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The map label for this gene is gutD [H]

Identifier: 126698348

GI number: 126698348

Start: 939165

End: 939938

Strand: Direct

Name: gutD [H]

Synonym: CD0768

Alternate gene names: 126698348

Gene position: 939165-939938 (Clockwise)

Preceding gene: 126698347

Following gene: 126698349

Centisome position: 21.89

GC content: 31.65

Gene sequence:

>774_bases
ATGAGAAAAGTGGCTTTAGTCGTTGGAGGAGGAAGAAGTTTAGGTGAATATTTATCTAAACATTTAGCTAAAGTAGGTTA
TGATGTTGCTATTGCAGATTTAAATGAAGACAACGCAAAAAAAGTAGCTGAAGAAATAAAAACTGAATTTGGTTGTAAAT
CTGTAGGATATAGTTGTAATGCCATAGATGAAAGACAGGTTATAAGTACTGTCAAAGCTATTGAAAATGATTTTGATAGA
ATAGATTTATTAGTGTACAATGCAGGAGTGGCTGTAAGTAAAAAAATAACTGATTTTGGATACAAAGATTTTAAATTTAT
TGTAGACGTAAATTTAAATGGGTACTTTCTATTTGCAAGAGAAGTATCTAAAGTCATGATAGCAAAAGGTATTGAGGGTA
GAATAATACAGATAAATTCAAAATCAGGTAGAGTGGGAAGCAAGCATAATTCAGGATATTCAGCAGGTAAATTTGCTGGA
GTAGGACTTACTCAAAGTTTAGCGCTAGATTTGGCAGAACATAAGATAACTGTAAATGCACTGATGCTCGGTAATTTACT
TGATTCTGATATGTTTGAAAGTTTAATTCCTCAATATGCAGTAAAATTGGGAATACCTGAATCAGAAGTCAAGCAAGTTT
ATATAGATAAAGTACCTTTAAAAAGAGGGTGTAGATTTATAGATGTTGCAAATATGCTTACATTTTATGCTTCAAAGGAA
GCTGAATACTGCACTGGTCAATCTATAAATATTACTGGTGGACAAGTTATGTAA

Upstream 100 bases:

>100_bases
AATTTAAAACGAATCTAATCATATTATAAGTAAATTATAGATAAAAGTCAATTTAACTAATCAAGTTAACTTTTAATGTG
ATAAAAAAGGGGAAATGAAA

Downstream 100 bases:

>100_bases
GGTTTTTATGGAGTGTCTCAAGATGAACTCTTTAGTTCATGAGGCACTTTTTTGTATAAAATTAAATATATTTTCAGCAT
TTAAACAATGAAAAAGAGGT

Product: sorbitol-6-phosphate dehydrogenase

Products: NA

Alternate protein names: Glucitol-6-phosphate dehydrogenase; Ketosephosphate reductase [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MRKVALVVGGGRSLGEYLSKHLAKVGYDVAIADLNEDNAKKVAEEIKTEFGCKSVGYSCNAIDERQVISTVKAIENDFDR
IDLLVYNAGVAVSKKITDFGYKDFKFIVDVNLNGYFLFAREVSKVMIAKGIEGRIIQINSKSGRVGSKHNSGYSAGKFAG
VGLTQSLALDLAEHKITVNALMLGNLLDSDMFESLIPQYAVKLGIPESEVKQVYIDKVPLKRGCRFIDVANMLTFYASKE
AEYCTGQSINITGGQVM

Sequences:

>Translated_257_residues
MRKVALVVGGGRSLGEYLSKHLAKVGYDVAIADLNEDNAKKVAEEIKTEFGCKSVGYSCNAIDERQVISTVKAIENDFDR
IDLLVYNAGVAVSKKITDFGYKDFKFIVDVNLNGYFLFAREVSKVMIAKGIEGRIIQINSKSGRVGSKHNSGYSAGKFAG
VGLTQSLALDLAEHKITVNALMLGNLLDSDMFESLIPQYAVKLGIPESEVKQVYIDKVPLKRGCRFIDVANMLTFYASKE
AEYCTGQSINITGGQVM
>Mature_257_residues
MRKVALVVGGGRSLGEYLSKHLAKVGYDVAIADLNEDNAKKVAEEIKTEFGCKSVGYSCNAIDERQVISTVKAIENDFDR
IDLLVYNAGVAVSKKITDFGYKDFKFIVDVNLNGYFLFAREVSKVMIAKGIEGRIIQINSKSGRVGSKHNSGYSAGKFAG
VGLTQSLALDLAEHKITVNALMLGNLLDSDMFESLIPQYAVKLGIPESEVKQVYIDKVPLKRGCRFIDVANMLTFYASKE
AEYCTGQSINITGGQVM

Specific function: Sorbitol metabolism. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=264, Percent_Identity=26.8939393939394, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI40254992, Length=254, Percent_Identity=28.3464566929134, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI19923817, Length=262, Percent_Identity=26.7175572519084, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI4504505, Length=217, Percent_Identity=30.8755760368664, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI59889578, Length=230, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI32483357, Length=256, Percent_Identity=25.78125, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI7705925, Length=260, Percent_Identity=25, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI310128830, Length=216, Percent_Identity=25.462962962963, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI310115468, Length=216, Percent_Identity=25.462962962963, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI4503817, Length=181, Percent_Identity=28.1767955801105, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789057, Length=258, Percent_Identity=60.8527131782946, Blast_Score=317, Evalue=4e-88,
Organism=Escherichia coli, GI1787335, Length=255, Percent_Identity=28.6274509803922, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1788459, Length=256, Percent_Identity=28.515625, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082100, Length=261, Percent_Identity=30.6513409961686, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=28.7937743190661, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI2367175, Length=256, Percent_Identity=29.6875, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=25.296442687747, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787905, Length=254, Percent_Identity=26.7716535433071, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=25.9842519685039, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789378, Length=259, Percent_Identity=26.2548262548263, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI2367365, Length=252, Percent_Identity=24.6031746031746, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=26.5873015873016, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17508895, Length=172, Percent_Identity=30.2325581395349, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=265, Percent_Identity=25.6603773584906, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17538182, Length=203, Percent_Identity=34.9753694581281, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=256, Percent_Identity=25.390625, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193203115, Length=208, Percent_Identity=24.5192307692308, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=208, Percent_Identity=24.5192307692308, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=208, Percent_Identity=26.4423076923077, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=214, Percent_Identity=29.4392523364486, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17536025, Length=258, Percent_Identity=25.5813953488372, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=259, Percent_Identity=28.957528957529, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=27.1653543307087, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17737361, Length=203, Percent_Identity=30.5418719211823, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24640492, Length=171, Percent_Identity=25.7309941520468, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28571526, Length=257, Percent_Identity=25.2918287937743, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859837, Length=205, Percent_Identity=29.7560975609756, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355631, Length=169, Percent_Identity=26.0355029585799, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24649181, Length=169, Percent_Identity=23.6686390532544, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281364892, Length=171, Percent_Identity=27.4853801169591, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.140 [H]

Molecular weight: Translated: 28088; Mature: 28088

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKVALVVGGGRSLGEYLSKHLAKVGYDVAIADLNEDNAKKVAEEIKTEFGCKSVGYSCN
CCEEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCHHCCCCCC
AIDERQVISTVKAIENDFDRIDLLVYNAGVAVSKKITDFGYKDFKFIVDVNLNGYFLFAR
CCCHHHHHHHHHHHHCCCCEEEEEEEECCCEEEHHHHHCCCCCEEEEEEECCCEEEEEHH
EVSKVMIAKGIEGRIIQINSKSGRVGSKHNSGYSAGKFAGVGLTQSLALDLAEHKITVNA
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHCEEEEHH
LMLGNLLDSDMFESLIPQYAVKLGIPESEVKQVYIDKVPLKRGCRFIDVANMLTFYASKE
EEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHCCEEEEHHHHHHHHHCCC
AEYCTGQSINITGGQVM
CCCCCCCEEECCCCCCC
>Mature Secondary Structure
MRKVALVVGGGRSLGEYLSKHLAKVGYDVAIADLNEDNAKKVAEEIKTEFGCKSVGYSCN
CCEEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCHHCCCCCC
AIDERQVISTVKAIENDFDRIDLLVYNAGVAVSKKITDFGYKDFKFIVDVNLNGYFLFAR
CCCHHHHHHHHHHHHCCCCEEEEEEEECCCEEEHHHHHCCCCCEEEEEEECCCEEEEEHH
EVSKVMIAKGIEGRIIQINSKSGRVGSKHNSGYSAGKFAGVGLTQSLALDLAEHKITVNA
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHCEEEEHH
LMLGNLLDSDMFESLIPQYAVKLGIPESEVKQVYIDKVPLKRGCRFIDVANMLTFYASKE
EEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHCCEEEEHHHHHHHHHCCC
AEYCTGQSINITGGQVM
CCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3553176; 9205837; 9278503; 6384188 [H]