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The map label for this gene is hrcA

Identifier: 13357983

GI number: 13357983

Start: 485044

End: 486117

Strand: Direct

Name: hrcA

Synonym: UU421

Alternate gene names: 13357983

Gene position: 485044-486117 (Clockwise)

Preceding gene: 13357982

Following gene: 13357984

Centisome position: 64.52

GC content: 26.26

Gene sequence:

>1074_bases
ATGAAGAATACTAAAACATCGCAAGAACAAGTAATAGAATTAAAATTAAGTGATCGGCAAAAAAAAGTATTAAAATCTAT
CGTCGATGAATACACTATTAGTGCAACACCGGTCTCTTCAAAACTTTTAGTACAAAAAGAATTCAAAGATCAATCTTCTG
CTACAATTCGTAACGAAATGATGTTTCTTGAAAAAAACGGATTAATTGAAAAACAGCACATTAGTGGTGGGCGTGTTCCA
TCACTAAAAGGTTATGATTTTTATAATAAAAATTTAATTAATAAAAATAATAATGTTTCTGATAATTTTAAAATGCGTTT
ACATAAAATCCTTAGTAAACGATATTCCAATATTGATGAAATTTTAAATGCTGCTGTAAGTATCATTAATGAAACAACCC
AATTACCAGCTGTTGTTACAAAAACAAGTAGTGATGAATTATTAAAACGAATTGATTTAGTAAAAATCAATGATAATTCG
GCGTTAGTGTTAATTGTAACTTCAAGCGAAAACATTTTAACTCATTCAATTAAGCTTGATAAAAACACAAAATTTAATGA
TTTACAAACGTGTTTTAGTGTTTTAGATGAACGATTAGTTGATACTAAACTTAGTTTAATCAGTTCTAAATTAGATTTAA
TTGTCGATATAGTTCGTAATAAACTTGAAGAAGTAGAATACTATTTTAGTAAAATTGTACATCGTGTTTTTGATTTTTAC
GCTTATAAACCTAACATTGATTCTAAAACTTATGGAGTTAAATACTTAACTAAACATTCTGAATTTGAAGATCAACAAAA
ACTAAATGATTTACTAAATTTATTAGAAGACAGTACAATTTGACAACAAATTGCTTTAAACAAAAAAACTGATGGGTTAG
CAAAAATTATGCTAGGAAATGAAATTGGCCACGAACATTTAGCCATTGCAACAACTCAAATTAATTTAGCAAACACTAAT
CATCAAATTACCGTTGTAGGTCCAACAAGAATGGATTATGCAAAAATCAAAGCTTTATTAGATTTTTTAAAAATTGAAAT
TGAAAAAATTTTAGGATCAACAAATGAACATTAA

Upstream 100 bases:

>100_bases
GAGAATAACATTGAATCAATCGCTTTTCAAATTGAATCAAAACTAAGTACAATTATTAATGATTTTGAAGAATTATGAAT
TAAAGGTGGAGGTTTCCTTA

Downstream 100 bases:

>100_bases
AAAAATTAAACGTGAATTTAATACTCATTACGAATTGATTAAAAAAGAAATTAAAAACTTAAATGAATATAAAAAAGAAT
TAGAATTCTTAATTGCAACA

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKNTKTSQEQVIELKLSDRQKKVLKSIVDEYTISATPVSSKLLVQKEFKDQSSATIRNEMMFLEKNGLIEKQHISGGRVP
SLKGYDFYNKNLINKNNNVSDNFKMRLHKILSKRYSNIDEILNAAVSIINETTQLPAVVTKTSSDELLKRIDLVKINDNS
ALVLIVTSSENILTHSIKLDKNTKFNDLQTCFSVLDERLVDTKLSLISSKLDLIVDIVRNKLEEVEYYFSKIVHRVFDFY
AYKPNIDSKTYGVKYLTKHSEFEDQQKLNDLLNLLEDSTIWQQIALNKKTDGLAKIMLGNEIGHEHLAIATTQINLANTN
HQITVVGPTRMDYAKIKALLDFLKIEIEKILGSTNEH

Sequences:

>Translated_357_residues
MKNTKTSQEQVIELKLSDRQKKVLKSIVDEYTISATPVSSKLLVQKEFKDQSSATIRNEMMFLEKNGLIEKQHISGGRVP
SLKGYDFYNKNLINKNNNVSDNFKMRLHKILSKRYSNIDEILNAAVSIINETTQLPAVVTKTSSDELLKRIDLVKINDNS
ALVLIVTSSENILTHSIKLDKNTKFNDLQTCFSVLDERLVDTKLSLISSKLDLIVDIVRNKLEEVEYYFSKIVHRVFDFY
AYKPNIDSKTYGVKYLTKHSEFEDQQKLNDLLNLLEDSTI*QQIALNKKTDGLAKIMLGNEIGHEHLAIATTQINLANTN
HQITVVGPTRMDYAKIKALLDFLKIEIEKILGSTNEH
>Mature_357_residues
MKNTKTSQEQVIELKLSDRQKKVLKSIVDEYTISATPVSSKLLVQKEFKDQSSATIRNEMMFLEKNGLIEKQHISGGRVP
SLKGYDFYNKNLINKNNNVSDNFKMRLHKILSKRYSNIDEILNAAVSIINETTQLPAVVTKTSSDELLKRIDLVKINDNS
ALVLIVTSSENILTHSIKLDKNTKFNDLQTCFSVLDERLVDTKLSLISSKLDLIVDIVRNKLEEVEYYFSKIVHRVFDFY
AYKPNIDSKTYGVKYLTKHSEFEDQQKLNDLLNLLEDSTI*QQIALNKKTDGLAKIMLGNEIGHEHLAIATTQINLANTN
HQITVVGPTRMDYAKIKALLDFLKIEIEKILGSTNEH

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons [H]

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005104
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991 [H]

Pfam domain/function: PF03444 DUF293; PF01628 HrcA [H]

EC number: NA

Molecular weight: Translated: 40588; Mature: 40588

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTKTSQEQVIELKLSDRQKKVLKSIVDEYTISATPVSSKLLVQKEFKDQSSATIRNEM
CCCCCCCHHHEEEEECCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCHHHHHHHHH
MFLEKNGLIEKQHISGGRVPSLKGYDFYNKNLINKNNNVSDNFKMRLHKILSKRYSNIDE
EEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHH
ILNAAVSIINETTQLPAVVTKTSSDELLKRIDLVKINDNSALVLIVTSSENILTHSIKLD
HHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCEEEECCCCEEEEEEECCCCEEEEEEEEC
KNTKFNDLQTCFSVLDERLVDTKLSLISSKLDLIVDIVRNKLEEVEYYFSKIVHRVFDFY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYKPNIDSKTYGVKYLTKHSEFEDQQKLNDLLNLLEDSTIQQIALNKKTDGLAKIMLGNE
CCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHEEEECCC
IGHEHLAIATTQINLANTNHQITVVGPTRMDYAKIKALLDFLKIEIEKILGSTNEH
CCCCEEEEEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKNTKTSQEQVIELKLSDRQKKVLKSIVDEYTISATPVSSKLLVQKEFKDQSSATIRNEM
CCCCCCCHHHEEEEECCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCHHHHHHHHH
MFLEKNGLIEKQHISGGRVPSLKGYDFYNKNLINKNNNVSDNFKMRLHKILSKRYSNIDE
EEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHH
ILNAAVSIINETTQLPAVVTKTSSDELLKRIDLVKINDNSALVLIVTSSENILTHSIKLD
HHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCEEEECCCCEEEEEEECCCCEEEEEEEEC
KNTKFNDLQTCFSVLDERLVDTKLSLISSKLDLIVDIVRNKLEEVEYYFSKIVHRVFDFY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYKPNIDSKTYGVKYLTKHSEFEDQQKLNDLLNLLEDSTIQQIALNKKTDGLAKIMLGNE
CCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHEEEECCC
IGHEHLAIATTQINLANTNHQITVVGPTRMDYAKIKALLDFLKIEIEKILGSTNEH
CCCCEEEEEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA