Click here to switch to the map view.

The map label for this gene is msrA2

Identifier: 13473810

GI number: 13473810

Start: 3601888

End: 3602475

Strand: Reverse

Name: msrA2

Synonym: mll4530

Alternate gene names: 13473810

Gene position: 3602475-3601888 (Counterclockwise)

Preceding gene: 13473811

Following gene: 13473807

Centisome position: 51.2

GC content: 62.41

Gene sequence:

>588_bases
ATGGACGAGAAGGCGGCCCCGGGCAGCGAGACGGCGATCTTCGCCGGCGGCTGCTTCTGGGGCGTGCAGGGCGTGTTCCA
GCACGTCAAGGGCGTCAGCAAGGCCGTCTCCGGCTATACTGGCGGCGCCAAGGATGACGCCGTCTACGAGACTGTCGGCA
CCGGCCGCACCGGCCACGCCGAATCCGTCGAGATCACCTACGATCCGTCCAAGGTGACCTACGGCCAGCTGCTGCAGGTC
TATTTCTCGGTCGCCCACAATCCGACGCAGCTGAATTTCCAGGGACCGGATTCCGGCACCCAGTACCGCTCGACGATCTT
CGCCGAGAACGACACGCAAAAGCAGATCGCGCAGAGCTATATCGACCAGCTTGACAAGGCCAAGCTCTACCCGGCGCCGA
TCGTTACCACGATCGAGACCGGCAAGACCTTCTACCCGGCCGAGAACTACCACCAGGACTTTCTGACGCTGAACCCGACC
TATCCCTACATCGTCTATAACGACCTGCCCAAGGTGGCGAACCTGAAGCAGCTGTTCCCGGCGCTGTACAGCGAGAAGCC
GGTGCTGGTGCTGTCGGCGAGCAATTGA

Upstream 100 bases:

>100_bases
CGCGCTGGCCGTGCTCGGTTTCGCGGCGGTGGCGGCGGCCGCATTCTGGCAGACCCCGGCGCGCTCGGCCGAGGACGCGG
TGGTGATCCCGCCGCCGGCA

Downstream 100 bases:

>100_bases
TCCATACCACCCAATGGCTTGCAGCGTTTTCGGGCACAGCATGGAACCAGGGGAAATGCGCGGGGAGCCAAAGCTCCCCG
CGCTGCTGGAACCAACCGGC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MDEKAAPGSETAIFAGGCFWGVQGVFQHVKGVSKAVSGYTGGAKDDAVYETVGTGRTGHAESVEITYDPSKVTYGQLLQV
YFSVAHNPTQLNFQGPDSGTQYRSTIFAENDTQKQIAQSYIDQLDKAKLYPAPIVTTIETGKTFYPAENYHQDFLTLNPT
YPYIVYNDLPKVANLKQLFPALYSEKPVLVLSASN

Sequences:

>Translated_195_residues
MDEKAAPGSETAIFAGGCFWGVQGVFQHVKGVSKAVSGYTGGAKDDAVYETVGTGRTGHAESVEITYDPSKVTYGQLLQV
YFSVAHNPTQLNFQGPDSGTQYRSTIFAENDTQKQIAQSYIDQLDKAKLYPAPIVTTIETGKTFYPAENYHQDFLTLNPT
YPYIVYNDLPKVANLKQLFPALYSEKPVLVLSASN
>Mature_195_residues
MDEKAAPGSETAIFAGGCFWGVQGVFQHVKGVSKAVSGYTGGAKDDAVYETVGTGRTGHAESVEITYDPSKVTYGQLLQV
YFSVAHNPTQLNFQGPDSGTQYRSTIFAENDTQKQIAQSYIDQLDKAKLYPAPIVTTIETGKTFYPAENYHQDFLTLNPT
YPYIVYNDLPKVANLKQLFPALYSEKPVLVLSASN

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=154, Percent_Identity=40.2597402597403, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI208609995, Length=154, Percent_Identity=40.2597402597403, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI208609993, Length=135, Percent_Identity=39.2592592592593, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1790665, Length=155, Percent_Identity=44.5161290322581, Blast_Score=125, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=35.1724137931034, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=36.144578313253, Blast_Score=91, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24664627, Length=144, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI45553131, Length=138, Percent_Identity=32.6086956521739, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA2_RHILO (Q98DV6)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105378.1
- ProteinModelPortal:   Q98DV6
- SMR:   Q98DV6
- GeneID:   1228039
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll4530
- NMPDR:   fig|266835.1.peg.3482
- HOGENOM:   HBG748152
- OMA:   RSTIFAE
- ProtClustDB:   PRK13014
- BRENDA:   1.8.4.11
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 21351; Mature: 21351

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: ACT_SITE 18-18

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEKAAPGSETAIFAGGCFWGVQGVFQHVKGVSKAVSGYTGGAKDDAVYETVGTGRTGHA
CCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCC
ESVEITYDPSKVTYGQLLQVYFSVAHNPTQLNFQGPDSGTQYRSTIFAENDTQKQIAQSY
CEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCHHHHHHHHH
IDQLDKAKLYPAPIVTTIETGKTFYPAENYHQDFLTLNPTYPYIVYNDLPKVANLKQLFP
HHHHHHCCCCCCCEEEEEECCCEECCCCCCCCCEEEECCCCCEEEECCCCCHHHHHHHHH
ALYSEKPVLVLSASN
HHHCCCCEEEEECCC
>Mature Secondary Structure
MDEKAAPGSETAIFAGGCFWGVQGVFQHVKGVSKAVSGYTGGAKDDAVYETVGTGRTGHA
CCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCC
ESVEITYDPSKVTYGQLLQVYFSVAHNPTQLNFQGPDSGTQYRSTIFAENDTQKQIAQSY
CEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCHHHHHHHHH
IDQLDKAKLYPAPIVTTIETGKTFYPAENYHQDFLTLNPTYPYIVYNDLPKVANLKQLFP
HHHHHHCCCCCCCEEEEEECCCEECCCCCCCCCEEEECCCCCEEEECCCCCHHHHHHHHH
ALYSEKPVLVLSASN
HHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968