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The map label for this gene is uao [H]

Identifier: 13474279

GI number: 13474279

Start: 4068906

End: 4070324

Strand: Reverse

Name: uao [H]

Synonym: mll5132

Alternate gene names: 13474279

Gene position: 4070324-4068906 (Counterclockwise)

Preceding gene: 13474284

Following gene: 13474278

Centisome position: 57.85

GC content: 63.57

Gene sequence:

>1419_bases
ATGCGTTACGAAAGAGACATGCGCGGCTACGGAGCCAATCCACCGGATCCGAAATGGCCAGGCGGGGCGCATGTCGCCGT
GCAATTCGTCGTCAATTACGAAGAGGGCGGCGAGAATTGCGTGCTGCATGGCGACAAGGCGTCGGAAGCCTTCCTGTCGG
AGATCGTCGGCGCCGCACCCTGGGTGGGCCAGCGCCATTGGAACATGGAATCGATCTACGAATATGGCGCGCGGGCCGGG
TTCTGGCGGCTGCTGCGCCTGTTCAGCGAATCGCAAGTTCCGGTAACCTGCTACGGCGTCGCCTCGGCACTTGCCCGCTC
GCCCGACCAGGTCACGGCCATGCAGGACGCCGGCTGGGAGATCGCCTCGCACGGGTTGCGGTGGATCGACTACCGCGATC
ATAGCGCCGAGGATGAGCGCCGCGACCTCGAAGCGGCGATCAAGCTGCATTACGAGGTGACGGGTCAGCGCCCGACCGGC
TGGTATACGGGCCGCACATCGGTCAACACAGTGCGGCTGGTGGCCGAAGAAGGCGGCTTTGACTACGTCTCCGACACCTA
TGACGACGAACTGCCCTACTGGTTCGAGCATGCCGGCGGCACGCAGCTCATCATTCCCTATACGCTCGACGCCAACGACA
TGCGCTTCGCCACGCCGCAAGGCTTCAATTCGGGCGACCAGTTCTTTGCCTATCTGAAGGACAGTTTCGACACGCTCTAT
GCCGAGGGCCAGGCCGGACGGCCGCGCATGATGAATATCGGCCTGCATTGCCGCCTCGTCGGGCGGCCGGGCCGGGTGGC
GGCGCTGAAGCGCTTCGTCGACTATGTGAAGTCGCACGACAAGGTCTGGCTGACGCGGCGCATCGATATCGCCAAGCACT
GGCAGGAGAACCATCCCTACAAACCGGCGGCGCTGCGCCCGTCGAAGATGGAATTCGAGATATTCGTCCACACTTTCGGT
GGCGTGTTCGAGCATTCGCCGTGGATCGCTGAGCGAGCCTACGAACTGGAACTCGGCCCGGCGCACGATACGGCCGGCGG
CCTGCACAATGCTCTCTGCCGCATCTTCCGTTCCGCCAGCGAGACCGAGCGGCTTGGCGTGCTCAACGCCCATCCCGACC
TTGCCGGCAAACTGGCCAAGGCCAGGCGGCTGACGGCGGAATCGACCAGGGAACAAGCCTCCGCCGGCCTCGACGCGCTG
ACCGACAAGGAACGCGAACTGTTCTCCAAGCTCAACGCCGCCTACGTCACCACCTTCGGTTTCCCCTTCATCATCGCGGT
GAAGGGCAAGACCAAGGAGGAAATCCTGGCGGAATTCGAGGCGCGCATCGGCAACAGCCGCGGCGTCGAATTCGAGACCG
CCTGCAAACAGGTCGAGCGCATTGCGCTGCTCCGCCTCAGAGACATGCTACCGCAATAG

Upstream 100 bases:

>100_bases
GAGCGGCACAAAAACACTTTCAAAAATTTCAAGGGAATGCGGCGGCAACCCTTTCGACTATCCTGATCACAACTTCCGGC
AGAGTCCGGCAGGAGGGGCA

Downstream 100 bases:

>100_bases
GTTTGAACCATGGATACGATCAGGATGCCAGAGCGCACCTACTACGCACCGCATGGCGGCCATCCCGGCCAATCTGAATT
GCTGACGGGCCGCGCCGTCT

Product: hypothetical protein

Products: NA

Alternate protein names: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; OHCU decarboxylase; Uricase; Urate oxidase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MRYERDMRGYGANPPDPKWPGGAHVAVQFVVNYEEGGENCVLHGDKASEAFLSEIVGAAPWVGQRHWNMESIYEYGARAG
FWRLLRLFSESQVPVTCYGVASALARSPDQVTAMQDAGWEIASHGLRWIDYRDHSAEDERRDLEAAIKLHYEVTGQRPTG
WYTGRTSVNTVRLVAEEGGFDYVSDTYDDELPYWFEHAGGTQLIIPYTLDANDMRFATPQGFNSGDQFFAYLKDSFDTLY
AEGQAGRPRMMNIGLHCRLVGRPGRVAALKRFVDYVKSHDKVWLTRRIDIAKHWQENHPYKPAALRPSKMEFEIFVHTFG
GVFEHSPWIAERAYELELGPAHDTAGGLHNALCRIFRSASETERLGVLNAHPDLAGKLAKARRLTAESTREQASAGLDAL
TDKERELFSKLNAAYVTTFGFPFIIAVKGKTKEEILAEFEARIGNSRGVEFETACKQVERIALLRLRDMLPQ

Sequences:

>Translated_472_residues
MRYERDMRGYGANPPDPKWPGGAHVAVQFVVNYEEGGENCVLHGDKASEAFLSEIVGAAPWVGQRHWNMESIYEYGARAG
FWRLLRLFSESQVPVTCYGVASALARSPDQVTAMQDAGWEIASHGLRWIDYRDHSAEDERRDLEAAIKLHYEVTGQRPTG
WYTGRTSVNTVRLVAEEGGFDYVSDTYDDELPYWFEHAGGTQLIIPYTLDANDMRFATPQGFNSGDQFFAYLKDSFDTLY
AEGQAGRPRMMNIGLHCRLVGRPGRVAALKRFVDYVKSHDKVWLTRRIDIAKHWQENHPYKPAALRPSKMEFEIFVHTFG
GVFEHSPWIAERAYELELGPAHDTAGGLHNALCRIFRSASETERLGVLNAHPDLAGKLAKARRLTAESTREQASAGLDAL
TDKERELFSKLNAAYVTTFGFPFIIAVKGKTKEEILAEFEARIGNSRGVEFETACKQVERIALLRLRDMLPQ
>Mature_472_residues
MRYERDMRGYGANPPDPKWPGGAHVAVQFVVNYEEGGENCVLHGDKASEAFLSEIVGAAPWVGQRHWNMESIYEYGARAG
FWRLLRLFSESQVPVTCYGVASALARSPDQVTAMQDAGWEIASHGLRWIDYRDHSAEDERRDLEAAIKLHYEVTGQRPTG
WYTGRTSVNTVRLVAEEGGFDYVSDTYDDELPYWFEHAGGTQLIIPYTLDANDMRFATPQGFNSGDQFFAYLKDSFDTLY
AEGQAGRPRMMNIGLHCRLVGRPGRVAALKRFVDYVKSHDKVWLTRRIDIAKHWQENHPYKPAALRPSKMEFEIFVHTFG
GVFEHSPWIAERAYELELGPAHDTAGGLHNALCRIFRSASETERLGVLNAHPDLAGKLAKARRLTAESTREQASAGLDAL
TDKERELFSKLNAAYVTTFGFPFIIAVKGKTKEEILAEFEARIGNSRGVEFETACKQVERIALLRLRDMLPQ

Specific function: Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5- ureidoimidazoline (OHCU) to (S)-allantoin [H]

COG id: COG0726

COG function: function code G; Predicted xylanase/chitin deacetylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the uricase family [H]

Homologues:

Organism=Homo sapiens, GI157743280, Length=163, Percent_Identity=34.3558282208589, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018020
- InterPro:   IPR017580
- InterPro:   IPR002042
- InterPro:   IPR019842 [H]

Pfam domain/function: PF09349 OHCU_decarbox; PF01014 Uricase [H]

EC number: =1.7.3.3 [H]

Molecular weight: Translated: 53290; Mature: 53290

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYERDMRGYGANPPDPKWPGGAHVAVQFVVNYEEGGENCVLHGDKASEAFLSEIVGAAP
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHCCCC
WVGQRHWNMESIYEYGARAGFWRLLRLFSESQVPVTCYGVASALARSPDQVTAMQDAGWE
CCCCCCCCHHHHHHHHCHHHHHHHHHHHCCCCCCEEEHHHHHHHHCCCCCEEHHHHCCCH
IASHGLRWIDYRDHSAEDERRDLEAAIKLHYEVTGQRPTGWYTGRTSVNTVRLVAEEGGF
HHHCCCEEEECCCCCCCHHHHHHHHHEEEEEEEECCCCCCEECCCCCCEEEEEEEECCCC
DYVSDTYDDELPYWFEHAGGTQLIIPYTLDANDMRFATPQGFNSGDQFFAYLKDSFDTLY
CCCCCCCCCCCCHHHHCCCCCEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHE
AEGQAGRPRMMNIGLHCRLVGRPGRVAALKRFVDYVKSHDKVWLTRRIDIAKHWQENHPY
ECCCCCCCEEEEECEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCCC
KPAALRPSKMEFEIFVHTFGGVFEHSPWIAERAYELELGPAHDTAGGLHNALCRIFRSAS
CCCCCCCCCEEEEEEEEECCCHHCCCCCHHHCEEEEECCCCCCCCCHHHHHHHHHHHCCC
ETERLGVLNAHPDLAGKLAKARRLTAESTREQASAGLDALTDKERELFSKLNAAYVTTFG
HHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHEEEECC
FPFIIAVKGKTKEEILAEFEARIGNSRGVEFETACKQVERIALLRLRDMLPQ
CEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRYERDMRGYGANPPDPKWPGGAHVAVQFVVNYEEGGENCVLHGDKASEAFLSEIVGAAP
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHCCCC
WVGQRHWNMESIYEYGARAGFWRLLRLFSESQVPVTCYGVASALARSPDQVTAMQDAGWE
CCCCCCCCHHHHHHHHCHHHHHHHHHHHCCCCCCEEEHHHHHHHHCCCCCEEHHHHCCCH
IASHGLRWIDYRDHSAEDERRDLEAAIKLHYEVTGQRPTGWYTGRTSVNTVRLVAEEGGF
HHHCCCEEEECCCCCCCHHHHHHHHHEEEEEEEECCCCCCEECCCCCCEEEEEEEECCCC
DYVSDTYDDELPYWFEHAGGTQLIIPYTLDANDMRFATPQGFNSGDQFFAYLKDSFDTLY
CCCCCCCCCCCCHHHHCCCCCEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHE
AEGQAGRPRMMNIGLHCRLVGRPGRVAALKRFVDYVKSHDKVWLTRRIDIAKHWQENHPY
ECCCCCCCEEEEECEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCCC
KPAALRPSKMEFEIFVHTFGGVFEHSPWIAERAYELELGPAHDTAGGLHNALCRIFRSAS
CCCCCCCCCEEEEEEEEECCCHHCCCCCHHHCEEEEECCCCCCCCCHHHHHHHHHHHCCC
ETERLGVLNAHPDLAGKLAKARRLTAESTREQASAGLDALTDKERELFSKLNAAYVTTFG
HHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHEEEECC
FPFIIAVKGKTKEEILAEFEARIGNSRGVEFETACKQVERIALLRLRDMLPQ
CEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8907179 [H]