Click here to switch to the map view.

The map label for this gene is gcvT [H]

Identifier: 13471337

GI number: 13471337

Start: 1079144

End: 1081597

Strand: Direct

Name: gcvT [H]

Synonym: mlr1280

Alternate gene names: 13471337

Gene position: 1079144-1081597 (Clockwise)

Preceding gene: 13471336

Following gene: 13471338

Centisome position: 15.34

GC content: 63.08

Gene sequence:

>2454_bases
ATGGCGGGTTTGCCGAGCACGGCGCGCGTGGTGATCATCGGAGGTGGCGTCGTCGGCACCTCCTCGCTCTATCATCTCGC
CAAGGCGGGCTGGACCGACTGCGTGCTCCTGGAAAAGAACGAGCTGACATCAGGCTCGACCTGGCATGCCGCCGGCAATG
TGCCGACCTTCTCCTCGTCCTGGTCGCTGATGAACATGCAGCGCTATTCGACCGAGCTCTATCGCGGCCTCGCCGACGCG
GTCGACTATCCGATGAACTACCACGTCACCGGCTCGCTGCGCCTTGCCCATACGAAAGAGCGCATGCAGGAATTCCAACG
CGCCAAGGGCATGGGCCGCTATCAAGGCATGGATATCGACGTGGTCGGCGTCGACGAGATCAAGCGCCGCTACCCCTTCA
TCGAGACGCATGATTTGAAAGGCGCGCTCTACGACCCGAGCGACGGCGACATCGATCCGGCGCAATTGACCCAGGCGCTG
GCCAAGGGGGCGCGCGACCTGGGTGCGAAAATCATCCGCTTCTGTCCCGTCACCGGCGTGCGCCGCGAGAAGGACGAATG
GGTGGTCACCACGCCGCAAGGCGAGATCCGCTGCGAAATCGTCGTCAATGCCGCCGGTTATCGTGCCGCCGAGGTCGGCC
GGATGTTCGGCCGCGAGGTGCCGATGATGGTGATGAGCCACCAGTACATCCTGTTCGAGGAAATCCCCGAACTGGCGGCC
TGGTCGAAGGAACAAGGCAAGAAGCTGCCGCTGCTGCGCGATGTCGATACGTCCTATTACCTTCGCCAGGAAAAGGCCGG
CATGAATCTCGGCCCCTATGAGCGCAATTGCCGTGCGCATTGGGCCACCCCTGGCGATCCGATGCCGGAGGATTTTTCCT
TCCAGCTCTTCCCCGACGATCTCGACCGGCTGGAACATTACCTGGCAGACGCCGTCGCCCGCGTGCCGATCCTGGGCACG
GCCGGCCTGTCCAAGGTCATCAACGGACCGATCCCCTATGCGCCGGACGGTAATCCGCTGATCGGGCCGATGCCCGGCGT
