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The map label for this gene is trpC

Identifier: 126696820

GI number: 126696820

Start: 1250371

End: 1251258

Strand: Reverse

Name: trpC

Synonym: P9301_14821

Alternate gene names: 126696820

Gene position: 1251258-1250371 (Counterclockwise)

Preceding gene: 126696821

Following gene: 126696819

Centisome position: 76.21

GC content: 29.73

Gene sequence:

>888_bases
ATGGAGATAAGACGCAGGCCACCAAATCCAACAGTAAGGGTAGAAAATTTAGAATATGCTGTACCTCATAGAGAAGCACA
AGCAAAAAATATTCTGGAAGAAATTGTATGGCACAAAGATATTGAAATTAAGAATTTTAAAAAAATAGTCTCTTTAGAAG
ATCTCATCAAAAAGATTGAAAAACTTCCAACTCCCAAAGATTTTTATAAAAATATTTTGGAGTCAAAAATAAAACCAGGA
GTTATTGCTGAAATAAAAAAAGCTAGTCCAAGTAAAGGAGTTATTAGAAAAGATTTTAACCCTGAAAACATAGCAATTTG
TTACGAAGGATTAGGTGCATCATGTATCTCAGTACTTACCGATAAAAGGTTCTTTCAAGGTAGTTATGAAATACTCGAAA
CTGTAAGGAGATCAACTAATCTCCCTCTACTCTGCAAAGATTTTATTATTTCTGCTTATCAGATTTATAAAGCAAGGGTA
TCTGGTGCTGATGCAATATTATTAATCGCTGCGATTTTAAGTGATGACGATTTAATTTATTTAAAGAAAATAGCTGATAA
TTTAAAGATGAGTGTTCTTGTTGAAGTCCATAATGCAGATGAATTAGAAAGGATTCTAAAGTTAAAATCTTTTAATTTGA
TTGGAATAAATAATAGGGACTTAAAGACTTTTAAAACAGATTTAAAAACATCAATAGAATTGATGCATACATATGCAGAT
ATATTTCTAAAACAAAATATTATTCCCATAAGTGAATCTGGAATTAATTGTGCCGAAGATTTAGAATCGCTTAGATCTAT
TGGCATCAAGGGAGTATTAATTGGTGAAACTTTTATGAGAGAAACGGATATTGAACAATCGTTCAAGAAATTATTTACCT
CAATTTAA

Upstream 100 bases:

>100_bases
TCAATTATCTAAAGAAGTTCATACTCATCCTACTCTTAGTGAAGTAGTTGAGGTCGCATATAAACAAGCAGCTTCTCAAA
TAAAATAATTTCTAAAATTA

Downstream 100 bases:

>100_bases
TATTGACTTCAAATCGTGCTATAAAATTGAATAAACAGAGTTGTACTGAATATATATGCAGGCTGTAATTTTAACAGGTA
TAGTCGCAGGATTTGTTCAT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MEIRRRPPNPTVRVENLEYAVPHREAQAKNILEEIVWHKDIEIKNFKKIVSLEDLIKKIEKLPTPKDFYKNILESKIKPG
VIAEIKKASPSKGVIRKDFNPENIAICYEGLGASCISVLTDKRFFQGSYEILETVRRSTNLPLLCKDFIISAYQIYKARV
SGADAILLIAAILSDDDLIYLKKIADNLKMSVLVEVHNADELERILKLKSFNLIGINNRDLKTFKTDLKTSIELMHTYAD
IFLKQNIIPISESGINCAEDLESLRSIGIKGVLIGETFMRETDIEQSFKKLFTSI

Sequences:

>Translated_295_residues
MEIRRRPPNPTVRVENLEYAVPHREAQAKNILEEIVWHKDIEIKNFKKIVSLEDLIKKIEKLPTPKDFYKNILESKIKPG
VIAEIKKASPSKGVIRKDFNPENIAICYEGLGASCISVLTDKRFFQGSYEILETVRRSTNLPLLCKDFIISAYQIYKARV
SGADAILLIAAILSDDDLIYLKKIADNLKMSVLVEVHNADELERILKLKSFNLIGINNRDLKTFKTDLKTSIELMHTYAD
IFLKQNIIPISESGINCAEDLESLRSIGIKGVLIGETFMRETDIEQSFKKLFTSI
>Mature_295_residues
MEIRRRPPNPTVRVENLEYAVPHREAQAKNILEEIVWHKDIEIKNFKKIVSLEDLIKKIEKLPTPKDFYKNILESKIKPG
VIAEIKKASPSKGVIRKDFNPENIAICYEGLGASCISVLTDKRFFQGSYEILETVRRSTNLPLLCKDFIISAYQIYKARV
SGADAILLIAAILSDDDLIYLKKIADNLKMSVLVEVHNADELERILKLKSFNLIGINNRDLKTFKTDLKTSIELMHTYAD
IFLKQNIIPISESGINCAEDLESLRSIGIKGVLIGETFMRETDIEQSFKKLFTSI

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=264, Percent_Identity=39.7727272727273, Blast_Score=171, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6322638, Length=281, Percent_Identity=34.5195729537367, Blast_Score=146, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_PROM0 (A3PED0)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001091706.1
- ProteinModelPortal:   A3PED0
- SMR:   A3PED0
- STRING:   A3PED0
- GeneID:   4911938
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_14821
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   PMAR167546:P9301ORF_1506-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 33627; Mature: 33627

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRRRPPNPTVRVENLEYAVPHREAQAKNILEEIVWHKDIEIKNFKKIVSLEDLIKKIE
CCCCCCCCCCCEEEECCEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
KLPTPKDFYKNILESKIKPGVIAEIKKASPSKGVIRKDFNPENIAICYEGLGASCISVLT
HCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEECCCCCCCEEEEECCCCHHHHHHHH
DKRFFQGSYEILETVRRSTNLPLLCKDFIISAYQIYKARVSGADAILLIAAILSDDDLIY
HHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEH
LKKIADNLKMSVLVEVHNADELERILKLKSFNLIGINNRDLKTFKTDLKTSIELMHTYAD
HHHHHCCCEEEEEEEECCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHH
IFLKQNIIPISESGINCAEDLESLRSIGIKGVLIGETFMRETDIEQSFKKLFTSI
HHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MEIRRRPPNPTVRVENLEYAVPHREAQAKNILEEIVWHKDIEIKNFKKIVSLEDLIKKIE
CCCCCCCCCCCEEEECCEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
KLPTPKDFYKNILESKIKPGVIAEIKKASPSKGVIRKDFNPENIAICYEGLGASCISVLT
HCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEECCCCCCCEEEEECCCCHHHHHHHH
DKRFFQGSYEILETVRRSTNLPLLCKDFIISAYQIYKARVSGADAILLIAAILSDDDLIY
HHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEH
LKKIADNLKMSVLVEVHNADELERILKLKSFNLIGINNRDLKTFKTDLKTSIELMHTYAD
HHHHHCCCEEEEEEEECCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHH
IFLKQNIIPISESGINCAEDLESLRSIGIKGVLIGETFMRETDIEQSFKKLFTSI
HHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA