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The map label for this gene is mntH

Identifier: 13472264

GI number: 13472264

Start: 2030057

End: 2031421

Strand: Direct

Name: mntH

Synonym: mlr2501

Alternate gene names: 13472264

Gene position: 2030057-2031421 (Clockwise)

Preceding gene: 13472262

Following gene: 13472265

Centisome position: 28.85

GC content: 63.66

Gene sequence:

>1365_bases
ATGTCAGACGCAGAAGCCACAGCCCCTCGATCCTCATGGCGGTTCGCCGGACGGGACGAGGACGACCAGCCCAGCCTGCG
CGAAGTCAATTCCACCATCGCGGTGCCGAGCTCGGGCGTCTGGTTCCGCCGGCTGTTCGCCTTCATGGGGCCGGGCTATA
TGGTTTCGGTCGGCTATATGGATCCGGGCAACTGGGCGACCGACCTCGCCGGCGGCGCCCAGTTCGGCTACACGCTGCTG
TTCGTCATCATGCTGTCCAACCTGATGGCGATCCTGTTGCAGGCGCTGGCCGCGCGGCTTGGCATCGCCACCGGCCGCGA
TCTCGCTCAGGCCTGCCGCGCCTATTATCCCCGCCCGGTCAATTTCGTGCTGTGGATCGCCTGCGAACTCGCCATCATCG
CCTGTGACCTCGCCGAAGTCATCGGCACCGCGATCGCATTGAAGCTTCTGTTCGGCATTCCGCTGATCGGCGGCGCGATC
CTCACCGCGCTCGACGCCTTCCTCGTGCTGCTGCTGATGAACAAGGGGTTCCGCTATCTCGAAGCCTTCGTCATCGCGCT
TTTGATCATCATCTTCAGCTGCTTTGCCATCCAGATCTTCGTCGCCGCTCCACCGGCCGGCACGATCCTGCATTCGATGT
TCGTGCCGTCCTCGGAGATCGTCACCAATCCGGCGATGCTCTACATCGCCATCGGCATCATCGGCGCCACGGTCATGCCG
CACAATCTCTATCTGCACTCCTCGATCGTGCAGACCCGTGCCTATGAGCGCACCGAAAAGGGCAAGCGCGACGCCATCAA
ATGGGCGACGACGGACTCCACCATCGCCCTGATGCTGGCTCTGTTCGTCAACGCCGCCATCCTGATCGTCTCGGCCGTCG
CCTTCCACAACACCGGCCACCAGGATGTCGCCGAGATCGACCAGGCTTTCGAGCTGCTGTCACCGCTGCTCGGCCTCGGC
ATCGCCTCGATCCTGTTCGCCGTGGCGCTGCTCGCCTCCGGCCTGAATTCGACGGTGACGGCGACGCTTGCCGGCCAGAT
CATCATGGAAGGCTTTCTGCGCCTGCGCATCCCCAACTGGGCGCGCCGGCTTCTGACGCGCGGCCTCGCCATCGTTCCCG
TGGTGGTCGTCACCGCGCTCTATGGCGAGAAAGGCACCGGCCAGCTGCTGGTGTTCAGCCAGGTGATCCTGTCGATGCAA
CTGCCCTTCGCGGTGGTGCCGCTGGTGCAGTTCGTTTCCGACAAGAAGAAGATGGGCAACCTCGCCATTCCGCGCGGCGT
CGCAGCCCTCGCCTGGGTGGTTGCCGCCATCATCCTCGTGCTCAATTTCAAGCTGCTCTACGACACCCTGTTCGGGGTTG
GCTGA

Upstream 100 bases:

>100_bases
ACGCCGGCAAAAAGCACAAACAATGAAATATAGCCTATTGCATAATGTTGAGCCATGGCATAGCTTATGGACGTCCCCGG
AAGTCTCGGAAAGCCCTTTC

Downstream 100 bases:

>100_bases
GTCTGGCGCGAATCCGGAGACAAACCGCAAGATCGCGCTATCTTTCCCGGTGCCATGAGCAAAATTGAAGACATCAGGAA
ATTCTACGCCCGGCTGATGG

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSDAEATAPRSSWRFAGRDEDDQPSLREVNSTIAVPSSGVWFRRLFAFMGPGYMVSVGYMDPGNWATDLAGGAQFGYTLL
FVIMLSNLMAILLQALAARLGIATGRDLAQACRAYYPRPVNFVLWIACELAIIACDLAEVIGTAIALKLLFGIPLIGGAI
LTALDAFLVLLLMNKGFRYLEAFVIALLIIIFSCFAIQIFVAAPPAGTILHSMFVPSSEIVTNPAMLYIAIGIIGATVMP
HNLYLHSSIVQTRAYERTEKGKRDAIKWATTDSTIALMLALFVNAAILIVSAVAFHNTGHQDVAEIDQAFELLSPLLGLG
IASILFAVALLASGLNSTVTATLAGQIIMEGFLRLRIPNWARRLLTRGLAIVPVVVVTALYGEKGTGQLLVFSQVILSMQ
LPFAVVPLVQFVSDKKKMGNLAIPRGVAALAWVVAAIILVLNFKLLYDTLFGVG

Sequences:

>Translated_454_residues
MSDAEATAPRSSWRFAGRDEDDQPSLREVNSTIAVPSSGVWFRRLFAFMGPGYMVSVGYMDPGNWATDLAGGAQFGYTLL
FVIMLSNLMAILLQALAARLGIATGRDLAQACRAYYPRPVNFVLWIACELAIIACDLAEVIGTAIALKLLFGIPLIGGAI
LTALDAFLVLLLMNKGFRYLEAFVIALLIIIFSCFAIQIFVAAPPAGTILHSMFVPSSEIVTNPAMLYIAIGIIGATVMP
HNLYLHSSIVQTRAYERTEKGKRDAIKWATTDSTIALMLALFVNAAILIVSAVAFHNTGHQDVAEIDQAFELLSPLLGLG
IASILFAVALLASGLNSTVTATLAGQIIMEGFLRLRIPNWARRLLTRGLAIVPVVVVTALYGEKGTGQLLVFSQVILSMQ
LPFAVVPLVQFVSDKKKMGNLAIPRGVAALAWVVAAIILVLNFKLLYDTLFGVG
>Mature_453_residues
SDAEATAPRSSWRFAGRDEDDQPSLREVNSTIAVPSSGVWFRRLFAFMGPGYMVSVGYMDPGNWATDLAGGAQFGYTLLF
VIMLSNLMAILLQALAARLGIATGRDLAQACRAYYPRPVNFVLWIACELAIIACDLAEVIGTAIALKLLFGIPLIGGAIL
TALDAFLVLLLMNKGFRYLEAFVIALLIIIFSCFAIQIFVAAPPAGTILHSMFVPSSEIVTNPAMLYIAIGIIGATVMPH
NLYLHSSIVQTRAYERTEKGKRDAIKWATTDSTIALMLALFVNAAILIVSAVAFHNTGHQDVAEIDQAFELLSPLLGLGI
ASILFAVALLASGLNSTVTATLAGQIIMEGFLRLRIPNWARRLLTRGLAIVPVVVVTALYGEKGTGQLLVFSQVILSMQL
PFAVVPLVQFVSDKKKMGNLAIPRGVAALAWVVAAIILVLNFKLLYDTLFGVG

Specific function: H(+)-stimulated, highly selective, manganese uptake system

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family

Homologues:

Organism=Homo sapiens, GI109255241, Length=433, Percent_Identity=38.568129330254, Blast_Score=265, Evalue=5e-71,
Organism=Homo sapiens, GI295293167, Length=442, Percent_Identity=38.4615384615385, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI295293175, Length=442, Percent_Identity=38.4615384615385, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI295293173, Length=442, Percent_Identity=38.4615384615385, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI10835169, Length=442, Percent_Identity=38.4615384615385, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI295293171, Length=442, Percent_Identity=38.4615384615385, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI295293169, Length=442, Percent_Identity=38.4615384615385, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI295293178, Length=442, Percent_Identity=38.4615384615385, Blast_Score=249, Evalue=5e-66,
Organism=Escherichia coli, GI1788736, Length=418, Percent_Identity=41.866028708134, Blast_Score=308, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI193210616, Length=486, Percent_Identity=32.7160493827161, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71999499, Length=465, Percent_Identity=34.8387096774194, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17569473, Length=381, Percent_Identity=36.745406824147, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI71993856, Length=259, Percent_Identity=36.2934362934363, Blast_Score=175, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6323062, Length=399, Percent_Identity=44.3609022556391, Blast_Score=289, Evalue=7e-79,
Organism=Saccharomyces cerevisiae, GI6324450, Length=462, Percent_Identity=37.4458874458874, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6321841, Length=406, Percent_Identity=41.1330049261084, Blast_Score=263, Evalue=5e-71,
Organism=Drosophila melanogaster, GI24648607, Length=413, Percent_Identity=36.319612590799, Blast_Score=255, Evalue=5e-68,
Organism=Drosophila melanogaster, GI281362176, Length=413, Percent_Identity=36.319612590799, Blast_Score=255, Evalue=5e-68,
Organism=Drosophila melanogaster, GI24648609, Length=413, Percent_Identity=36.319612590799, Blast_Score=255, Evalue=5e-68,
Organism=Drosophila melanogaster, GI45553443, Length=413, Percent_Identity=36.319612590799, Blast_Score=255, Evalue=5e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MNTH_RHILO (Q98I99)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_103831.1
- GeneID:   1226492
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr2501
- NMPDR:   fig|266835.1.peg.1935
- HOGENOM:   HBG312498
- OMA:   KFGYALL
- ProtClustDB:   PRK00701
- HAMAP:   MF_00221
- InterPro:   IPR023056
- InterPro:   IPR001046
- PANTHER:   PTHR11706
- PRINTS:   PR00447
- TIGRFAMs:   TIGR01197

Pfam domain/function: PF01566 Nramp

EC number: NA

Molecular weight: Translated: 48834; Mature: 48702

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb501c24)-; HASH(0x103cec50)-; HASH(0xe6fa6b4)-; HASH(0xfb94f34)-; HASH(0x10ef0614)-; HASH(0xeaba178)-; HASH(0x10643dac)-; HASH(0xeffbc94)-; HASH(0x1047a2c4)-; HASH(0x1035a594)-; HASH(0xef762a0)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAEATAPRSSWRFAGRDEDDQPSLREVNSTIAVPSSGVWFRRLFAFMGPGYMVSVGYM
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEECC
DPGNWATDLAGGAQFGYTLLFVIMLSNLMAILLQALAARLGIATGRDLAQACRAYYPRPV
CCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
NFVLWIACELAIIACDLAEVIGTAIALKLLFGIPLIGGAILTALDAFLVLLLMNKGFRYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EAFVIALLIIIFSCFAIQIFVAAPPAGTILHSMFVPSSEIVTNPAMLYIAIGIIGATVMP
HHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCC
HNLYLHSSIVQTRAYERTEKGKRDAIKWATTDSTIALMLALFVNAAILIVSAVAFHNTGH
CHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QDVAEIDQAFELLSPLLGLGIASILFAVALLASGLNSTVTATLAGQIIMEGFLRLRIPNW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHH
ARRLLTRGLAIVPVVVVTALYGEKGTGQLLVFSQVILSMQLPFAVVPLVQFVSDKKKMGN
HHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
LAIPRGVAALAWVVAAIILVLNFKLLYDTLFGVG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
SDAEATAPRSSWRFAGRDEDDQPSLREVNSTIAVPSSGVWFRRLFAFMGPGYMVSVGYM
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEECC
DPGNWATDLAGGAQFGYTLLFVIMLSNLMAILLQALAARLGIATGRDLAQACRAYYPRPV
CCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
NFVLWIACELAIIACDLAEVIGTAIALKLLFGIPLIGGAILTALDAFLVLLLMNKGFRYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EAFVIALLIIIFSCFAIQIFVAAPPAGTILHSMFVPSSEIVTNPAMLYIAIGIIGATVMP
HHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCC
HNLYLHSSIVQTRAYERTEKGKRDAIKWATTDSTIALMLALFVNAAILIVSAVAFHNTGH
CHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QDVAEIDQAFELLSPLLGLGIASILFAVALLASGLNSTVTATLAGQIIMEGFLRLRIPNW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHH
ARRLLTRGLAIVPVVVVTALYGEKGTGQLLVFSQVILSMQLPFAVVPLVQFVSDKKKMGN
HHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
LAIPRGVAALAWVVAAIILVLNFKLLYDTLFGVG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11214968