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The map label for this gene is livH [H]

Identifier: 13470930

GI number: 13470930

Start: 596840

End: 597793

Strand: Reverse

Name: livH [H]

Synonym: mll0760

Alternate gene names: 13470930

Gene position: 597793-596840 (Counterclockwise)

Preceding gene: 13470931

Following gene: 13470929

Centisome position: 8.5

GC content: 65.09

Gene sequence:

>954_bases
GTGAAGGACGCCGCGACGGCTGCGATCGCCAACATCAACTCGACGCTGGCCTTCTGGGACGCCGGACAAAACATCTGGTA
CGGCATTTCGCTGGGCTCGGTGCTGCTGCTCGCGGCGATCGGGCTTGCCATCACCTTCGGCGTCATGGGCGTCATCAACA
TGGCGCATGGCGAGATGGTGATGCTCGGCGCCTACACGACCTTCGTCGTCCAGCAGGTGATCCGCACATCCTTTCCCGGC
CTGTTCGACTGGTCGCTGGTCATCGCGCTGCCGCTTGCCTTTCTGGTCGCCGCCCTCGTCGGTCTCGCCATCGAACGCGG
CGTCATCCGCTTCCTCTATGGCCGGCCGCTGGAGACGCTGCTGGCGACCTGGGGCGTGTCGCTGATCCTGCAGCAGGCTG
TGCGCTCGATCTTCGGGCCGACCAACCAGGAGGTCGGCAACCCCTCCTGGATGTCGGGGTCGTTCGATATCGGCCAGCTG
GCCATCACCTGGAACCGGCTCTGGATCCTGGTGTTCGCGCTCACCGTCTTCGGCGTGCTGCTCTACGTGATGAAGCGCAC
GCCCTGGGGCCTGCAGATGCGCGCCGTCACCGCCAACCGCCGCATGGCCGCCTCCATGGGCATCAGGACACCGTGGGTCG
ATGCGCTGACCTTCGCGTTGGGATCCGGCATTGCCGGTATCGCCGGCGTCGCGCTCAGCCAGATCGACAATGTCTCGCCC
AATCTCGGCCGCGGCTACATCATCGACAGTTTCATGGTCGTCGTCTTCGGCGGCGTCGGCAATCTCTGGGGCACGCTGGT
CGGCGCCTTTTCGCTGGGCATCGTCAACAAGTTCCTCGAGCCATATGCCGGCGCGGTGCTGGGCAAGATCGTCGTGCTGG
TGCTGATCATCCTGTTCATCCAGAAGCGCCCGCGCGGCCTGTTCGCGCTCAAGGGCAGGGCGGTGGAAGCATGA

Upstream 100 bases:

>100_bases
CGATGCAGACAAGCTCGCCGCAATCGCCCTGATCGGCTCGCGCGGCGATCGTGACGCGGTTTCACTGCTCACCTCGGTCG
AGGCCAATGCCTCGGGCGCC

Downstream 100 bases:

>100_bases
TCACGGGACGCTTCTTCGCCGCTGGCGCTGACCGCCGCATCGCGATCACGATTCTCATCCTGCTGGCTGCCGCCATTGTC
GTGCCGCTGCTCAATCTTGC

Product: ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MKDAATAAIANINSTLAFWDAGQNIWYGISLGSVLLLAAIGLAITFGVMGVINMAHGEMVMLGAYTTFVVQQVIRTSFPG
LFDWSLVIALPLAFLVAALVGLAIERGVIRFLYGRPLETLLATWGVSLILQQAVRSIFGPTNQEVGNPSWMSGSFDIGQL
AITWNRLWILVFALTVFGVLLYVMKRTPWGLQMRAVTANRRMAASMGIRTPWVDALTFALGSGIAGIAGVALSQIDNVSP
NLGRGYIIDSFMVVVFGGVGNLWGTLVGAFSLGIVNKFLEPYAGAVLGKIVVLVLIILFIQKRPRGLFALKGRAVEA

Sequences:

>Translated_317_residues
MKDAATAAIANINSTLAFWDAGQNIWYGISLGSVLLLAAIGLAITFGVMGVINMAHGEMVMLGAYTTFVVQQVIRTSFPG
LFDWSLVIALPLAFLVAALVGLAIERGVIRFLYGRPLETLLATWGVSLILQQAVRSIFGPTNQEVGNPSWMSGSFDIGQL
AITWNRLWILVFALTVFGVLLYVMKRTPWGLQMRAVTANRRMAASMGIRTPWVDALTFALGSGIAGIAGVALSQIDNVSP
NLGRGYIIDSFMVVVFGGVGNLWGTLVGAFSLGIVNKFLEPYAGAVLGKIVVLVLIILFIQKRPRGLFALKGRAVEA
>Mature_317_residues
MKDAATAAIANINSTLAFWDAGQNIWYGISLGSVLLLAAIGLAITFGVMGVINMAHGEMVMLGAYTTFVVQQVIRTSFPG
LFDWSLVIALPLAFLVAALVGLAIERGVIRFLYGRPLETLLATWGVSLILQQAVRSIFGPTNQEVGNPSWMSGSFDIGQL
AITWNRLWILVFALTVFGVLLYVMKRTPWGLQMRAVTANRRMAASMGIRTPWVDALTFALGSGIAGIAGVALSQIDNVSP
NLGRGYIIDSFMVVVFGGVGNLWGTLVGAFSLGIVNKFLEPYAGAVLGKIVVLVLIILFIQKRPRGLFALKGRAVEA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=300, Percent_Identity=30.6666666666667, Blast_Score=96, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 33993; Mature: 33993

Theoretical pI: Translated: 10.59; Mature: 10.59

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDAATAAIANINSTLAFWDAGQNIWYGISLGSVLLLAAIGLAITFGVMGVINMAHGEMV
CCCHHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
MLGAYTTFVVQQVIRTSFPGLFDWSLVIALPLAFLVAALVGLAIERGVIRFLYGRPLETL
EEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LATWGVSLILQQAVRSIFGPTNQEVGNPSWMSGSFDIGQLAITWNRLWILVFALTVFGVL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LYVMKRTPWGLQMRAVTANRRMAASMGIRTPWVDALTFALGSGIAGIAGVALSQIDNVSP
HHHHHCCCCCCEEEEECCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
NLGRGYIIDSFMVVVFGGVGNLWGTLVGAFSLGIVNKFLEPYAGAVLGKIVVLVLIILFI
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKRPRGLFALKGRAVEA
HCCCCCEEEECCCCCCC
>Mature Secondary Structure
MKDAATAAIANINSTLAFWDAGQNIWYGISLGSVLLLAAIGLAITFGVMGVINMAHGEMV
CCCHHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
MLGAYTTFVVQQVIRTSFPGLFDWSLVIALPLAFLVAALVGLAIERGVIRFLYGRPLETL
EEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LATWGVSLILQQAVRSIFGPTNQEVGNPSWMSGSFDIGQLAITWNRLWILVFALTVFGVL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LYVMKRTPWGLQMRAVTANRRMAASMGIRTPWVDALTFALGSGIAGIAGVALSQIDNVSP
HHHHHCCCCCCEEEEECCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
NLGRGYIIDSFMVVVFGGVGNLWGTLVGAFSLGIVNKFLEPYAGAVLGKIVVLVLIILFI
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKRPRGLFALKGRAVEA
HCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]