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The map label for this gene is serA [H]

Identifier: 13471134

GI number: 13471134

Start: 846801

End: 847826

Strand: Reverse

Name: serA [H]

Synonym: mll1021

Alternate gene names: 13471134

Gene position: 847826-846801 (Counterclockwise)

Preceding gene: 13471135

Following gene: 13471132

Centisome position: 12.05

GC content: 63.45

Gene sequence:

>1026_bases
ATGAGCGCTCAAGGCTTGCCCAGCGTTCTCGCGTTTGAACGCTACGACCCGACTGACGCCTCGCTAGACTGGCTGCGCGA
GCGTGGGGTCAACGTCATTTTCGGCAATGCGCTCTGGGAAATGCCGTTCAAGCGCTTCACCGAGGATGAGCTGATTGCCA
AGGCGCATGGCTGTATCGCCTTGATGGGGGCAAGCGGCACCCGCATCACCAGGCGCGTGATGCAGGCGCTTCCGGATCTG
CGCTACATCTCAAAATATGGCATTGGCGTCGACAGCATCGACATCGACGCCGCCACTGAGCACGGCATTCTGGTTTCGAG
TACGCCGAACGATTTTCAGATCTTCACGGTCAGCGAGCACGCGGTCGCCCTGATGCTGGCGGTTGCCAAACAACTTGGCA
CGTGGACGCCCGAATTCATGCGGCGTGGCGGGTGGCGCGGCCTGACACACGGCGCGACGCTGCGCGGCGCCACCGTCGGC
ATCGTCGGCCTCGGCCGCATCGGCCGTGGCGTGGCGCAACGGCTGTCGGGCTGGGAGGCCCGCATCCTTGCCTATGATCC
CTTCCTGAAGGAAGCGCCTCCAGGCATCGAACTCGTCGACTTCCCCACCCTGGTGGAGCAATCCGACTTCCTGACGCTGC
ACGCAACGCCGAGCCCGGATAACCATCACATCCTGAACGCTGCCGCGTTCGCGAAGATGAAACCGTCAGCTATCGTCGTG
AACACCGGGCGCGGATCGCTGATCGACTACACGGCCCTGCGAGCAGCGCTGGCCAATGGCCAAATCGCGGGTGCGGCTCT
CGACGTGTTCGACCAGGAGCCGCCGAAGACCGACGATCCGCTGTTTTCGCTACCCAACGTCTTGTGCACGCCGCACGTCG
CCGCCTGGACGACTGAAGGAACTCAGGCCATCGGCTGGCATGCGGCCAAGAACCTGTGGGCGATGATGAGTGGCGAAGGA
CATGCCGATATCGTCAACCCGCAAGCCAGGCAGCGCAGGAGTGCGGCCTTGCTCGGCGACGTGTGA

Upstream 100 bases:

>100_bases
TGGCGAGCTTGCTGGACTGACGGCGCCTCGAAGCGGATTGAAATCGGCAAGAACTGTTCCGTCGGGACAATCGAAGGTAT
TCGAGGAGATCGCCACTATC

Downstream 100 bases:

>100_bases
TTCCACGAGGCTTCATGAATGCCCAACACCCCTCCTGGCTTCAGGTTCGGACTGGTGGGCGAGGGGGACCTCAGGGAAGA
AACTGTAAACAGGCCGAAGA

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MSAQGLPSVLAFERYDPTDASLDWLRERGVNVIFGNALWEMPFKRFTEDELIAKAHGCIALMGASGTRITRRVMQALPDL
RYISKYGIGVDSIDIDAATEHGILVSSTPNDFQIFTVSEHAVALMLAVAKQLGTWTPEFMRRGGWRGLTHGATLRGATVG
IVGLGRIGRGVAQRLSGWEARILAYDPFLKEAPPGIELVDFPTLVEQSDFLTLHATPSPDNHHILNAAAFAKMKPSAIVV
NTGRGSLIDYTALRAALANGQIAGAALDVFDQEPPKTDDPLFSLPNVLCTPHVAAWTTEGTQAIGWHAAKNLWAMMSGEG
HADIVNPQARQRRSAALLGDV

Sequences:

>Translated_341_residues
MSAQGLPSVLAFERYDPTDASLDWLRERGVNVIFGNALWEMPFKRFTEDELIAKAHGCIALMGASGTRITRRVMQALPDL
RYISKYGIGVDSIDIDAATEHGILVSSTPNDFQIFTVSEHAVALMLAVAKQLGTWTPEFMRRGGWRGLTHGATLRGATVG
IVGLGRIGRGVAQRLSGWEARILAYDPFLKEAPPGIELVDFPTLVEQSDFLTLHATPSPDNHHILNAAAFAKMKPSAIVV
NTGRGSLIDYTALRAALANGQIAGAALDVFDQEPPKTDDPLFSLPNVLCTPHVAAWTTEGTQAIGWHAAKNLWAMMSGEG
HADIVNPQARQRRSAALLGDV
>Mature_340_residues
SAQGLPSVLAFERYDPTDASLDWLRERGVNVIFGNALWEMPFKRFTEDELIAKAHGCIALMGASGTRITRRVMQALPDLR
YISKYGIGVDSIDIDAATEHGILVSSTPNDFQIFTVSEHAVALMLAVAKQLGTWTPEFMRRGGWRGLTHGATLRGATVGI
VGLGRIGRGVAQRLSGWEARILAYDPFLKEAPPGIELVDFPTLVEQSDFLTLHATPSPDNHHILNAAAFAKMKPSAIVVN
TGRGSLIDYTALRAALANGQIAGAALDVFDQEPPKTDDPLFSLPNVLCTPHVAAWTTEGTQAIGWHAAKNLWAMMSGEGH
ADIVNPQARQRRSAALLGDV

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=333, Percent_Identity=34.5345345345345, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI6912396, Length=277, Percent_Identity=34.2960288808664, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI4557497, Length=265, Percent_Identity=34.7169811320755, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI61743967, Length=265, Percent_Identity=34.7169811320755, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI145580578, Length=263, Percent_Identity=33.0798479087452, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4557499, Length=263, Percent_Identity=33.0798479087452, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI145580575, Length=266, Percent_Identity=32.7067669172932, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI87082289, Length=287, Percent_Identity=36.2369337979094, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1787645, Length=335, Percent_Identity=33.4328358208955, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1789279, Length=258, Percent_Identity=31.7829457364341, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87081824, Length=231, Percent_Identity=29.8701298701299, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788660, Length=245, Percent_Identity=27.7551020408163, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=301, Percent_Identity=29.2358803986711, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI25147481, Length=307, Percent_Identity=28.9902280130293, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320925, Length=306, Percent_Identity=32.3529411764706, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322116, Length=306, Percent_Identity=31.3725490196078, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6324055, Length=280, Percent_Identity=30.3571428571429, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=239, Percent_Identity=25.1046025104602, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19921140, Length=326, Percent_Identity=32.5153374233129, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24646446, Length=266, Percent_Identity=34.2105263157895, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24646448, Length=266, Percent_Identity=34.2105263157895, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24646452, Length=266, Percent_Identity=34.2105263157895, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24646450, Length=266, Percent_Identity=34.2105263157895, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI62472511, Length=267, Percent_Identity=34.0823970037453, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI28571528, Length=279, Percent_Identity=32.9749103942652, Blast_Score=130, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24585516, Length=307, Percent_Identity=29.9674267100977, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28574286, Length=285, Percent_Identity=29.4736842105263, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45552429, Length=251, Percent_Identity=30.6772908366534, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI45551003, Length=251, Percent_Identity=30.6772908366534, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI28574284, Length=251, Percent_Identity=30.6772908366534, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24585514, Length=280, Percent_Identity=29.2857142857143, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI28574282, Length=280, Percent_Identity=29.2857142857143, Blast_Score=117, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36857; Mature: 36725

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQGLPSVLAFERYDPTDASLDWLRERGVNVIFGNALWEMPFKRFTEDELIAKAHGCIA
CCCCCCCHHHEECCCCCCCCHHHHHHHCCCEEEECCHHHHCHHHHCCHHHHHHHHCCEEE
LMGASGTRITRRVMQALPDLRYISKYGIGVDSIDIDAATEHGILVSSTPNDFQIFTVSEH
EECCCCHHHHHHHHHHCCCHHHHHHHCCCCCCEECCCCCCCCEEEECCCCCEEEEEECHH
AVALMLAVAKQLGTWTPEFMRRGGWRGLTHGATLRGATVGIVGLGRIGRGVAQRLSGWEA
HHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCEECCCEEEEEEHHHHHHHHHHHHCCCCE
RILAYDPFLKEAPPGIELVDFPTLVEQSDFLTLHATPSPDNHHILNAAAFAKMKPSAIVV
EEEEECCHHHHCCCCCEEECCHHHHCCCCEEEEEECCCCCCCEEEEHHHHHHCCCCEEEE
NTGRGSLIDYTALRAALANGQIAGAALDVFDQEPPKTDDPLFSLPNVLCTPHVAAWTTEG
ECCCCCCHHHHHHHHHHHCCCCCHHEEEHHCCCCCCCCCCHHHCCCHHHCCCCEEEECCC
TQAIGWHAAKNLWAMMSGEGHADIVNPQARQRRSAALLGDV
CCHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAQGLPSVLAFERYDPTDASLDWLRERGVNVIFGNALWEMPFKRFTEDELIAKAHGCIA
CCCCCCHHHEECCCCCCCCHHHHHHHCCCEEEECCHHHHCHHHHCCHHHHHHHHCCEEE
LMGASGTRITRRVMQALPDLRYISKYGIGVDSIDIDAATEHGILVSSTPNDFQIFTVSEH
EECCCCHHHHHHHHHHCCCHHHHHHHCCCCCCEECCCCCCCCEEEECCCCCEEEEEECHH
AVALMLAVAKQLGTWTPEFMRRGGWRGLTHGATLRGATVGIVGLGRIGRGVAQRLSGWEA
HHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCEECCCEEEEEEHHHHHHHHHHHHCCCCE
RILAYDPFLKEAPPGIELVDFPTLVEQSDFLTLHATPSPDNHHILNAAAFAKMKPSAIVV
EEEEECCHHHHCCCCCEEECCHHHHCCCCEEEEEECCCCCCCEEEEHHHHHHCCCCEEEE
NTGRGSLIDYTALRAALANGQIAGAALDVFDQEPPKTDDPLFSLPNVLCTPHVAAWTTEG
ECCCCCCHHHHHHHHHHHCCCCCHHEEEHHCCCCCCCCCCHHHCCCHHHCCCCEEEECCC
TQAIGWHAAKNLWAMMSGEGHADIVNPQARQRRSAALLGDV
CCHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]