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The map label for this gene is pleC [H]

Identifier: 13470769

GI number: 13470769

Start: 411726

End: 413246

Strand: Direct

Name: pleC [H]

Synonym: mlr0562

Alternate gene names: 13470769

Gene position: 411726-413246 (Clockwise)

Preceding gene: 13470764

Following gene: 13470771

Centisome position: 5.85

GC content: 62.98

Gene sequence:

>1521_bases
ATGCCCTTGCAACGCTCGAACACAGCGGACAAGTTCATTGTGGACCGCAGGAAACCCCATCGCAACAGCGATGTGGCGCG
CGCGGTGCGCAAGACGCGCGACCGTCTTTCGCAGCAGGCCGGCAATCCCGATTTCGACCGCGAATTGTTGAAACTCCATG
CCGGCGCCATGACAAGCGGCGCCGTGGTGATCCCGTTGCTCGTCCTGGCGATCGCCGCTGCCGGCTGGCTCGCCGGCGTC
GGCAACGAGATCGGGCTCTGGGCGTTGTTCACGCTCACTTGCTATACGATCGTCGCCTTCATGGCGCGACGCATCGAGCG
CACGGAAGCGTCCGAGCTTAACCCCTTGCAAACGCGACGGGAATTCCTGGTAGGCCATTTCCTTTGCGGCCTCGGCTGGG
GCTGGTTCGTCGTGCTCGGCTGCGGCGCCTGCGCGGTCGACCAGTTTCCGGTGGTCAAGGCGGTGGTGCTGCTTCTTGCC
ATGGCCGGGACGGCGCTCATGGCCTCATCGCTGAGCGGCGCGCTGCTGGCGACTTTCGCCGTACCGGTGGCGCTCTATGC
CTATGTCGGTACCAGGCTGTGGATGCCGGTGGAGGCGATGATGGCCGGGCTGCTTGTCCTGTCGCTGCCTTTCTTCGTCT
ATGTCGCCCGTCAGCTCAACCGCGCCTCGCTGATGCTGTTGTCGTTCCGCTCCGAAAAGGATGCGCTGATCGCCGAGCTG
GAGACAGCGAAATCCATGTCGGACGAGGCGCGGCGGCGGGCCGAGGACGCCAATCTGGCAAAGTCGCGTTTCCTCGCTTC
GATGAGCCACGAATTGCGCACGCCACTCAACGCCATTCTCGGCTTTTCCGAGGTTATGGCGAACGAGGTGCTGGGGCCTA
TGAGCAATCCCACCTATCGCGATTATGCCCATGACGTGCATGATTCCGGCCAGCACCTGCTCGACCTGATCAACGAAATC
CTCGATCTGTCGCGCATAGAAGCCGGTCGCTACCAGCTCAACGAAGAGCCGGTGATGTTGCTCAACATCGTCGAGGATTG
CTGCCATATGATGGAGTTGAAGGCGCGCAACAAGGATATCCGCGTCGTCCAGGATTTCGAACAGACATTGCCGCGGCTGT
TCGCAGACGAGCGCGCCGTGCGCCAGATCACGCTCAACCTTCTGTCCAATGCCATAAAGTTCACCGCCACCGGCGGCGAA
ATCCGCGTCCGCGTCGGCTGGACGGCGGGCGGCGGGCAATACATCTCCGTCAAGGACAATGGTCCGGGGATTCCCGAGGA
CGAGATCCCGGTCGTGCTCTCGGCCTTCGGCCAGGGCTCGATCGCCATCAAGAGCGCCGAACAAGGCACCGGGCTCGGCC
TGCCGATCGTGCAAGGCCTGCTTGCAATGCATGGCGGCGAGTTCGAACTTCATTCCAAACTGCGTGAAGGCACGGAGGCG
ATTGCCATCTTCCCCCTGAGCCGGGTGATGGAAGAACTGCCGGCGTTGCCGACCGCGGCGGTGGCGGCGCGACGGCGGTA
A

Upstream 100 bases:

>100_bases
TCTCGGCGACCAGGAACGGCTCATATGGCAAACGGTTGGTTAATCATTCGAACGTAGCTTAACACCTTGAAATCGCTGCG
CGCATAAATTGAAGTTTTTG

Downstream 100 bases:

>100_bases
CGGACCTCGTCAGCGTCCGATGTGCCTTGCACCTAGATCCGAACCGCCGCCGCCATGCCTGAACTGGTTAGCGCCGCCGC
CTTGACCAGGCCCGCGCCAA

Product: histidine kinase sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MPLQRSNTADKFIVDRRKPHRNSDVARAVRKTRDRLSQQAGNPDFDRELLKLHAGAMTSGAVVIPLLVLAIAAAGWLAGV
GNEIGLWALFTLTCYTIVAFMARRIERTEASELNPLQTRREFLVGHFLCGLGWGWFVVLGCGACAVDQFPVVKAVVLLLA
MAGTALMASSLSGALLATFAVPVALYAYVGTRLWMPVEAMMAGLLVLSLPFFVYVARQLNRASLMLLSFRSEKDALIAEL
ETAKSMSDEARRRAEDANLAKSRFLASMSHELRTPLNAILGFSEVMANEVLGPMSNPTYRDYAHDVHDSGQHLLDLINEI
LDLSRIEAGRYQLNEEPVMLLNIVEDCCHMMELKARNKDIRVVQDFEQTLPRLFADERAVRQITLNLLSNAIKFTATGGE
IRVRVGWTAGGGQYISVKDNGPGIPEDEIPVVLSAFGQGSIAIKSAEQGTGLGLPIVQGLLAMHGGEFELHSKLREGTEA
IAIFPLSRVMEELPALPTAAVAARRR

Sequences:

>Translated_506_residues
MPLQRSNTADKFIVDRRKPHRNSDVARAVRKTRDRLSQQAGNPDFDRELLKLHAGAMTSGAVVIPLLVLAIAAAGWLAGV
GNEIGLWALFTLTCYTIVAFMARRIERTEASELNPLQTRREFLVGHFLCGLGWGWFVVLGCGACAVDQFPVVKAVVLLLA
MAGTALMASSLSGALLATFAVPVALYAYVGTRLWMPVEAMMAGLLVLSLPFFVYVARQLNRASLMLLSFRSEKDALIAEL
ETAKSMSDEARRRAEDANLAKSRFLASMSHELRTPLNAILGFSEVMANEVLGPMSNPTYRDYAHDVHDSGQHLLDLINEI
LDLSRIEAGRYQLNEEPVMLLNIVEDCCHMMELKARNKDIRVVQDFEQTLPRLFADERAVRQITLNLLSNAIKFTATGGE
IRVRVGWTAGGGQYISVKDNGPGIPEDEIPVVLSAFGQGSIAIKSAEQGTGLGLPIVQGLLAMHGGEFELHSKLREGTEA
IAIFPLSRVMEELPALPTAAVAARRR
>Mature_505_residues
PLQRSNTADKFIVDRRKPHRNSDVARAVRKTRDRLSQQAGNPDFDRELLKLHAGAMTSGAVVIPLLVLAIAAAGWLAGVG
NEIGLWALFTLTCYTIVAFMARRIERTEASELNPLQTRREFLVGHFLCGLGWGWFVVLGCGACAVDQFPVVKAVVLLLAM
AGTALMASSLSGALLATFAVPVALYAYVGTRLWMPVEAMMAGLLVLSLPFFVYVARQLNRASLMLLSFRSEKDALIAELE
TAKSMSDEARRRAEDANLAKSRFLASMSHELRTPLNAILGFSEVMANEVLGPMSNPTYRDYAHDVHDSGQHLLDLINEIL
DLSRIEAGRYQLNEEPVMLLNIVEDCCHMMELKARNKDIRVVQDFEQTLPRLFADERAVRQITLNLLSNAIKFTATGGEI
RVRVGWTAGGGQYISVKDNGPGIPEDEIPVVLSAFGQGSIAIKSAEQGTGLGLPIVQGLLAMHGGEFELHSKLREGTEAI
AIFPLSRVMEELPALPTAAVAARRR

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=247, Percent_Identity=33.6032388663968, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI87081816, Length=303, Percent_Identity=33.993399339934, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI48994928, Length=237, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788713, Length=262, Percent_Identity=33.206106870229, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=33.739837398374, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=29.6943231441048, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=28.8888888888889, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87082128, Length=210, Percent_Identity=31.9047619047619, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788549, Length=238, Percent_Identity=25.6302521008403, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790436, Length=248, Percent_Identity=25.4032258064516, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1790300, Length=270, Percent_Identity=25.1851851851852, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1786783, Length=276, Percent_Identity=25.3623188405797, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788393, Length=232, Percent_Identity=23.2758620689655, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788279, Length=210, Percent_Identity=25.2380952380952, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55375; Mature: 55244

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLQRSNTADKFIVDRRKPHRNSDVARAVRKTRDRLSQQAGNPDFDRELLKLHAGAMTSG
CCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
AVVIPLLVLAIAAAGWLAGVGNEIGLWALFTLTCYTIVAFMARRIERTEASELNPLQTRR
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EFLVGHFLCGLGWGWFVVLGCGACAVDQFPVVKAVVLLLAMAGTALMASSLSGALLATFA
HHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
VPVALYAYVGTRLWMPVEAMMAGLLVLSLPFFVYVARQLNRASLMLLSFRSEKDALIAEL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHH
ETAKSMSDEARRRAEDANLAKSRFLASMSHELRTPLNAILGFSEVMANEVLGPMSNPTYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
DYAHDVHDSGQHLLDLINEILDLSRIEAGRYQLNEEPVMLLNIVEDCCHMMELKARNKDI
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCH
RVVQDFEQTLPRLFADERAVRQITLNLLSNAIKFTATGGEIRVRVGWTAGGGQYISVKDN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEEEEECCCCEEEEEECC
GPGIPEDEIPVVLSAFGQGSIAIKSAEQGTGLGLPIVQGLLAMHGGEFELHSKLREGTEA
CCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCE
IAIFPLSRVMEELPALPTAAVAARRR
EEEHHHHHHHHHCCCCCHHHHHHCCC
>Mature Secondary Structure 
PLQRSNTADKFIVDRRKPHRNSDVARAVRKTRDRLSQQAGNPDFDRELLKLHAGAMTSG
CCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
AVVIPLLVLAIAAAGWLAGVGNEIGLWALFTLTCYTIVAFMARRIERTEASELNPLQTRR
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EFLVGHFLCGLGWGWFVVLGCGACAVDQFPVVKAVVLLLAMAGTALMASSLSGALLATFA
HHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
VPVALYAYVGTRLWMPVEAMMAGLLVLSLPFFVYVARQLNRASLMLLSFRSEKDALIAEL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHH
ETAKSMSDEARRRAEDANLAKSRFLASMSHELRTPLNAILGFSEVMANEVLGPMSNPTYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
DYAHDVHDSGQHLLDLINEILDLSRIEAGRYQLNEEPVMLLNIVEDCCHMMELKARNKDI
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCH
RVVQDFEQTLPRLFADERAVRQITLNLLSNAIKFTATGGEIRVRVGWTAGGGQYISVKDN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEEEEECCCCEEEEEECC
GPGIPEDEIPVVLSAFGQGSIAIKSAEQGTGLGLPIVQGLLAMHGGEFELHSKLREGTEA
CCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCE
IAIFPLSRVMEELPALPTAAVAARRR
EEEHHHHHHHHHCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]