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The map label for this gene is pcm [H]

Identifier: 13471178

GI number: 13471178

Start: 903136

End: 903789

Strand: Reverse

Name: pcm [H]

Synonym: mll1078

Alternate gene names: 13471178

Gene position: 903789-903136 (Counterclockwise)

Preceding gene: 13471179

Following gene: 13471177

Centisome position: 12.85

GC content: 67.28

Gene sequence:

>654_bases
ATGAATTTGCCAATCGATGACCGCGAAGGATTTGCCGCTTTCCTGTTGCGCCTGCGCGGCAGGGGAACCGTGCCGAAGGC
GCTGATCGCGGCTTTCGAGGCAACACCGCGGCGCGGTTTCCTGCCGGCCCACTTCCACCAGCTCGCCTGGTCAGACCGCA
TGCTGCCGATCGAATGCGGCGAGGCGATCGAAGGTGCCGACATGCAGGCGGCGGTAATCGCGGCCCTTGCCATCGAAGCG
GGAAACCGCGTGCTCGAGATCGGCACCGGCTCCGGCTATACGGCGGCGGTGATGTCGCGGCTGGCGGCGCGGATCGTCAC
CATCGACCGCTACAAGACCCTGGTCGAGCAGGCCAGGCAGCGTTTCGAGGCGCTTGGCATCGGCAATGTCATCGTGCGCC
AGGCTGACGGCTCCGGCGGCCTGCCTGCCGAAGGCCCGTTCGACCGCATCGTCGCTTGGGCCGCCTTCGACAGCCTGCCG
CGCTTCCTGCTCGACCAATTGTCGAGCGGCGGCATCGTCATCGCGCCGATCGGGCCGGAAGAGGGCGAGCAGGTTCTGGC
CAAGCTCACCAAGGTCGGCAGCCGTTTCGAGCGCGAGGATATCGGCCTCGTGCGGCTGCAGCCGATCCTGCGCAGCGTCG
CGGCGGTCATCTAG

Upstream 100 bases:

>100_bases
CCGACCTCCATGCGCTGCGCAACCGTCTGGTGTCGGTGACGCCGCTGCAGCTCGACCTTACCGCGCATGAGATCCGTGAC
CAGCTGAGCAAGGCGCTTGC

Downstream 100 bases:

>100_bases
TTTCCGGCAGAGCACTGGTCCGCGTTTGAACAGCTGTTCGGCCTCGTGATCCATGCGGCCAGCTATCCCCAAATGTTTTA
AGAAAATTTTCGTCGGATTC

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MNLPIDDREGFAAFLLRLRGRGTVPKALIAAFEATPRRGFLPAHFHQLAWSDRMLPIECGEAIEGADMQAAVIAALAIEA
GNRVLEIGTGSGYTAAVMSRLAARIVTIDRYKTLVEQARQRFEALGIGNVIVRQADGSGGLPAEGPFDRIVAWAAFDSLP
RFLLDQLSSGGIVIAPIGPEEGEQVLAKLTKVGSRFEREDIGLVRLQPILRSVAAVI

Sequences:

>Translated_217_residues
MNLPIDDREGFAAFLLRLRGRGTVPKALIAAFEATPRRGFLPAHFHQLAWSDRMLPIECGEAIEGADMQAAVIAALAIEA
GNRVLEIGTGSGYTAAVMSRLAARIVTIDRYKTLVEQARQRFEALGIGNVIVRQADGSGGLPAEGPFDRIVAWAAFDSLP
RFLLDQLSSGGIVIAPIGPEEGEQVLAKLTKVGSRFEREDIGLVRLQPILRSVAAVI
>Mature_217_residues
MNLPIDDREGFAAFLLRLRGRGTVPKALIAAFEATPRRGFLPAHFHQLAWSDRMLPIECGEAIEGADMQAAVIAALAIEA
GNRVLEIGTGSGYTAAVMSRLAARIVTIDRYKTLVEQARQRFEALGIGNVIVRQADGSGGLPAEGPFDRIVAWAAFDSLP
RFLLDQLSSGGIVIAPIGPEEGEQVLAKLTKVGSRFEREDIGLVRLQPILRSVAAVI

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI226530908, Length=141, Percent_Identity=29.0780141843972, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789100, Length=199, Percent_Identity=36.6834170854271, Blast_Score=128, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71983477, Length=189, Percent_Identity=28.042328042328, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193207222, Length=138, Percent_Identity=31.1594202898551, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17981723, Length=194, Percent_Identity=28.3505154639175, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 23327; Mature: 23327

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS01279 PCMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLPIDDREGFAAFLLRLRGRGTVPKALIAAFEATPRRGFLPAHFHQLAWSDRMLPIECG
CCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCC
EAIEGADMQAAVIAALAIEAGNRVLEIGTGSGYTAAVMSRLAARIVTIDRYKTLVEQARQ
CCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFEALGIGNVIVRQADGSGGLPAEGPFDRIVAWAAFDSLPRFLLDQLSSGGIVIAPIGPE
HHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
EGEQVLAKLTKVGSRFEREDIGLVRLQPILRSVAAVI
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNLPIDDREGFAAFLLRLRGRGTVPKALIAAFEATPRRGFLPAHFHQLAWSDRMLPIECG
CCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCC
EAIEGADMQAAVIAALAIEAGNRVLEIGTGSGYTAAVMSRLAARIVTIDRYKTLVEQARQ
CCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFEALGIGNVIVRQADGSGGLPAEGPFDRIVAWAAFDSLPRFLLDQLSSGGIVIAPIGPE
HHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
EGEQVLAKLTKVGSRFEREDIGLVRLQPILRSVAAVI
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9304864; 11481430 [H]