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The map label for this gene is tyrS [H]

Identifier: 126696853

GI number: 126696853

Start: 1282340

End: 1283578

Strand: Reverse

Name: tyrS [H]

Synonym: P9301_15151

Alternate gene names: 126696853

Gene position: 1283578-1282340 (Counterclockwise)

Preceding gene: 126696854

Following gene: 126696852

Centisome position: 78.18

GC content: 32.12

Gene sequence:

>1239_bases
ATGTCAGATAATTTAATATTGCCATCATGGCTGTCAAGAGGAATAGAAGAATATTTTCCAATTAAAGGAACAGATCAAAC
CTTTTCGGAGATAATTGATCATGCGAAAAAAAATAATAAAAAATTAAGGGTTAAACTCGGGATCGATCCAACTGGAACAG
ATATTCATCTTGGGCACAGCATATTGTTTAAAAAACTTAGGGCATTTCAGGATAATGGACATATTGCAGTTCTAATTATT
GGTGATTTTACTGCTCAAATTGGAGACCCAACCGGAAAAAACAAAACAAGAGTTCAGTTATCGGAAAAACAAGTTAAGGA
TAATGCAAAAACATACTTAACCCAACTAGGGATGGGAAAGCCAGCTAATGAATCTATTTTAGATTTTGATTCAAAAGATA
GAATAGAAATTAGATATAACAGTGAATGGTTAAAAGGATTAAATCTTAACTCTATAATCGAATTAATGGGGAGTGCAACA
GTTAGTCAAATGCTAGCTAAGGAGGAATTTAATAAAAGGTACACTTCGCAAGTTCCAATTGCTTTGCATGAATTCTTATA
TCCACTATTACAAGGTTACGATTCGGTAGTCGTTCAAGCAGATATTGAGCTTGGAGGTACAGATCAGAAATTTAATATTG
CAATAGGAAGAGATCTTCAAAGGCATTTTAAACAAGAACCCCAATTTGGTGTTCTGCTGCCAATTTTGACAGGTTTAGAT
GGAATTAAGAAGATGAGTAAATCTGAATTTAACACCGTCGGTTTGACTGAAGATCCTCTTTCAATGTATTCAAAATTAGA
AAAAGTACCTGATAATTTAATACCTGCCTATTTTGAATTACTTACTGAATTAGATTTAAGTTTTCTGGAAAACTCAAATC
CTCGTGAATTACAGAGAAGAATGGCTTTAGAAGTTACTACTTTATTCCATGGGGATGAAAAAGCATTAAAGGCGCAATCA
AACTGTGAAAAATTATTCCTTGGACACAAAGAAAAAGTTGGAGAAATTCCAGAGATTTCTTTAAAAGAAGTAGTTTTTCC
AGTTAAGCTTTTTTACTTGTTAAGTGCTCTAAAACTTTTCAAATCTAGCAGCGAATCCAAAAGATCTATTAAAGGTGGAG
GTGTAAAAATTGATAGTGAGAAAGTAATAAATCCTGATTTGGTTTTTAATTCAAAAAATGATTTGGAAGGGAAAATTTTG
CAAATTGGAAAAAAAATAATTAAGAGGTTTGAAAACTGA

Upstream 100 bases:

>100_bases
GGGATTACCCCTGATCAAATGTTCGATCAAATGAATAAAACCTTAATAAGAATGAAGGATGAACTTGATAAAACTTCTTA
AATTTAACTGTTAAAGATTC

Downstream 100 bases:

>100_bases
AAATTGATGAATAAAAGATTTAATTCAGAAGATAAAATAATATTGGCAATTGATGGATTAGATGTAAGTCAAGCAAAATT
ACTTCTGGAAAAATGTCCTG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSDNLILPSWLSRGIEEYFPIKGTDQTFSEIIDHAKKNNKKLRVKLGIDPTGTDIHLGHSILFKKLRAFQDNGHIAVLII
GDFTAQIGDPTGKNKTRVQLSEKQVKDNAKTYLTQLGMGKPANESILDFDSKDRIEIRYNSEWLKGLNLNSIIELMGSAT
VSQMLAKEEFNKRYTSQVPIALHEFLYPLLQGYDSVVVQADIELGGTDQKFNIAIGRDLQRHFKQEPQFGVLLPILTGLD
GIKKMSKSEFNTVGLTEDPLSMYSKLEKVPDNLIPAYFELLTELDLSFLENSNPRELQRRMALEVTTLFHGDEKALKAQS
NCEKLFLGHKEKVGEIPEISLKEVVFPVKLFYLLSALKLFKSSSESKRSIKGGGVKIDSEKVINPDLVFNSKNDLEGKIL
QIGKKIIKRFEN

Sequences:

>Translated_412_residues
MSDNLILPSWLSRGIEEYFPIKGTDQTFSEIIDHAKKNNKKLRVKLGIDPTGTDIHLGHSILFKKLRAFQDNGHIAVLII
GDFTAQIGDPTGKNKTRVQLSEKQVKDNAKTYLTQLGMGKPANESILDFDSKDRIEIRYNSEWLKGLNLNSIIELMGSAT
VSQMLAKEEFNKRYTSQVPIALHEFLYPLLQGYDSVVVQADIELGGTDQKFNIAIGRDLQRHFKQEPQFGVLLPILTGLD
GIKKMSKSEFNTVGLTEDPLSMYSKLEKVPDNLIPAYFELLTELDLSFLENSNPRELQRRMALEVTTLFHGDEKALKAQS
NCEKLFLGHKEKVGEIPEISLKEVVFPVKLFYLLSALKLFKSSSESKRSIKGGGVKIDSEKVINPDLVFNSKNDLEGKIL
QIGKKIIKRFEN
>Mature_411_residues
SDNLILPSWLSRGIEEYFPIKGTDQTFSEIIDHAKKNNKKLRVKLGIDPTGTDIHLGHSILFKKLRAFQDNGHIAVLIIG
DFTAQIGDPTGKNKTRVQLSEKQVKDNAKTYLTQLGMGKPANESILDFDSKDRIEIRYNSEWLKGLNLNSIIELMGSATV
SQMLAKEEFNKRYTSQVPIALHEFLYPLLQGYDSVVVQADIELGGTDQKFNIAIGRDLQRHFKQEPQFGVLLPILTGLDG
IKKMSKSEFNTVGLTEDPLSMYSKLEKVPDNLIPAYFELLTELDLSFLENSNPRELQRRMALEVTTLFHGDEKALKAQSN
CEKLFLGHKEKVGEIPEISLKEVVFPVKLFYLLSALKLFKSSSESKRSIKGGGVKIDSEKVINPDLVFNSKNDLEGKILQ
IGKKIIKRFEN

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=436, Percent_Identity=27.9816513761468, Blast_Score=136, Evalue=4e-32,
Organism=Escherichia coli, GI1787925, Length=388, Percent_Identity=29.3814432989691, Blast_Score=129, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI25145802, Length=322, Percent_Identity=25.776397515528, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325160, Length=302, Percent_Identity=27.1523178807947, Blast_Score=93, Evalue=9e-20,
Organism=Drosophila melanogaster, GI20130383, Length=398, Percent_Identity=25.8793969849246, Blast_Score=118, Evalue=8e-27,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 46485; Mature: 46354

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNLILPSWLSRGIEEYFPIKGTDQTFSEIIDHAKKNNKKLRVKLGIDPTGTDIHLGHS
CCCCEECHHHHHCCHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCHH
ILFKKLRAFQDNGHIAVLIIGDFTAQIGDPTGKNKTRVQLSEKQVKDNAKTYLTQLGMGK
HHHHHHHHHCCCCCEEEEEEECCHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCC
PANESILDFDSKDRIEIRYNSEWLKGLNLNSIIELMGSATVSQMLAKEEFNKRYTSQVPI
CCCCCCCCCCCCCCEEEEECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ALHEFLYPLLQGYDSVVVQADIELGGTDQKFNIAIGRDLQRHFKQEPQFGVLLPILTGLD
HHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEEEECHHHHHHHHCCCCCCCHHHHHHCHH
GIKKMSKSEFNTVGLTEDPLSMYSKLEKVPDNLIPAYFELLTELDLSFLENSNPRELQRR
HHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
MALEVTTLFHGDEKALKAQSNCEKLFLGHKEKVGEIPEISLKEVVFPVKLFYLLSALKLF
HHHHHHHHEECCHHHHHHHHCHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KSSSESKRSIKGGGVKIDSEKVINPDLVFNSKNDLEGKILQIGKKIIKRFEN
HCCCHHHHHCCCCCEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDNLILPSWLSRGIEEYFPIKGTDQTFSEIIDHAKKNNKKLRVKLGIDPTGTDIHLGHS
CCCEECHHHHHCCHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCHH
ILFKKLRAFQDNGHIAVLIIGDFTAQIGDPTGKNKTRVQLSEKQVKDNAKTYLTQLGMGK
HHHHHHHHHCCCCCEEEEEEECCHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCC
PANESILDFDSKDRIEIRYNSEWLKGLNLNSIIELMGSATVSQMLAKEEFNKRYTSQVPI
CCCCCCCCCCCCCCEEEEECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ALHEFLYPLLQGYDSVVVQADIELGGTDQKFNIAIGRDLQRHFKQEPQFGVLLPILTGLD
HHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEEEECHHHHHHHHCCCCCCCHHHHHHCHH
GIKKMSKSEFNTVGLTEDPLSMYSKLEKVPDNLIPAYFELLTELDLSFLENSNPRELQRR
HHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
MALEVTTLFHGDEKALKAQSNCEKLFLGHKEKVGEIPEISLKEVVFPVKLFYLLSALKLF
HHHHHHHHEECCHHHHHHHHCHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KSSSESKRSIKGGGVKIDSEKVINPDLVFNSKNDLEGKILQIGKKIIKRFEN
HCCCHHHHHCCCCCEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA