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The map label for this gene is trpC

Identifier: 13470815

GI number: 13470815

Start: 480482

End: 481294

Strand: Direct

Name: trpC

Synonym: mlr0615

Alternate gene names: 13470815

Gene position: 480482-481294 (Clockwise)

Preceding gene: 13470814

Following gene: 13470816

Centisome position: 6.83

GC content: 63.35

Gene sequence:

>813_bases
GTGTCTGACATTCTGCGCAAGATCGAGGCCTACAAGCGCGACGAGATCGCCGCCGCCAAGGCACACGTGCCGCTGGCCGA
GATCAAGGCGCGGGCGAAGGACGCCGACGCACCACGCGGCTTTCTTGCAGCCCTGGAGGCAAAGCGCAGATCAGGCCGCT
TCGCCCTGATCGCCGAAATCAAGAAGGCGAGCCCCTCCAAAGGCCTGATCCGTGCCGATTTCGATCCGCCGGCACTGGCG
CAGGCCTATGAGAAAGGCGGCGCCGCCTGTCTTTCGGTATTGACCGATGCGCCGTCCTTCCAGGGCGCGCCGGAATTCCT
CACCAAGGCAAGGGCAGCCGTCGCCCTGCCCGCCCTGCGCAAGGATTTCCTGTTCGATCCCTATCAGGTCTATGAGGCGC
GCGCCTGGGGCGCGGATGCTATCCTGATCATCATGGCCAGCGTCGACGATGCGCTGGCGAGCGCATTGGAAGCGACCGCA
TTCGAACTCGGCATGGATGCGCTGATCGAGGTACATGACGAAGCCGAGACGCAACGAGCGCTAAAGCTGTCGTCGCGGCT
GATCGGCATAAACAACCGCAATCTGAGAACGTTCGAGACCAGCCTCGAAACCTCCGAGCGGCTGGCAACGATGGTGCCGG
CCGACCGCTTGCTGGTCAGTGAGAGCGGCATCTTCACACATGACGATTGCCTCAGGCTGCAGAAGAAGGACATCGGCACC
TTCCTTGTCGGCGAGAGCCTGATGCGGCAGGAGGATGTCACCGCGGCGACCCGCATTCTGCTGACGGGCAAGGCGCTGGC
CGAGGTCGTCTGA

Upstream 100 bases:

>100_bases
GACGCTCGGCGACGGCATCGCGCTCGCAGCGCAAGCCATAGACAGCGGCCGGGCGTTGCAGGTGCTCGACCGGCTGGTCG
AAATTTCGAACGGGTGAACC

Downstream 100 bases:

>100_bases
CGATGACATCAGCCCTCACCCATCTCGGCGCGCAGGGCGAGGCCAATATGGTCGATGTCGGCGACAAGGAAGAGACGACG
CGCACGGCGATCGCAGAAGG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MSDILRKIEAYKRDEIAAAKAHVPLAEIKARAKDADAPRGFLAALEAKRRSGRFALIAEIKKASPSKGLIRADFDPPALA
QAYEKGGAACLSVLTDAPSFQGAPEFLTKARAAVALPALRKDFLFDPYQVYEARAWGADAILIIMASVDDALASALEATA
FELGMDALIEVHDEAETQRALKLSSRLIGINNRNLRTFETSLETSERLATMVPADRLLVSESGIFTHDDCLRLQKKDIGT
FLVGESLMRQEDVTAATRILLTGKALAEVV

Sequences:

>Translated_270_residues
MSDILRKIEAYKRDEIAAAKAHVPLAEIKARAKDADAPRGFLAALEAKRRSGRFALIAEIKKASPSKGLIRADFDPPALA
QAYEKGGAACLSVLTDAPSFQGAPEFLTKARAAVALPALRKDFLFDPYQVYEARAWGADAILIIMASVDDALASALEATA
FELGMDALIEVHDEAETQRALKLSSRLIGINNRNLRTFETSLETSERLATMVPADRLLVSESGIFTHDDCLRLQKKDIGT
FLVGESLMRQEDVTAATRILLTGKALAEVV
>Mature_269_residues
SDILRKIEAYKRDEIAAAKAHVPLAEIKARAKDADAPRGFLAALEAKRRSGRFALIAEIKKASPSKGLIRADFDPPALAQ
AYEKGGAACLSVLTDAPSFQGAPEFLTKARAAVALPALRKDFLFDPYQVYEARAWGADAILIIMASVDDALASALEATAF
ELGMDALIEVHDEAETQRALKLSSRLIGINNRNLRTFETSLETSERLATMVPADRLLVSESGIFTHDDCLRLQKKDIGTF
LVGESLMRQEDVTAATRILLTGKALAEVV

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=264, Percent_Identity=40.530303030303, Blast_Score=167, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=221, Percent_Identity=37.10407239819, Blast_Score=146, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_RHILO (Q98ME3)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102384.1
- ProteinModelPortal:   Q98ME3
- GeneID:   1225047
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr0615
- NMPDR:   fig|266835.1.peg.489
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- ProtClustDB:   PRK00278
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 29284; Mature: 29153

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILRKIEAYKRDEIAAAKAHVPLAEIKARAKDADAPRGFLAALEAKRRSGRFALIAEI
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEH
KKASPSKGLIRADFDPPALAQAYEKGGAACLSVLTDAPSFQGAPEFLTKARAAVALPALR
HHCCCCCCEEEECCCCHHHHHHHHHCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KDFLFDPYQVYEARAWGADAILIIMASVDDALASALEATAFELGMDALIEVHDEAETQRA
HHHCCCHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
LKLSSRLIGINNRNLRTFETSLETSERLATMVPADRLLVSESGIFTHDDCLRLQKKDIGT
HHHHHHEECCCCCCCEEHHHHHHHHHHHHHHCCHHHHEEECCCCCCCHHHHHHHHHHCCH
FLVGESLMRQEDVTAATRILLTGKALAEVV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure 
SDILRKIEAYKRDEIAAAKAHVPLAEIKARAKDADAPRGFLAALEAKRRSGRFALIAEI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEH
KKASPSKGLIRADFDPPALAQAYEKGGAACLSVLTDAPSFQGAPEFLTKARAAVALPALR
HHCCCCCCEEEECCCCHHHHHHHHHCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KDFLFDPYQVYEARAWGADAILIIMASVDDALASALEATAFELGMDALIEVHDEAETQRA
HHHCCCHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
LKLSSRLIGINNRNLRTFETSLETSERLATMVPADRLLVSESGIFTHDDCLRLQKKDIGT
HHHHHHEECCCCCCCEEHHHHHHHHHHHHHHCCHHHHEEECCCCCCCHHHHHHHHHHCCH
FLVGESLMRQEDVTAATRILLTGKALAEVV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968