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The map label for this gene is msrA1

Identifier: 13471707

GI number: 13471707

Start: 1469242

End: 1469760

Strand: Reverse

Name: msrA1

Synonym: mll1760

Alternate gene names: 13471707

Gene position: 1469760-1469242 (Counterclockwise)

Preceding gene: 13471708

Following gene: 13471706

Centisome position: 20.89

GC content: 60.69

Gene sequence:

>519_bases
ATGGCGACTTCGACCGAACGCGCAGTGCTTGCCGGTGGCTGTTTCTGGGGCATGCAGGATTTGATACGGCGCTATCCCGG
CGTCATCTCCACGCGTGTCGGCTATAGTGGCGGCGATGTAGCCAACGCCACCTATCGCAACCACGGTACCCATGCCGAAG
CCATCGAGATCAATTTCGATCCGGCCGTGATCAGCTATCGCACGCTGCTGGAGCGCTTTTTCCAGATCCACGATCCGACG
ACGCGCAACCGCCAGGGCAACGATGTCGGCATGAGCTACCGTTCGGCGATCTACTACACAAGCGATGAGCAAAAGCGCGT
CGCCGAAGACACCATTGCCGATGTCGATGCTTCCGGCCTGTGGCCCGGCAAGGTCGTCACGGAAGTCGCGCCGGCCGGCG
CCTTCTGGGAAGCCGAGCCCGAGCACCAGGATTATCTGGAGAAATATCCGAACGGCTATACCTGCCATTTCGTCAGGCCG
GGCTGGAAGCTGCCGGTACGCGAGAAGGCCGTATCCTAA

Upstream 100 bases:

>100_bases
GACGACAATGCCCATCTATTGGGAAATCCAATTTTGTCTGCGCAATTCCGGGCGGGAAACCGCTACATGAGGTGGAATTG
CCTTTTTGAGGAGACGTGAC

Downstream 100 bases:

>100_bases
CGGTTGGCATAAAGCATCGTTGGGAATGATATCGAAAGCCGCCGGGTGTCCGGCGGCTTTTCTTTTTTGGGCAATCACTC
GCAGTTGTTGCTGTTCGCGG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 1; Peptide-methionine (S)-S-oxide reductase 1; Peptide Met(O) reductase 1

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MATSTERAVLAGGCFWGMQDLIRRYPGVISTRVGYSGGDVANATYRNHGTHAEAIEINFDPAVISYRTLLERFFQIHDPT
TRNRQGNDVGMSYRSAIYYTSDEQKRVAEDTIADVDASGLWPGKVVTEVAPAGAFWEAEPEHQDYLEKYPNGYTCHFVRP
GWKLPVREKAVS

Sequences:

>Translated_172_residues
MATSTERAVLAGGCFWGMQDLIRRYPGVISTRVGYSGGDVANATYRNHGTHAEAIEINFDPAVISYRTLLERFFQIHDPT
TRNRQGNDVGMSYRSAIYYTSDEQKRVAEDTIADVDASGLWPGKVVTEVAPAGAFWEAEPEHQDYLEKYPNGYTCHFVRP
GWKLPVREKAVS
>Mature_171_residues
ATSTERAVLAGGCFWGMQDLIRRYPGVISTRVGYSGGDVANATYRNHGTHAEAIEINFDPAVISYRTLLERFFQIHDPTT
RNRQGNDVGMSYRSAIYYTSDEQKRVAEDTIADVDASGLWPGKVVTEVAPAGAFWEAEPEHQDYLEKYPNGYTCHFVRPG
WKLPVREKAVS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=170, Percent_Identity=39.4117647058824, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI208609995, Length=170, Percent_Identity=39.4117647058824, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI208609993, Length=120, Percent_Identity=40, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=45.3947368421053, Blast_Score=122, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17533973, Length=140, Percent_Identity=40, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320881, Length=165, Percent_Identity=35.1515151515151, Blast_Score=106, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=38.2978723404255, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=38.9705882352941, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24664631, Length=141, Percent_Identity=36.8794326241135, Blast_Score=80, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA1_RHILO (Q98JV5)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_103274.1
- ProteinModelPortal:   Q98JV5
- SMR:   Q98JV5
- GeneID:   1225935
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll1760
- NMPDR:   fig|266835.1.peg.1378
- HOGENOM:   HBG748152
- OMA:   VPNATYR
- ProtClustDB:   PRK14054
- BRENDA:   1.8.4.11
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 19281; Mature: 19149

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: ACT_SITE 14-14

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATSTERAVLAGGCFWGMQDLIRRYPGVISTRVGYSGGDVANATYRNHGTHAEAIEINFD
CCCCCCCEEEECHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCEECCCCCCCEEEEEECC
PAVISYRTLLERFFQIHDPTTRNRQGNDVGMSYRSAIYYTSDEQKRVAEDTIADVDASGL
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHCCCCCCC
WPGKVVTEVAPAGAFWEAEPEHQDYLEKYPNGYTCHFVRPGWKLPVREKAVS
CCCHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCHHHCCCC
>Mature Secondary Structure 
ATSTERAVLAGGCFWGMQDLIRRYPGVISTRVGYSGGDVANATYRNHGTHAEAIEINFD
CCCCCCEEEECHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCEECCCCCCCEEEEEECC
PAVISYRTLLERFFQIHDPTTRNRQGNDVGMSYRSAIYYTSDEQKRVAEDTIADVDASGL
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHCCCCCCC
WPGKVVTEVAPAGAFWEAEPEHQDYLEKYPNGYTCHFVRPGWKLPVREKAVS
CCCHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968