Click here to switch to the map view.

The map label for this gene is cobH [H]

Identifier: 13471413

GI number: 13471413

Start: 1155729

End: 1156361

Strand: Direct

Name: cobH [H]

Synonym: mlr1379

Alternate gene names: 13471413

Gene position: 1155729-1156361 (Clockwise)

Preceding gene: 13471412

Following gene: 13471414

Centisome position: 16.43

GC content: 66.51

Gene sequence:

>633_bases
ATGGCCGCCTACGACTACATTCACGACGGCACGGCGATCTACGAGCGCTCCTTCGCCATCATCCGCGCCGAGGCGGACCT
TTCTCGCTTCTCCGAAGCCGAGGCTGATGTGGCGATCCGCATGATCCATGCCTGCGGCCAGGTCGAAGCATCGAGCCATT
TCGTTTTCTCGCCCGACTTCGTCGCTTCAGCGCGCAAGGCTCTTGCCGCCGGCGCACCGATTTTCTGCGACGCGGAAATG
GTCTCCCACGGCGTCACCCGCGCCCGGCTGCCGGCCGGCAACGAGGTGATCTGCACGCTGCGCGACCCGCGCACGCACGA
CATTGCCAAGGCGATCGGCAACACCCGCTCCGCCGCCGCCATAGACCTGTGGGGCGAACGCATAGCGGGTTCGGTCGTCG
CGATCGGCAATGCGCCGACCGCACTGTTCTACCTGCTGGAAAAGCTGCGTGATGGCGCGCCGAAGCCGGCGGCCATCATC
GGTATGCCGGTCGGCTTCGTCGGCGCCGCTGAATCGAAAGATGCGCTGGCCGAGAATTCTTATGGCGTGCCCTATGCCAT
CGTCCGCGGCCGGCTCGGCGGCAGCGCCATGACCGCAGCCGCGCTCAATTCCCTGGCGAGGCCCGGCCTGTGA

Upstream 100 bases:

>100_bases
GATTTCAAGGCGAGACCGCCGCTGCTTGCCTGACAAGGCTCGGGCCGGCGGCAATCGCCGAGGCTTACCGACAGGCCCAA
ACTAAAAAACGGAAATGAGC

Downstream 100 bases:

>100_bases
ACGCGCTTCCCAATGCCAATTCACGGGGCAAGCTCGTCGGCGTCGGTACCGGTCCGGGTGACCCCGAACTGTTGACGCTG
AAGGCCGCGCGCGCCCTAGC

Product: precorrin-8X methylmutase

Products: NA

Alternate protein names: HBA synthase; Precorrin isomerase [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MAAYDYIHDGTAIYERSFAIIRAEADLSRFSEAEADVAIRMIHACGQVEASSHFVFSPDFVASARKALAAGAPIFCDAEM
VSHGVTRARLPAGNEVICTLRDPRTHDIAKAIGNTRSAAAIDLWGERIAGSVVAIGNAPTALFYLLEKLRDGAPKPAAII
GMPVGFVGAAESKDALAENSYGVPYAIVRGRLGGSAMTAAALNSLARPGL

Sequences:

>Translated_210_residues
MAAYDYIHDGTAIYERSFAIIRAEADLSRFSEAEADVAIRMIHACGQVEASSHFVFSPDFVASARKALAAGAPIFCDAEM
VSHGVTRARLPAGNEVICTLRDPRTHDIAKAIGNTRSAAAIDLWGERIAGSVVAIGNAPTALFYLLEKLRDGAPKPAAII
GMPVGFVGAAESKDALAENSYGVPYAIVRGRLGGSAMTAAALNSLARPGL
>Mature_209_residues
AAYDYIHDGTAIYERSFAIIRAEADLSRFSEAEADVAIRMIHACGQVEASSHFVFSPDFVASARKALAAGAPIFCDAEMV
SHGVTRARLPAGNEVICTLRDPRTHDIAKAIGNTRSAAAIDLWGERIAGSVVAIGNAPTALFYLLEKLRDGAPKPAAIIG
MPVGFVGAAESKDALAENSYGVPYAIVRGRLGGSAMTAAALNSLARPGL

Specific function: Catalyzes the conversion of precorrin-8X to hydrogenobyrinic acid; a methyl migration reaction during the transformation of precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: =5.4.1.2 [H]

Molecular weight: Translated: 21974; Mature: 21843

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAYDYIHDGTAIYERSFAIIRAEADLSRFSEAEADVAIRMIHACGQVEASSHFVFSPDF
CCCCCCCCCCHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHH
VASARKALAAGAPIFCDAEMVSHGVTRARLPAGNEVICTLRDPRTHDIAKAIGNTRSAAA
HHHHHHHHHCCCCEEECHHHHHCCCCEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCHH
IDLWGERIAGSVVAIGNAPTALFYLLEKLRDGAPKPAAIIGMPVGFVGAAESKDALAENS
HHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHCCC
YGVPYAIVRGRLGGSAMTAAALNSLARPGL
CCCCHHHEECCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AAYDYIHDGTAIYERSFAIIRAEADLSRFSEAEADVAIRMIHACGQVEASSHFVFSPDF
CCCCCCCCCHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHH
VASARKALAAGAPIFCDAEMVSHGVTRARLPAGNEVICTLRDPRTHDIAKAIGNTRSAAA
HHHHHHHHHCCCCEEECHHHHHCCCCEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCHH
IDLWGERIAGSVVAIGNAPTALFYLLEKLRDGAPKPAAIIGMPVGFVGAAESKDALAENS
HHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHCCC
YGVPYAIVRGRLGGSAMTAAALNSLARPGL
CCCCHHHEECCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521; 1732194 [H]