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The map label for this gene is gltA [H]

Identifier: 13470829

GI number: 13470829

Start: 496901

End: 498202

Strand: Direct

Name: gltA [H]

Synonym: mlr0629

Alternate gene names: 13470829

Gene position: 496901-498202 (Clockwise)

Preceding gene: 13470828

Following gene: 13470844

Centisome position: 7.06

GC content: 62.29

Gene sequence:

>1302_bases
GTGGGCGGCGCGAACCAAGAGGCTACGGCAACGCTTCAATTCGCTGGCAAGACCCATGAATTCAAGGTGCGAAGCGGCTC
CGTCGGACCCGACGTCATCGACATCGCCTCGCTCTACAGCACGACCGGCGCCTTCACCTACGACCCCGGCTTCACTTCGA
CGGCAAGCTGCGAGTCCGAAATCACCTTCATCGACGGCGACGCCGGTATTCTCCTCCACCGCGGCTATCCGATCGACCAG
TTGGCCGAACACGGCGACTTCCTCGAAGTCTGCTACCTCCTGCTCTACGGCGAATTGCCGACCAAGGCGCAGAAGGACGA
TTTCGATTACCGCGTGACGCGCCACACCATGGTGCACGAGCAGATGTCGCGCTTCTTCACCGGTTTCCGCCGCGACGCGC
ACCCGATGGCGGTGATGTGCGGCGTGGTGGGCGCGCTGTCGGCCTTCTATCACGACTCCACCGACATCTCGGACCCCTAC
CAGCGCATGGTCGCCTCGATGCGTCTGATCGCCAAGATGCCGACGATCGCGGCCATGGCCTACAAGTACCACATCGGCCA
GCCCTTCATTTACCCAAAGAACGATCTCGGCTTCGCGGCAAACTTCCTGCATATGTGCTTTGCCGTGCCGTGCGAAGAGT
ACAAGATCAACCCGGTGCTGGCGCGCGCCATGGAGCGCATCTTCATCCTGCACGCAGATCACGAGCAGAACGCCTCGACC
TCGACGGTTCGCCTCGCCGGCTCGTCGGGCGCCAACCCGTTCGCCTGCATCGCCGCCGGCATCGCTTGCTTGTGGGGCCC
GGCCCATGGCGGTGCCAATGAAGCGGCGCTCAACATGCTGGGCGAGATCGGCCATGTCGATCACATCCCGGAGTTCATCG
CCCGCGCCAAGGACAAGAACGACCCGTTCCGGCTGATGGGCTTTGGCCACCGCGTCTACAAGAACTACGATCCTCGTGCG
AAAATCATGCAGAAGACGGCGCACGAGGTTCTGGGCGAACTCGGCATCAAGGACGATCCGCTGCTCGACATCGCCATGGA
ACTGGAAAAGATCGCGCTGACCGATCCCTATTTCATCGAGAAGAAGCTGTATCCGAATGTCGACTTCTATTCCGGCATCA
CGCTGAAGGCGCTGGGCTTCCCCACCACCATGTTCACCGTTCTGTTCGCGGTCGCCCGCACCGTCGGCTGGATCGCGCAG
TGGAAAGAGATGATCGAGGACCCGCGCCAGAAGATTGGCCGCCCGCGCCAGCTCTACACGGGTGCGCCGGAGCGCGACTA
CGTGCCGATCGCCAAGCGCTGA

Upstream 100 bases:

>100_bases
ATTGCGGTGATTTCGACGTGTCGCTTTGCAGAATTTGCCTTTGCCGGCATGAGGAAACAACAAGGAGTTTGCAATGACCG
AAGCTGCGAAAAAACTGGAT

Downstream 100 bases:

>100_bases
CCGAAGCTGTCTTGATCATAAAAAAGGCGCCTCTCAGGGCGCCTTTTTTATATGGCGCAGCACCACGCCCGCCGCGATCT
CGCCCGACGGCTTGTCCGTC

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MGGANQEATATLQFAGKTHEFKVRSGSVGPDVIDIASLYSTTGAFTYDPGFTSTASCESEITFIDGDAGILLHRGYPIDQ
LAEHGDFLEVCYLLLYGELPTKAQKDDFDYRVTRHTMVHEQMSRFFTGFRRDAHPMAVMCGVVGALSAFYHDSTDISDPY
QRMVASMRLIAKMPTIAAMAYKYHIGQPFIYPKNDLGFAANFLHMCFAVPCEEYKINPVLARAMERIFILHADHEQNAST
STVRLAGSSGANPFACIAAGIACLWGPAHGGANEAALNMLGEIGHVDHIPEFIARAKDKNDPFRLMGFGHRVYKNYDPRA
KIMQKTAHEVLGELGIKDDPLLDIAMELEKIALTDPYFIEKKLYPNVDFYSGITLKALGFPTTMFTVLFAVARTVGWIAQ
WKEMIEDPRQKIGRPRQLYTGAPERDYVPIAKR

Sequences:

>Translated_433_residues
MGGANQEATATLQFAGKTHEFKVRSGSVGPDVIDIASLYSTTGAFTYDPGFTSTASCESEITFIDGDAGILLHRGYPIDQ
LAEHGDFLEVCYLLLYGELPTKAQKDDFDYRVTRHTMVHEQMSRFFTGFRRDAHPMAVMCGVVGALSAFYHDSTDISDPY
QRMVASMRLIAKMPTIAAMAYKYHIGQPFIYPKNDLGFAANFLHMCFAVPCEEYKINPVLARAMERIFILHADHEQNAST
STVRLAGSSGANPFACIAAGIACLWGPAHGGANEAALNMLGEIGHVDHIPEFIARAKDKNDPFRLMGFGHRVYKNYDPRA
KIMQKTAHEVLGELGIKDDPLLDIAMELEKIALTDPYFIEKKLYPNVDFYSGITLKALGFPTTMFTVLFAVARTVGWIAQ
WKEMIEDPRQKIGRPRQLYTGAPERDYVPIAKR
>Mature_432_residues
GGANQEATATLQFAGKTHEFKVRSGSVGPDVIDIASLYSTTGAFTYDPGFTSTASCESEITFIDGDAGILLHRGYPIDQL
AEHGDFLEVCYLLLYGELPTKAQKDDFDYRVTRHTMVHEQMSRFFTGFRRDAHPMAVMCGVVGALSAFYHDSTDISDPYQ
RMVASMRLIAKMPTIAAMAYKYHIGQPFIYPKNDLGFAANFLHMCFAVPCEEYKINPVLARAMERIFILHADHEQNASTS
TVRLAGSSGANPFACIAAGIACLWGPAHGGANEAALNMLGEIGHVDHIPEFIARAKDKNDPFRLMGFGHRVYKNYDPRAK
IMQKTAHEVLGELGIKDDPLLDIAMELEKIALTDPYFIEKKLYPNVDFYSGITLKALGFPTTMFTVLFAVARTVGWIAQW
KEMIEDPRQKIGRPRQLYTGAPERDYVPIAKR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=400, Percent_Identity=25.75, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1786939, Length=428, Percent_Identity=69.8598130841121, Blast_Score=632, Evalue=0.0,
Organism=Escherichia coli, GI1786527, Length=370, Percent_Identity=30.8108108108108, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17555174, Length=421, Percent_Identity=28.2660332541568, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319850, Length=337, Percent_Identity=27.0029673590504, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324328, Length=332, Percent_Identity=28.0120481927711, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325257, Length=375, Percent_Identity=24, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640126, Length=408, Percent_Identity=28.1862745098039, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24640124, Length=408, Percent_Identity=28.1862745098039, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21356863, Length=356, Percent_Identity=28.3707865168539, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48176; Mature: 48045

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGANQEATATLQFAGKTHEFKVRSGSVGPDVIDIASLYSTTGAFTYDPGFTSTASCESE
CCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCC
ITFIDGDAGILLHRGYPIDQLAEHGDFLEVCYLLLYGELPTKAQKDDFDYRVTRHTMVHE
EEEEECCCCEEEECCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
QMSRFFTGFRRDAHPMAVMCGVVGALSAFYHDSTDISDPYQRMVASMRLIAKMPTIAAMA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHH
YKYHIGQPFIYPKNDLGFAANFLHMCFAVPCEEYKINPVLARAMERIFILHADHEQNAST
HHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHEEEEECCCCCCCCC
STVRLAGSSGANPFACIAAGIACLWGPAHGGANEAALNMLGEIGHVDHIPEFIARAKDKN
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCC
DPFRLMGFGHRVYKNYDPRAKIMQKTAHEVLGELGIKDDPLLDIAMELEKIALTDPYFIE
CCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHH
KKLYPNVDFYSGITLKALGFPTTMFTVLFAVARTVGWIAQWKEMIEDPRQKIGRPRQLYT
HHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
GAPERDYVPIAKR
CCCCCCCCCCCCC
>Mature Secondary Structure 
GGANQEATATLQFAGKTHEFKVRSGSVGPDVIDIASLYSTTGAFTYDPGFTSTASCESE
CCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCC
ITFIDGDAGILLHRGYPIDQLAEHGDFLEVCYLLLYGELPTKAQKDDFDYRVTRHTMVHE
EEEEECCCCEEEECCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
QMSRFFTGFRRDAHPMAVMCGVVGALSAFYHDSTDISDPYQRMVASMRLIAKMPTIAAMA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHH
YKYHIGQPFIYPKNDLGFAANFLHMCFAVPCEEYKINPVLARAMERIFILHADHEQNAST
HHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHEEEEECCCCCCCCC
STVRLAGSSGANPFACIAAGIACLWGPAHGGANEAALNMLGEIGHVDHIPEFIARAKDKN
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCC
DPFRLMGFGHRVYKNYDPRAKIMQKTAHEVLGELGIKDDPLLDIAMELEKIALTDPYFIE
CCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHH
KKLYPNVDFYSGITLKALGFPTTMFTVLFAVARTVGWIAQWKEMIEDPRQKIGRPRQLYT
HHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
GAPERDYVPIAKR
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8526514 [H]