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The map label for this gene is hsrA [H]

Identifier: 13471334

GI number: 13471334

Start: 1076188

End: 1077630

Strand: Direct

Name: hsrA [H]

Synonym: mlr1277

Alternate gene names: 13471334

Gene position: 1076188-1077630 (Clockwise)

Preceding gene: 13471333

Following gene: 13471336

Centisome position: 15.3

GC content: 64.8

Gene sequence:

>1443_bases
ATGACCGCAGAACTATCCGCCGGCGCCACGGATCGCTCCGATGTGACGGCCAGAGCCTTGCTCCTGCTGCCGCTGACGGT
CGCCTGCGGTGTGTTCATGACCAGCCTCGACCAGAATGTCGTGGTGACGGCGCTGCCCGGCATCGGCGAAAGCCTTGCCC
GCCCACCGAGCCAGCTCGGCCTGTTGATCACCGTCTATGTCGCCAGCCTGATCATATCGATGCCGCTCGGCGGCTGGGCC
GCCGACCGCTTCGGCCTGCGCAATGTCTACTGCTTTGCCTTGCTGGTGTTCGCCACCTCCTCGGCGCTCTGCGGCCTGTC
GAACGACATCTGGACACTGGTCGGCGCCCGCGCGCTGCAGGGATTTGGCGGGGCGCTGATGGGCACGCTCGACCAGGTCG
TCATCCTGTCGAGTTTTCCCCGCAACCGGACGCTGAAGATCAACATGTATATCTCGGTCGCCAGCCAGACCGGGCCGCTG
GTTGGGCCGCTCGTCGGCGGCGCGCTGACCACCTACATTTCCTGGCGCTGGATTTTCTTCATCAATGTGCCGTTCGCGCT
GGCGGCGGCAGTCCTTGCCGCCTCACTGTTCCCGACCATGACCAAGCCCGTTCGCACGCGGTTCGATTTTCCAGGCTTCC
TGCTGGTCGGCAGCGGCATGATCCTGCTGGTGTTCGGCATGGACTCGCTGGCCGCCAAGGACGCCGGCGGCGGCATGATT
GCCGGCGAACTGGCGCTGGCGGTCGTCATCCTGTCGATTGCCTCGCTCTACTGCCTGCGCGTGCCCAATCCCCTGCTCGA
TTTAAAACTCCTGCGCATCCGCACCTTCCGCATCTCGTTCCTCACCGGCGGCGGGCTGGACACGATCGGGCTGAGCTCCG
TCGCCTTCCTGCTGCCGCTGATGTTCCAGCTCGGCTTCGGCATGAGCGCGGTGCAGGCGGGATCGCTGACTTTCGTCGCC
GCGCTCGGTTCGGTGATCATGCGCCTCTTCATGCCGCGCGTCCTCAACCGGTTCGGCTTCCGCCGCGTGCTGGTCATAAA
CACGCCTGTTGTTGCCGCGATGGTCGCCGGCTTCGCCTTGATGCAGGCGACGACGCCGGTCTGGATCGTGCTTGGCTACA
TCTTTGCTTTCGGCGTTTTTCGTTCCGTCCAATGGGCCTCGACCGGAAATCTCGCCTATTCCGACATCGCCCCCGACCAA
CTCGCCCGCTTCAGCGCGCTTTACTACATTCTCTGGCAGCTCGCGGTGGCGGTCAGCGTCGGCCTGGCGGCGGCCATGCT
GTCGTTCCTGGCCGGCGGCGGGCCTGCCGTGACCAATGATTTCCGGATCCTGTTCGCGATCGAGGGCGTCATCACGCTCT
GCGCGCTGCTTGCCTACCTCAAGCTGACACCGCAGGACGGCGCCCATGTCAGCGGCCACGGTGCACAGATGAATACGGAA
TAG

Upstream 100 bases:

>100_bases
CGCCGGCGGCCATGGTGGAAAAACGTGGCCGCCAGATCGGCCCAAGGGGCATAAAAATCCCGTCTCAGGCTCGGCACTTT
CGTTTGGTTCGAACATCCCC

Downstream 100 bases:

>100_bases
CCTTTGCCGGGCAGCCGCTCTATTCGCTGAACGTCACCCACTCTTCCAGCGGCACGCGGTCGGTGCGGAAGGCGTTTTCC
GGCTTGGAGGTGTCCTCATA

Product: transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MTAELSAGATDRSDVTARALLLLPLTVACGVFMTSLDQNVVVTALPGIGESLARPPSQLGLLITVYVASLIISMPLGGWA
ADRFGLRNVYCFALLVFATSSALCGLSNDIWTLVGARALQGFGGALMGTLDQVVILSSFPRNRTLKINMYISVASQTGPL
VGPLVGGALTTYISWRWIFFINVPFALAAAVLAASLFPTMTKPVRTRFDFPGFLLVGSGMILLVFGMDSLAAKDAGGGMI
AGELALAVVILSIASLYCLRVPNPLLDLKLLRIRTFRISFLTGGGLDTIGLSSVAFLLPLMFQLGFGMSAVQAGSLTFVA
ALGSVIMRLFMPRVLNRFGFRRVLVINTPVVAAMVAGFALMQATTPVWIVLGYIFAFGVFRSVQWASTGNLAYSDIAPDQ
LARFSALYYILWQLAVAVSVGLAAAMLSFLAGGGPAVTNDFRILFAIEGVITLCALLAYLKLTPQDGAHVSGHGAQMNTE

Sequences:

>Translated_480_residues
MTAELSAGATDRSDVTARALLLLPLTVACGVFMTSLDQNVVVTALPGIGESLARPPSQLGLLITVYVASLIISMPLGGWA
ADRFGLRNVYCFALLVFATSSALCGLSNDIWTLVGARALQGFGGALMGTLDQVVILSSFPRNRTLKINMYISVASQTGPL
VGPLVGGALTTYISWRWIFFINVPFALAAAVLAASLFPTMTKPVRTRFDFPGFLLVGSGMILLVFGMDSLAAKDAGGGMI
AGELALAVVILSIASLYCLRVPNPLLDLKLLRIRTFRISFLTGGGLDTIGLSSVAFLLPLMFQLGFGMSAVQAGSLTFVA
ALGSVIMRLFMPRVLNRFGFRRVLVINTPVVAAMVAGFALMQATTPVWIVLGYIFAFGVFRSVQWASTGNLAYSDIAPDQ
LARFSALYYILWQLAVAVSVGLAAAMLSFLAGGGPAVTNDFRILFAIEGVITLCALLAYLKLTPQDGAHVSGHGAQMNTE
>Mature_479_residues
TAELSAGATDRSDVTARALLLLPLTVACGVFMTSLDQNVVVTALPGIGESLARPPSQLGLLITVYVASLIISMPLGGWAA
DRFGLRNVYCFALLVFATSSALCGLSNDIWTLVGARALQGFGGALMGTLDQVVILSSFPRNRTLKINMYISVASQTGPLV
GPLVGGALTTYISWRWIFFINVPFALAAAVLAASLFPTMTKPVRTRFDFPGFLLVGSGMILLVFGMDSLAAKDAGGGMIA
GELALAVVILSIASLYCLRVPNPLLDLKLLRIRTFRISFLTGGGLDTIGLSSVAFLLPLMFQLGFGMSAVQAGSLTFVAA
LGSVIMRLFMPRVLNRFGFRRVLVINTPVVAAMVAGFALMQATTPVWIVLGYIFAFGVFRSVQWASTGNLAYSDIAPDQL
ARFSALYYILWQLAVAVSVGLAAAMLSFLAGGGPAVTNDFRILFAIEGVITLCALLAYLKLTPQDGAHVSGHGAQMNTE

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=464, Percent_Identity=33.4051724137931, Blast_Score=261, Evalue=9e-71,
Organism=Escherichia coli, GI1788392, Length=420, Percent_Identity=35.2380952380952, Blast_Score=188, Evalue=9e-49,
Organism=Escherichia coli, GI87081983, Length=308, Percent_Identity=30.8441558441558, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1789042, Length=348, Percent_Identity=25.5747126436782, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1788710, Length=343, Percent_Identity=27.4052478134111, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322958, Length=415, Percent_Identity=25.7831325301205, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325455, Length=158, Percent_Identity=31.6455696202532, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50759; Mature: 50628

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAELSAGATDRSDVTARALLLLPLTVACGVFMTSLDQNVVVTALPGIGESLARPPSQLG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCHHHHH
LLITVYVASLIISMPLGGWAADRFGLRNVYCFALLVFATSSALCGLSNDIWTLVGARALQ
HHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
GFGGALMGTLDQVVILSSFPRNRTLKINMYISVASQTGPLVGPLVGGALTTYISWRWIFF
HCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHEEEEEE
INVPFALAAAVLAASLFPTMTKPVRTRFDFPGFLLVGSGMILLVFGMDSLAAKDAGGGMI
EECHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCEEECCCEEEEEECCHHHHCCCCCCCCH
AGELALAVVILSIASLYCLRVPNPLLDLKLLRIRTFRISFLTGGGLDTIGLSSVAFLLPL
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEEEEEEEECCCCCHHHHHHHHHHHHH
MFQLGFGMSAVQAGSLTFVAALGSVIMRLFMPRVLNRFGFRRVLVINTPVVAAMVAGFAL
HHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHH
MQATTPVWIVLGYIFAFGVFRSVQWASTGNLAYSDIAPDQLARFSALYYILWQLAVAVSV
HHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
GLAAAMLSFLAGGGPAVTNDFRILFAIEGVITLCALLAYLKLTPQDGAHVSGHGAQMNTE
HHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCC
>Mature Secondary Structure 
TAELSAGATDRSDVTARALLLLPLTVACGVFMTSLDQNVVVTALPGIGESLARPPSQLG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCHHHHH
LLITVYVASLIISMPLGGWAADRFGLRNVYCFALLVFATSSALCGLSNDIWTLVGARALQ
HHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
GFGGALMGTLDQVVILSSFPRNRTLKINMYISVASQTGPLVGPLVGGALTTYISWRWIFF
HCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHEEEEEE
INVPFALAAAVLAASLFPTMTKPVRTRFDFPGFLLVGSGMILLVFGMDSLAAKDAGGGMI
EECHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCEEECCCEEEEEECCHHHHCCCCCCCCH
AGELALAVVILSIASLYCLRVPNPLLDLKLLRIRTFRISFLTGGGLDTIGLSSVAFLLPL
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEEEEEEEECCCCCHHHHHHHHHHHHH
MFQLGFGMSAVQAGSLTFVAALGSVIMRLFMPRVLNRFGFRRVLVINTPVVAAMVAGFAL
HHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHH
MQATTPVWIVLGYIFAFGVFRSVQWASTGNLAYSDIAPDQLARFSALYYILWQLAVAVSV
HHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
GLAAAMLSFLAGGGPAVTNDFRILFAIEGVITLCALLAYLKLTPQDGAHVSGHGAQMNTE
HHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]