVFDEAENRLHAQKAVLAWC
CEEECEEEEECCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
LGA
CCC
>Mature Secondary Structure 
SVRHFTDLSTVSEGDLRFMLDDAVVRKARLKAGERTRPLEGKVLAMIFDKPSTRTRVSF
CCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEEH
DVGMRQLGGETIMLTGTEMQLGRSETIADTAKVLSRYVDAIMIRTTSHDRLLELTENATV
HHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCHHEEECCCCCE
PVINGLTDDTHPCQLMADIMTFEEHRGPVAGKTIAWTGDGNNVLHSLLEASARFRFNLNV
EEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCEEEEEEEE
AVPEGSEPAQKHIDWSKAHGGKLHFTRSPEEAVDQADCVVTDCWVSMGQEHRARGHNVFS
ECCCCCCHHHHCCCHHHCCCCEEEEECCHHHHHHHHHHEEEHHHHHCCHHHHHCCCCCCC
PYQVNAKLMAHAKPDALFMHCLPAHRGEEVTDEVIDGPHSVVFDEAENRLHAQKAVLAWC
CEEECEEEEECCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
LGA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968