Click here to switch to the map view.

The map label for this gene is obgE

Identifier: 13358024

GI number: 13358024

Start: 524749

End: 526056

Strand: Reverse

Name: obgE

Synonym: UU461

Alternate gene names: 13358024

Gene position: 526056-524749 (Counterclockwise)

Preceding gene: 13358025

Following gene: 13358023

Centisome position: 69.98

GC content: 28.36

Gene sequence:

>1308_bases
ATGGCATTTATTGATAAATGTAAAATCGTATTGATTGCAGGTAATGGTGGGGATGGAATTGTTTCATGACGTCGTGAAAC
TCATGTTCCAGAAGGTGGACCAGCTGGTGGAAATGGTGGAAATGGTGGGTCAATCTGATTTGTTGGTAATCACAATGAAA
CTTCATTAGAATTTTTAAAATATAAAAAAATTATTCGTGCAAAACATGGTGAAAAAGGCGATATTAAAAATCAACATGGT
GCGAATGCGGAAGATGTTTTTATTAATGTGCCACTAGGAACAGTTGTTTATAATCCTATCACTAATGAAATTTTGGCAGA
TATTAATATTGATCAACAAAAATATTTAGTTGCCCAAGGTGGTTTAGGCGGTCATGGAAATACACATTTTAAATCGCCTT
TTAATAAAGCACCAAATTTATATGAATTAGGAGAATTAGGTGAAAATGTTGAAGTTTTATTAGAATTAAAAACTATTGCT
GATATTGGAATTATAGGATTACCAAATGCAGGAAAATCAACATTAATTTCTACATTTACAAATGCTAAACCAAAAACGGC
AAATTACATGTTTACAACTTTAAATCCCGTTTTAGGTACAATTTATCGTGATCAAAATCGTATCATTTTTGCAGATATTC
CTGGTTTAATTGAAGGAGCACATACAGGAGTTGGCTTGGGGCATGATTTTTTAAAACATATCGAACGTTGTTTTTTATTA
ATTCATTTAATTTCTTTAGATCCTAATGATAATCCTGATATTATTAATGCTTATGAAACGATTGTTAATGAATTAAAACA
ATATAAACAAAATTTAGTTAACAAACCAATTGTATTGGTTGCTAATAAAATAGATCAAATTGGAGCATTAGAAAATTTGC
AGATTCTAAAAGAATATTTAAAAAATAATCAAGAAATTAAAATTATATCTGCGTTAACAAATTTACATGTAGATAATATG
TTAGATGATGTTATTAAAATTTACTTTGCACAAAAAAAGATTTATGAGCAACGACTTAAAGAACAATTACCAGTTGATCA
AATTTTAAAATGAACGAGTGATATTCCTAAAAGTAAAGAATTAGATAAAACTATTGAAATTATAAAAGTTGATGATCATA
TTTTTGAAGTCTTTGGTGAATATTTAAAATATTGAGCACATCGCATTCCCTTAAAAACGCAAGATAATTTAATTCGTTTT
AATCAAAAACTTCAAAGCATCAATTTTAACCAGCAATTACTACAAGCTGGAGCAGTAGCGGGGGATAGTATTAAAATATA
TGATATTACATTAGAATTTGAAGAGTAA

Upstream 100 bases:

>100_bases
ATAATGAATTTAACAAAAAACGTTTAGAATTAAAAAAGCGTAATAAAGCAAATGAACGAATAAAATATAAAGTTGAAGAT
GATCAAAAAGGAAAATAAGC

Downstream 100 bases:

>100_bases
ATAAATTATGAATAATGATTTGATTAAATATCTACAATGGTTGAAAAATGATTTTATAAAATTTTTAAATGACGCACAAA
CGAATAATGTTATTTTGGGC

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MAFIDKCKIVLIAGNGGDGIVSWRRETHVPEGGPAGGNGGNGGSIWFVGNHNETSLEFLKYKKIIRAKHGEKGDIKNQHG
ANAEDVFINVPLGTVVYNPITNEILADINIDQQKYLVAQGGLGGHGNTHFKSPFNKAPNLYELGELGENVEVLLELKTIA
DIGIIGLPNAGKSTLISTFTNAKPKTANYMFTTLNPVLGTIYRDQNRIIFADIPGLIEGAHTGVGLGHDFLKHIERCFLL
IHLISLDPNDNPDIINAYETIVNELKQYKQNLVNKPIVLVANKIDQIGALENLQILKEYLKNNQEIKIISALTNLHVDNM
LDDVIKIYFAQKKIYEQRLKEQLPVDQILKWTSDIPKSKELDKTIEIIKVDDHIFEVFGEYLKYWAHRIPLKTQDNLIRF
NQKLQSINFNQQLLQAGAVAGDSIKIYDITLEFEE

Sequences:

>Translated_435_residues
MAFIDKCKIVLIAGNGGDGIVS*RRETHVPEGGPAGGNGGNGGSI*FVGNHNETSLEFLKYKKIIRAKHGEKGDIKNQHG
ANAEDVFINVPLGTVVYNPITNEILADINIDQQKYLVAQGGLGGHGNTHFKSPFNKAPNLYELGELGENVEVLLELKTIA
DIGIIGLPNAGKSTLISTFTNAKPKTANYMFTTLNPVLGTIYRDQNRIIFADIPGLIEGAHTGVGLGHDFLKHIERCFLL
IHLISLDPNDNPDIINAYETIVNELKQYKQNLVNKPIVLVANKIDQIGALENLQILKEYLKNNQEIKIISALTNLHVDNM
LDDVIKIYFAQKKIYEQRLKEQLPVDQILK*TSDIPKSKELDKTIEIIKVDDHIFEVFGEYLKY*AHRIPLKTQDNLIRF
NQKLQSINFNQQLLQAGAVAGDSIKIYDITLEFEE
>Mature_434_residues
AFIDKCKIVLIAGNGGDGIVS*RRETHVPEGGPAGGNGGNGGSI*FVGNHNETSLEFLKYKKIIRAKHGEKGDIKNQHGA
NAEDVFINVPLGTVVYNPITNEILADINIDQQKYLVAQGGLGGHGNTHFKSPFNKAPNLYELGELGENVEVLLELKTIAD
IGIIGLPNAGKSTLISTFTNAKPKTANYMFTTLNPVLGTIYRDQNRIIFADIPGLIEGAHTGVGLGHDFLKHIERCFLLI
HLISLDPNDNPDIINAYETIVNELKQYKQNLVNKPIVLVANKIDQIGALENLQILKEYLKNNQEIKIISALTNLHVDNML
DDVIKIYFAQKKIYEQRLKEQLPVDQILK*TSDIPKSKELDKTIEIIKVDDHIFEVFGEYLKY*AHRIPLKTQDNLIRFN
QKLQSINFNQQLLQAGAVAGDSIKIYDITLEFEE

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=331, Percent_Identity=35.6495468277946, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI111955139, Length=291, Percent_Identity=37.4570446735395, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI111955063, Length=206, Percent_Identity=37.378640776699, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI58761500, Length=111, Percent_Identity=35.1351351351351, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI4758796, Length=175, Percent_Identity=33.7142857142857, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789574, Length=329, Percent_Identity=44.0729483282675, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1787454, Length=125, Percent_Identity=34.4, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=286, Percent_Identity=37.4125874125874, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17552324, Length=359, Percent_Identity=30.3621169916435, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17509631, Length=198, Percent_Identity=25.7575757575758, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=161, Percent_Identity=40.3726708074534, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6319281, Length=183, Percent_Identity=30.6010928961749, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI20129375, Length=325, Percent_Identity=37.5384615384615, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24585318, Length=276, Percent_Identity=39.8550724637681, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI17981711, Length=258, Percent_Identity=27.5193798449612, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356473, Length=134, Percent_Identity=33.5820895522388, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 47880; Mature: 47748

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFIDKCKIVLIAGNGGDGIVSRRETHVPEGGPAGGNGGNGGSIFVGNHNETSLEFLKYK
CCCCCCEEEEEEECCCCCCCCCCHHCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHH
KIIRAKHGEKGDIKNQHGANAEDVFINVPLGTVVYNPITNEILADINIDQQKYLVAQGGL
HHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHEEECCHHHHHHCCCCCCCCEEEEEECCC
GGHGNTHFKSPFNKAPNLYELGELGENVEVLLELKTIADIGIIGLPNAGKSTLISTFTNA
CCCCCCCCCCCHHCCCCCHHHHHCCCCCEEEEEEHHHHCCCEEECCCCCCHHHHHHHCCC
KPKTANYMFTTLNPVLGTIYRDQNRIIFADIPGLIEGAHTGVGLGHDFLKHIERCFLLIH
CCCCCCEEEEEHHHHHHHHEECCCCEEEEECCHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LISLDPNDNPDIINAYETIVNELKQYKQNLVNKPIVLVANKIDQIGALENLQILKEYLKN
HEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHCCHHHHHHHHHHHHC
NQEIKIISALTNLHVDNMLDDVIKIYFAQKKIYEQRLKEQLPVDQILKTSDIPKSKELDK
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC
TIEIIKVDDHIFEVFGEYLKYAHRIPLKTQDNLIRFNQKLQSINFNQQLLQAGAVAGDSI
EEEEEEECHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCE
KIYDITLEFEE
EEEEEEEEECC
>Mature Secondary Structure 
AFIDKCKIVLIAGNGGDGIVSRRETHVPEGGPAGGNGGNGGSIFVGNHNETSLEFLKYK
CCCCCEEEEEEECCCCCCCCCCHHCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHH
KIIRAKHGEKGDIKNQHGANAEDVFINVPLGTVVYNPITNEILADINIDQQKYLVAQGGL
HHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHEEECCHHHHHHCCCCCCCCEEEEEECCC
GGHGNTHFKSPFNKAPNLYELGELGENVEVLLELKTIADIGIIGLPNAGKSTLISTFTNA
CCCCCCCCCCCHHCCCCCHHHHHCCCCCEEEEEEHHHHCCCEEECCCCCCHHHHHHHCCC
KPKTANYMFTTLNPVLGTIYRDQNRIIFADIPGLIEGAHTGVGLGHDFLKHIERCFLLIH
CCCCCCEEEEEHHHHHHHHEECCCCEEEEECCHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LISLDPNDNPDIINAYETIVNELKQYKQNLVNKPIVLVANKIDQIGALENLQILKEYLKN
HEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHCCHHHHHHHHHHHHC
NQEIKIISALTNLHVDNMLDDVIKIYFAQKKIYEQRLKEQLPVDQILKTSDIPKSKELDK
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC
TIEIIKVDDHIFEVFGEYLKYAHRIPLKTQDNLIRFNQKLQSINFNQQLLQAGAVAGDSI
EEEEEEECHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCE
KIYDITLEFEE
EEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA