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The map label for this gene is lytC [H]

Identifier: 126698619

GI number: 126698619

Start: 1214547

End: 1216586

Strand: Direct

Name: lytC [H]

Synonym: CD1035

Alternate gene names: 126698619

Gene position: 1214547-1216586 (Clockwise)

Preceding gene: 126698618

Following gene: 126698620

Centisome position: 28.31

GC content: 30.78

Gene sequence:

>2040_bases
ATGTTAAGTAAGGAGATTAATATGAGAAGAAATACAAAATTATTAACAACAGGAATTCTTTCAATGGCAATCGTCACACC
TACAATGGCATTTGCTACTGAATCTAATGCTATGGAAAATAACGCTGATTTAAATATAAACTTAGAGAAAAAAAGTATCG
TTTTAGGTAGTACCTCAAAAGTCAGTGTTAAGTTTAAAGAAAAACCAGATGCAGATAGCATTACATTAAAGTATAAATGC
TATGATATGCCATTGGATACAACTTTAAACTACAATCAATCAACTGAGTCATATGAAGGAACTATCAATTATAATAAAGA
CCCAGAATATCTAAATGTTTGGGAACTACAAGGGATAACAATAAACAGCAAAAATAATCCTAAAACTTTAAACAAACAAG
AACTAGAAAAGATGGGATTAAATTTAAAAGACTATAATGTAACACAGGAATGTATAATTGAAGATATAACTTCTAGAAAA
GATGTAAATAAATATTTAAGAAAAACTTCTGCACCTATTACAGAACTTACAGGAAGTGATAGATACGAAACAGCAGTTAA
AATAAGTAAAGAAGGCTGGAAAAATGGTTCAGATAAGGTAGTTATAATAAATGGGGATGTAAGTATAGATGGCATTATAT
CAACTCCACTAGCAACTACATATAATGCTCCAATACTTTTGGTTGAAAAAAACAATGTACCTAATAGTGTAAAATCAGAA
TTAAAGCGTTTAAATCCTAGAGATGTAATTATAATTGGAGATGAGAATGCTATTTCTAAAACTACTGCTAATCAAATTAA
ATCGACTGTAAATGCTAGTCAAACACGTCTAAAGGGCTCTAATAGATATGAGACATCTTTATTGATAGCAAAGGAAATAG
ATAAAAATCATGATGTGGAAAAAGTATACATAACAAATGCTAATGGCGGAGAAGTGGATGCACTTACTATAGCAGCAAAA
GCAGGTCAAGACAAGCAACCAATTATATTAACTGATAAAAATAGTATTACAGACAATACATATAAATGGTTAAAGAGTGA
GGATTTACAAAATGCTTATTTTATAGGTGGCCCTCAAATGATATCAACAAATGTTATAAATAAGGTAAATGATATAACTA
AAGATAATGTTACTAATAATAGAGTATATGGAGCAGATAGACACGAAACAAATGCAAACGTAATAAAAAAATTCTATACA
GATGATGAGTTAGAGGCTGTTTTAGTAGCTAAATCAGATGTACTTGTTGATGCTTTAGCAGCAGGTCCATTGGCTGCGAA
CTTAAAATCTCCAATACTTATAACACCAAAGACATATGTATCTGCATACCATAAAGAAAACTTAGAAGCTAAATCGGCAA
ATAAGGTATATAAAATAGGTGGAGGATTGACTTCTAAGGTAATGAGCTCTATAGCATCATCATTATCTAAACACAATACG
ACTCCAACAGAACCAGGAAATAGTGGGGGCAAGACAGTTATGATTGACCCAGGACATGGTGGTTCGGACACTGGAACAAC
AGGTAAACCATTAGGGGGTATTAGAGAAAAAGACTATACATTAAATACTTCACTTGCGACAACTGAATATTTACGTTCAA
AGGGATTCAATGTAATAATGACAAGAGACACAGATAAGACTTTATCTCTTGGAAATAGAACTGCTTTATCTAACTCTTTG
AGACCAGATTTATTTACGAGTATACACTATAATGCATCTGATACAACTGGGAATGGTGTAGAAGTATTTTATAAGCTTAA
AGATAAAGATGGAGGAACTACTAAGACTGTAGCTACAAATATATTAAATAGAATTTTAGAGAAATTTAATCTAAAAAATA
GAGGTGCAAAAACAAGAACACTATCAACTGACCCTACAAAAGATTATTTATATGTTTTAAGAAATAATGATATGCCAGCT
GTACTTGTAGAATGTGCATTTTTGGATAATGAGAAAGATATGAGTTTACTTAATACATCAAATAAAGTAAAAGAAATGGG
TACACAAATAGGTAAAGGCATAGAAGATTCATTAAAATAG

Upstream 100 bases:

>100_bases
TTTTAGAAGTTTATTTTTTATATAATTATTTATAATTTTGGGTAAAAACACTTTGATATATTTTCAAAAGATAAAAGATT
AAAAAACAAGGTAGAAATTT

Downstream 100 bases:

>100_bases
TCTACAATGAGAGCATAGAAAAATTTAAAATAAATTAATCTGCAATTTTAAATTTAAACTAAAGCTATAAGATAAGAATG
TAATTATAATAGTAATAAAG

Product: N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MLSKEINMRRNTKLLTTGILSMAIVTPTMAFATESNAMENNADLNINLEKKSIVLGSTSKVSVKFKEKPDADSITLKYKC
YDMPLDTTLNYNQSTESYEGTINYNKDPEYLNVWELQGITINSKNNPKTLNKQELEKMGLNLKDYNVTQECIIEDITSRK
DVNKYLRKTSAPITELTGSDRYETAVKISKEGWKNGSDKVVIINGDVSIDGIISTPLATTYNAPILLVEKNNVPNSVKSE
LKRLNPRDVIIIGDENAISKTTANQIKSTVNASQTRLKGSNRYETSLLIAKEIDKNHDVEKVYITNANGGEVDALTIAAK
AGQDKQPIILTDKNSITDNTYKWLKSEDLQNAYFIGGPQMISTNVINKVNDITKDNVTNNRVYGADRHETNANVIKKFYT
DDELEAVLVAKSDVLVDALAAGPLAANLKSPILITPKTYVSAYHKENLEAKSANKVYKIGGGLTSKVMSSIASSLSKHNT
TPTEPGNSGGKTVMIDPGHGGSDTGTTGKPLGGIREKDYTLNTSLATTEYLRSKGFNVIMTRDTDKTLSLGNRTALSNSL
RPDLFTSIHYNASDTTGNGVEVFYKLKDKDGGTTKTVATNILNRILEKFNLKNRGAKTRTLSTDPTKDYLYVLRNNDMPA
VLVECAFLDNEKDMSLLNTSNKVKEMGTQIGKGIEDSLK

Sequences:

>Translated_679_residues
MLSKEINMRRNTKLLTTGILSMAIVTPTMAFATESNAMENNADLNINLEKKSIVLGSTSKVSVKFKEKPDADSITLKYKC
YDMPLDTTLNYNQSTESYEGTINYNKDPEYLNVWELQGITINSKNNPKTLNKQELEKMGLNLKDYNVTQECIIEDITSRK
DVNKYLRKTSAPITELTGSDRYETAVKISKEGWKNGSDKVVIINGDVSIDGIISTPLATTYNAPILLVEKNNVPNSVKSE
LKRLNPRDVIIIGDENAISKTTANQIKSTVNASQTRLKGSNRYETSLLIAKEIDKNHDVEKVYITNANGGEVDALTIAAK
AGQDKQPIILTDKNSITDNTYKWLKSEDLQNAYFIGGPQMISTNVINKVNDITKDNVTNNRVYGADRHETNANVIKKFYT
DDELEAVLVAKSDVLVDALAAGPLAANLKSPILITPKTYVSAYHKENLEAKSANKVYKIGGGLTSKVMSSIASSLSKHNT
TPTEPGNSGGKTVMIDPGHGGSDTGTTGKPLGGIREKDYTLNTSLATTEYLRSKGFNVIMTRDTDKTLSLGNRTALSNSL
RPDLFTSIHYNASDTTGNGVEVFYKLKDKDGGTTKTVATNILNRILEKFNLKNRGAKTRTLSTDPTKDYLYVLRNNDMPA
VLVECAFLDNEKDMSLLNTSNKVKEMGTQIGKGIEDSLK
>Mature_679_residues
MLSKEINMRRNTKLLTTGILSMAIVTPTMAFATESNAMENNADLNINLEKKSIVLGSTSKVSVKFKEKPDADSITLKYKC
YDMPLDTTLNYNQSTESYEGTINYNKDPEYLNVWELQGITINSKNNPKTLNKQELEKMGLNLKDYNVTQECIIEDITSRK
DVNKYLRKTSAPITELTGSDRYETAVKISKEGWKNGSDKVVIINGDVSIDGIISTPLATTYNAPILLVEKNNVPNSVKSE
LKRLNPRDVIIIGDENAISKTTANQIKSTVNASQTRLKGSNRYETSLLIAKEIDKNHDVEKVYITNANGGEVDALTIAAK
AGQDKQPIILTDKNSITDNTYKWLKSEDLQNAYFIGGPQMISTNVINKVNDITKDNVTNNRVYGADRHETNANVIKKFYT
DDELEAVLVAKSDVLVDALAAGPLAANLKSPILITPKTYVSAYHKENLEAKSANKVYKIGGGLTSKVMSSIASSLSKHNT
TPTEPGNSGGKTVMIDPGHGGSDTGTTGKPLGGIREKDYTLNTSLATTEYLRSKGFNVIMTRDTDKTLSLGNRTALSNSL
RPDLFTSIHYNASDTTGNGVEVFYKLKDKDGGTTKTVATNILNRILEKFNLKNRGAKTRTLSTDPTKDYLYVLRNNDMPA
VLVECAFLDNEKDMSLLNTSNKVKEMGTQIGKGIEDSLK

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788776, Length=265, Percent_Identity=24.5283018867925, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 74678; Mature: 74678

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKEINMRRNTKLLTTGILSMAIVTPTMAFATESNAMENNADLNINLEKKSIVLGSTSK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCEEEEECCCE
VSVKFKEKPDADSITLKYKCYDMPLDTTLNYNQSTESYEGTINYNKDPEYLNVWELQGIT
EEEEECCCCCCCCEEEEEEEEECCCCCEECCCCCCCCCCCEEECCCCCCEEEEEEEEEEE
INSKNNPKTLNKQELEKMGLNLKDYNVTQECIIEDITSRKDVNKYLRKTSAPITELTGSD
ECCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCC
RYETAVKISKEGWKNGSDKVVIINGDVSIDGIISTPLATTYNAPILLVEKNNVPNSVKSE
CCEEEEEEEHHCCCCCCCEEEEEECCEEECCEECCCCCCCCCCCEEEEECCCCCHHHHHH
LKRLNPRDVIIIGDENAISKTTANQIKSTVNASQTRLKGSNRYETSLLIAKEIDKNHDVE
HHHCCCCEEEEECCCCCCHHHHHHHHHHHHCHHHHHCCCCCCCEEEEEEEECCCCCCCCE
KVYITNANGGEVDALTIAAKAGQDKQPIILTDKNSITDNTYKWLKSEDLQNAYFIGGPQM
EEEEECCCCCCEEEEEEEECCCCCCCCEEEECCCCCCCHHHHHHHCCCCCCEEEECCCCE
ISTNVINKVNDITKDNVTNNRVYGADRHETNANVIKKFYTDDELEAVLVAKSDVLVDALA
EHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHCCCCCCEEEEEECCCHHHHHHH
AGPLAANLKSPILITPKTYVSAYHKENLEAKSANKVYKIGGGLTSKVMSSIASSLSKHNT
CCCCHHCCCCCEEECCHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCC
TPTEPGNSGGKTVMIDPGHGGSDTGTTGKPLGGIREKDYTLNTSLATTEYLRSKGFNVIM
CCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHCCCEEEE
TRDTDKTLSLGNRTALSNSLRPDLFTSIHYNASDTTGNGVEVFYKLKDKDGGTTKTVATN
ECCCCCHHCCCCCHHHCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHH
ILNRILEKFNLKNRGAKTRTLSTDPTKDYLYVLRNNDMPAVLVECAFLDNEKDMSLLNTS
HHHHHHHHCCCCCCCCCCEECCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHCCH
NKVKEMGTQIGKGIEDSLK
HHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure
MLSKEINMRRNTKLLTTGILSMAIVTPTMAFATESNAMENNADLNINLEKKSIVLGSTSK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCEEEEECCCE
VSVKFKEKPDADSITLKYKCYDMPLDTTLNYNQSTESYEGTINYNKDPEYLNVWELQGIT
EEEEECCCCCCCCEEEEEEEEECCCCCEECCCCCCCCCCCEEECCCCCCEEEEEEEEEEE
INSKNNPKTLNKQELEKMGLNLKDYNVTQECIIEDITSRKDVNKYLRKTSAPITELTGSD
ECCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCC
RYETAVKISKEGWKNGSDKVVIINGDVSIDGIISTPLATTYNAPILLVEKNNVPNSVKSE
CCEEEEEEEHHCCCCCCCEEEEEECCEEECCEECCCCCCCCCCCEEEEECCCCCHHHHHH
LKRLNPRDVIIIGDENAISKTTANQIKSTVNASQTRLKGSNRYETSLLIAKEIDKNHDVE
HHHCCCCEEEEECCCCCCHHHHHHHHHHHHCHHHHHCCCCCCCEEEEEEEECCCCCCCCE
KVYITNANGGEVDALTIAAKAGQDKQPIILTDKNSITDNTYKWLKSEDLQNAYFIGGPQM
EEEEECCCCCCEEEEEEEECCCCCCCCEEEECCCCCCCHHHHHHHCCCCCCEEEECCCCE
ISTNVINKVNDITKDNVTNNRVYGADRHETNANVIKKFYTDDELEAVLVAKSDVLVDALA
EHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHCCCCCCEEEEEECCCHHHHHHH
AGPLAANLKSPILITPKTYVSAYHKENLEAKSANKVYKIGGGLTSKVMSSIASSLSKHNT
CCCCHHCCCCCEEECCHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCC
TPTEPGNSGGKTVMIDPGHGGSDTGTTGKPLGGIREKDYTLNTSLATTEYLRSKGFNVIM
CCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHCCCEEEE
TRDTDKTLSLGNRTALSNSLRPDLFTSIHYNASDTTGNGVEVFYKLKDKDGGTTKTVATN
ECCCCCHHCCCCCHHHCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHH
ILNRILEKFNLKNRGAKTRTLSTDPTKDYLYVLRNNDMPAVLVECAFLDNEKDMSLLNTS
HHHHHHHHCCCCCCCCCCEECCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHCCH
NKVKEMGTQIGKGIEDSLK
HHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]