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The map label for this gene is glmU

Identifier: 13470986

GI number: 13470986

Start: 665678

End: 667054

Strand: Reverse

Name: glmU

Synonym: mll0836

Alternate gene names: 13470986

Gene position: 667054-665678 (Counterclockwise)

Preceding gene: 13470987

Following gene: 13470983

Centisome position: 9.48

GC content: 63.47

Gene sequence:

>1377_bases
ATGAGCCAGAGATCCTGCCTGTCCGTCATTCTCGCCGCCGGCGAAGGCACGCGCATGAAGAGCGCGCTGCCGAAGGTGTT
GCACCAGATCGCAGGCCTGCCGATGGTCGCCCATGTGGTGAAGGCGGCCGACGCCGCCGGTGCCAGCAGCGATGCGATCG
TCATCGGCCATGGCGCGGAAGAGATGCGCAAGGCGGTGACGAAGTTCTCGCCCAAGGCCGAAACCTTCGTGCAGGAAGAA
CGCCTGGGTACGGCGCATGCTGTTCTTGCCGCCCGCGAAGCGATATCAAGGGGTTATGACGACATCCTGGTGATGTTCGG
CGACACGCCGCTGATCGATGCGGAAGCGCTGAACTTGGCGCGGCTGAAGCTCGCCGAAGGTGCGGCCGTCGCGGTGATTG
GCTTCCGTCCGCCTCTTCCAAACGGCTATGGCCGGCTGGTCGAAAAAGGCGGCAAGCTGATCGCCATCCGCGAGGAAAAG
GATTGTTCCGAGGCGGAGAAGAAGATTGGCTTCTGCAATGCCGGCATGATGGCGGTGGCCGGTGCCCACGCGCTGAAGCT
GCTCGACGCGGTCGGCAACAAGAATGCCAAGGGCGAATATTATCTGACCGACATCGTCGAGATCGCAGGTGCGCAAGGCC
TTGATGTCGTCGCCACCGAGGCCAGTTTCGAGAATGCGCTCGGCATCAACAACCGCGCCGAACTGGCCCAGGCCGAAGGC
ATCTGGCAGGCACGTCGCCGCCAAGAGGCGATGCTGTCGGGCGTGACGCTGATCGCGCCGGAGACCGTGTATTTCTCGCA
CGACACCGAGATCGGCGCCGACACCGTCGTCGAGCCCAATGTCTGGTTCGGCCCGGGCGTGAAGATCGCCGGCGGCGCCA
AGATCCATGCCTTCAGCCATATTGAAGGCGCGACCATTGCCGCGAACTGCGATGTCGGGCCGTTCGCGCGCTTGCGGCCG
GGTGCCGATCTTCGGAACAAGGCAAAGGTCGGCAATTTCTGCGAGGTCAAGCAGGCTGTTATCGAGGAAGGCGCCAAGGT
CAACCATTTGACCTATATCGGCGATGCCCGCGTCGGCGCGGGCGCCAATATCGGCGCCGGCACCATCACCTGCAATTATG
ATGGCTTTTCGAAATTCTTTACCGATATCGGCGAGGGCGCCTTTGTCGGCTCGAACTCCTCGCTGGTGGCGCCCGTATCG
ATCGGCAAGGGCGGCTACATCGCTTCCGGCAGCGTGATCACCGAAAGCGTGCCCGACGATGCGCTGGCCTTCGGCCGCGC
CCGCCAGAAGACGATCCCCGGCAAGGGCAAGGAATTGCGCGAGCGTTTCGCTTCGGCTGCGGCGGCGAAGAAGAAGGCGG
CCGGCGCCGATCACTAG

Upstream 100 bases:

>100_bases
CTTGCTCGACTATCTCACCGGAATTTAACCGCATTGGTGCAGCATGGCGCCACTGCTATCTTGTCTTGATTCCCAATCCT
TTTCCTATGGTTGTTCGCCT

Downstream 100 bases:

>100_bases
CGGTCAGTTGGCCGGCGCCGTATCTCGACCGAAAGTGGCGGTCACCTCGATCTTGCCGACGATGGCTTTGTTGAAATCAT
CGAGGTCTTCGGCAGGGATC

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSQRSCLSVILAAGEGTRMKSALPKVLHQIAGLPMVAHVVKAADAAGASSDAIVIGHGAEEMRKAVTKFSPKAETFVQEE
RLGTAHAVLAAREAISRGYDDILVMFGDTPLIDAEALNLARLKLAEGAAVAVIGFRPPLPNGYGRLVEKGGKLIAIREEK
DCSEAEKKIGFCNAGMMAVAGAHALKLLDAVGNKNAKGEYYLTDIVEIAGAQGLDVVATEASFENALGINNRAELAQAEG
IWQARRRQEAMLSGVTLIAPETVYFSHDTEIGADTVVEPNVWFGPGVKIAGGAKIHAFSHIEGATIAANCDVGPFARLRP
GADLRNKAKVGNFCEVKQAVIEEGAKVNHLTYIGDARVGAGANIGAGTITCNYDGFSKFFTDIGEGAFVGSNSSLVAPVS
IGKGGYIASGSVITESVPDDALAFGRARQKTIPGKGKELRERFASAAAAKKKAAGADH

Sequences:

>Translated_458_residues
MSQRSCLSVILAAGEGTRMKSALPKVLHQIAGLPMVAHVVKAADAAGASSDAIVIGHGAEEMRKAVTKFSPKAETFVQEE
RLGTAHAVLAAREAISRGYDDILVMFGDTPLIDAEALNLARLKLAEGAAVAVIGFRPPLPNGYGRLVEKGGKLIAIREEK
DCSEAEKKIGFCNAGMMAVAGAHALKLLDAVGNKNAKGEYYLTDIVEIAGAQGLDVVATEASFENALGINNRAELAQAEG
IWQARRRQEAMLSGVTLIAPETVYFSHDTEIGADTVVEPNVWFGPGVKIAGGAKIHAFSHIEGATIAANCDVGPFARLRP
GADLRNKAKVGNFCEVKQAVIEEGAKVNHLTYIGDARVGAGANIGAGTITCNYDGFSKFFTDIGEGAFVGSNSSLVAPVS
IGKGGYIASGSVITESVPDDALAFGRARQKTIPGKGKELRERFASAAAAKKKAAGADH
>Mature_457_residues
SQRSCLSVILAAGEGTRMKSALPKVLHQIAGLPMVAHVVKAADAAGASSDAIVIGHGAEEMRKAVTKFSPKAETFVQEER
LGTAHAVLAAREAISRGYDDILVMFGDTPLIDAEALNLARLKLAEGAAVAVIGFRPPLPNGYGRLVEKGGKLIAIREEKD
CSEAEKKIGFCNAGMMAVAGAHALKLLDAVGNKNAKGEYYLTDIVEIAGAQGLDVVATEASFENALGINNRAELAQAEGI
WQARRRQEAMLSGVTLIAPETVYFSHDTEIGADTVVEPNVWFGPGVKIAGGAKIHAFSHIEGATIAANCDVGPFARLRPG
ADLRNKAKVGNFCEVKQAVIEEGAKVNHLTYIGDARVGAGANIGAGTITCNYDGFSKFFTDIGEGAFVGSNSSLVAPVSI
GKGGYIASGSVITESVPDDALAFGRARQKTIPGKGKELRERFASAAAAKKKAAGADH

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=452, Percent_Identity=40.4867256637168, Blast_Score=329, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_RHILO (Q98LX2)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102555.1
- ProteinModelPortal:   Q98LX2
- SMR:   Q98LX2
- GeneID:   1225218
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll0836
- NMPDR:   fig|266835.1.peg.660
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   PRK14353
- BRENDA:   2.3.1.157
- BRENDA:   2.7.7.23
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 47737; Mature: 47606

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 349-349 BINDING 78-78 BINDING 144-144 BINDING 158-158 BINDING 173-173 BINDING 373-373 BINDING 391-391 BINDING 426-426

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRSCLSVILAAGEGTRMKSALPKVLHQIAGLPMVAHVVKAADAAGASSDAIVIGHGAE
CCCHHHHHHHEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECCHH
EMRKAVTKFSPKAETFVQEERLGTAHAVLAAREAISRGYDDILVMFGDTPLIDAEALNLA
HHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHH
RLKLAEGAAVAVIGFRPPLPNGYGRLVEKGGKLIAIREEKDCSEAEKKIGFCNAGMMAVA
HEEECCCCEEEEEECCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCCHHHHH
GAHALKLLDAVGNKNAKGEYYLTDIVEIAGAQGLDVVATEASFENALGINNRAELAQAEG
HHHHHHHHHHHCCCCCCCCEEHHHHHHHCCCCCCEEEEECCCHHHHCCCCCHHHHHHHHH
IWQARRRQEAMLSGVTLIAPETVYFSHDTEIGADTVVEPNVWFGPGVKIAGGAKIHAFSH
HHHHHHHHHHHHCCEEEEECCEEEEECCCCCCCCCEECCCCEECCCEEEECCCEEEEEEC
IEGATIAANCDVGPFARLRPGADLRNKAKVGNFCEVKQAVIEEGAKVNHLTYIGDARVGA
CCCCEEEECCCCCCCHHCCCCCCCCCHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCC
GANIGAGTITCNYDGFSKFFTDIGEGAFVGSNSSLVAPVSIGKGGYIASGSVITESVPDD
CCCCCCCEEEECCCCHHHHHHHCCCCEEECCCCCEEEEEEECCCCEEECCCEEECCCCCH
ALAFGRARQKTIPGKGKELRERFASAAAAKKKAAGADH
HHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SQRSCLSVILAAGEGTRMKSALPKVLHQIAGLPMVAHVVKAADAAGASSDAIVIGHGAE
CCHHHHHHHEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECCHH
EMRKAVTKFSPKAETFVQEERLGTAHAVLAAREAISRGYDDILVMFGDTPLIDAEALNLA
HHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHH
RLKLAEGAAVAVIGFRPPLPNGYGRLVEKGGKLIAIREEKDCSEAEKKIGFCNAGMMAVA
HEEECCCCEEEEEECCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCCHHHHH
GAHALKLLDAVGNKNAKGEYYLTDIVEIAGAQGLDVVATEASFENALGINNRAELAQAEG
HHHHHHHHHHHCCCCCCCCEEHHHHHHHCCCCCCEEEEECCCHHHHCCCCCHHHHHHHHH
IWQARRRQEAMLSGVTLIAPETVYFSHDTEIGADTVVEPNVWFGPGVKIAGGAKIHAFSH
HHHHHHHHHHHHCCEEEEECCEEEEECCCCCCCCCEECCCCEECCCEEEECCCEEEEEEC
IEGATIAANCDVGPFARLRPGADLRNKAKVGNFCEVKQAVIEEGAKVNHLTYIGDARVGA
CCCCEEEECCCCCCCHHCCCCCCCCCHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCC
GANIGAGTITCNYDGFSKFFTDIGEGAFVGSNSSLVAPVSIGKGGYIASGSVITESVPDD
CCCCCCCEEEECCCCHHHHHHHCCCCEEECCCCCEEEEEEECCCCEEECCCEEECCCCCH
ALAFGRARQKTIPGKGKELRERFASAAAAKKKAAGADH
HHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968