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The map label for this gene is argD

Identifier: 13474700

GI number: 13474700

Start: 4536857

End: 4538056

Strand: Direct

Name: argD

Synonym: mlr5646

Alternate gene names: 13474700

Gene position: 4536857-4538056 (Clockwise)

Preceding gene: 13474698

Following gene: 13474701

Centisome position: 64.48

GC content: 65.0

Gene sequence:

>1200_bases
ATGAGCGGTTCGGCGCTTTACGAGACCTTTGCTCGCGCTCCCCTGGCTTTCGACCACGGGGAAGGCACCTGGCTGGTTAC
CGACAAGGGCGAGCGATATCTCGATTTCGCCGGCGGCATCGCGGTCAATTCGCTCGGCCACAGCCATCCGCATCTGGTCG
CGGCGCTGACCGAGCAGGCGGCAAAGCTGTGGCACGTCTCCAATCTCTATGAGATCCCCGGACAGAGCCGGCTCGGCCAG
CGCCTGGTCGATGCCACCTTCGCCGACAAGGTGTTCTTCACCAATTCCGGCGCCGAGGCGCTGGAATGCGCGATCAAGAC
GGCGCGACGCTACCATTTCGTCAAGGGCCATCCCGAGCGCTTCCGCGTCATCACCTTCGAAGGCGCCTTCCATGGCCGCA
CGCTGGCGACCATCGCGGCCGGCGGTCAGTACAAATACCTCGAAGGCTTCGGCCCCAAGGTCGAAGGCTTCGACCAGGTC
GGCTTCGACGACATCGATGCCGCCGAGAAGGCGATTACGCCGGAAACCGCCGCGATCCTGATCGAACCGGTGCAGGGCGA
GGGCGGCATCCGCCCGGTCCCGACGCAGTCACTGAAGCGGCTGCGGCAGCTTTGCGACCAGCACGGCCTGTTGTTGATCT
ATGACGAGGTCCAGTGCGGCATCGGCCGCACCGGAAAGCTGTTCGCGCATGAATGGTCAGGCGTGGCGCCCGACATCATG
GCGATCGCCAAGGGCATTGGCGGCGGCTTCCCGATGGGCGCTTGCCTCGCAACCGATGAAGCAGCTGTCGGCATGACGGC
TGGCGTGCACGGCACCACCTTCGGCGGCAATCCGCTGGCGATGGCGGTCGGCAATGCCGTGCTCGACGTAGTGCTGGAAG
ACGGCTTCCTCGAGGACGTCCAGCGCAAGGCATTGCTGATGAAGCAAGGCCTGGCGGCGATCGCCGACGAGTTTCCCGAT
GTCGTCGAAGACATCCGGGGCACCGGCCTCATGCTTGGCCTCAAATGCGCCATGCCCAACACCAAGGTGAACATGGCGCT
GCGCGACCAGCATTTGCTGGCGGTTCCGGCCGGCGACAACGTCATTCGCCTGCTGCCGCCACTCACCGTCACCGACGCCG
AGATCCACGAAGCGCTCAATCGCATCCGTGCCGGTGCCAAAGGCCTGGCGGATGCCATCGCCGTGGCCGCCGCGAAGTAA

Upstream 100 bases:

>100_bases
GCGACGTTTTCGTTGACTTCATGGCCGAAAAACACGATAAGCCGCACAAGGCCGCCGCTTTGGCGGCTTTTTTGATTTTC
CGGTACCGGAGACGCATATA

Downstream 100 bases:

>100_bases
TTCCGGAAAATTGCTGATGTCAGTTCGCCATTTCACCGATCTTTCCACTGTTTCCGAGGGCGACCTGCGCTTCATGCTGG
ACGACGCGGTGGTGCGAAAG

Product: acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSGSALYETFARAPLAFDHGEGTWLVTDKGERYLDFAGGIAVNSLGHSHPHLVAALTEQAAKLWHVSNLYEIPGQSRLGQ
RLVDATFADKVFFTNSGAEALECAIKTARRYHFVKGHPERFRVITFEGAFHGRTLATIAAGGQYKYLEGFGPKVEGFDQV
GFDDIDAAEKAITPETAAILIEPVQGEGGIRPVPTQSLKRLRQLCDQHGLLLIYDEVQCGIGRTGKLFAHEWSGVAPDIM
AIAKGIGGGFPMGACLATDEAAVGMTAGVHGTTFGGNPLAMAVGNAVLDVVLEDGFLEDVQRKALLMKQGLAAIADEFPD
VVEDIRGTGLMLGLKCAMPNTKVNMALRDQHLLAVPAGDNVIRLLPPLTVTDAEIHEALNRIRAGAKGLADAIAVAAAK

Sequences:

>Translated_399_residues
MSGSALYETFARAPLAFDHGEGTWLVTDKGERYLDFAGGIAVNSLGHSHPHLVAALTEQAAKLWHVSNLYEIPGQSRLGQ
RLVDATFADKVFFTNSGAEALECAIKTARRYHFVKGHPERFRVITFEGAFHGRTLATIAAGGQYKYLEGFGPKVEGFDQV
GFDDIDAAEKAITPETAAILIEPVQGEGGIRPVPTQSLKRLRQLCDQHGLLLIYDEVQCGIGRTGKLFAHEWSGVAPDIM
AIAKGIGGGFPMGACLATDEAAVGMTAGVHGTTFGGNPLAMAVGNAVLDVVLEDGFLEDVQRKALLMKQGLAAIADEFPD
VVEDIRGTGLMLGLKCAMPNTKVNMALRDQHLLAVPAGDNVIRLLPPLTVTDAEIHEALNRIRAGAKGLADAIAVAAAK
>Mature_398_residues
SGSALYETFARAPLAFDHGEGTWLVTDKGERYLDFAGGIAVNSLGHSHPHLVAALTEQAAKLWHVSNLYEIPGQSRLGQR
LVDATFADKVFFTNSGAEALECAIKTARRYHFVKGHPERFRVITFEGAFHGRTLATIAAGGQYKYLEGFGPKVEGFDQVG
FDDIDAAEKAITPETAAILIEPVQGEGGIRPVPTQSLKRLRQLCDQHGLLLIYDEVQCGIGRTGKLFAHEWSGVAPDIMA
IAKGIGGGFPMGACLATDEAAVGMTAGVHGTTFGGNPLAMAVGNAVLDVVLEDGFLEDVQRKALLMKQGLAAIADEFPDV
VEDIRGTGLMLGLKCAMPNTKVNMALRDQHLLAVPAGDNVIRLLPPLTVTDAEIHEALNRIRAGAKGLADAIAVAAAK

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=377, Percent_Identity=33.6870026525199, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI284507298, Length=297, Percent_Identity=35.3535353535354, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI13994255, Length=437, Percent_Identity=30.8924485125858, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI37574042, Length=427, Percent_Identity=27.4004683840749, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI226442705, Length=427, Percent_Identity=26.463700234192, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI226442709, Length=392, Percent_Identity=27.5510204081633, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI24119277, Length=404, Percent_Identity=26.2376237623762, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI188536080, Length=420, Percent_Identity=22.8571428571429, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI38679950, Length=420, Percent_Identity=22.8571428571429, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI38679946, Length=420, Percent_Identity=22.8571428571429, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1789759, Length=368, Percent_Identity=45.1086956521739, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1788044, Length=382, Percent_Identity=42.9319371727749, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI145693181, Length=396, Percent_Identity=35.8585858585859, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1789016, Length=410, Percent_Identity=36.5853658536585, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1787560, Length=396, Percent_Identity=34.8484848484849, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1786991, Length=399, Percent_Identity=32.8320802005013, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1786349, Length=330, Percent_Identity=32.1212121212121, Blast_Score=121, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI25144271, Length=375, Percent_Identity=34.4, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=32.4137931034483, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25144274, Length=275, Percent_Identity=34.9090909090909, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71992977, Length=429, Percent_Identity=27.039627039627, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71981843, Length=158, Percent_Identity=32.2784810126582, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17541228, Length=447, Percent_Identity=24.6085011185682, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324432, Length=387, Percent_Identity=36.6925064599483, Blast_Score=266, Evalue=5e-72,
Organism=Saccharomyces cerevisiae, GI6323470, Length=393, Percent_Identity=31.8066157760814, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324386, Length=301, Percent_Identity=27.906976744186, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=367, Percent_Identity=23.7057220708447, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21357415, Length=379, Percent_Identity=34.0369393139842, Blast_Score=227, Evalue=9e-60,
Organism=Drosophila melanogaster, GI28574759, Length=422, Percent_Identity=33.175355450237, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI161085790, Length=435, Percent_Identity=32.4137931034483, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21356575, Length=433, Percent_Identity=29.5612009237875, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI281366494, Length=304, Percent_Identity=26.9736842105263, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24667139, Length=304, Percent_Identity=26.9736842105263, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24667143, Length=304, Percent_Identity=26.9736842105263, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ARGD_RHILO (Q98BB7)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_106269.1
- ProteinModelPortal:   Q98BB7
- SMR:   Q98BB7
- GeneID:   1228930
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr5646
- NMPDR:   fig|266835.1.peg.4373
- HOGENOM:   HBG725944
- OMA:   NATFADR
- ProtClustDB:   PRK01278
- BRENDA:   2.6.1.11
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 42417; Mature: 42286

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 130-130 BINDING 133-133 BINDING 272-272 BINDING 273-273

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGSALYETFARAPLAFDHGEGTWLVTDKGERYLDFAGGIAVNSLGHSHPHLVAALTEQA
CCCHHHHHHHHCCCCEEECCCCEEEEECCCCEEEEECCCEEECCCCCCCCHHHHHHHHHH
AKLWHVSNLYEIPGQSRLGQRLVDATFADKVFFTNSGAEALECAIKTARRYHFVKGHPER
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHEEECCCCCE
FRVITFEGAFHGRTLATIAAGGQYKYLEGFGPKVEGFDQVGFDDIDAAEKAITPETAAIL
EEEEEEECCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEE
IEPVQGEGGIRPVPTQSLKRLRQLCDQHGLLLIYDEVQCGIGRTGKLFAHEWSGVAPDIM
EEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEECCCCCCHHHH
AIAKGIGGGFPMGACLATDEAAVGMTAGVHGTTFGGNPLAMAVGNAVLDVVLEDGFLEDV
HHHHHCCCCCCCCCEEECCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHH
QRKALLMKQGLAAIADEFPDVVEDIRGTGLMLGLKCAMPNTKVNMALRDQHLLAVPAGDN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEECCEEEEECCCCC
VIRLLPPLTVTDAEIHEALNRIRAGAKGLADAIAVAAAK
EEEECCCCEECHHHHHHHHHHHHHCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGSALYETFARAPLAFDHGEGTWLVTDKGERYLDFAGGIAVNSLGHSHPHLVAALTEQA
CCHHHHHHHHCCCCEEECCCCEEEEECCCCEEEEECCCEEECCCCCCCCHHHHHHHHHH
AKLWHVSNLYEIPGQSRLGQRLVDATFADKVFFTNSGAEALECAIKTARRYHFVKGHPER
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHEEECCCCCE
FRVITFEGAFHGRTLATIAAGGQYKYLEGFGPKVEGFDQVGFDDIDAAEKAITPETAAIL
EEEEEEECCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEE
IEPVQGEGGIRPVPTQSLKRLRQLCDQHGLLLIYDEVQCGIGRTGKLFAHEWSGVAPDIM
EEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEECCCCCCHHHH
AIAKGIGGGFPMGACLATDEAAVGMTAGVHGTTFGGNPLAMAVGNAVLDVVLEDGFLEDV
HHHHHCCCCCCCCCEEECCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHH
QRKALLMKQGLAAIADEFPDVVEDIRGTGLMLGLKCAMPNTKVNMALRDQHLLAVPAGDN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEECCEEEEECCCCC
VIRLLPPLTVTDAEIHEALNRIRAGAKGLADAIAVAAAK
EEEECCCCEECHHHHHHHHHHHHHCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968