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The map label for this gene is livM [H]

Identifier: 13470929

GI number: 13470929

Start: 595608

End: 596843

Strand: Reverse

Name: livM [H]

Synonym: mll0759

Alternate gene names: 13470929

Gene position: 596843-595608 (Counterclockwise)

Preceding gene: 13470930

Following gene: 13470928

Centisome position: 8.48

GC content: 63.92

Gene sequence:

>1236_bases
ATGATCACGGGACGCTTCTTCGCCGCTGGCGCTGACCGCCGCATCGCGATCACGATTCTCATCCTGCTGGCTGCCGCCAT
TGTCGTGCCGCTGCTCAATCTTGCGGTATCGCCGACCAGCGCCTTCTACGTCCCGGCCTATATAGTGGCGCTAACCGGCA
AATATCTCTGCTATGCGCTGCTGGCGCTCGCGCTCGACCTGGTCTGGGGCTATTGCGGCATCCTTTCGCTCGGCCACGGC
GCCTTCTTCGCGCTCGGCGGCTATGCGATGGGCATGTATCTGATGCGCCAGATCGGTTCGCGCGGCGTCTACGGCAACCC
GATCCTGCCCGATTTCATGGTGTTCCTGAACTACAAGGAATTGCCGTGGTTCTGGTATGGCTTCGACCATTTCTGGTTTG
CGGCGATCATGGTTCTGGCCGTGCCCGGCCTGCTTGCCTTCGTCTTCGGCTGGTTCGCCTTCCGCAGCCGCGTCACCGGC
GTCTATCTCTCCATCATCACCCAGGCGATGACCTATGCGCTGCTGCTCGCCTTCTTCCGCAACGATATGGGTTTCGGCGG
CAATAACGGCCTGACCGATTTCAAGGATATTCTGGGCTTCAACGTGCAGGCCGACGCAACGCGTTCGGCGCTGTTCGCCG
CCAGCGCGGCGATGCTGGCGCTCGCCGTGTTCATCACCTGGGCGATCGTCGGCTCCAAATACGGCAAGCTCCTGATGGCG
GTGCGCGACGCGGAGAGCCGCACGCGCTTCCTCGGCTGGCGGGCGGAGAATGTGAAACTGTTCGCCTTCACCGTCTCGGC
CGTCATGGCCGGCATTGCCGGCGCGCTCTACGTGCCGCAGGTCGGCATCATCAATCCCGGTGAGTTCGAACCGTCCAATT
CGATCGAGGTGGTGATCTGGGCCGCCGTCGGCGGGCGCGGCACCATTGTCGGGCCGATCATCGGCGCGCTGCTGGTCAAT
GCCGGCAAATCCTGGTTCACCGGCGTGCTGCCGGAATTGTGGCTGTTCGCGCTCGGCGGCCTGTTCGTGGCCGTCACCCT
GCTCTTGCCGAAGGGCATCATCGGTATGTGGGACAGCTGGCGCGGCAATGCGAAGGCGTTGCGCGCGGCCTCCGTCGCTG
AAGAAGCCGGCACCAAGGTTGCAGTGGCGTCCGCGACCTCAAAGCCCGCTCGCTCGCCGGCGAGGAATCCAGGCGAATGG
TCCTTGTCCGACCCTGAACCGCAGGCGGCGGAGTAG

Upstream 100 bases:

>100_bases
GCGCGGTGCTGGGCAAGATCGTCGTGCTGGTGCTGATCATCCTGTTCATCCAGAAGCGCCCGCGCGGCCTGTTCGCGCTC
AAGGGCAGGGCGGTGGAAGC

Downstream 100 bases:

>100_bases
GAACCATGAGCAAGTCGAACACCATCCTCTATCTCGACGGCGTCTCGGTCTCCTTCGACGGTTTTCGCGCCATCAACAAT
TTGTCGCTGGTGCTCGACAA

Product: ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MITGRFFAAGADRRIAITILILLAAAIVVPLLNLAVSPTSAFYVPAYIVALTGKYLCYALLALALDLVWGYCGILSLGHG
AFFALGGYAMGMYLMRQIGSRGVYGNPILPDFMVFLNYKELPWFWYGFDHFWFAAIMVLAVPGLLAFVFGWFAFRSRVTG
VYLSIITQAMTYALLLAFFRNDMGFGGNNGLTDFKDILGFNVQADATRSALFAASAAMLALAVFITWAIVGSKYGKLLMA
VRDAESRTRFLGWRAENVKLFAFTVSAVMAGIAGALYVPQVGIINPGEFEPSNSIEVVIWAAVGGRGTIVGPIIGALLVN
AGKSWFTGVLPELWLFALGGLFVAVTLLLPKGIIGMWDSWRGNAKALRAASVAEEAGTKVAVASATSKPARSPARNPGEW
SLSDPEPQAAE

Sequences:

>Translated_411_residues
MITGRFFAAGADRRIAITILILLAAAIVVPLLNLAVSPTSAFYVPAYIVALTGKYLCYALLALALDLVWGYCGILSLGHG
AFFALGGYAMGMYLMRQIGSRGVYGNPILPDFMVFLNYKELPWFWYGFDHFWFAAIMVLAVPGLLAFVFGWFAFRSRVTG
VYLSIITQAMTYALLLAFFRNDMGFGGNNGLTDFKDILGFNVQADATRSALFAASAAMLALAVFITWAIVGSKYGKLLMA
VRDAESRTRFLGWRAENVKLFAFTVSAVMAGIAGALYVPQVGIINPGEFEPSNSIEVVIWAAVGGRGTIVGPIIGALLVN
AGKSWFTGVLPELWLFALGGLFVAVTLLLPKGIIGMWDSWRGNAKALRAASVAEEAGTKVAVASATSKPARSPARNPGEW
SLSDPEPQAAE
>Mature_411_residues
MITGRFFAAGADRRIAITILILLAAAIVVPLLNLAVSPTSAFYVPAYIVALTGKYLCYALLALALDLVWGYCGILSLGHG
AFFALGGYAMGMYLMRQIGSRGVYGNPILPDFMVFLNYKELPWFWYGFDHFWFAAIMVLAVPGLLAFVFGWFAFRSRVTG
VYLSIITQAMTYALLLAFFRNDMGFGGNNGLTDFKDILGFNVQADATRSALFAASAAMLALAVFITWAIVGSKYGKLLMA
VRDAESRTRFLGWRAENVKLFAFTVSAVMAGIAGALYVPQVGIINPGEFEPSNSIEVVIWAAVGGRGTIVGPIIGALLVN
AGKSWFTGVLPELWLFALGGLFVAVTLLLPKGIIGMWDSWRGNAKALRAASVAEEAGTKVAVASATSKPARSPARNPGEW
SLSDPEPQAAE

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=361, Percent_Identity=25.4847645429363, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 44121; Mature: 44121

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITGRFFAAGADRRIAITILILLAAAIVVPLLNLAVSPTSAFYVPAYIVALTGKYLCYAL
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LALALDLVWGYCGILSLGHGAFFALGGYAMGMYLMRQIGSRGVYGNPILPDFMVFLNYKE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCC
LPWFWYGFDHFWFAAIMVLAVPGLLAFVFGWFAFRSRVTGVYLSIITQAMTYALLLAFFR
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NDMGFGGNNGLTDFKDILGFNVQADATRSALFAASAAMLALAVFITWAIVGSKYGKLLMA
HCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRDAESRTRFLGWRAENVKLFAFTVSAVMAGIAGALYVPQVGIINPGEFEPSNSIEVVIW
HHHHHHHHHHHEEEECCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEE
AAVGGRGTIVGPIIGALLVNAGKSWFTGVLPELWLFALGGLFVAVTLLLPKGIIGMWDSW
EEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCC
RGNAKALRAASVAEEAGTKVAVASATSKPARSPARNPGEWSLSDPEPQAAE
CCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MITGRFFAAGADRRIAITILILLAAAIVVPLLNLAVSPTSAFYVPAYIVALTGKYLCYAL
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LALALDLVWGYCGILSLGHGAFFALGGYAMGMYLMRQIGSRGVYGNPILPDFMVFLNYKE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCC
LPWFWYGFDHFWFAAIMVLAVPGLLAFVFGWFAFRSRVTGVYLSIITQAMTYALLLAFFR
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NDMGFGGNNGLTDFKDILGFNVQADATRSALFAASAAMLALAVFITWAIVGSKYGKLLMA
HCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRDAESRTRFLGWRAENVKLFAFTVSAVMAGIAGALYVPQVGIINPGEFEPSNSIEVVIW
HHHHHHHHHHHEEEECCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEE
AAVGGRGTIVGPIIGALLVNAGKSWFTGVLPELWLFALGGLFVAVTLLLPKGIIGMWDSW
EEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCC
RGNAKALRAASVAEEAGTKVAVASATSKPARSPARNPGEWSLSDPEPQAAE
CCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]