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The map label for this gene is tktA

Identifier: 13358151

GI number: 13358151

Start: 733597

End: 735558

Strand: Reverse

Name: tktA

Synonym: UU586

Alternate gene names: 13358151

Gene position: 735558-733597 (Counterclockwise)

Preceding gene: 13358152

Following gene: 13358150

Centisome position: 97.85

GC content: 29.56

Gene sequence:

>1962_bases
ATGAATCGTTATGTTAACGCAATGCGTTCACTTGCTTTACAGGCTATTAATAAAGCAAAGCAAGGTCACAGTGGAATGAG
TATTTCAGCTGCACCTATTGTTTATACCCTTTATAAGGGATTAATGACTATTTCAAAATCACATCCAAAGTGATTTAATC
GCGATCGTTTGGTTTTATCAGCTGGTCATGGATCGATGGCATTATATCCTGTTTTTTATTTTTCATCATTATTAACATTA
GATGACATTAAAAATTTTCGCAATGATAATTATTTAACACCAGGTCATCCTGAAGTGTTGGCTAATAATTATATTGATGC
ATCAACAGGACCACTAGGGCAAGGGGTTGCTAATGCAGTTGGTATGGCAATTACTGAAAGTTATTTAAGAACTGAATTTG
CTACTCTTAAAGGTGTTATTGATCATTATACTTATTGTATTGTTGGCGATGGGGACCTACAAGAGGGAATTTGTTATGAG
GCAATGAGTATTGCTGGAAAATTAAAATTATCGAAATTAATTATTTTACATGATTCAAATGATTACCAATTAGATTCAGC
AGTAAGTGATGTTAATATTGAAGATTTAAAAATGCGTGTTGAATCAATGGGTTGAAATTATCTAAAAACAGATAATAATC
CTGAAAATATTTTCAAAGCAATTGCTGAAGCTAAATGAAAAAAGAATGTTAAACCAACGTTTATTGAAGTCAAAACAATC
ATTGGTGAGGGGACATCTTTTGAAAATAGTAATGAAGCGCATGCTGCAGCAATTTCTAATGATGAATTAGAAAAATTTTC
TAAGCGTTTTCATATTAAAACAAATAATTTTGAATTTCATCAGGAAATTTTTGATCACTTCTTTTTTAATGTTGTAGCTC
GGGGCGAAAGTGCTTATAATCAATGACAACAATTAGTTGACCAATATATGCAAACTAATCCAGAACAAATGCAACGTTTA
TTAAATTATATTAATGGTAATTATGAAGATTTAAATAAATTATTAGATGAAAATAAAATTACTAATTTAAATGATTCTAC
TCGCAGTTATTTAAAACAATATTTTAATCAATTAAAAGATTTAAAATCAGCTCTTGTTTTATCTGCTGATTTAGCTAAAT
CAACTTTCACAAAAATAGGCGAAGGCGCTTTTAACGATAACCATAAAAATCCATATATTAAATTCGGTATTCGTGAATTT
GCTATGGCAGGAGCGATGAATGGAATAAGTTTACATCAAGGCGTTAAAGCGATAGGAGGCACTTTTTTAGCTTTTTCTGA
TTATATGAAACCAGCAATTCGTTTAGCTGCCATTAGTAATTTAGCTAATTTATTTATTTTTAGTCACGATAGTTATGCAG
TGGGTGGTGATGGACCTACACATCAACCTGTCGATCAATTACCAATGTTAAGAGCAATTCCAAATGTAGAAGTAATTCGT
CCTGCTGATCATTATGAAGTTAAATATGCTCTTTCATATAGTTTTAAACAAAAACAAAAACCGATTTGTTTAATTACTTC
ACGTCAAACTATTAAACAAATTAATGATCAAAAACCACAAGATTTTAGTAAGGGAGCATATATTATTAATTCGCCTTTTT
CTTTTTGTAAAGATGTAGATTACACGATTATTGCTAGTGGTAGTGAAGTTAGTTTAGCAAATGACGCAGCAAAAGAACTT
TTTGAAAAACATAAACTTAAAATTAAAGTTATTTCTGCTTTTAACTTAAATTTATTTTTACGTCAAAAACCTGAAGATAT
TAAGAGCCTTTTAGCTTCAAAAAATGGTCTATTAGCAATTGAAGCATCAAGCGAAATGCTTTGATGAAAATTATCAATTT
ATACAAATAAATTTATACAAATTGCTGCTAATCAATTTGGGCGTAGTGCAGATGGTGATAAATTAATGAATGAATTTGGT
TTTAGTGTTAAAAATATTATTAATCAACTTTTAAACCAATAA

Upstream 100 bases:

>100_bases
CCGTTGGAAATGATGCAAATAAAGCAATTAACAAATTAGAAGAAATTTTAATTGAACAGAAATTAATTTAAATATCTTTA
TTTAGTGGAGACTATTAAAT

Downstream 100 bases:

>100_bases
TAAGGAATATCATGAATAAGTATAATATTTATGTAGATCACACATTATTAAAAGCTGACGCAAGTTTAGAAGAGATTCAT
AAGTTGTGTGAAGAAGCAGA

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 653; Mature: 653

Protein sequence:

>653_residues
MNRYVNAMRSLALQAINKAKQGHSGMSISAAPIVYTLYKGLMTISKSHPKWFNRDRLVLSAGHGSMALYPVFYFSSLLTL
DDIKNFRNDNYLTPGHPEVLANNYIDASTGPLGQGVANAVGMAITESYLRTEFATLKGVIDHYTYCIVGDGDLQEGICYE
AMSIAGKLKLSKLIILHDSNDYQLDSAVSDVNIEDLKMRVESMGWNYLKTDNNPENIFKAIAEAKWKKNVKPTFIEVKTI
IGEGTSFENSNEAHAAAISNDELEKFSKRFHIKTNNFEFHQEIFDHFFFNVVARGESAYNQWQQLVDQYMQTNPEQMQRL
LNYINGNYEDLNKLLDENKITNLNDSTRSYLKQYFNQLKDLKSALVLSADLAKSTFTKIGEGAFNDNHKNPYIKFGIREF
AMAGAMNGISLHQGVKAIGGTFLAFSDYMKPAIRLAAISNLANLFIFSHDSYAVGGDGPTHQPVDQLPMLRAIPNVEVIR
PADHYEVKYALSYSFKQKQKPICLITSRQTIKQINDQKPQDFSKGAYIINSPFSFCKDVDYTIIASGSEVSLANDAAKEL
FEKHKLKIKVISAFNLNLFLRQKPEDIKSLLASKNGLLAIEASSEMLWWKLSIYTNKFIQIAANQFGRSADGDKLMNEFG
FSVKNIINQLLNQ

Sequences:

>Translated_653_residues
MNRYVNAMRSLALQAINKAKQGHSGMSISAAPIVYTLYKGLMTISKSHPK*FNRDRLVLSAGHGSMALYPVFYFSSLLTL
DDIKNFRNDNYLTPGHPEVLANNYIDASTGPLGQGVANAVGMAITESYLRTEFATLKGVIDHYTYCIVGDGDLQEGICYE
AMSIAGKLKLSKLIILHDSNDYQLDSAVSDVNIEDLKMRVESMG*NYLKTDNNPENIFKAIAEAK*KKNVKPTFIEVKTI
IGEGTSFENSNEAHAAAISNDELEKFSKRFHIKTNNFEFHQEIFDHFFFNVVARGESAYNQ*QQLVDQYMQTNPEQMQRL
LNYINGNYEDLNKLLDENKITNLNDSTRSYLKQYFNQLKDLKSALVLSADLAKSTFTKIGEGAFNDNHKNPYIKFGIREF
AMAGAMNGISLHQGVKAIGGTFLAFSDYMKPAIRLAAISNLANLFIFSHDSYAVGGDGPTHQPVDQLPMLRAIPNVEVIR
PADHYEVKYALSYSFKQKQKPICLITSRQTIKQINDQKPQDFSKGAYIINSPFSFCKDVDYTIIASGSEVSLANDAAKEL
FEKHKLKIKVISAFNLNLFLRQKPEDIKSLLASKNGLLAIEASSEML**KLSIYTNKFIQIAANQFGRSADGDKLMNEFG
FSVKNIINQLLNQ
>Mature_653_residues
MNRYVNAMRSLALQAINKAKQGHSGMSISAAPIVYTLYKGLMTISKSHPK*FNRDRLVLSAGHGSMALYPVFYFSSLLTL
DDIKNFRNDNYLTPGHPEVLANNYIDASTGPLGQGVANAVGMAITESYLRTEFATLKGVIDHYTYCIVGDGDLQEGICYE
AMSIAGKLKLSKLIILHDSNDYQLDSAVSDVNIEDLKMRVESMG*NYLKTDNNPENIFKAIAEAK*KKNVKPTFIEVKTI
IGEGTSFENSNEAHAAAISNDELEKFSKRFHIKTNNFEFHQEIFDHFFFNVVARGESAYNQ*QQLVDQYMQTNPEQMQRL
LNYINGNYEDLNKLLDENKITNLNDSTRSYLKQYFNQLKDLKSALVLSADLAKSTFTKIGEGAFNDNHKNPYIKFGIREF
AMAGAMNGISLHQGVKAIGGTFLAFSDYMKPAIRLAAISNLANLFIFSHDSYAVGGDGPTHQPVDQLPMLRAIPNVEVIR
PADHYEVKYALSYSFKQKQKPICLITSRQTIKQINDQKPQDFSKGAYIINSPFSFCKDVDYTIIASGSEVSLANDAAKEL
FEKHKLKIKVISAFNLNLFLRQKPEDIKSLLASKNGLLAIEASSEML**KLSIYTNKFIQIAANQFGRSADGDKLMNEFG
FSVKNIINQLLNQ

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=651, Percent_Identity=27.3425499231951, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI4507521, Length=651, Percent_Identity=27.3425499231951, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI133778974, Length=666, Percent_Identity=23.7237237237237, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI225637461, Length=594, Percent_Identity=23.2323232323232, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI225637459, Length=594, Percent_Identity=23.2323232323232, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI225637463, Length=594, Percent_Identity=23.2323232323232, Blast_Score=110, Evalue=4e-24,
Organism=Escherichia coli, GI48994911, Length=662, Percent_Identity=34.1389728096677, Blast_Score=350, Evalue=2e-97,
Organism=Escherichia coli, GI1788808, Length=662, Percent_Identity=32.02416918429, Blast_Score=318, Evalue=7e-88,
Organism=Caenorhabditis elegans, GI17539652, Length=664, Percent_Identity=24.8493975903614, Blast_Score=142, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6325331, Length=658, Percent_Identity=34.3465045592705, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6319593, Length=662, Percent_Identity=33.987915407855, Blast_Score=340, Evalue=4e-94,
Organism=Drosophila melanogaster, GI45551847, Length=583, Percent_Identity=25.7289879931389, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI45550715, Length=583, Percent_Identity=25.7289879931389, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24666278, Length=659, Percent_Identity=23.9757207890744, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24645119, Length=543, Percent_Identity=25.9668508287293, Blast_Score=122, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72309; Mature: 72309

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRYVNAMRSLALQAINKAKQGHSGMSISAAPIVYTLYKGLMTISKSHPKFNRDRLVLSA
CCHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
GHGSMALYPVFYFSSLLTLDDIKNFRNDNYLTPGHPEVLANNYIDASTGPLGQGVANAVG
CCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHH
MAITESYLRTEFATLKGVIDHYTYCIVGDGDLQEGICYEAMSIAGKLKLSKLIILHDSND
HHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHEEEEEEEEEECCCC
YQLDSAVSDVNIEDLKMRVESMGNYLKTDNNPENIFKAIAEAKKKNVKPTFIEVKTIIGE
CCHHHHHCCCCHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEHHCC
GTSFENSNEAHAAAISNDELEKFSKRFHIKTNNFEFHQEIFDHFFFNVVARGESAYNQQQ
CCCCCCCCCCCEEECCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHCCCHHCCHHH
LVDQYMQTNPEQMQRLLNYINGNYEDLNKLLDENKITNLNDSTRSYLKQYFNQLKDLKSA
HHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LVLSADLAKSTFTKIGEGAFNDNHKNPYIKFGIREFAMAGAMNGISLHQGVKAIGGTFLA
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECHHHHHHHHCCCCCHHHHHHHHHCCHHHH
FSDYMKPAIRLAAISNLANLFIFSHDSYAVGGDGPTHQPVDQLPMLRAIPNVEVIRPADH
HHHHHHHHHHHHHHHHHHHEEEECCCCEEECCCCCCCCCHHHCCHHHHCCCCEEECCCCC
YEVKYALSYSFKQKQKPICLITSRQTIKQINDQKPQDFSKGAYIINSPFSFCKDVDYTII
CEEEEEEEECHHHCCCCEEEEECHHHHHHHCCCCCCCCCCCEEEEECCHHHHCCCCEEEE
ASGSEVSLANDAAKELFEKHKLKIKVISAFNLNLFLRQKPEDIKSLLASKNGLLAIEASS
ECCCCEEHHHHHHHHHHHHHCEEEEEEEEECEEEEEECCCHHHHHHHHCCCCEEEEECCC
EMLKLSIYTNKFIQIAANQFGRSADGDKLMNEFGFSVKNIINQLLNQ
CEEEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MNRYVNAMRSLALQAINKAKQGHSGMSISAAPIVYTLYKGLMTISKSHPKFNRDRLVLSA
CCHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
GHGSMALYPVFYFSSLLTLDDIKNFRNDNYLTPGHPEVLANNYIDASTGPLGQGVANAVG
CCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHH
MAITESYLRTEFATLKGVIDHYTYCIVGDGDLQEGICYEAMSIAGKLKLSKLIILHDSND
HHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHEEEEEEEEEECCCC
YQLDSAVSDVNIEDLKMRVESMGNYLKTDNNPENIFKAIAEAKKKNVKPTFIEVKTIIGE
CCHHHHHCCCCHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEHHCC
GTSFENSNEAHAAAISNDELEKFSKRFHIKTNNFEFHQEIFDHFFFNVVARGESAYNQQQ
CCCCCCCCCCCEEECCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHCCCHHCCHHH
LVDQYMQTNPEQMQRLLNYINGNYEDLNKLLDENKITNLNDSTRSYLKQYFNQLKDLKSA
HHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LVLSADLAKSTFTKIGEGAFNDNHKNPYIKFGIREFAMAGAMNGISLHQGVKAIGGTFLA
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECHHHHHHHHCCCCCHHHHHHHHHCCHHHH
FSDYMKPAIRLAAISNLANLFIFSHDSYAVGGDGPTHQPVDQLPMLRAIPNVEVIRPADH
HHHHHHHHHHHHHHHHHHHEEEECCCCEEECCCCCCCCCHHHCCHHHHCCCCEEECCCCC
YEVKYALSYSFKQKQKPICLITSRQTIKQINDQKPQDFSKGAYIINSPFSFCKDVDYTII
CEEEEEEEECHHHCCCCEEEEECHHHHHHHCCCCCCCCCCCEEEEECCHHHHCCCCEEEE
ASGSEVSLANDAAKELFEKHKLKIKVISAFNLNLFLRQKPEDIKSLLASKNGLLAIEASS
ECCCCEEHHHHHHHHHHHHHCEEEEEEEEECEEEEEECCCHHHHHHHHCCCCEEEEECCC
EMLKLSIYTNKFIQIAANQFGRSADGDKLMNEFGFSVKNIINQLLNQ
CEEEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633; 11271496 [H]