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The map label for this gene is mmuM [H]

Identifier: 13471338

GI number: 13471338

Start: 1081594

End: 1082499

Strand: Direct

Name: mmuM [H]

Synonym: mlr1281

Alternate gene names: 13471338

Gene position: 1081594-1082499 (Clockwise)

Preceding gene: 13471337

Following gene: 13471339

Centisome position: 15.37

GC content: 66.45

Gene sequence:

>906_bases
ATGAAGAATGTCATCCTCACCGATGGTGGCATGGGCCAGGAACTGGTCCGGCGCAGCAAATCCGAGCCGACGCCGTTGTG
GTCAGCCAGGGTCCTGATCGACGAACCCGATCTGGTGCGCGACCTGCATGCCGAATTCATTCGCGCCGGCGCCCGCGTGA
TCACCATCAACACCTATTCGGCGACACCTGAGCGGCTAGCGCGCGAGGGTGCCGAGGACCTGTTCAAGCCGCTGCAGAAG
CGCGGCATCGAATTGGCCAGGCAAGCGTGTGACGAGGCCGGCGAGGCAGCGATCGCCGGCTGCCTGTCGCCGCTTTTCGG
CAGCTACGCCCCGGCGCTGACCATTTCCTATCAGGAGACGCTCGACATCTACCGCCGTATCGTTGCCGAGCAGGCGGATG
GCGTCGATCTCTTCCTCTGCGAAACCATGGCCTCGTCCGATGAGGCGCGGGCGGCCGTCACCGCGGCATCGGAAAGCGGC
AAGCCGGTCTGGGTGTCGTGGACGCTCGCCGATCACGGCACGCCGCGGCTGCGCAGCGGCGAAACAATAGCCGCCGCGGC
AAGCGCGCTCGATGGCCTGCCGATAGCGGCGCGGCTGCTCAACTGCTGCCGGCCGGAAACGATCGCCGCCGCCTTGCCTG
AACTGATCGACCTCGGCGGCCCGGTTGGCGCCTATGCCAATGGCTTCACCTCCACGGAGGCGCTCAAGCACGGCGGTACC
GTCGATGTGCTGCACGCCCGCCACGACCTCGCCCCGGACGCCTATGCCGAGCAAGCGATCGGCTGGGTGGAGGCAGGTGC
TGACATCGTCGGCGGCTGCTGCGAAGTCGGACCGCCGCACATTGCCGCGCTGCGCGATCGACTGCAGCAGGACAGTTACG
AAATTTCGGGGGTTTTGCATGCCTAG

Upstream 100 bases:

>100_bases
CCGGCACCTCCGTCGAGGTCGAAATCTTCGGCGACCGTTTCCAGGCGGTCGTGCAGAAGGACGAGCCGCTCTGGGATCCC
AGGAACGAAAGGCTGCGCGC

Downstream 100 bases:

>100_bases
ACCATCGTCTCGCATTTCCGGCATCGTGCCTTCGGGCAAGGATGGCTGGGAGGTTCACTTCGCTGCCTGGACGCGCAAGG
AAGCCGGTGAGGACATCATC

Product: hypothetical protein

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKNVILTDGGMGQELVRRSKSEPTPLWSARVLIDEPDLVRDLHAEFIRAGARVITINTYSATPERLAREGAEDLFKPLQK
RGIELARQACDEAGEAAIAGCLSPLFGSYAPALTISYQETLDIYRRIVAEQADGVDLFLCETMASSDEARAAVTAASESG
KPVWVSWTLADHGTPRLRSGETIAAAASALDGLPIAARLLNCCRPETIAAALPELIDLGGPVGAYANGFTSTEALKHGGT
VDVLHARHDLAPDAYAEQAIGWVEAGADIVGGCCEVGPPHIAALRDRLQQDSYEISGVLHA

Sequences:

>Translated_301_residues
MKNVILTDGGMGQELVRRSKSEPTPLWSARVLIDEPDLVRDLHAEFIRAGARVITINTYSATPERLAREGAEDLFKPLQK
RGIELARQACDEAGEAAIAGCLSPLFGSYAPALTISYQETLDIYRRIVAEQADGVDLFLCETMASSDEARAAVTAASESG
KPVWVSWTLADHGTPRLRSGETIAAAASALDGLPIAARLLNCCRPETIAAALPELIDLGGPVGAYANGFTSTEALKHGGT
VDVLHARHDLAPDAYAEQAIGWVEAGADIVGGCCEVGPPHIAALRDRLQQDSYEISGVLHA
>Mature_301_residues
MKNVILTDGGMGQELVRRSKSEPTPLWSARVLIDEPDLVRDLHAEFIRAGARVITINTYSATPERLAREGAEDLFKPLQK
RGIELARQACDEAGEAAIAGCLSPLFGSYAPALTISYQETLDIYRRIVAEQADGVDLFLCETMASSDEARAAVTAASESG
KPVWVSWTLADHGTPRLRSGETIAAAASALDGLPIAARLLNCCRPETIAAALPELIDLGGPVGAYANGFTSTEALKHGGT
VDVLHARHDLAPDAYAEQAIGWVEAGADIVGGCCEVGPPHIAALRDRLQQDSYEISGVLHA

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Homo sapiens, GI157266337, Length=311, Percent_Identity=25.4019292604502, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI169790923, Length=322, Percent_Identity=26.7080745341615, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI13162290, Length=315, Percent_Identity=25.3968253968254, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786456, Length=306, Percent_Identity=31.3725490196078, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1790450, Length=323, Percent_Identity=25.6965944272446, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17535405, Length=325, Percent_Identity=26.4615384615385, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24585077, Length=327, Percent_Identity=26.605504587156, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 31953; Mature: 31953

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVILTDGGMGQELVRRSKSEPTPLWSARVLIDEPDLVRDLHAEFIRAGARVITINTYS
CCCEEECCCCCCHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECC
ATPERLAREGAEDLFKPLQKRGIELARQACDEAGEAAIAGCLSPLFGSYAPALTISYQET
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHH
LDIYRRIVAEQADGVDLFLCETMASSDEARAAVTAASESGKPVWVSWTLADHGTPRLRSG
HHHHHHHHHHCCCCCEEEEEHHHCCCCHHHHHEEECCCCCCEEEEEEEECCCCCCCCCCC
ETIAAAASALDGLPIAARLLNCCRPETIAAALPELIDLGGPVGAYANGFTSTEALKHGGT
CHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHCCCC
VDVLHARHDLAPDAYAEQAIGWVEAGADIVGGCCEVGPPHIAALRDRLQQDSYEISGVLH
EEEEECHHCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHCCHHHCEEEC
A
C
>Mature Secondary Structure
MKNVILTDGGMGQELVRRSKSEPTPLWSARVLIDEPDLVRDLHAEFIRAGARVITINTYS
CCCEEECCCCCCHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECC
ATPERLAREGAEDLFKPLQKRGIELARQACDEAGEAAIAGCLSPLFGSYAPALTISYQET
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHH
LDIYRRIVAEQADGVDLFLCETMASSDEARAAVTAASESGKPVWVSWTLADHGTPRLRSG
HHHHHHHHHHCCCCCEEEEEHHHCCCCHHHHHEEECCCCCCEEEEEEEECCCCCCCCCCC
ETIAAAASALDGLPIAARLLNCCRPETIAAALPELIDLGGPVGAYANGFTSTEALKHGGT
CHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHCCCC
VDVLHARHDLAPDAYAEQAIGWVEAGADIVGGCCEVGPPHIAALRDRLQQDSYEISGVLH
EEEEECHHCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHCCHHHCEEEC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]