GCCCAATGCCTTCGAGGCCTGCGTCTTCACTTTCGGCATCGCCCAGGGTGGTGGCGCCGGCAAGGTGCTGGCCGAATGGG
TCACCCAGGGCCAGACCGAATGGGATATGTGGTCCTGCGATCCGCGCCGTTTCACGTCCTTTGCCTCGGCGCCGGATTAT
TGCGTCGCCAAGGGCATGGAAATCTACGGCAATGAATACGCCATCCAGTTCCCGCGCCACGCCTGGCCGGAAGGGCGCGA
CCGCAAACTGTCGCCGATCCATGATCGCACAAAAGCGCTCGGCGGTCGCTTCGACGCCTATAATGGCTGGGAACGCGCCA
CCTGGTACGCGAAGGACGGCGACGACATTTCCGAGGAAGCGACGCTGACTTTCCGCCGCGACGGGCCCTGGCAGCATCGC
GTGCGCGAAGAATGCCTGGCGGTGCGCGACGCCGCCGGCATCCTCGACCTGCCCGGCTTCTCGCGCTTCCGGTTGCAAGG
CCCTGGCGCGCGTGACTGGCTGGCGACGATGATCACCGGCCTGGTGCCGAAACCTGGCCGCATCGGCCTCGGTTACTTCT
CCGACGACAAGGGCCGTATCGTCACCGAGATGTCGATCATGGCGCTTGCCGAAGACCTCTTCTTTTTGATCACCGCTTCC
GTTGCAGAGCAGCACGACTTCGAGTGGCTGCAGTACCATCTGCCGCAACCCAATGAACTCACTCTGCAAAACCTCACCGA
GGCCTTCAGTTGCCAGATCCTGTCCGGGCCGAAATCCCGCGACATCCTCTCGGAATTGACGGCCGCCGACCTTTCGCTGC
CCTGGCTTTCGCACCAGTCGGTGCAGATATCAGGGCACTGGTGCCAATTGGTGCGTGTGTCCTTTGTCGGCGAACTCGGG
TGGGAAATCCACACCAAGGTCGATGACACGGCAGCGGTCTTCGACGCCGTGTGGGCGGCGGGACAAAAACACGGACTGAA
GCCATTCGGCATGTACGCACTGGATTCGCTCAGGCTCGAAAAAGGCTACCGCACCTGGAAGGGCGATCTGTCGACCGACT
ATTCCATCCTGCAAGGCGGGCTCGAGCGTTTCGTCAAATGGGAAAAGCCCGATTTCCGCGGCAAGGCAGCACTTCAGAAC
GAGAAGCAGCAAGGCGTGAAGAAGCGCTTCGTCACGCTGGTCGTCGAGAACCCCGGCGATTGCGACGCGCCCTACATGTC
GACGCTGTGGCATGGCGGCCAGATCGTCGGCGAGACCACCTCGGGGGGCTGGGGCCATCGCATCGACAAGTCGATCGCGC
TCGGCATGCTGCGCGTGGATTTGACCGAGCCCGGCACCTCCGTCGAGGTCGAAATCTTCGGCGACCGTTTCCAGGCGGTC
GTGCAGAAGGACGAGCCGCTCTGGGATCCCAGGAACGAAAGGCTGCGCGCATGA

Upstream 100 bases:

>100_bases
AGGCAAGCCCTATCGCTGGCGCAATCCAGGCACCGAGCCGGCGGTTGTCATCTGGGTGGTTTCGCCGCCGGTTTATTGAA
ATAAGATTTGGGAGAAGAAC

Downstream 100 bases:

>100_bases
AGAATGTCATCCTCACCGATGGTGGCATGGGCCAGGAACTGGTCCGGCGCAGCAAATCCGAGCCGACGCCGTTGTGGTCA
GCCAGGGTCCTGATCGACGA

Product: dimethylglycine dehydrogenase precursor

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 817; Mature: 816

Protein sequence:

>817_residues
MAGLPSTARVVIIGGGVVGTSSLYHLAKAGWTDCVLLEKNELTSGSTWHAAGNVPTFSSSWSLMNMQRYSTELYRGLADA
VDYPMNYHVTGSLRLAHTKERMQEFQRAKGMGRYQGMDIDVVGVDEIKRRYPFIETHDLKGALYDPSDGDIDPAQLTQAL
AKGARDLGAKIIRFCPVTGVRREKDEWVVTTPQGEIRCEIVVNAAGYRAAEVGRMFGREVPMMVMSHQYILFEEIPELAA
WSKEQGKKLPLLRDVDTSYYLRQEKAGMNLGPYERNCRAHWATPGDPMPEDFSFQLFPDDLDRLEHYLADAVARVPILGT
AGLSKVINGPIPYAPDGNPLIGPMPGVPNAFEACVFTFGIAQGGGAGKVLAEWVTQGQTEWDMWSCDPRRFTSFASAPDY
CVAKGMEIYGNEYAIQFPRHAWPEGRDRKLSPIHDRTKALGGRFDAYNGWERATWYAKDGDDISEEATLTFRRDGPWQHR
VREECLAVRDAAGILDLPGFSRFRLQGPGARDWLATMITGLVPKPGRIGLGYFSDDKGRIVTEMSIMALAEDLFFLITAS
VAEQHDFEWLQYHLPQPNELTLQNLTEAFSCQILSGPKSRDILSELTAADLSLPWLSHQSVQISGHWCQLVRVSFVGELG
WEIHTKVDDTAAVFDAVWAAGQKHGLKPFGMYALDSLRLEKGYRTWKGDLSTDYSILQGGLERFVKWEKPDFRGKAALQN
EKQQGVKKRFVTLVVENPGDCDAPYMSTLWHGGQIVGETTSGGWGHRIDKSIALGMLRVDLTEPGTSVEVEIFGDRFQAV
VQKDEPLWDPRNERLRA

Sequences:

>Translated_817_residues
MAGLPSTARVVIIGGGVVGTSSLYHLAKAGWTDCVLLEKNELTSGSTWHAAGNVPTFSSSWSLMNMQRYSTELYRGLADA
VDYPMNYHVTGSLRLAHTKERMQEFQRAKGMGRYQGMDIDVVGVDEIKRRYPFIETHDLKGALYDPSDGDIDPAQLTQAL
AKGARDLGAKIIRFCPVTGVRREKDEWVVTTPQGEIRCEIVVNAAGYRAAEVGRMFGREVPMMVMSHQYILFEEIPELAA
WSKEQGKKLPLLRDVDTSYYLRQEKAGMNLGPYERNCRAHWATPGDPMPEDFSFQLFPDDLDRLEHYLADAVARVPILGT
AGLSKVINGPIPYAPDGNPLIGPMPGVPNAFEACVFTFGIAQGGGAGKVLAEWVTQGQTEWDMWSCDPRRFTSFASAPDY
CVAKGMEIYGNEYAIQFPRHAWPEGRDRKLSPIHDRTKALGGRFDAYNGWERATWYAKDGDDISEEATLTFRRDGPWQHR
VREECLAVRDAAGILDLPGFSRFRLQGPGARDWLATMITGLVPKPGRIGLGYFSDDKGRIVTEMSIMALAEDLFFLITAS
VAEQHDFEWLQYHLPQPNELTLQNLTEAFSCQILSGPKSRDILSELTAADLSLPWLSHQSVQISGHWCQLVRVSFVGELG
WEIHTKVDDTAAVFDAVWAAGQKHGLKPFGMYALDSLRLEKGYRTWKGDLSTDYSILQGGLERFVKWEKPDFRGKAALQN
EKQQGVKKRFVTLVVENPGDCDAPYMSTLWHGGQIVGETTSGGWGHRIDKSIALGMLRVDLTEPGTSVEVEIFGDRFQAV
VQKDEPLWDPRNERLRA
>Mature_816_residues
AGLPSTARVVIIGGGVVGTSSLYHLAKAGWTDCVLLEKNELTSGSTWHAAGNVPTFSSSWSLMNMQRYSTELYRGLADAV
DYPMNYHVTGSLRLAHTKERMQEFQRAKGMGRYQGMDIDVVGVDEIKRRYPFIETHDLKGALYDPSDGDIDPAQLTQALA
KGARDLGAKIIRFCPVTGVRREKDEWVVTTPQGEIRCEIVVNAAGYRAAEVGRMFGREVPMMVMSHQYILFEEIPELAAW
SKEQGKKLPLLRDVDTSYYLRQEKAGMNLGPYERNCRAHWATPGDPMPEDFSFQLFPDDLDRLEHYLADAVARVPILGTA
GLSKVINGPIPYAPDGNPLIGPMPGVPNAFEACVFTFGIAQGGGAGKVLAEWVTQGQTEWDMWSCDPRRFTSFASAPDYC
VAKGMEIYGNEYAIQFPRHAWPEGRDRKLSPIHDRTKALGGRFDAYNGWERATWYAKDGDDISEEATLTFRRDGPWQHRV
REECLAVRDAAGILDLPGFSRFRLQGPGARDWLATMITGLVPKPGRIGLGYFSDDKGRIVTEMSIMALAEDLFFLITASV
AEQHDFEWLQYHLPQPNELTLQNLTEAFSCQILSGPKSRDILSELTAADLSLPWLSHQSVQISGHWCQLVRVSFVGELGW
EIHTKVDDTAAVFDAVWAAGQKHGLKPFGMYALDSLRLEKGYRTWKGDLSTDYSILQGGLERFVKWEKPDFRGKAALQNE
KQQGVKKRFVTLVVENPGDCDAPYMSTLWHGGQIVGETTSGGWGHRIDKSIALGMLRVDLTEPGTSVEVEIFGDRFQAVV
QKDEPLWDPRNERLRA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=821, Percent_Identity=36.9062119366626, Blast_Score=532, Evalue=1e-151,
Organism=Homo sapiens, GI197927446, Length=877, Percent_Identity=32.6111744583808, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI21361378, Length=877, Percent_Identity=32.6111744583808, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI194306651, Length=827, Percent_Identity=29.6251511487303, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI44662838, Length=408, Percent_Identity=22.7941176470588, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI257796258, Length=397, Percent_Identity=22.4181360201511, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI257796256, Length=290, Percent_Identity=24.4827586206897, Blast_Score=79, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI32563613, Length=843, Percent_Identity=27.7580071174377, Blast_Score=267, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71994045, Length=798, Percent_Identity=27.0676691729323, Blast_Score=259, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI71994052, Length=804, Percent_Identity=26.865671641791, Blast_Score=256, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17541536, Length=454, Percent_Identity=23.568281938326, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20130091, Length=872, Percent_Identity=29.1284403669725, Blast_Score=346, Evalue=4e-95,
Organism=Drosophila melanogaster, GI28571104, Length=845, Percent_Identity=27.6923076923077, Blast_Score=304, Evalue=2e-82,
Organism=Drosophila melanogaster, GI20129441, Length=332, Percent_Identity=24.0963855421687, Blast_Score=80, Evalue=7e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 91260; Mature: 91129

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGLPSTARVVIIGGGVVGTSSLYHLAKAGWTDCVLLEKNELTSGSTWHAAGNVPTFSSS
CCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCCCCCCCCC
WSLMNMQRYSTELYRGLADAVDYPMNYHVTGSLRLAHTKERMQEFQRAKGMGRYQGMDID
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCEE
VVGVDEIKRRYPFIETHDLKGALYDPSDGDIDPAQLTQALAKGARDLGAKIIRFCPVTGV
EECHHHHHHHCCCEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RREKDEWVVTTPQGEIRCEIVVNAAGYRAAEVGRMFGREVPMMVMSHQYILFEEIPELAA
CCCCCCEEEECCCCCEEEEEEEECCCCCHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHH
WSKEQGKKLPLLRDVDTSYYLRQEKAGMNLGPYERNCRAHWATPGDPMPEDFSFQLFPDD
CCHHCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCEEEECCHH
LDRLEHYLADAVARVPILGTAGLSKVINGPIPYAPDGNPLIGPMPGVPNAFEACVFTFGI
HHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
AQGGGAGKVLAEWVTQGQTEWDMWSCDPRRFTSFASAPDYCVAKGMEIYGNEYAIQFPRH
CCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHCCHHCCCCEEEEECCCC
AWPEGRDRKLSPIHDRTKALGGRFDAYNGWERATWYAKDGDDISEEATLTFRRDGPWQHR
CCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCHHHH
VREECLAVRDAAGILDLPGFSRFRLQGPGARDWLATMITGLVPKPGRIGLGYFSDDKGRI
HHHHHHHHHHCCCEEECCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEECCEEECCCCCE
VTEMSIMALAEDLFFLITASVAEQHDFEWLQYHLPQPNELTLQNLTEAFSCQILSGPKSR
EHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCCCHHHHHHHHHEEEEECCCCHH
DILSELTAADLSLPWLSHQSVQISGHWCQLVRVSFVGELGWEIHTKVDDTAAVFDAVWAA
HHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHC
GQKHGLKPFGMYALDSLRLEKGYRTWKGDLSTDYSILQGGLERFVKWEKPDFRGKAALQN
CHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHC
EKQQGVKKRFVTLVVENPGDCDAPYMSTLWHGGQIVGETTSGGWGHRIDKSIALGMLRVD
HHHHHHHEEEEEEEEECCCCCCCCHHHHHHCCCEEEEECCCCCCCCHHHHHHHEEEEEEE
LTEPGTSVEVEIFGDRFQAVVQKDEPLWDPRNERLRA
ECCCCCEEEEEEECHHHHHHHHCCCCCCCCCHHCCCC
>Mature Secondary Structure 
AGLPSTARVVIIGGGVVGTSSLYHLAKAGWTDCVLLEKNELTSGSTWHAAGNVPTFSSS
CCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCCCCCCCCC
WSLMNMQRYSTELYRGLADAVDYPMNYHVTGSLRLAHTKERMQEFQRAKGMGRYQGMDID
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCEE
VVGVDEIKRRYPFIETHDLKGALYDPSDGDIDPAQLTQALAKGARDLGAKIIRFCPVTGV
EECHHHHHHHCCCEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RREKDEWVVTTPQGEIRCEIVVNAAGYRAAEVGRMFGREVPMMVMSHQYILFEEIPELAA
CCCCCCEEEECCCCCEEEEEEEECCCCCHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHH
WSKEQGKKLPLLRDVDTSYYLRQEKAGMNLGPYERNCRAHWATPGDPMPEDFSFQLFPDD
CCHHCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCEEEECCHH
LDRLEHYLADAVARVPILGTAGLSKVINGPIPYAPDGNPLIGPMPGVPNAFEACVFTFGI
HHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
AQGGGAGKVLAEWVTQGQTEWDMWSCDPRRFTSFASAPDYCVAKGMEIYGNEYAIQFPRH
CCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHCCHHCCCCEEEEECCCC
AWPEGRDRKLSPIHDRTKALGGRFDAYNGWERATWYAKDGDDISEEATLTFRRDGPWQHR
CCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCHHHH
VREECLAVRDAAGILDLPGFSRFRLQGPGARDWLATMITGLVPKPGRIGLGYFSDDKGRI
HHHHHHHHHHCCCEEECCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEECCEEECCCCCE
VTEMSIMALAEDLFFLITASVAEQHDFEWLQYHLPQPNELTLQNLTEAFSCQILSGPKSR
EHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCCCHHHHHHHHHEEEEECCCCHH
DILSELTAADLSLPWLSHQSVQISGHWCQLVRVSFVGELGWEIHTKVDDTAAVFDAVWAA
HHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHC
GQKHGLKPFGMYALDSLRLEKGYRTWKGDLSTDYSILQGGLERFVKWEKPDFRGKAALQN
CHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHC
EKQQGVKKRFVTLVVENPGDCDAPYMSTLWHGGQIVGETTSGGWGHRIDKSIALGMLRVD
HHHHHHHEEEEEEEEECCCCCCCCHHHHHHCCCEEEEECCCCCCCCHHHHHHHEEEEEEE
LTEPGTSVEVEIFGDRFQAVVQKDEPLWDPRNERLRA
ECCCCCEEEEEEECHHHHHHHHCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA