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The map label for this gene is clpP

Identifier: 126696838

GI number: 126696838

Start: 1270054

End: 1270665

Strand: Direct

Name: clpP

Synonym: P9301_15001

Alternate gene names: 126696838

Gene position: 1270054-1270665 (Clockwise)

Preceding gene: 126696837

Following gene: 126696839

Centisome position: 77.35

GC content: 37.75

Gene sequence:

>612_bases
ATGCCAATAGGAACTCCAAGCGTGCCTTACAGACTTCCAGGAAGTCAATACGAAAGATGGGTCGACATATATACAAGACT
AGGTGTTGAAAGAATTCTTTTTCTCGGACAAGAAGTGAATGATGGTATTGCTAATAGCCTTGTTGCACAAATGCTTTATT
TAGATTCTGATGATAATTCCAAACCTATCTATCTGTATATAAATAGCCCAGGAGGATCAGTAACTGCTGGCTTAGCAATT
TATGACACTATTAAATACGTAAAAAGTGATGTAGTAACCATATGCGTAGGCCTCGCAGCTTCCATGGGAGCGTTCCTATT
GGCCGCTGGTACAAAAGGTAAAAGAGTTGCTTTGCCCCACAGCAGAATAATGATTCATCAACCCTTAGGAGGGACATCTC
AACGCCAAGCGAGTGATATTGAAATAGAAGCTAAGGAAATTTTAAGAATTAAAGATATGTTAAACATGTCTATGGCAGAT
ATGACAGGCCAATCATTTGAGAAAATTGAAAAGGATACTGATAGAGATTATTTTCTAAGTGCGGAAGAAGCAAAAAATTA
TGGATTAATTGATAGAGTAATCACACATCCAAGCGAAGCAAATCAGTCTTAA

Upstream 100 bases:

>100_bases
CCCACAAGAAGCCCTAGATTATGGAGTTATCGATAGAATACTTACAAGTCAAAAAGATCTACCAAATAAAATTTAACACT
CACAAAACTATTTTAAAATC

Downstream 100 bases:

>100_bases
ACTTTCTAAATTAATATTTTAATTTTAATTTTTTAAATTAATAATTTTTTTGGTTTATTGCCACCTTAATGTCTAAAATA
TTAATTATCAAATGCAAAGA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 203; Mature: 202

Protein sequence:

>203_residues
MPIGTPSVPYRLPGSQYERWVDIYTRLGVERILFLGQEVNDGIANSLVAQMLYLDSDDNSKPIYLYINSPGGSVTAGLAI
YDTIKYVKSDVVTICVGLAASMGAFLLAAGTKGKRVALPHSRIMIHQPLGGTSQRQASDIEIEAKEILRIKDMLNMSMAD
MTGQSFEKIEKDTDRDYFLSAEEAKNYGLIDRVITHPSEANQS

Sequences:

>Translated_203_residues
MPIGTPSVPYRLPGSQYERWVDIYTRLGVERILFLGQEVNDGIANSLVAQMLYLDSDDNSKPIYLYINSPGGSVTAGLAI
YDTIKYVKSDVVTICVGLAASMGAFLLAAGTKGKRVALPHSRIMIHQPLGGTSQRQASDIEIEAKEILRIKDMLNMSMAD
MTGQSFEKIEKDTDRDYFLSAEEAKNYGLIDRVITHPSEANQS
>Mature_202_residues
PIGTPSVPYRLPGSQYERWVDIYTRLGVERILFLGQEVNDGIANSLVAQMLYLDSDDNSKPIYLYINSPGGSVTAGLAIY
DTIKYVKSDVVTICVGLAASMGAFLLAAGTKGKRVALPHSRIMIHQPLGGTSQRQASDIEIEAKEILRIKDMLNMSMADM
TGQSFEKIEKDTDRDYFLSAEEAKNYGLIDRVITHPSEANQS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=182, Percent_Identity=51.6483516483517, Blast_Score=195, Evalue=2e-50,
Organism=Escherichia coli, GI1786641, Length=182, Percent_Identity=61.5384615384615, Blast_Score=232, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17538017, Length=179, Percent_Identity=55.3072625698324, Blast_Score=193, Evalue=5e-50,
Organism=Drosophila melanogaster, GI20129427, Length=182, Percent_Identity=52.1978021978022, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_PROM9 (Q319H4)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_397907.1
- ProteinModelPortal:   Q319H4
- SMR:   Q319H4
- STRING:   Q319H4
- GeneID:   3766226
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_1411
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   ANKLCAQ
- ProtClustDB:   PRK00277
- BioCyc:   PMAR74546:PMT9312_1411-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22367; Mature: 22236

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 101-101 ACT_SITE 126-126

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIGTPSVPYRLPGSQYERWVDIYTRLGVERILFLGQEVNDGIANSLVAQMLYLDSDDNS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
KPIYLYINSPGGSVTAGLAIYDTIKYVKSDVVTICVGLAASMGAFLLAAGTKGKRVALPH
CCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEECCC
SRIMIHQPLGGTSQRQASDIEIEAKEILRIKDMLNMSMADMTGQSFEKIEKDTDRDYFLS
CEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEE
AEEAKNYGLIDRVITHPSEANQS
HHHCCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PIGTPSVPYRLPGSQYERWVDIYTRLGVERILFLGQEVNDGIANSLVAQMLYLDSDDNS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
KPIYLYINSPGGSVTAGLAIYDTIKYVKSDVVTICVGLAASMGAFLLAAGTKGKRVALPH
CCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEECCC
SRIMIHQPLGGTSQRQASDIEIEAKEILRIKDMLNMSMADMTGQSFEKIEKDTDRDYFLS
CEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEE
AEEAKNYGLIDRVITHPSEANQS
HHHCCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA