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The map label for this gene is emrK [H]

Identifier: 13471111

GI number: 13471111

Start: 821863

End: 823116

Strand: Reverse

Name: emrK [H]

Synonym: mll0995

Alternate gene names: 13471111

Gene position: 823116-821863 (Counterclockwise)

Preceding gene: 13471112

Following gene: 13471110

Centisome position: 11.7

GC content: 63.8

Gene sequence:

>1254_bases
ATGACGAAGCATCTTCTCGACCCTGAAGCCATCTCCAGCGCTGCGGCGAGCGGCGAGCTCCGATCGCCAGTGTCGGCCCC
TTTGCCGCTTCTGACGCCGGTGACCTCGAATGAAATCGTACCGGTACCGCCGACCGGGCGCCGGAACTTCAAGCGTGTCC
TTGCCGCAGTCGTGGTTCTGGCGGGCACCGCCGCGGCCGCCTACTACGGGCATGATTACTGGACGACAGGTCGATATCTG
GAATCGACCGATGACGCCTATGTGAAGGCTGATTCGACGACAATTGCACCAAAGGTCTCGGGTTACATCGCCGAGGTGTT
GGTCCGCGACAACCAGAAGGTTACGGTGGGGCAGGTCCTGGCGCGCATCGACGACCGCGACTTCCGCGCCGCGCTCGATC
AGGCCCAAGCCGACATGCGGGCCGCCGAGGCGACCGTCCGAAATCTCGACGCTCAGATCGTGCTGCAGCGGGCGCTGATT
GAGCAGGCGAGGGCAACAGTCGCTGCAACTCAGGCCTCGCTGAGGTTCGCCGCGGTTGACGCCGACCGTTACGCCACGCT
GGCCAAGAGTGGCACTGGAACAACGCAGAAGGCCGAGGCCAGCCGCGCCGGGGCAGACCAGCTAGCAGCAGGGCTGGCGC
GCGACCAAGCTGCGGTCGTTGCGGCTGAGGTCAGGATCGATGTTCTCGCTACCGAACGCGACAAGGCGCTTGCTCAGGTG
GACCGTGCGCAGGCCGCCGGCGAGCAGGCTAGGCTCAATCTCTCCTATGCAACTATCACTGCGCCGGTCGACGGTACAGT
CGGCGCGCGTACGCTGAGGATTGGCCAATATGTCGGAGCCGGCACTCAGCTGATGGCGGTGGTGCCGCAGAATGCCGTTT
ATGTGGTTGCCAATTTCAAGGAGACACAGCTCACTTATGTTCGCGGCGGTCAGCCGGTGCGTGTTGCCATCGACGGCTTT
CCTGGCGTCGAGCTTGAGGGCCACGTCGACAGCTTGTCCCCGGCAAGCGGTCTCGAATTCGCACTCCTGCCGCCCGACAA
TGCGACCGGCAATTTTACCAAGATCGTGCAGCGCATCCCCGTGAAGATAATGATCGAGGACCAGGAGCTCGGTGGCCTGC
TAAGGGCCGGCATGTCGGTCGAACCGACCATCGACACCAAGGCAACGGTGCTTGCCGCGGATGGCCTGTCCGCACGGCCC
GCCACGCTATCCATCAATTGGAACACCGAGGCCGCGACGAAGCGCGCCGAGTAG

Upstream 100 bases:

>100_bases
TGAGCTTCACGACATGCGGCCCAGGGTCTGCCTGCGGAGGCTGTGCAGCGATGGGCGACACCGAGTGCGTATCGAAAAAC
TTGCAAAGCGAGCGTCGGCA

Downstream 100 bases:

>100_bases
GCATTAGCAGCCATGACAAGCATCGCGTCATCCATGCCGGCTCCGGCTCGACCTGCCCGGAACGAGACCGGAAGTGCTGG
CACTGCCGCTTCACCGCGCG

Product: secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTKHLLDPEAISSAAASGELRSPVSAPLPLLTPVTSNEIVPVPPTGRRNFKRVLAAVVVLAGTAAAAYYGHDYWTTGRYL
ESTDDAYVKADSTTIAPKVSGYIAEVLVRDNQKVTVGQVLARIDDRDFRAALDQAQADMRAAEATVRNLDAQIVLQRALI
EQARATVAATQASLRFAAVDADRYATLAKSGTGTTQKAEASRAGADQLAAGLARDQAAVVAAEVRIDVLATERDKALAQV
DRAQAAGEQARLNLSYATITAPVDGTVGARTLRIGQYVGAGTQLMAVVPQNAVYVVANFKETQLTYVRGGQPVRVAIDGF
PGVELEGHVDSLSPASGLEFALLPPDNATGNFTKIVQRIPVKIMIEDQELGGLLRAGMSVEPTIDTKATVLAADGLSARP
ATLSINWNTEAATKRAE

Sequences:

>Translated_417_residues
MTKHLLDPEAISSAAASGELRSPVSAPLPLLTPVTSNEIVPVPPTGRRNFKRVLAAVVVLAGTAAAAYYGHDYWTTGRYL
ESTDDAYVKADSTTIAPKVSGYIAEVLVRDNQKVTVGQVLARIDDRDFRAALDQAQADMRAAEATVRNLDAQIVLQRALI
EQARATVAATQASLRFAAVDADRYATLAKSGTGTTQKAEASRAGADQLAAGLARDQAAVVAAEVRIDVLATERDKALAQV
DRAQAAGEQARLNLSYATITAPVDGTVGARTLRIGQYVGAGTQLMAVVPQNAVYVVANFKETQLTYVRGGQPVRVAIDGF
PGVELEGHVDSLSPASGLEFALLPPDNATGNFTKIVQRIPVKIMIEDQELGGLLRAGMSVEPTIDTKATVLAADGLSARP
ATLSINWNTEAATKRAE
>Mature_416_residues
TKHLLDPEAISSAAASGELRSPVSAPLPLLTPVTSNEIVPVPPTGRRNFKRVLAAVVVLAGTAAAAYYGHDYWTTGRYLE
STDDAYVKADSTTIAPKVSGYIAEVLVRDNQKVTVGQVLARIDDRDFRAALDQAQADMRAAEATVRNLDAQIVLQRALIE
QARATVAATQASLRFAAVDADRYATLAKSGTGTTQKAEASRAGADQLAAGLARDQAAVVAAEVRIDVLATERDKALAQVD
RAQAAGEQARLNLSYATITAPVDGTVGARTLRIGQYVGAGTQLMAVVPQNAVYVVANFKETQLTYVRGGQPVRVAIDGFP
GVELEGHVDSLSPASGLEFALLPPDNATGNFTKIVQRIPVKIMIEDQELGGLLRAGMSVEPTIDTKATVLAADGLSARPA
TLSINWNTEAATKRAE

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=345, Percent_Identity=34.2028985507246, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI1789041, Length=359, Percent_Identity=31.7548746518106, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790519, Length=314, Percent_Identity=33.7579617834395, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI87081951, Length=325, Percent_Identity=27.6923076923077, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789637, Length=334, Percent_Identity=29.0419161676647, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790024, Length=288, Percent_Identity=23.9583333333333, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790012, Length=286, Percent_Identity=25.5244755244755, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43969; Mature: 43838

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHLLDPEAISSAAASGELRSPVSAPLPLLTPVTSNEIVPVPPTGRRNFKRVLAAVVVL
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCEEECCCCCCHHHHHHHHHHHHH
AGTAAAAYYGHDYWTTGRYLESTDDAYVKADSTTIAPKVSGYIAEVLVRDNQKVTVGQVL
HCCHHHHHCCCCEECCCCEECCCCCCEEEECCCEECCHHHHHHEEHHCCCCCEEEHHHHH
ARIDDRDFRAALDQAQADMRAAEATVRNLDAQIVLQRALIEQARATVAATQASLRFAAVD
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEC
ADRYATLAKSGTGTTQKAEASRAGADQLAAGLARDQAAVVAAEVRIDVLATERDKALAQV
CHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHCCCCEEEEEEEEEEEEECCHHHHHHHH
DRAQAAGEQARLNLSYATITAPVDGTVGARTLRIGQYVGAGTQLMAVVPQNAVYVVANFK
HHHHHCCCHHEEEEEEEEEEECCCCCCCCEEEEECHHCCCCCEEEEEECCCEEEEEEECC
ETQLTYVRGGQPVRVAIDGFPGVELEGHVDSLSPASGLEFALLPPDNATGNFTKIVQRIP
CEEEEEEECCCEEEEEECCCCCCEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCC
VKIMIEDQELGGLLRAGMSVEPTIDTKATVLAADGLSARPATLSINWNTEAATKRAE
EEEEEECHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCHHCCCCCC
>Mature Secondary Structure 
TKHLLDPEAISSAAASGELRSPVSAPLPLLTPVTSNEIVPVPPTGRRNFKRVLAAVVVL
CCCCCCHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCEEECCCCCCHHHHHHHHHHHHH
AGTAAAAYYGHDYWTTGRYLESTDDAYVKADSTTIAPKVSGYIAEVLVRDNQKVTVGQVL
HCCHHHHHCCCCEECCCCEECCCCCCEEEECCCEECCHHHHHHEEHHCCCCCEEEHHHHH
ARIDDRDFRAALDQAQADMRAAEATVRNLDAQIVLQRALIEQARATVAATQASLRFAAVD
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEC
ADRYATLAKSGTGTTQKAEASRAGADQLAAGLARDQAAVVAAEVRIDVLATERDKALAQV
CHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHCCCCEEEEEEEEEEEEECCHHHHHHHH
DRAQAAGEQARLNLSYATITAPVDGTVGARTLRIGQYVGAGTQLMAVVPQNAVYVVANFK
HHHHHCCCHHEEEEEEEEEEECCCCCCCCEEEEECHHCCCCCEEEEEECCCEEEEEEECC
ETQLTYVRGGQPVRVAIDGFPGVELEGHVDSLSPASGLEFALLPPDNATGNFTKIVQRIP
CEEEEEEECCCEEEEEECCCCCCEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCC
VKIMIEDQELGGLLRAGMSVEPTIDTKATVLAADGLSARPATLSINWNTEAATKRAE
EEEEEECHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]