Click here to switch to the map view.

The map label for this gene is pyrH

Identifier: 13358077

GI number: 13358077

Start: 634834

End: 635541

Strand: Reverse

Name: pyrH

Synonym: UU513

Alternate gene names: 13358077

Gene position: 635541-634834 (Counterclockwise)

Preceding gene: 13358078

Following gene: 13358076

Centisome position: 84.55

GC content: 27.12

Gene sequence:

>708_bases
ATGCGAAAACAACGAATTGTAATTAAAATTTCTGGAGCTTGCTTAAAACAAAATGATAGTTCAATAATTGATTTTATAAA
GATTAATGATTTAGCAGAACAAATTGAAAAAATTTCTAAGAAATATATTGTATCAATTGTTTTAGGTGGTGGCAATATTT
GACGAGGTAGCATTGCCAAAGAGCTAGATATGGATCGTAATTTAGCTGATAATATGGGTATGATGGCAACTATTATAAAT
GGGTTAGCTTTAGAAAATGCTTTAAATCATTTGAATGTTAACACTATTGTTTTATCTGCAATTAAATGTGATAAATTAGT
TCATGAATCATCTGCTAATAATATAAAAAAAGCTATTGAAAAAGAACAAGTAATGATTTTTGTGGCTGGAACAGGATTTC
CATATTTTACAACTGATTCGTGTGCAGCAATTAGAGCTGCTGAAACAGAATCTAGTATAATTTTAATGGGCAAAAATGGT
GTTGATGGTGTCTATGATAGTGATCCAAAAATTAATCCTAATGCACAATTTTATGAACATATTACATTTAATATGGCCCT
TACTCAAAATTTAAAAGTTATGGATGCAACAGCTTTAGCTTTGTGTCAAGAAAATAATATAAATTTATTAGTTTTTAATA
TTGATAAACCAAATGCAATTGTTGATGTTTTAGAGAAAAAAAATAAATACACAATTGTTTCAAAATAA

Upstream 100 bases:

>100_bases
CACAAATGAAAAAATAATTTTTAAATGTAAAAATAGAAGGAAACAAAGTTTCTTTCTATTTTTATAGTGTAGTCAATAAG
GAATATGAAAGGAAATTCAT

Downstream 100 bases:

>100_bases
TTTTTTAAGGAGATTTTATGAATTTTAAAATTTATGAAACTAAAATCAGAGAAGAATTTGAATTAGTGTTAAAATGAATG
CACAATGAATTTATTAAATT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MRKQRIVIKISGACLKQNDSSIIDFIKINDLAEQIEKISKKYIVSIVLGGGNIWRGSIAKELDMDRNLADNMGMMATIIN
GLALENALNHLNVNTIVLSAIKCDKLVHESSANNIKKAIEKEQVMIFVAGTGFPYFTTDSCAAIRAAETESSIILMGKNG
VDGVYDSDPKINPNAQFYEHITFNMALTQNLKVMDATALALCQENNINLLVFNIDKPNAIVDVLEKKNKYTIVSK

Sequences:

>Translated_235_residues
MRKQRIVIKISGACLKQNDSSIIDFIKINDLAEQIEKISKKYIVSIVLGGGNI*RGSIAKELDMDRNLADNMGMMATIIN
GLALENALNHLNVNTIVLSAIKCDKLVHESSANNIKKAIEKEQVMIFVAGTGFPYFTTDSCAAIRAAETESSIILMGKNG
VDGVYDSDPKINPNAQFYEHITFNMALTQNLKVMDATALALCQENNINLLVFNIDKPNAIVDVLEKKNKYTIVSK
>Mature_235_residues
MRKQRIVIKISGACLKQNDSSIIDFIKINDLAEQIEKISKKYIVSIVLGGGNI*RGSIAKELDMDRNLADNMGMMATIIN
GLALENALNHLNVNTIVLSAIKCDKLVHESSANNIKKAIEKEQVMIFVAGTGFPYFTTDSCAAIRAAETESSIILMGKNG
VDGVYDSDPKINPNAQFYEHITFNMALTQNLKVMDATALALCQENNINLLVFNIDKPNAIVDVLEKKNKYTIVSK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=35.6223175965665, Blast_Score=157, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 25720; Mature: 25720

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKQRIVIKISGACLKQNDSSIIDFIKINDLAEQIEKISKKYIVSIVLGGGNIRGSIAKE
CCCCEEEEEECCCEEECCCCCEEEEEEHHHHHHHHHHHHHEEEEEEEEECCCCCCHHHHH
LDMDRNLADNMGMMATIINGLALENALNHLNVNTIVLSAIKCDKLVHESSANNIKKAIEK
HCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHCCHHHHHHHHCC
EQVMIFVAGTGFPYFTTDSCAAIRAAETESSIILMGKNGVDGVYDSDPKINPNAQFYEHI
CEEEEEEEECCCCEEECCCCCEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEE
TFNMALTQNLKVMDATALALCQENNINLLVFNIDKPNAIVDVLEKKNKYTIVSK
EEEEEEECCCEEEHHHEEEEEECCCCEEEEEECCCCHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MRKQRIVIKISGACLKQNDSSIIDFIKINDLAEQIEKISKKYIVSIVLGGGNIRGSIAKE
CCCCEEEEEECCCEEECCCCCEEEEEEHHHHHHHHHHHHHEEEEEEEEECCCCCCHHHHH
LDMDRNLADNMGMMATIINGLALENALNHLNVNTIVLSAIKCDKLVHESSANNIKKAIEK
HCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHCCHHHHHHHHCC
EQVMIFVAGTGFPYFTTDSCAAIRAAETESSIILMGKNGVDGVYDSDPKINPNAQFYEHI
CEEEEEEEECCCCEEECCCCCEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEE
TFNMALTQNLKVMDATALALCQENNINLLVFNIDKPNAIVDVLEKKNKYTIVSK
EEEEEEECCCEEEHHHEEEEEECCCCEEEEEECCCCHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11048724 [H]