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The map label for this gene is glyS

Identifier: 13358056

GI number: 13358056

Start: 590546

End: 591967

Strand: Direct

Name: glyS

Synonym: UU493

Alternate gene names: 13358056

Gene position: 590546-591967 (Clockwise)

Preceding gene: 13358055

Following gene: 13358057

Centisome position: 78.56

GC content: 26.72

Gene sequence:

>1422_bases
ATGAGATATAAATTTAAAACACAAGAAGACTTAGTAAATCATTTAAAATCTGTTGGTTTTGTTTTTGCAAATTCAGAAAT
ATATAATGGATTAGCTAACGCATGAGATTATGGACCATTAGGTGTATTATTAAAAAATAATTTAAAAAATTTGTGGTGGA
AGGAATTTGTTACTAAACAAAAAAACATTGTAGGTTTAGATAGTGCCATCATTTTAAACCCCTTAGTATGAAAAGCAAGT
GGACATTTAGATAATTTTTCAGACCCATTAATTGATTGTAAAAGTTGTAAAACAAGATATCGTGCTGACAAATTGATTGA
ATCTTTTAATAAAGATATTCATATTGCTGAAAATTCTACTAATGAAGAATTTATGAAAGTTTTAAATGATCATAAGATCT
TCTGTCCTACATGCAAACAATTTAATTGAACTGATATTCGTCATTTTAACCTTATGTTTAAAACACACCAAGGAGTAATT
GAAGATCCTAAAAACATCGTTTATTTAAGACCAGAAACCGCTCAAGGTATTTTTGTTAACTTTAAAAATGTTCAGCGATC
AATGCGTTTACACTTACCATTTGGGATTGCACAAATAGGTAAATCATTTAGAAATGAAATAACTCCTGGTAATTTTATTT
TTAGAACTCGTGAATTTGAACAAATGGAAATTGAATTTTTCTTAAAAGAAGAAATTGCATATGATGTTTTTGATAAATAT
TTAAACCAAATTCAAAATTGATTAGTTACTTGTTGCGGATTAGATTTGAATAATTTAAGAAAACATGAACATCCCAAAGA
AGAATTATCACACTATTCAAAAAAAACAATTGATTTTGAATATAATTTCTTACATGGTTTTTCTGAATTATATGGAATTG
CATACCGAACTAATTATGATTTATCTGTGCATATGAATTTATCAAAAAAAGATTTAACATATTTTGATGAAGAAACTAAG
CAAAAATATATTCCTCATGTTATTGAACCATCAGTTGGTGTAGAAAGATTATTGTATGCTATTTTAACTGAGGCTACATT
TATTGAAAAACTAGCAAATGATGAAGACCGAATTTTAATGAATTTAAAATATGATCTAGCCCCTTATAAAATTGCTGTAA
TGCCATTAGTTAATAAATTAAAAGAAAAAGCAGAAGCAGTTTATAATAAAATTTTGGATTTAAATATTTCAGTAACTTTT
GATAATAGCGGAAGTATAGGCAAACGCTATCGCCGTCAAGATGCTATAGGAACAATTTATTGTATAACAATTGATTATGA
TTCATTTGGTGATGAACACGATCCTACTTTTACTATTCGTGAACGAAACACAATGGCTCAAAAAAGAATTAAATTATCAG
AGTTATCTTTATATTTAAGCCAAAAAGCTCATGAAGATTTTCAAAAGCAATGTCAAAAATAA

Upstream 100 bases:

>100_bases
AAAAATATTAAATTCTGTTCTTTATGATCAATTAGGAATTTATTTAACGATAATAAAAAATATTTAAATAAAAAAGGATT
TTAAAAAATAGGCAATAATT

Downstream 100 bases:

>100_bases
CTAACAATGTTTTTTTAACAATTCGTAATGCTATAAATATTTCCGATGTTATTCAAAATTACATTAAAGTAATTAAAAAG
GGTAATAATTATTGAGCTAT

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MRYKFKTQEDLVNHLKSVGFVFANSEIYNGLANAWDYGPLGVLLKNNLKNLWWKEFVTKQKNIVGLDSAIILNPLVWKAS
GHLDNFSDPLIDCKSCKTRYRADKLIESFNKDIHIAENSTNEEFMKVLNDHKIFCPTCKQFNWTDIRHFNLMFKTHQGVI
EDPKNIVYLRPETAQGIFVNFKNVQRSMRLHLPFGIAQIGKSFRNEITPGNFIFRTREFEQMEIEFFLKEEIAYDVFDKY
LNQIQNWLVTCCGLDLNNLRKHEHPKEELSHYSKKTIDFEYNFLHGFSELYGIAYRTNYDLSVHMNLSKKDLTYFDEETK
QKYIPHVIEPSVGVERLLYAILTEATFIEKLANDEDRILMNLKYDLAPYKIAVMPLVNKLKEKAEAVYNKILDLNISVTF
DNSGSIGKRYRRQDAIGTIYCITIDYDSFGDEHDPTFTIRERNTMAQKRIKLSELSLYLSQKAHEDFQKQCQK

Sequences:

>Translated_473_residues
MRYKFKTQEDLVNHLKSVGFVFANSEIYNGLANA*DYGPLGVLLKNNLKNLWWKEFVTKQKNIVGLDSAIILNPLV*KAS
GHLDNFSDPLIDCKSCKTRYRADKLIESFNKDIHIAENSTNEEFMKVLNDHKIFCPTCKQFN*TDIRHFNLMFKTHQGVI
EDPKNIVYLRPETAQGIFVNFKNVQRSMRLHLPFGIAQIGKSFRNEITPGNFIFRTREFEQMEIEFFLKEEIAYDVFDKY
LNQIQN*LVTCCGLDLNNLRKHEHPKEELSHYSKKTIDFEYNFLHGFSELYGIAYRTNYDLSVHMNLSKKDLTYFDEETK
QKYIPHVIEPSVGVERLLYAILTEATFIEKLANDEDRILMNLKYDLAPYKIAVMPLVNKLKEKAEAVYNKILDLNISVTF
DNSGSIGKRYRRQDAIGTIYCITIDYDSFGDEHDPTFTIRERNTMAQKRIKLSELSLYLSQKAHEDFQKQCQK
>Mature_473_residues
MRYKFKTQEDLVNHLKSVGFVFANSEIYNGLANA*DYGPLGVLLKNNLKNLWWKEFVTKQKNIVGLDSAIILNPLV*KAS
GHLDNFSDPLIDCKSCKTRYRADKLIESFNKDIHIAENSTNEEFMKVLNDHKIFCPTCKQFN*TDIRHFNLMFKTHQGVI
EDPKNIVYLRPETAQGIFVNFKNVQRSMRLHLPFGIAQIGKSFRNEITPGNFIFRTREFEQMEIEFFLKEEIAYDVFDKY
LNQIQN*LVTCCGLDLNNLRKHEHPKEELSHYSKKTIDFEYNFLHGFSELYGIAYRTNYDLSVHMNLSKKDLTYFDEETK
QKYIPHVIEPSVGVERLLYAILTEATFIEKLANDEDRILMNLKYDLAPYKIAVMPLVNKLKEKAEAVYNKILDLNISVTF
DNSGSIGKRYRRQDAIGTIYCITIDYDSFGDEHDPTFTIRERNTMAQKRIKLSELSLYLSQKAHEDFQKQCQK

Specific function: Catalyzes the attachment of glycine to tRNA(Gly) [H]

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI116805340, Length=369, Percent_Identity=29.5392953929539, Blast_Score=139, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI32564541, Length=335, Percent_Identity=30.1492537313433, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17554996, Length=335, Percent_Identity=30.1492537313433, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325338, Length=369, Percent_Identity=29.5392953929539, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6319597, Length=401, Percent_Identity=25.9351620947631, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24664462, Length=338, Percent_Identity=30.4733727810651, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21357965, Length=338, Percent_Identity=30.4733727810651, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.14 [H]

Molecular weight: Translated: 54759; Mature: 54759

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYKFKTQEDLVNHLKSVGFVFANSEIYNGLANADYGPLGVLLKNNLKNLWWKEFVTKQK
CCCCCCCHHHHHHHHHHHCEEEECHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
NIVGLDSAIILNPLVKASGHLDNFSDPLIDCKSCKTRYRADKLIESFNKDIHIAENSTNE
CEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHH
EFMKVLNDHKIFCPTCKQFNTDIRHFNLMFKTHQGVIEDPKNIVYLRPETAQGIFVNFKN
HHHHHHHCCCEECCCHHHCCCCHHHEEEEEEECCCCCCCCCCEEEECCCCCCEEEEEHHH
VQRSMRLHLPFGIAQIGKSFRNEITPGNFIFRTREFEQMEIEFFLKEEIAYDVFDKYLNQ
HHHHEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
IQNLVTCCGLDLNNLRKHEHPKEELSHYSKKTIDFEYNFLHGFSELYGIAYRTNYDLSVH
HHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHEEEEEHHHHHHHHHHHHEEEEECCEEEEE
MNLSKKDLTYFDEETKQKYIPHVIEPSVGVERLLYAILTEATFIEKLANDEDRILMNLKY
ECCCCCCCHHHCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
DLAPYKIAVMPLVNKLKEKAEAVYNKILDLNISVTFDNSGSIGKRYRRQDAIGTIYCITI
CCCCCEEHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHCCCEEEEEEEE
DYDSFGDEHDPTFTIRERNTMAQKRIKLSELSLYLSQKAHEDFQKQCQK
ECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRYKFKTQEDLVNHLKSVGFVFANSEIYNGLANADYGPLGVLLKNNLKNLWWKEFVTKQK
CCCCCCCHHHHHHHHHHHCEEEECHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
NIVGLDSAIILNPLVKASGHLDNFSDPLIDCKSCKTRYRADKLIESFNKDIHIAENSTNE
CEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHH
EFMKVLNDHKIFCPTCKQFNTDIRHFNLMFKTHQGVIEDPKNIVYLRPETAQGIFVNFKN
HHHHHHHCCCEECCCHHHCCCCHHHEEEEEEECCCCCCCCCCEEEECCCCCCEEEEEHHH
VQRSMRLHLPFGIAQIGKSFRNEITPGNFIFRTREFEQMEIEFFLKEEIAYDVFDKYLNQ
HHHHEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
IQNLVTCCGLDLNNLRKHEHPKEELSHYSKKTIDFEYNFLHGFSELYGIAYRTNYDLSVH
HHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHEEEEEHHHHHHHHHHHHEEEEECCEEEEE
MNLSKKDLTYFDEETKQKYIPHVIEPSVGVERLLYAILTEATFIEKLANDEDRILMNLKY
ECCCCCCCHHHCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
DLAPYKIAVMPLVNKLKEKAEAVYNKILDLNISVTFDNSGSIGKRYRRQDAIGTIYCITI
CCCCCEEHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHCCCEEEEEEEE
DYDSFGDEHDPTFTIRERNTMAQKRIKLSELSLYLSQKAHEDFQKQCQK
ECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA