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The map label for this gene is ilvC

Identifier: 126696839

GI number: 126696839

Start: 1270777

End: 1271766

Strand: Direct

Name: ilvC

Synonym: P9301_15011

Alternate gene names: 126696839

Gene position: 1270777-1271766 (Clockwise)

Preceding gene: 126696838

Following gene: 126696840

Centisome position: 77.4

GC content: 37.58

Gene sequence:

>990_bases
ATGACCCAACTCTTTTACGACACAGATGCAGATCTAAGTCTTTTAAATAATAAAACAATAGCGATTATTGGATATGGATC
ACAAGGTCATGCACATGCCCTAAATCTTAAAGATAGCGGTATGGATGTAATTGTTGGATTATATAAAGGAAGTAAGTCTG
AAAGCAAAGCTATTAGCGATGGTCTAAAAGTATTTAGCGTTTCTGAAGCTTGCGAAAAAGCAGACTGGATTATGATTCTC
CTCCCCGATGAGTTTCAGAAAGACGTTTACCTTAAAGAAATAGAACCAAACTTAAAAGAAGGAAAGATACTAAGTTTTGC
TCATGGCTTCAATATAAGATTCGGACTAATCAAGCCTCCTAGTTTTGTGGATGTTGTAATGATTGCCCCAAAAGGACCTG
GACACACTGTTCGTTGGGAATATCAGAATGGTCAAGGAGTTCCAGCACTGTTTGCAGTTGAGCAGGATTCTTCCGGAAGT
GCAAGATCATTGGCAATGGCTTACGCTAAAGGGATTGGCGGAACGAGAGCTGGGATTCTTGAAACAAACTTTAAAGAAGA
AACAGAAACTGATTTATTTGGCGAACAAGCGGTTTTGTGCGGAGGATTATCAGAACTGGTTAAATCAGGATTCGAAACTC
TTGTTGAGGCAGGTTATCAACCCGAACTTGCTTACTTCGAATGCTTACATGAAGTTAAACTTATTGTTGATTTAATGGTG
AAGGGAGGCTTATCTCAAATGAGAGATTCCATTTCAAATACTGCAGAATATGGAGATTATGTAAGTGGTAAAAGACTTAT
CAATAGTGATACAAAGAAAGAAATGCAGAAAATCCTAAAAGATATTCAAGATGGAACTTTCGCTAAGAATTTTGTCGAAG
AATGCGATAAGGACAAACCATTAATGACAAAATTAAGAGAGGAGAACTCAAAACATGAAATTGAGAAAGTGGGTAAAAGT
CTGCGCTCGATGTTCAGTTGGCTGAAATAA

Upstream 100 bases:

>100_bases
TAATATTTTAATTTTAATTTTTTAAATTAATAATTTTTTTGGTTTATTGCCACCTTAATGTCTAAAATATTAATTATCAA
ATGCAAAGAAGCTACAACTA

Downstream 100 bases:

>100_bases
ATTTATTTTTAATATTCCTTGGATCGATTGGTTTTGATTTTTTAATCGGCGATCCAAGATTTTTAATCCACCCAGTTCAA
GTAATTGGCTTTTACATAAA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MTQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAISDGLKVFSVSEACEKADWIMIL
LPDEFQKDVYLKEIEPNLKEGKILSFAHGFNIRFGLIKPPSFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDSSGS
ARSLAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMV
KGGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDKDKPLMTKLREENSKHEIEKVGKS
LRSMFSWLK

Sequences:

>Translated_329_residues
MTQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAISDGLKVFSVSEACEKADWIMIL
LPDEFQKDVYLKEIEPNLKEGKILSFAHGFNIRFGLIKPPSFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDSSGS
ARSLAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMV
KGGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDKDKPLMTKLREENSKHEIEKVGKS
LRSMFSWLK
>Mature_328_residues
TQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAISDGLKVFSVSEACEKADWIMILL
PDEFQKDVYLKEIEPNLKEGKILSFAHGFNIRFGLIKPPSFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDSSGSA
RSLAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMVK
GGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDKDKPLMTKLREENSKHEIEKVGKSL
RSMFSWLK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=312, Percent_Identity=36.5384615384615, Blast_Score=165, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6323387, Length=324, Percent_Identity=33.9506172839506, Blast_Score=152, Evalue=6e-38,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_PROM0 (A3PEE9)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001091725.1
- ProteinModelPortal:   A3PEE9
- SMR:   A3PEE9
- STRING:   A3PEE9
- GeneID:   4912838
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_15011
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   PMAR167546:P9301ORF_1528-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36405; Mature: 36274

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAISD
CCEEEECCCCCCEEECCCEEEEEEECCCCCEEEECCCCCCCEEEEEEECCCCCHHHHHHH
GLKVFSVSEACEKADWIMILLPDEFQKDVYLKEIEPNLKEGKILSFAHGFNIRFGLIKPP
HHHHEEHHHHHHCCCEEEEEECCCCCCCEEHHHCCCCCCCCCEEEEECCCEEEEEEECCC
SFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDSSGSARSLAMAYAKGIGGTRAGIL
CCEEEEEEECCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCEE
ETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMV
ECCCCCHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KGGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDKDKP
HCCHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCH
LMTKLREENSKHEIEKVGKSLRSMFSWLK
HHHHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAISD
CEEEECCCCCCEEECCCEEEEEEECCCCCEEEECCCCCCCEEEEEEECCCCCHHHHHHH
GLKVFSVSEACEKADWIMILLPDEFQKDVYLKEIEPNLKEGKILSFAHGFNIRFGLIKPP
HHHHEEHHHHHHCCCEEEEEECCCCCCCEEHHHCCCCCCCCCEEEEECCCEEEEEEECCC
SFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDSSGSARSLAMAYAKGIGGTRAGIL
CCEEEEEEECCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCEE
ETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMV
ECCCCCHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KGGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDKDKP
HCCHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCH
LMTKLREENSKHEIEKVGKSLRSMFSWLK
HHHHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA