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The map label for this gene is 13473576

Identifier: 13473576

GI number: 13473576

Start: 3372617

End: 3373333

Strand: Reverse

Name: 13473576

Synonym: mll4221

Alternate gene names: NA

Gene position: 3373333-3372617 (Counterclockwise)

Preceding gene: 13473577

Following gene: 13473575

Centisome position: 47.94

GC content: 68.06

Gene sequence:

>717_bases
ATGCTTCGCGTCCTGGTGACCAGGCCGGAACCGGGCGCCTCTCGCACAGCGCTGCGGCTTCAGGAGACGGGCTTTCAACC
GGTCGTTCTGCCTTTGACCGAAACGGTGGCTTTGCCTGCCGATGCGGGGTTCGTCACCGGCGATGCCGTCGCGGTTGCCG
TTACCAGCGCCAACGCCGTGCGCCATGCTTCGAACGAGGTCATCGCGGCGCTTGCTGCCCTGCCTTGCCATGCCGTGGGC
GCCAGGACCGCCGAAGCGGCGCGCATGAGGGGGTTCACTTCCGTCATTGAAGGCCCGGGCGATGCCGAGGCGCTGGCCGA
CGCCATCGCGGCGGCGTTGCCCGGCAAGGCAATCACCTATCTCTGCGGACGCGTGCGGTTTGCGATGTTCGAACAGCGGA
TGGAAGCGGCTGGCGTCCGGGTCCGCGCCGTGGAGACGTATGACACGCTCCCGGTGCCGTATTCCGACGGGACTATCCTT
GCGCTGCTGTCCGGCCAGCCGGTCGATGCGGTGCTGCTCTACTCGGCCAAGGCGGCCGCCGCGATGCAGGCCTTGACCAA
ACGGCCTGCCCTGCAAGAGGCCTTTGAAAAGACACAGGTTTTCGCGCTTTCCGCGCGCATAGCCGCCGCCTTCGGCGGCG
GCGCCGGCAAAGCAATCCGCATCGCCGCGCGACCCGACGGGGAGGCGCTGCTGGCGCTTTTGCGGGTGCTGCCCTGA

Upstream 100 bases:

>100_bases
TGCAGGGACCAGCACAGGATGCCGCCCGCATCGGCGATGAGGCCGCACGGACGGTGCGGGCCAAGGCCGGGGAAAAATTC
TTCGACGGCTGGGTCTGACG

Downstream 100 bases:

>100_bases
GCCGCGTCATCACACCGCCCCTTTTCACCGCTTGGTGATGTGCTAGACCCTTTCTGAACCATCACGCGCCGGCAGGCGTT
GAGACGAAGCGAATTTTGCG

Product: uroporphyrinogen-III synthase

Products: uroporphyrinogen III; H2O

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MLRVLVTRPEPGASRTALRLQETGFQPVVLPLTETVALPADAGFVTGDAVAVAVTSANAVRHASNEVIAALAALPCHAVG
ARTAEAARMRGFTSVIEGPGDAEALADAIAAALPGKAITYLCGRVRFAMFEQRMEAAGVRVRAVETYDTLPVPYSDGTIL
ALLSGQPVDAVLLYSAKAAAAMQALTKRPALQEAFEKTQVFALSARIAAAFGGGAGKAIRIAARPDGEALLALLRVLP

Sequences:

>Translated_238_residues
MLRVLVTRPEPGASRTALRLQETGFQPVVLPLTETVALPADAGFVTGDAVAVAVTSANAVRHASNEVIAALAALPCHAVG
ARTAEAARMRGFTSVIEGPGDAEALADAIAAALPGKAITYLCGRVRFAMFEQRMEAAGVRVRAVETYDTLPVPYSDGTIL
ALLSGQPVDAVLLYSAKAAAAMQALTKRPALQEAFEKTQVFALSARIAAAFGGGAGKAIRIAARPDGEALLALLRVLP
>Mature_238_residues
MLRVLVTRPEPGASRTALRLQETGFQPVVLPLTETVALPADAGFVTGDAVAVAVTSANAVRHASNEVIAALAALPCHAVG
ARTAEAARMRGFTSVIEGPGDAEALADAIAAALPGKAITYLCGRVRFAMFEQRMEAAGVRVRAVETYDTLPVPYSDGTIL
ALLSGQPVDAVLLYSAKAAAAMQALTKRPALQEAFEKTQVFALSARIAAAFGGGAGKAIRIAARPDGEALLALLRVLP

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 24557; Mature: 24557

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRVLVTRPEPGASRTALRLQETGFQPVVLPLTETVALPADAGFVTGDAVAVAVTSANAV
CEEEEEECCCCCCCHHEEEHHHCCCCEEEEECCCEEECCCCCCEEECCEEEEEEECCHHH
RHASNEVIAALAALPCHAVGARTAEAARMRGFTSVIEGPGDAEALADAIAAALPGKAITY
HHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHH
LCGRVRFAMFEQRMEAAGVRVRAVETYDTLPVPYSDGTILALLSGQPVDAVLLYSAKAAA
HHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCEEEEECCCCCCEEEEEHHHHHH
AMQALTKRPALQEAFEKTQVFALSARIAAAFGGGAGKAIRIAARPDGEALLALLRVLP
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure
MLRVLVTRPEPGASRTALRLQETGFQPVVLPLTETVALPADAGFVTGDAVAVAVTSANAV
CEEEEEECCCCCCCHHEEEHHHCCCCEEEEECCCEEECCCCCCEEECCEEEEEEECCHHH
RHASNEVIAALAALPCHAVGARTAEAARMRGFTSVIEGPGDAEALADAIAAALPGKAITY
HHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHH
LCGRVRFAMFEQRMEAAGVRVRAVETYDTLPVPYSDGTILALLSGQPVDAVLLYSAKAAA
HHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCEEEEECCCCCCEEEEEHHHHHH
AMQALTKRPALQEAFEKTQVFALSARIAAAFGGGAGKAIRIAARPDGEALLALLRVLP
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA