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The map label for this gene is ahcY

Identifier: 13474244

GI number: 13474244

Start: 4033063

End: 4034463

Strand: Reverse

Name: ahcY

Synonym: mll5088

Alternate gene names: 13474244

Gene position: 4034463-4033063 (Counterclockwise)

Preceding gene: 13474245

Following gene: 13474243

Centisome position: 57.34

GC content: 62.74

Gene sequence:

>1401_bases
ATGACGGGTAGCAAGGATTATGTGGTCGCCGACATCTCGCTTGCCGGCTGGGGCCGCAAGGAACTCGATATCGCCGAAAC
CGAAATGCCGGGCCTAATGGCCTGCCGCGAGGAATTCGGCGCCAAGAAGCCGCTGAAGGGCGCGCGCATCACCGGCTCGC
TCCATATGACAATCCAGACCGCGGTGCTGATCGAGACGCTGAAGGCGCTCGGCGCCGATATCCGCTGGGCCTCCTGCAAC
ATCTTCTCGACCCAGGACCACGCCGCCGCGGCCATCGCCGAGGCCGGCATTCCGGTCTTCGCCGTCAAGGGCGAGAGCCT
CGAACAATATTGGGACTATACCGACCGGATCTTCCAGTGGGCGGACGGCGGCCTCTCCAACATGATCCTCGACGATGGCG
GCGACGCCACCATGTACATCCTGATCGGCGCCCGCGCCGAAGCCGGCGAGGACGTGCTGTCCAACCCGCAGAGCGAGGAA
GAGGAATATTTCTACGCTCAGGTCAAGAAGCGGCTGAAGGCTTCGCCGGGCTTCTTCACCAAGCAGAAGGCTGCGATCCG
CGGCGTCACCGAAGAGACGACCACCGGCGTCAACCGGCTCTACCAGCTGCAGAAGAAGGGCCTGCTGCCCTTCCCCGCCA
TCAACGTCAACGATTCCGTCACCAAGTCGAAATTCGACAACAAGTATGGCTGCAAGGAATCGCTGGTCGACGGCATCCGT
CGCGGCACCGACACGATGATGGCCGGCAAGGTCGCGGTCGTCTGCGGCTATGGCGACGTCGGCAAGGGCTCATCGGCTTC
GCTCAAGGGCGCCGGCGCCCGCGTCAAGGTCACCGAGGTCGACCCGATCTGTGCGCTGCAGGCGGCGATGGACGGCTTTG
AAGTGGTGACGCTGGAAGACGCGGCCCCGACCGCCGACATCGTCATCACCACCACCGGCAACAAGGACGTCGTCACCCTC
GACCATATGCGGTCGATGAAGGACATGGTGATCGTCGGCAATATCGGCCACTTCGACAACGAGATCCAGGTCGCCTCGCT
GCGCAATCTGAAATGGACCAACGTCAAGCCGCAGGTCGACATGATCACCTTCCCTGACGGCAAGCGGATGATCCTCCTGT
CGGAAGGCCGCCTGCTCAATCTCGGCAACGCCACCGGCCATCCGAGCTTCGTCATGTCGGCGTCCTTCACCAACCAGGTG
CTGGCCCAGATCGAGCTGTTCACCAAGGGCGAACAGTACCAGAACCAGGTCTATGTCCTGCCCAAGCATCTCGACGAGAA
GGTCGCACGCCTGCACCTCGACAAGCTCGGCGCACGCCTGACCGAACTGTCGGGTGAGCAGGCCGCCTATATCGGCGTCA
CGCCGCAGGGTCCGTTCAAGCCGGAACACTACCGCTATTAA

Upstream 100 bases:

>100_bases
CTGCTAGTCAGGCCGGCAATTCGCGCCCTTCGACGCGCCGACCGGCGCGGGCGCATCCGCAACCAATTCGCAGCATAACA
ATTCGCATCGGAGTACTGCC

Downstream 100 bases:

>100_bases
CCAAAGCTAAATTTACTACCAGATATTGAGGCCGGGTGATTGACTTTTCGCCCGGCCTTATTTTTGCGCGCGATCAGCCT
TCACGGCGATTCGGCGAGGG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTGSKDYVVADISLAGWGRKELDIAETEMPGLMACREEFGAKKPLKGARITGSLHMTIQTAVLIETLKALGADIRWASCN
IFSTQDHAAAAIAEAGIPVFAVKGESLEQYWDYTDRIFQWADGGLSNMILDDGGDATMYILIGARAEAGEDVLSNPQSEE
EEYFYAQVKKRLKASPGFFTKQKAAIRGVTEETTTGVNRLYQLQKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
RGTDTMMAGKVAVVCGYGDVGKGSSASLKGAGARVKVTEVDPICALQAAMDGFEVVTLEDAAPTADIVITTTGNKDVVTL
DHMRSMKDMVIVGNIGHFDNEIQVASLRNLKWTNVKPQVDMITFPDGKRMILLSEGRLLNLGNATGHPSFVMSASFTNQV
LAQIELFTKGEQYQNQVYVLPKHLDEKVARLHLDKLGARLTELSGEQAAYIGVTPQGPFKPEHYRY

Sequences:

>Translated_466_residues
MTGSKDYVVADISLAGWGRKELDIAETEMPGLMACREEFGAKKPLKGARITGSLHMTIQTAVLIETLKALGADIRWASCN
IFSTQDHAAAAIAEAGIPVFAVKGESLEQYWDYTDRIFQWADGGLSNMILDDGGDATMYILIGARAEAGEDVLSNPQSEE
EEYFYAQVKKRLKASPGFFTKQKAAIRGVTEETTTGVNRLYQLQKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
RGTDTMMAGKVAVVCGYGDVGKGSSASLKGAGARVKVTEVDPICALQAAMDGFEVVTLEDAAPTADIVITTTGNKDVVTL
DHMRSMKDMVIVGNIGHFDNEIQVASLRNLKWTNVKPQVDMITFPDGKRMILLSEGRLLNLGNATGHPSFVMSASFTNQV
LAQIELFTKGEQYQNQVYVLPKHLDEKVARLHLDKLGARLTELSGEQAAYIGVTPQGPFKPEHYRY
>Mature_465_residues
TGSKDYVVADISLAGWGRKELDIAETEMPGLMACREEFGAKKPLKGARITGSLHMTIQTAVLIETLKALGADIRWASCNI
FSTQDHAAAAIAEAGIPVFAVKGESLEQYWDYTDRIFQWADGGLSNMILDDGGDATMYILIGARAEAGEDVLSNPQSEEE
EYFYAQVKKRLKASPGFFTKQKAAIRGVTEETTTGVNRLYQLQKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRR
GTDTMMAGKVAVVCGYGDVGKGSSASLKGAGARVKVTEVDPICALQAAMDGFEVVTLEDAAPTADIVITTTGNKDVVTLD
HMRSMKDMVIVGNIGHFDNEIQVASLRNLKWTNVKPQVDMITFPDGKRMILLSEGRLLNLGNATGHPSFVMSASFTNQVL
AQIELFTKGEQYQNQVYVLPKHLDEKVARLHLDKLGARLTELSGEQAAYIGVTPQGPFKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=468, Percent_Identity=57.0512820512821, Blast_Score=499, Evalue=1e-141,
Organism=Homo sapiens, GI298286489, Length=467, Percent_Identity=52.4625267665953, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI195539349, Length=467, Percent_Identity=52.4625267665953, Blast_Score=470, Evalue=1e-132,
Organism=Homo sapiens, GI24308043, Length=467, Percent_Identity=52.4625267665953, Blast_Score=470, Evalue=1e-132,
Organism=Homo sapiens, GI195539337, Length=467, Percent_Identity=52.4625267665953, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=56.5909090909091, Blast_Score=465, Evalue=1e-131,
Organism=Homo sapiens, GI21361647, Length=467, Percent_Identity=51.3918629550321, Blast_Score=446, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=58.494623655914, Blast_Score=516, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6320882, Length=480, Percent_Identity=54.1666666666667, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=59.3073593073593, Blast_Score=513, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24656245, Length=468, Percent_Identity=50.4273504273504, Blast_Score=450, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45553387, Length=466, Percent_Identity=50.8583690987124, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45553385, Length=465, Percent_Identity=50.752688172043, Blast_Score=434, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_RHILO (Q98CM3)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105812.1
- ProteinModelPortal:   Q98CM3
- SMR:   Q98CM3
- GeneID:   1228473
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll5088
- NMPDR:   fig|266835.1.peg.3916
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- ProtClustDB:   PRK05476
- BRENDA:   3.3.1.1
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 50820; Mature: 50688

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 57-57 BINDING 132-132 BINDING 192-192 BINDING 222-222 BINDING 226-226 BINDING 227-227 BINDING 279-279 BINDING 314-314 BINDING 380-380

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSKDYVVADISLAGWGRKELDIAETEMPGLMACREEFGAKKPLKGARITGSLHMTIQT
CCCCCCEEEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEHHH
AVLIETLKALGADIRWASCNIFSTQDHAAAAIAEAGIPVFAVKGESLEQYWDYTDRIFQW
HHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHCCCCEEEECCCHHHHHHCHHHHHHHH
ADGGLSNMILDDGGDATMYILIGARAEAGEDVLSNPQSEEEEYFYAQVKKRLKASPGFFT
CCCCCCEEEEECCCCEEEEEEEECCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC
KQKAAIRGVTEETTTGVNRLYQLQKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
CCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHH
RGTDTMMAGKVAVVCGYGDVGKGSSASLKGAGARVKVTEVDPICALQAAMDGFEVVTLED
CCCCCEEECCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCEEEEEEEC
AAPTADIVITTTGNKDVVTLDHMRSMKDMVIVGNIGHFDNEIQVASLRNLKWTNVKPQVD
CCCCCCEEEEECCCCCEEEHHHHHCCCCEEEEECCCCCCCCEEEEEECCCEECCCCCCEE
MITFPDGKRMILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQIELFTKGEQYQNQVYVL
EEECCCCCEEEEEECCCEEECCCCCCCCCEEEECHHHHHHHHHHHEEECCCCCCCEEEEE
PKHLDEKVARLHLDKLGARLTELSGEQAAYIGVTPQGPFKPEHYRY
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TGSKDYVVADISLAGWGRKELDIAETEMPGLMACREEFGAKKPLKGARITGSLHMTIQT
CCCCCEEEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEHHH
AVLIETLKALGADIRWASCNIFSTQDHAAAAIAEAGIPVFAVKGESLEQYWDYTDRIFQW
HHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHCCCCEEEECCCHHHHHHCHHHHHHHH
ADGGLSNMILDDGGDATMYILIGARAEAGEDVLSNPQSEEEEYFYAQVKKRLKASPGFFT
CCCCCCEEEEECCCCEEEEEEEECCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC
KQKAAIRGVTEETTTGVNRLYQLQKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
CCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHH
RGTDTMMAGKVAVVCGYGDVGKGSSASLKGAGARVKVTEVDPICALQAAMDGFEVVTLED
CCCCCEEECCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCEEEEEEEC
AAPTADIVITTTGNKDVVTLDHMRSMKDMVIVGNIGHFDNEIQVASLRNLKWTNVKPQVD
CCCCCCEEEEECCCCCEEEHHHHHCCCCEEEEECCCCCCCCEEEEEECCCEECCCCCCEE
MITFPDGKRMILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQIELFTKGEQYQNQVYVL
EEECCCCCEEEEEECCCEEECCCCCCCCCEEEECHHHHHHHHHHHEEECCCCCCCEEEEE
PKHLDEKVARLHLDKLGARLTELSGEQAAYIGVTPQGPFKPEHYRY
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968